针刺调控不同信号通路防治缺血性脑血管病的研究进展
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摘要
缺血性脑血管病(ICVD)的患病率、发病率及病死率均随年龄的增长而递增,针刺治疗该病疗效显著。笔者从针刺调控Notch、MAPK/ERK、PI 3K/Akt、JAK/STAT、Eph/Ephrin、NF-κB 6大信号通路进行综述,对各信号通路的组成、结构,它们与ICVD发病的联系,与针刺防治ICVD的相关研究展开详细的叙述,为探索针刺调控相关信号通路防治ICVD的机制研究提供新思路。
China is in the "high death zone" of the world cerebrovascular disease(CVD)map.The prevention and treatment of ischemic CVD(ICVD)have become the top priority in clinical practice.It has been demonstrated that acupuncture therapy has a positive role in bettering clinical symptoms of ICVD patients.Findings of recent experimental studies displayed that electroacupuncture(EA)intervention is effective in reducing the cerebral infarcted volume and cellular injury,promoting proliferation,migration and differentiation of nerve stem cells,facilitating the regeneration of nerve tissue,bettering dysneuria and limb locomotor ability,etc.in ICVD rats,which are closely associated with its effects in regulating different intracellular signaling pathways.In the present study,we review the progress of recent experimental studies on the underlying mechanisms of EA in improving ICVD from six major signaling pathways including Notch,mitogen-activated protein kinases(MAPK)/extracellular signal regulated protein kinases(ERK),phosphatidy linositol-3-kinase(PI3K)/protein kinase B(Akt),Janus kinase-signal transducer and activator of transcription(JAK-STAT),erythropoietin-producing hepatocyte receptor(Eph)/Ephrin,nuclear factor of kappa B(NF-κB)and their compositions,which may provide new therapeutic targets for acupuncture treatment of ICVD.More attention should be paid to the comparison of the efficacy of acupuncture of different acupoint combinations(traditional acupoint formulas)in relieving ICVD.
China is in the "high death zone" of the world cerebrovascular disease(CVD)map.The prevention and treatment of ischemic CVD(ICVD)have become the top priority in clinical practice.It has been demonstrated that acupuncture therapy has a positive role in bettering clinical symptoms of ICVD patients.Findings of recent experimental studies displayed that electroacupuncture(EA)intervention is effective in reducing the cerebral infarcted volume and cellular injury,promoting proliferation,migration and differentiation of nerve stem cells,facilitating the regeneration of nerve tissue,bettering dysneuria and limb locomotor ability,etc.in ICVD rats,which are closely associated with its effects in regulating different intracellular signaling pathways.In the present study,we review the progress of recent experimental studies on the underlying mechanisms of EA in improving ICVD from six major signaling pathways including Notch,mitogen-activated protein kinases(MAPK)/extracellular signal regulated protein kinases(ERK),phosphatidy linositol-3-kinase(PI3K)/protein kinase B(Akt),Janus kinase-signal transducer and activator of transcription(JAK-STAT),erythropoietin-producing hepatocyte receptor(Eph)/Ephrin,nuclear factor of kappa B(NF-κB)and their compositions,which may provide new therapeutic targets for acupuncture treatment of ICVD.More attention should be paid to the comparison of the efficacy of acupuncture of different acupoint combinations(traditional acupoint formulas)in relieving ICVD.
引文
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