抗线粒体抗体-M2阳性体检人群患原发性胆汁性肝硬化相关指标调查分析
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摘要
目的了解体检人群中原发性胆汁性肝硬化(PBC)患病率及潜在患病风险。方法通过检测2015年1—12月9 137名体检者自身抗体AMA-M2,分析PBC的患病率、患病特点。结果在9 137名普通健康体检者中,检出AMA-M2阳性有209例,这209例如中有10例诊断为PBC,患病率是109.44/10~5,男性患病率低于女性。确诊10例PBC患者中AMA-M2>800 RU/mL;2例600 RU/mL Objective To know the morbidity and potential prevalence risk of primary biliary cirrhosis related indicators in anti-mitochondrial antibody-M2 positive physical examination group. Methods The autoantibody AMA-M2 of 9 137 cases of physical examination people from January to December 2015 was tested thus analyzing the morbidity and disease features of PBC. Results Of 9 137 cases of common healthy physical examination people, there were 209 cases with positive AMA-M2, and 10 cases were diagnosed with PBC, and the morbidity was 109.44/10~5, and the morbidity in males was lower than that in females, and AMA-M2> 800 RU/mL in 10 cases, 600 RU/mL< AMA-M2< 800 RU/mL in 2 cases, 1 case with hepatic adipose infiltration, 1 case with hypertriglyceridemia, and the other was 25 RU/mL < AMA-M2 <100 RU/mL, with hepatic adipose infiltration, chronic cholecystitis, gallstones, drinking history. Conclusion Testing the AMA-M2 antibody is of great significance to the early discovery and early intervention of PBC, and the attention of PBC and testing of AMA-M2 can relieve the economic burden to the patients and society.
引文
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[2]landor KD,Gershwin ME,Poupon R,et a1.Primary biliary cirrhosis[J].Hepatology,2009,50(1):291-308.
[3]Kaplan MM,Gershwin ME.Primary biliary cirrhosis[J].N Engl J Med,2005,353(12):1261-1273.
[4]Sood S,Gow PJ,Christie JM,et al.Epidemiology of primary biliary cirrhosis in Victoria,Australia:high prevalence in migrant populations[J].Gastroenterology,2004,17(2):470-475.
[5]Liu H,Liu Y,Wang L,et al.Prevalence of primary biliary cirrhosis in adults referring hospital for annual health check-up in Southern China[J].BMC Gastroenterol.2010,10:100-104.
[6]姜小华,仲人前,方晓云,等.原发性胆汁性肝硬化特异性AMA-M2抗体在5011名体检人群的筛查分析[J].中华检验医学杂志,2003,26(9):553-555.
[7]吴旭伶,邹欣,徐永玲,等.抗线粒体抗体M2亚型检测的经济价值研究[J].中国卫生资源,2014,1(17):51-54.
[8]何宇晴,刘强,叶震璇,等.抗M2型线粒体抗体筛查11024例结果分析[J].中国现代医药杂志,2015,17(11):1-3.
[9]贾继东,尤红.原发性胆汁性肝硬化(又名原发性胆汁性胆管炎)诊断和治疗共识(2015)[J].中华肝脏病杂志,2016,24(l):5-13.
[10]郭亚平,王春光,刘欣.抗线粒体抗体-M2阳性体检人群原发性胆汁性肝硬化相关指标的调查分析[J].中华肝脏病杂志,2014,22(10):735-738.
[11]Hu CJ,Zhang FC,Li YZ.Progress on the animal model forr primary biliary cirrhosis[J].Chin Rheumatol,2010,14:62-64.
[12]韩英,朱疆.原发性胆汁性肝硬化瘙痒及乏力机制的研究[J].中华肝脏病杂志,2011,19(5):323-325.
[13]高丽霞,张奉春,王立,等.原发性胆汁性肝硬化合并干燥综合征的临床研究[J].中华内科杂志,2012,51(11):851-854.
[14]Dorner T,Feist E,Held C,et al.Differential recognition of the 52KD Ro(SSA)antigen by sera from patients with primary biliarycirrhosis and primary Sj觟gren's syndrome[J].Hepatology,1996,24:1404-1408.