复方异丙托溴铵与布地奈德联合匹多莫德对儿童支气管哮喘效果及对免疫功能的影响
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摘要
目的:探讨复方异丙托溴铵与布地奈德联合匹多莫德对支气管哮喘患儿防治的效果及其对免疫功能的影响。方法:我院在2014年1月~2016年1月收治了128例支气管哮喘患儿为对象来研究并把其随机分配,对照组分别选取异丙托溴铵与布地奈德、布地奈德联合匹多莫德、异丙托溴铵联合匹多莫德三组方式来治疗,观察组使用复方异丙托溴铵与布地奈德联合口服匹多莫德分散片进行治疗。治疗后,对2组患儿的临床疗效、哮喘控制程度进行比较,并比较观察组患儿治疗前后免疫功能指标差异。结果:观察组患儿治疗后日间症状发作程度明显轻于对照组[(0.42±0.11)分比(0.99±0.16)分],差异比较显著。观察组在治疗后IgA、IgM水平下降较多,IgG的水平升高,差异显著,总T淋巴细胞、抑制性T淋巴细胞、辅助性T淋巴细胞、自然杀伤细胞水平明显升高,而总B淋巴细胞水平明显降低,差异显著。结论:使用复方异丙托溴铵以及布地奈德与匹多莫德联合可有效防治儿童支气管哮喘,并改善免疫功能。
Objective To study the effect of compound ipratropium bromide and budesonide combined with pidotimod support on children with bronchial asthma control effect and its influence on immune function.Methods In our hospital in 2014.1-2016.1 treated 128 cases of bronchial asthma as object to study and to random allocation,the control group was treated with compound ipratropium bromide and budesonide atomization support to treatment,on the basis of the above,the observation group was treated with pidotimod dispersible tablets combined treatment.After treatment,the clinical efficacies of the 2 groups were compared,and the degrees of asthma control were compared,and the differences of immune function indexes were compared before and after treatment in the observation group.Results Compared with the control group(0.42 + 0.11)(0.99 + 0.16),the day after treatment in the observation group was significantly less than that in the control group.The observation group after treatment in IgA and IgM levels decreased more,elevated levels of IgG,and the difference is significant,total T cells,inhibition of T lymphocytes,helper T lymphocytes,natural killer cell level increased significantly,and the total level of B lymphocyte decreased significantly,the difference was significant.Conclusion Compound isopropyl ipratropium bromide and budesonide and pidotimod joint can be effective prevention and treatment of children with bronchial asthma,and improve the immune function.
Objective To study the effect of compound ipratropium bromide and budesonide combined with pidotimod support on children with bronchial asthma control effect and its influence on immune function.Methods In our hospital in 2014.1-2016.1 treated 128 cases of bronchial asthma as object to study and to random allocation,the control group was treated with compound ipratropium bromide and budesonide atomization support to treatment,on the basis of the above,the observation group was treated with pidotimod dispersible tablets combined treatment.After treatment,the clinical efficacies of the 2 groups were compared,and the degrees of asthma control were compared,and the differences of immune function indexes were compared before and after treatment in the observation group.Results Compared with the control group(0.42 + 0.11)(0.99 + 0.16),the day after treatment in the observation group was significantly less than that in the control group.The observation group after treatment in IgA and IgM levels decreased more,elevated levels of IgG,and the difference is significant,total T cells,inhibition of T lymphocytes,helper T lymphocytes,natural killer cell level increased significantly,and the total level of B lymphocyte decreased significantly,the difference was significant.Conclusion Compound isopropyl ipratropium bromide and budesonide and pidotimod joint can be effective prevention and treatment of children with bronchial asthma,and improve the immune function.
引文
[1]郭妍妍.槐杞黄颗粒联合孟鲁司特钠治疗儿童咳嗽变异性哮喘临床观察[J].儿科药学杂志,2014,10(3):25-28.
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[3]景晓平,陈文霞.槐杞黄颗粒预防支气管哮喘儿童呼吸道反复感染的临床观察[J].上海中医药大学学报,2014,20(3):39-42.
[4]姚劲,周瑶,刘峰,等.布地奈德福莫特罗联合槐杞黄治疗儿童哮喘的疗效[J].江苏医药,2014,7(13):1572-1574.
[5]杨晋,刘峰,周瑶,等.槐杞黄对哮喘气道及血清IL-13水平的影响[J].南京医科大学学报(自然科学版),2014,34(9):1248-1252.
[6]孙晓敏,沈照波.槐杞黄颗粒对哮喘非急性发作期患儿淋巴细胞亚群及TNF-α的影响[J].中国实用医药,2014,9(26):171-172.
[7]刘红,孙伟,涂玥,等.槐杞黄颗粒延缓慢性肾脏病机制[J].中国中西医结合肾病杂志,2014,15(10):926-928.
[8]Takahide Teramoto,Eiko Matsui,Toshiyuki Fukao,et al.RepeatedDose Pharmacokinetics of Inhaled Ciclesonide(CIC-HFA)in Japanese Children with Bronchial Asthma:A Phase I Study[J].Allergology International,2012,614:.
[9]耿海云,曹力,王薇,等.槐杞黄颗粒治疗儿童原发性肾病综合征的前瞻性随机对照临床研究[J].中国当代儿科杂志,2015,6(1):31-34.
[10]张书琳,崔岚巍.槐耳及其复方制剂槐杞黄颗粒的研究进展[J].医学综述,2015,24(1):114-116.
[11]孙彦珍,袁雪晶,孙轶秋.哮喘免疫机制与中医药的调控作用研究进展[J].南京中医药大学学报,2013,8(5):497-500.
[12]蔡晓华.匹多莫德对支气管哮喘患儿免疫功能的影响及疗效分析[J].重庆医学,2014,6(12):1508-1511.
[13]童蕾,李云,钟礼立,等.长沙市儿童哮喘危险因素调查分析[J].湖南师范大学学报(医学版),2014,11(1):19-23.谌洪飞.扎鲁司特联合沙美特罗替卡松粉吸入剂对儿童支气管哮喘临床疗效及肺功能的影响[J].临床合理用药杂志,2014,7(18):35-36.
[14]Sultanova N.G..Comparative study of influence of system and local treatment by Ronkoleykin on indicators of immune status of children with atopic bronchial asthma[J].Saratov Journal of Medical Scientific Research,2010,63:.
[15]V.I.Petrov,N.V.Maljuzhinskaya,I.N.Shishimorov.Clinical efficiency of desloratadine therapy in children with persistent form of allergic rhinitis and its effect on bronchial asthma symptoms[J].Saratov Journal of Medical Scientific Research,2010,61:.
[16]李智敬,张晶.匹多莫德治疗支气管哮喘患儿的疗效及对免疫功能的影响研究[J].中国卫生产业,2014,7(29):116-117.
[17]马静.布地奈德对支气管哮喘患儿免疫功能及炎性因子的影响[J].航空航天医学杂志,2014,1(9):1208-1210.
[18]Geun-Mi Park,Hye Won Han,Jae Youn Kim,Eun Lee,Hyun-Ju Cho,Jisun Yoon,Soo-Jong Hong,Song-I.Yang,Hyeon-Jong Yang,Jinho Yu.Association of symptom control with changes in lung function,bronchial hyperresponsiveness,and exhaled nitric oxide after inhaled corticosteroid treatment in children with asthma[J].Allergology International,2016,:.
[19]Suh D I,Lee J K,Kim C K,Koh Y Y.Bronchial hyperresponsiveness to methacholine and adenosine 5'-monophosphate,and the presence and degree of atopy in young children with asthma.[J].Clinical and Experimental Allergy,2011,413:.
[20]姜增凯,贾萍,叶晓歌.孟鲁司特钠联合沙美特罗替卡松粉吸入剂治疗支气管哮喘的临床疗效及其对炎性因子、肺功能、免疫功能的影响研究[J].实用心脑肺血管病杂志,2016,23(4):49-52.
[2]朱太幸.普米克令舒联合特布他林雾化吸入治疗小儿哮喘急性发作的临床疗效观察[J].湖南师范大学学报(医学版),2010,7(4):60-61.
[3]景晓平,陈文霞.槐杞黄颗粒预防支气管哮喘儿童呼吸道反复感染的临床观察[J].上海中医药大学学报,2014,20(3):39-42.
[4]姚劲,周瑶,刘峰,等.布地奈德福莫特罗联合槐杞黄治疗儿童哮喘的疗效[J].江苏医药,2014,7(13):1572-1574.
[5]杨晋,刘峰,周瑶,等.槐杞黄对哮喘气道及血清IL-13水平的影响[J].南京医科大学学报(自然科学版),2014,34(9):1248-1252.
[6]孙晓敏,沈照波.槐杞黄颗粒对哮喘非急性发作期患儿淋巴细胞亚群及TNF-α的影响[J].中国实用医药,2014,9(26):171-172.
[7]刘红,孙伟,涂玥,等.槐杞黄颗粒延缓慢性肾脏病机制[J].中国中西医结合肾病杂志,2014,15(10):926-928.
[8]Takahide Teramoto,Eiko Matsui,Toshiyuki Fukao,et al.RepeatedDose Pharmacokinetics of Inhaled Ciclesonide(CIC-HFA)in Japanese Children with Bronchial Asthma:A Phase I Study[J].Allergology International,2012,614:.
[9]耿海云,曹力,王薇,等.槐杞黄颗粒治疗儿童原发性肾病综合征的前瞻性随机对照临床研究[J].中国当代儿科杂志,2015,6(1):31-34.
[10]张书琳,崔岚巍.槐耳及其复方制剂槐杞黄颗粒的研究进展[J].医学综述,2015,24(1):114-116.
[11]孙彦珍,袁雪晶,孙轶秋.哮喘免疫机制与中医药的调控作用研究进展[J].南京中医药大学学报,2013,8(5):497-500.
[12]蔡晓华.匹多莫德对支气管哮喘患儿免疫功能的影响及疗效分析[J].重庆医学,2014,6(12):1508-1511.
[13]童蕾,李云,钟礼立,等.长沙市儿童哮喘危险因素调查分析[J].湖南师范大学学报(医学版),2014,11(1):19-23.谌洪飞.扎鲁司特联合沙美特罗替卡松粉吸入剂对儿童支气管哮喘临床疗效及肺功能的影响[J].临床合理用药杂志,2014,7(18):35-36.
[14]Sultanova N.G..Comparative study of influence of system and local treatment by Ronkoleykin on indicators of immune status of children with atopic bronchial asthma[J].Saratov Journal of Medical Scientific Research,2010,63:.
[15]V.I.Petrov,N.V.Maljuzhinskaya,I.N.Shishimorov.Clinical efficiency of desloratadine therapy in children with persistent form of allergic rhinitis and its effect on bronchial asthma symptoms[J].Saratov Journal of Medical Scientific Research,2010,61:.
[16]李智敬,张晶.匹多莫德治疗支气管哮喘患儿的疗效及对免疫功能的影响研究[J].中国卫生产业,2014,7(29):116-117.
[17]马静.布地奈德对支气管哮喘患儿免疫功能及炎性因子的影响[J].航空航天医学杂志,2014,1(9):1208-1210.
[18]Geun-Mi Park,Hye Won Han,Jae Youn Kim,Eun Lee,Hyun-Ju Cho,Jisun Yoon,Soo-Jong Hong,Song-I.Yang,Hyeon-Jong Yang,Jinho Yu.Association of symptom control with changes in lung function,bronchial hyperresponsiveness,and exhaled nitric oxide after inhaled corticosteroid treatment in children with asthma[J].Allergology International,2016,:.
[19]Suh D I,Lee J K,Kim C K,Koh Y Y.Bronchial hyperresponsiveness to methacholine and adenosine 5'-monophosphate,and the presence and degree of atopy in young children with asthma.[J].Clinical and Experimental Allergy,2011,413:.
[20]姜增凯,贾萍,叶晓歌.孟鲁司特钠联合沙美特罗替卡松粉吸入剂治疗支气管哮喘的临床疗效及其对炎性因子、肺功能、免疫功能的影响研究[J].实用心脑肺血管病杂志,2016,23(4):49-52.