p53蛋白在心力衰竭发生发展及治疗中的作用研究进展
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摘要
p53蛋白是一种调控转录的序列特异性DNA结合蛋白,是研究较为广泛的肿瘤抑制因子,其在促进心力衰竭的发生发展中亦具有重要作用。p53蛋白可通过参与氧化应激、心肌细胞凋亡、炎症反应、心肌肥厚和血管生成等来调控心力衰竭的发生发展,丹参酮ⅡA、蕨麻、暖心胶囊等中药、中成药可通过调节p53蛋白的表达改善心力衰竭的进展。
引文
[1]Ziaeian B,Fonarow GC. Epidemiology and aetiology of heart failure[J]. Nat Rev Cardiol,2016,13(6):368-378.
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[3]Joerger AC,Fersht AR. Structural biology of the tumor suppressor p53[J]. Annu Rev Biochem,2008,77(1):557-582.
[4]Walter K,Warnecke G,Bowater R,et al. Tumor suppressor p53binds with high affinity to CTG. CAG trinucleotide repeats and induces topological alterations in mismatched duplexes[J]. J Biol Chem,2005,280(52):42497-42507.
[5]Brázda V,Coufal J. Recognition of local DNA structures by p53protein[J]. Int J Mol Sci,2017,18(2):375.
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[8]Matoba S,Kang JG,Patino WD,et al. p53 regulates mitochondrial respiration[J]. Science,2006,312(5780):1650-1653.
[9]Kortlever RM,Higgins PJ,Bernards R. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence[J]. Nat Cell Biol,2006,8(8):877-884.
[10]Roger L,Gadea G,Roux P. Control of cell migration:a tumour suppressor function for p53[J]. Bio Cell,2006,98(3):141-152.
[11]Wang X,Guo K,Zeng Q,et al. p53 Functions as a negative regulator of osteoblastogenesis,osteoblast-dependent osteoclastogenesis,and bone remodeling[J]. J Cell Biol,2006,172(1):115-125.
[12]Tsutsui H,Kinugawa S,Matsushima S. Oxidative stress and heart failure[J]. Am J Physiol Heart Circ Physiol,2011,301(6):2181-2190.
[13]Heiko BE,Dale A. Mitochondria in the diabetic heart[J]. Cardiovasc Res,2010,88(2):229-240.
[14]Nakamura H,Matoba S,Iwai-Kanai E,et al. p53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation[J]. Circ Heart Fail,2012,5(1):106-115.
[15]Miyashita T,Krajewski S,Krajewska M,et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo[J]. Oncogene,1994,9(6):1799-1805.
[16]Sun A,Zou Y,Wang P,et al. Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice[J]. J Am Heart Assoc,2014,3(5):e000779.
[17]Crighton D,Wilkinson S,O'Prey J,et al. DRAM,a p53-induced modulator of autophagy,is critical for apoptosis[J]. Cell,2006,126(1):121-134.
[18]Bensaad K,Tsuruta A,Selak MA,et al. TIGAR,a p53-inducible regulator of glycolysis and apoptosis[J]. Cell,2006,126(1):107-120.
[19]Heymans S,Hirsch E,Anker SD,et al. Inflammation as a therapeutic target in heart failure? A scientific statement from the translational research committee of the heart failure association of the european society of cardiology[J]. Eur J Heart Fail,2009,11(2):119-129.
[20]Yoshida Y,Shimizu I,Minamino T. Inhibition of adipose inflammation as a novel therapeutic target for heart failure[J]. J Card Fail,2012,18(10):S151-S151.
[21]Shimizu I,Yoshida Y,Katsuno T,et al. Adipose tissue inflammation in diabetes and heart failure[J]. Microbes Infect,2013,15(1):11-17.
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[26]Gogiraju R,Xu X,Bochenek ML,et al. Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice[J]. J Am Heart Assoc,2015,4(2):e001770.
[27]Oka T,Akazawa H,Naito AT,et al. Angiogenesis and cardiac hypertrophy:maintenance of cardiac function and causative roles in heart failure[J]. Circ Res,2014,114(3):565-571.
[28]Gogiraju R,Steinbreche JH,Lehnart SE,et al. Deletion Of p53 in endothelial cells prevents cardiac fibrosis and heart failure induced by pressureoverload in mice via enhanced angiogenesis[J]. Circ Res,2008,103(5):e35-e70.
[29]Chi J,Li Z,Hong X,et al. Inhalation of hydrogen attenuates progression of chronic heart failure via suppression of oxidative stress and p53 related to apoptosis pathway in rats[J]. Front Physiol,2018,9:1026.
[30]Patel TH,Kimura H,Weiss CR,et al. Constitutively active HIF-1αimproves perfusion and arterial remodeling in an endovascular model of limb ischemia[J]. Cardiovasc Res,2005,68(1):144-154.
[31]Samper E,Flores JM,Blasco MA. Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc/mice with short telomeres[J]. Embo Rep,2001,2(9):800-807.
[32]王建刚,江凤林,冯俊,等.丹参酮ⅡA对血管紧张素Ⅱ诱导的心肌细胞肥大与凋亡干预的研究[J].中国现代医学杂志,2007,17(18):2202-2204.
[33]王伊林,单晓彤,柴花,等.丹参酮ⅡA磺酸钠腹腔注射对阿霉素心肌病大鼠心功能及左心室纤维化的影响[J].山东医药,2016,56(7):34-36.
[34]李建宇,李灵芝,龚海英,等.蕨麻对缺氧诱导心肌细胞凋亡的影响[J].中华老年心脑血管病杂志,2007,9(9):619-622.
[35]潘光明,盛小刚,张磊,等.暖心胶囊对心力衰竭模型大鼠的心肌细胞及p53蛋白表达的影响[J].上海中医药杂志,2010,44(11):69-72.
[2]Ponikowski P,Anker SD,Alhabib KF,et al. Heart failure:preventing disease and death worldwide[J]. Esc Heart Failure,2015,1(1):4-25.
[3]Joerger AC,Fersht AR. Structural biology of the tumor suppressor p53[J]. Annu Rev Biochem,2008,77(1):557-582.
[4]Walter K,Warnecke G,Bowater R,et al. Tumor suppressor p53binds with high affinity to CTG. CAG trinucleotide repeats and induces topological alterations in mismatched duplexes[J]. J Biol Chem,2005,280(52):42497-42507.
[5]Brázda V,Coufal J. Recognition of local DNA structures by p53protein[J]. Int J Mol Sci,2017,18(2):375.
[6]Tutton S,Azzam GA,Stong N,et al. Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres[J].EMBO J,2016,35(2):193-207.
[7]Dumble M,Gatza C,Tyner S,et al. Insights into aging obtained from p53 mutant mouse models[J]. Ann N Y Acad Sci,2010,1019(1):171-177.
[8]Matoba S,Kang JG,Patino WD,et al. p53 regulates mitochondrial respiration[J]. Science,2006,312(5780):1650-1653.
[9]Kortlever RM,Higgins PJ,Bernards R. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence[J]. Nat Cell Biol,2006,8(8):877-884.
[10]Roger L,Gadea G,Roux P. Control of cell migration:a tumour suppressor function for p53[J]. Bio Cell,2006,98(3):141-152.
[11]Wang X,Guo K,Zeng Q,et al. p53 Functions as a negative regulator of osteoblastogenesis,osteoblast-dependent osteoclastogenesis,and bone remodeling[J]. J Cell Biol,2006,172(1):115-125.
[12]Tsutsui H,Kinugawa S,Matsushima S. Oxidative stress and heart failure[J]. Am J Physiol Heart Circ Physiol,2011,301(6):2181-2190.
[13]Heiko BE,Dale A. Mitochondria in the diabetic heart[J]. Cardiovasc Res,2010,88(2):229-240.
[14]Nakamura H,Matoba S,Iwai-Kanai E,et al. p53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation[J]. Circ Heart Fail,2012,5(1):106-115.
[15]Miyashita T,Krajewski S,Krajewska M,et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo[J]. Oncogene,1994,9(6):1799-1805.
[16]Sun A,Zou Y,Wang P,et al. Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice[J]. J Am Heart Assoc,2014,3(5):e000779.
[17]Crighton D,Wilkinson S,O'Prey J,et al. DRAM,a p53-induced modulator of autophagy,is critical for apoptosis[J]. Cell,2006,126(1):121-134.
[18]Bensaad K,Tsuruta A,Selak MA,et al. TIGAR,a p53-inducible regulator of glycolysis and apoptosis[J]. Cell,2006,126(1):107-120.
[19]Heymans S,Hirsch E,Anker SD,et al. Inflammation as a therapeutic target in heart failure? A scientific statement from the translational research committee of the heart failure association of the european society of cardiology[J]. Eur J Heart Fail,2009,11(2):119-129.
[20]Yoshida Y,Shimizu I,Minamino T. Inhibition of adipose inflammation as a novel therapeutic target for heart failure[J]. J Card Fail,2012,18(10):S151-S151.
[21]Shimizu I,Yoshida Y,Katsuno T,et al. Adipose tissue inflammation in diabetes and heart failure[J]. Microbes Infect,2013,15(1):11-17.
[22]Heinzel FR,Hohendanner F,Jin G,et al. Myocardial hypertrophy and its role in heart failure with preserved ejection fraction[J]. J Appl Physiol,2015,119(10):1233-1242.
[23]Leri A,Franco S,Zacheo A,et al. Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation[J]. EMBO J,2003,22(1):131-139.
[24]Das B,Young D,Vasanji A,et al. Influence of p53 in the transition of myotrophin-induced cardiac hypertrophy to heart failure[J].Cardiovasc Res,2010,87(3):524-534.
[25]Huang CY,Pai PY,Kuo CH,et al. p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure[J]. Cell Death Dis,2017,8(8):e2990.
[26]Gogiraju R,Xu X,Bochenek ML,et al. Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice[J]. J Am Heart Assoc,2015,4(2):e001770.
[27]Oka T,Akazawa H,Naito AT,et al. Angiogenesis and cardiac hypertrophy:maintenance of cardiac function and causative roles in heart failure[J]. Circ Res,2014,114(3):565-571.
[28]Gogiraju R,Steinbreche JH,Lehnart SE,et al. Deletion Of p53 in endothelial cells prevents cardiac fibrosis and heart failure induced by pressureoverload in mice via enhanced angiogenesis[J]. Circ Res,2008,103(5):e35-e70.
[29]Chi J,Li Z,Hong X,et al. Inhalation of hydrogen attenuates progression of chronic heart failure via suppression of oxidative stress and p53 related to apoptosis pathway in rats[J]. Front Physiol,2018,9:1026.
[30]Patel TH,Kimura H,Weiss CR,et al. Constitutively active HIF-1αimproves perfusion and arterial remodeling in an endovascular model of limb ischemia[J]. Cardiovasc Res,2005,68(1):144-154.
[31]Samper E,Flores JM,Blasco MA. Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc/mice with short telomeres[J]. Embo Rep,2001,2(9):800-807.
[32]王建刚,江凤林,冯俊,等.丹参酮ⅡA对血管紧张素Ⅱ诱导的心肌细胞肥大与凋亡干预的研究[J].中国现代医学杂志,2007,17(18):2202-2204.
[33]王伊林,单晓彤,柴花,等.丹参酮ⅡA磺酸钠腹腔注射对阿霉素心肌病大鼠心功能及左心室纤维化的影响[J].山东医药,2016,56(7):34-36.
[34]李建宇,李灵芝,龚海英,等.蕨麻对缺氧诱导心肌细胞凋亡的影响[J].中华老年心脑血管病杂志,2007,9(9):619-622.
[35]潘光明,盛小刚,张磊,等.暖心胶囊对心力衰竭模型大鼠的心肌细胞及p53蛋白表达的影响[J].上海中医药杂志,2010,44(11):69-72.