增液通便方敷脐联合蜡袋灸治疗气阴两虚型2型糖尿病便秘患者30例临床观察
|
摘要
目的探讨增液通便方敷脐联合蜡袋灸治疗气阴两虚型2型糖尿病便秘患者的临床疗效。方法 90例气阴两虚型2型糖尿病便秘患者随机分为敷脐组、敷脐加灸疗组、对照组(六味安消胶囊)各30例,3组疗程均为2周。于治疗前、治疗后、停药3个月后(随访时)观察便秘症状积分、中医自我症状积分和生活质量评分,并判定临床疗效。结果与治疗前比较,敷脐组和敷脐加灸疗组治疗后、随访时便秘症状及中医自我症状积分降低,生活质量评分升高(P<0.01);与对照组同期比较,敷脐组和敷脐加灸疗组在治疗后、随访时便秘症状及中医自我症状积分均降低(P<0.05),敷脐加灸疗组生活质量评分明显升高(P<0.05)。3组治疗后临床疗效总有效率比较,差异无统计学意义(P>0.05),随访时敷脐组(71.43%)及敷脐加灸疗组(89.66%)临床疗效明显高于对照组(20.00%),且敷脐加灸疗组的总有效率明显高于敷脐组(P<0.01)。结论增液通便方敷脐治疗气阴两虚型2型糖尿病便秘的效果优于六味安消胶囊,且增液通便方敷脐联合蜡袋灸对生活质量的影响和对便秘效果的远期疗效优于单纯敷脐治疗。
Objective To observe the effect of navel application of Zengye Tongbian Formula( ZTF) combined with waxbag moxibustion( WM) in the treatment of diabetic constipation with qi and yin deficiency. Methods Totally90 cases of diabetic constipation with qi and yin deficiency were randomly assigned to treatment group A( navel application of ZTF),treatment group B( navel application of ZTF with WM) and control group( Liuwei Anxiao Capsules). The course of the treatment lasted for 2 weeks. The constipation symptom score,TCM symptom scores and quality of life( QOL) were evaluated before treatment,two weeks after treatment and 3 months after the ending of treatment to determine the clinical efficacy. Results The constipation symptom scores and TCM symptom scores declined,while the quality of life improved significantly after treatment and during follow-ups in the treatment groups A and B( P < 0. 01). Compared with the control group,the constipation symptom scores and TCM symptom scores in the treatment groups A and B were significantly lower( P < 0. 05),and the QOL in group B was significantly higher( P < 0. 05). There was no significant difference in the total efficiency rates among the groups after treatments( P >0. 05). During follow-ups,the efficiency rates in group A and B were 71. 43% and 89. 66%,respectively,which were significantly higher than the 20. 00% in the control group and indicated that group B had better results( P <0. 01). Conclusion The clinical effect of navel application of ZTF was better than Liuwei Anxiao Capsules in the treatment of diabetic constipation with qi and yin deficiency. Moreover,the effect on QOL and long-term effect on constipation of navel application of ZTF with WM were superior to navel application alone.
Objective To observe the effect of navel application of Zengye Tongbian Formula( ZTF) combined with waxbag moxibustion( WM) in the treatment of diabetic constipation with qi and yin deficiency. Methods Totally90 cases of diabetic constipation with qi and yin deficiency were randomly assigned to treatment group A( navel application of ZTF),treatment group B( navel application of ZTF with WM) and control group( Liuwei Anxiao Capsules). The course of the treatment lasted for 2 weeks. The constipation symptom score,TCM symptom scores and quality of life( QOL) were evaluated before treatment,two weeks after treatment and 3 months after the ending of treatment to determine the clinical efficacy. Results The constipation symptom scores and TCM symptom scores declined,while the quality of life improved significantly after treatment and during follow-ups in the treatment groups A and B( P < 0. 01). Compared with the control group,the constipation symptom scores and TCM symptom scores in the treatment groups A and B were significantly lower( P < 0. 05),and the QOL in group B was significantly higher( P < 0. 05). There was no significant difference in the total efficiency rates among the groups after treatments( P >0. 05). During follow-ups,the efficiency rates in group A and B were 71. 43% and 89. 66%,respectively,which were significantly higher than the 20. 00% in the control group and indicated that group B had better results( P <0. 01). Conclusion The clinical effect of navel application of ZTF was better than Liuwei Anxiao Capsules in the treatment of diabetic constipation with qi and yin deficiency. Moreover,the effect on QOL and long-term effect on constipation of navel application of ZTF with WM were superior to navel application alone.
引文
[1]张会琴,徐敏丽,王改仙,等.分型辨证糖尿病性便秘的规范化研究[J].中国中医药现代远程教育,2007,5(3):10-11.
[2]夏上,黄梅芳,朱端平,等.结肠黑变病38例临床分析[J].临床消化病杂志,2005,17(5):239-240.
[3]Kahn CR,Weir GC,King GL,et al.Joslin糖尿病学[M].14版.潘长玉,主译.北京:人民卫生出版社,2006:338-347.
[4]Longstrcth GL,Thom Pson WG,Chey WD,et al.Functional Bowel Disorders[J].Gastroenterology,2006,130(5):1480-1491.
[5]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:233-237.
[6]中华人民共和国卫生部.中药新药临床研究指导原则(第三辑)[M].1997:143-147.
[7]中国中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:20.
[8]孙振球.医学统计学[M].北京:人民卫生出版社,2002:53.
[9]Ware JE Jr,Sherboume CD.The MOS 36-item short-form health survey(SF-36)[J].Med Care,1992,30(6):473-483.
[10]陈睿.神阙穴敷贴治疗便秘[J].中国针灸,2002,22(8):540-541.
[11]白亚平,吕金仓,吴中秋.闪罐法治疗便秘[J].中国针灸,2002,22(8):541.
[12]王秀珍.指压点穴加按摩治习惯性便秘[J].中国针灸,2002,22(8):541.
[13]姜旭强,李晓清.温针灸治疗老年习惯性便秘体会[J].新疆中医药,2001,19(4):38-39.
[14]马秋霞,颜峰.中药增液汤静脉输液制作研究[J].中医函授通讯,1987(3):47.
[15]仝小林,王红,曹丽英,等.养阴注射液对内毒素高热动物模型影响的实验研究[J].中国医药学报,1998,13(5):30.
[16]黄建平,李谷霞,邢蜀林,等.增液口服液的药理作用[J].中成药,1996,18(7):29.
[17]倪峰,洪花辉,王翠平,等.增液口服液的药效学研究[J].福建中医学院学报,1995,5(4):26.
[18]乔鸿儒,王海林,郭培鑫.临床方药精粹[M].济南:山东科学技术出版社,2000:5.
[19]荒木佳代,须釜孝子,中山美惠.腹部薄荷热敷对皮肤温度及肠蠕动的影响[J].国外医学护理学分册,2004,23(3):111-112.
[20]徐勇刚.金氏药饼灸临床应用举隅[J].实用中医药,2008,24(1):51.
[2]夏上,黄梅芳,朱端平,等.结肠黑变病38例临床分析[J].临床消化病杂志,2005,17(5):239-240.
[3]Kahn CR,Weir GC,King GL,et al.Joslin糖尿病学[M].14版.潘长玉,主译.北京:人民卫生出版社,2006:338-347.
[4]Longstrcth GL,Thom Pson WG,Chey WD,et al.Functional Bowel Disorders[J].Gastroenterology,2006,130(5):1480-1491.
[5]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:233-237.
[6]中华人民共和国卫生部.中药新药临床研究指导原则(第三辑)[M].1997:143-147.
[7]中国中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:20.
[8]孙振球.医学统计学[M].北京:人民卫生出版社,2002:53.
[9]Ware JE Jr,Sherboume CD.The MOS 36-item short-form health survey(SF-36)[J].Med Care,1992,30(6):473-483.
[10]陈睿.神阙穴敷贴治疗便秘[J].中国针灸,2002,22(8):540-541.
[11]白亚平,吕金仓,吴中秋.闪罐法治疗便秘[J].中国针灸,2002,22(8):541.
[12]王秀珍.指压点穴加按摩治习惯性便秘[J].中国针灸,2002,22(8):541.
[13]姜旭强,李晓清.温针灸治疗老年习惯性便秘体会[J].新疆中医药,2001,19(4):38-39.
[14]马秋霞,颜峰.中药增液汤静脉输液制作研究[J].中医函授通讯,1987(3):47.
[15]仝小林,王红,曹丽英,等.养阴注射液对内毒素高热动物模型影响的实验研究[J].中国医药学报,1998,13(5):30.
[16]黄建平,李谷霞,邢蜀林,等.增液口服液的药理作用[J].中成药,1996,18(7):29.
[17]倪峰,洪花辉,王翠平,等.增液口服液的药效学研究[J].福建中医学院学报,1995,5(4):26.
[18]乔鸿儒,王海林,郭培鑫.临床方药精粹[M].济南:山东科学技术出版社,2000:5.
[19]荒木佳代,须釜孝子,中山美惠.腹部薄荷热敷对皮肤温度及肠蠕动的影响[J].国外医学护理学分册,2004,23(3):111-112.
[20]徐勇刚.金氏药饼灸临床应用举隅[J].实用中医药,2008,24(1):51.