正清风痛宁电致孔给药肾俞、邱氏穴在肾绞痛治疗中的应用
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摘要
目的验证正清风痛宁电致孔给药肾俞、邱氏穴治疗肾绞痛的临床效果。方法共筛选2016年9月~2017年9月于本院住院的75例肾绞痛患者作为研究对象,并随机分成实验组、对照组A和对照组B,每组25例。实验组应用正清风痛宁电致孔给药肾俞、邱氏穴,对照组A应用氟比洛芬酯注射液静脉滴注,对照组B应用生理盐水电致孔给药肾俞、邱氏穴。通过比较三组治疗前后的VAS评分、疼痛缓解维持时间积分,腹部平片、泌尿系B超及肾功能的评价积分以判定疗效。结果三组治疗后的VAS评分、疼痛缓解维持时间积分、腹部平片、泌尿系B超及肾功能的评价积分较治疗前均明显降低,且实验组治疗后的积分明显低于对照组A、B(P<0.05)。治疗组的总有效率为92.0%,对照组A为68.0%,对照组B为56.0%,实验组的疗效明显优于对照组A、B(P=0.024)。结论正清风痛宁电致孔给药肾俞、邱氏穴治疗肾绞痛的效果显著,为临床推广应用提供科学依据。
Objective To verify the clinical effect of Zhengqing Fengtongning via electroporation to Shenshu and Qiu acupoint in the treatment of renal colic.Methods A total of 75 inpatients with renal colic treated in our hospital from September 2016 to September 2017 were screened as research objects.They were randomly divided into the experimental group,control group A and control group B,and there were 25 patients in each group.In the experimental group,Zhengqing Fengtongning via electroporation to Shenshu and Qiu acupoint was applied,while in the control group A,Flurbiprofen Axetil injection for intravenous dripping,and in the control group B,normal saline via electroporation to Shenshu and Qiu acupoint was adopted.VAS score,score of pain relief maintenance time,and score of abdominal plain film,B ultrasound in urinary system,and renal function evaluation before and after treatment were compared in order to evaluate the effect.Results VAS score,score of pain relief maintenance time,and score of abdominal plain film,B ultrasound in urinary system,and renal function evaluation among the three groups after treatment were all significantly lower than those before therapy.The score of these indexes in the experimental group were greatly lower than those in the control group A and B(P<0.05).The total effective rate was 92.0% in the treatment group,and 68.0% in control group A and 56.0% in the control group B,and the curative effect in the experimental group was significantly better than that in the control group(P=0.024).Conclusion Zhengqing Fengtongning via electroporation to Shenshu and Qiu acupoint in the treatment of renal colic can obtain a remarkable effect,which provide scientific basis for clinical application and promotion.
Objective To verify the clinical effect of Zhengqing Fengtongning via electroporation to Shenshu and Qiu acupoint in the treatment of renal colic.Methods A total of 75 inpatients with renal colic treated in our hospital from September 2016 to September 2017 were screened as research objects.They were randomly divided into the experimental group,control group A and control group B,and there were 25 patients in each group.In the experimental group,Zhengqing Fengtongning via electroporation to Shenshu and Qiu acupoint was applied,while in the control group A,Flurbiprofen Axetil injection for intravenous dripping,and in the control group B,normal saline via electroporation to Shenshu and Qiu acupoint was adopted.VAS score,score of pain relief maintenance time,and score of abdominal plain film,B ultrasound in urinary system,and renal function evaluation before and after treatment were compared in order to evaluate the effect.Results VAS score,score of pain relief maintenance time,and score of abdominal plain film,B ultrasound in urinary system,and renal function evaluation among the three groups after treatment were all significantly lower than those before therapy.The score of these indexes in the experimental group were greatly lower than those in the control group A and B(P<0.05).The total effective rate was 92.0% in the treatment group,and 68.0% in control group A and 56.0% in the control group B,and the curative effect in the experimental group was significantly better than that in the control group(P=0.024).Conclusion Zhengqing Fengtongning via electroporation to Shenshu and Qiu acupoint in the treatment of renal colic can obtain a remarkable effect,which provide scientific basis for clinical application and promotion.
引文
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[2]国家中医药管理局.中医病症诊断疗效标准[M].南京:南京大学出版社,1994:26-27.
[3]陈新,毛兵,车德亚,等.正清风痛宁注射液电致孔透皮给药治疗痛风性关节炎临床观察[J].中国中医急症,2014,23(4):706-708.
[4]蒋春舫,程平.肾绞痛的药物治疗[J].临床急诊杂志.2011,12(3):145-146.
[5]黎忠于,唐晓波,汤胜华,等.复方麝香注射液穴位注射对泌尿系结石肾绞痛的镇痛作用观察[J].中国中医急症,2011,20(2):179-180.
[6]吴晶金,彭江云.祛风散寒除湿中药正清风痛宁缓释片对小鼠软骨细胞TGF-β、IL-1β、Fst I-1、TIMP-3表达水平的影响[J].风湿病与关节炎,2014,3(1):19-24.
[7]孙霞,于晓佳,邱明丰.青风藤药理与临床研究进展[J].中国中西医结合外科杂志,2005,11(4):363-364.
[8]陈家佳,张英.正清风痛宁关节腔注射液治疗类风湿关节炎疗效观察[J].内蒙古中医药,2011,30(10):21-22
[9]甘文,袁艳辉.正清风痛宁针片连用治疗痛风性关节炎31例[J].中医药导报,2007,13(12):50.
[10]邱云桥.穴位指压治疗肾绞痛临床观察[J].中国中医急症,2013,22(9):1608-1609.
[11]许军峰.针灸治疗肾绞痛近况[J].针灸临床杂志,2009,25(8):52-54.
[12]李涛城.针刺邱氏穴对输卵管结石排出的临床观察[D].广州:广州中医药大学,2016.
[13]Brown MB,Traynor MJ,Martin GP,et al.Transdermal drug delivery systems:skin perturbation devices[J].Methods Mol Biol,2008,437:119-139.
[14]岳奇峰,郝保华,邓周虎.电致孔条件下不同电学参数对青藤碱透皮给药的影响[J].中草药,2006,37(11),1639-1641.
[15]陈芳.电致孔对药物透皮转运的影响[D].上海:上海医药工业研究院,2005.
[16]李连,何泽云,李旭华,等.正清风痛宁穴位透皮法治疗慢性肾炎的临床观察[J].湖南中医药大学学报,2015,35(11):45-47.