环糊精包埋姜油树脂工艺研究
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摘要
采用超声法制备姜油树脂/β-环糊精包合物,以姜油树脂中姜酚的包合率和包合物的产率为指标进行综合评价。通过单因素及正交试验,考察姜油树脂/β-环糊精投料质量比、超声温度、超声时间3个因素对于姜油树脂/β-环糊精包合物的包合工艺影响,得到最佳的包合物制备工艺条件。结果表明:姜油树脂/β-环糊精包合物的最佳包合工艺条件为主客体投料比为1∶10(g/g)、超声温度为55℃、超声时间为21 min。在此优化条件下进行验证,得到其平均包合率为54.64%,平均包合物产率为39.07%,平均综合评价值为48.41%。
The gingerol content entrapped cyclodextrin and the compound yield were investigated by ultrasonic method for the preparation between ginger oleoresin and β-cyclodextrin.The optimum conditions for the preparation of inclusion compound were obtained by the study of single factor and orthogonal experiment.The single factors included the ginger oleoresin/β-CD feeding quality ratio,ultrasonic temperature and ultrasonic time.The results showed that the parameters for the preparation of inclusion compound were as follows,the quality ratio between ginger oleoresin and β-CD was 1∶10(g/g),ultrasonic temperature was 55 ℃,ultrasonic time was 21 min.Under the optimized conditions,the average inclusion rate was 54.64%,the average inclusion yield was 39.07%,and the average comprehensive evaluation value was 48.41%.
The gingerol content entrapped cyclodextrin and the compound yield were investigated by ultrasonic method for the preparation between ginger oleoresin and β-cyclodextrin.The optimum conditions for the preparation of inclusion compound were obtained by the study of single factor and orthogonal experiment.The single factors included the ginger oleoresin/β-CD feeding quality ratio,ultrasonic temperature and ultrasonic time.The results showed that the parameters for the preparation of inclusion compound were as follows,the quality ratio between ginger oleoresin and β-CD was 1∶10(g/g),ultrasonic temperature was 55 ℃,ultrasonic time was 21 min.Under the optimized conditions,the average inclusion rate was 54.64%,the average inclusion yield was 39.07%,and the average comprehensive evaluation value was 48.41%.
引文
[1]刘利萍,王秀珍,毛威.姜油树脂/β-环糊精包合物的制备工艺优化和表征[J].中国药学杂志,2007,42(15):1164-1167.
[2]刘利萍,毛威,王秀珍,等.姜油树脂/β-环糊精包合物的稳定性考察[J].华西药学杂志,2007,22(3):310-311.
[3]黄雪松,宴日安,吴建中.姜酚的生物活性述评[J].暨南大学学报(自然科学与医学版),2005,26(3):434-439.
[4]肖若蕾,罗兵华.姜油树脂β-环糊精包合物的制备工艺研究[J].现代中药研究与实践,2004,18(4):60-61.
[5]余静,白珍明.β-环糊精及衍生物在食品工业中的应用研究[J].中国食品添加剂,2008(6):118-122.
[6]许梅.超声法制备香附挥发油β-环糊精包合物研究[J].时珍国医国药,2000,11(8):694-695.
[7]易军,李晓芳,苏建湘,等.超声法制备石菖蒲挥发油β-环糊精包合物[J].时珍国医国药,2006,17(3):381-383.
[8]LIU L P,MAO W,WANG X Z,et al.Preparation of Calcium Alginate Microcapsules Loaded with Ginger Oleoresin by Internal Gelation Method[J].Chinese Journal of Pharmaceuticals,2007,38(4):285-287.
[2]刘利萍,毛威,王秀珍,等.姜油树脂/β-环糊精包合物的稳定性考察[J].华西药学杂志,2007,22(3):310-311.
[3]黄雪松,宴日安,吴建中.姜酚的生物活性述评[J].暨南大学学报(自然科学与医学版),2005,26(3):434-439.
[4]肖若蕾,罗兵华.姜油树脂β-环糊精包合物的制备工艺研究[J].现代中药研究与实践,2004,18(4):60-61.
[5]余静,白珍明.β-环糊精及衍生物在食品工业中的应用研究[J].中国食品添加剂,2008(6):118-122.
[6]许梅.超声法制备香附挥发油β-环糊精包合物研究[J].时珍国医国药,2000,11(8):694-695.
[7]易军,李晓芳,苏建湘,等.超声法制备石菖蒲挥发油β-环糊精包合物[J].时珍国医国药,2006,17(3):381-383.
[8]LIU L P,MAO W,WANG X Z,et al.Preparation of Calcium Alginate Microcapsules Loaded with Ginger Oleoresin by Internal Gelation Method[J].Chinese Journal of Pharmaceuticals,2007,38(4):285-287.