自拟降气化痰汤联合针灸治疗卒中相关性肺炎的疗效和安全性分析
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摘要
目的:探究自拟降气化痰汤联合针灸治疗卒中相关性肺炎的效果,以及对血清炎症因子的影响。方法:将2015年5月-2018年3月期间本院98例卒中相关性肺炎患者随机分成两组,对照组采用单纯西药治疗,而观察组加用自拟降气化痰汤联合针灸治疗。比较两组的临床疗效、病情恢复、血清炎症水平以及不良反应。结果:治疗组的临床总有效率明显的高于对照组;治疗后,对照组的CPIS、NIHSS评分明显的低于对照组,血清IL-6、TNF-α以及CRP水平也明显的低于对照组,比较差异具有显著性(P<0.05)。结论:自拟降气化痰汤联合针灸治疗卒中相关性肺炎疗效好,能有效降低机体炎症反应,且安全性高。
Objective:To investigate the efficacy and safety of Jiangqi Huayu Decoction combined with acupuncture in the treatment of stroke-associated pneumonia and its effect on serum inflammatory factors.Methods:From May 2015 to March 2018,98 patients with stroke-associated pneumonia were randomly divided into two groups.The control group was treated with simple treatment while the observation group was treated with self-made Jiangqi Huayu Decoction combined with acupuncture on the basis of the control group.The clinical efficacy,recovery of the disease,serum inflammation levels and adverse reactions were compared between the two groups.Results:The clinical total effective rate of the treatment group was significantly higher than that of the control group.After treatment,the CPIS and NIHSS scores of the control group were significantly lower than those of the control group.The serum IL-6,TNF-α and CRP levels were also significantly lower than those of the control group.The difference was significant(P<0.05).Conclusion:Self-made Jiangqi Huayu Decoction combined with acupuncture and moxibustion has a good curative effect on stroke-related pneumonia and can effectively reduce the inflammatory reaction and has high safety.
Objective:To investigate the efficacy and safety of Jiangqi Huayu Decoction combined with acupuncture in the treatment of stroke-associated pneumonia and its effect on serum inflammatory factors.Methods:From May 2015 to March 2018,98 patients with stroke-associated pneumonia were randomly divided into two groups.The control group was treated with simple treatment while the observation group was treated with self-made Jiangqi Huayu Decoction combined with acupuncture on the basis of the control group.The clinical efficacy,recovery of the disease,serum inflammation levels and adverse reactions were compared between the two groups.Results:The clinical total effective rate of the treatment group was significantly higher than that of the control group.After treatment,the CPIS and NIHSS scores of the control group were significantly lower than those of the control group.The serum IL-6,TNF-α and CRP levels were also significantly lower than those of the control group.The difference was significant(P<0.05).Conclusion:Self-made Jiangqi Huayu Decoction combined with acupuncture and moxibustion has a good curative effect on stroke-related pneumonia and can effectively reduce the inflammatory reaction and has high safety.
引文
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[17] 郭欢.半夏厚朴汤加减治疗卒中相关性肺炎的临床观察[J].中国中医急症,2016,25(7):1447-1449.
[18] 张丽娜,孙波.清金化痰汤对于卒中相关性肺炎的疗效、白细胞计数及C反应蛋白的影响[J].长春中医药大学学报,2017,33(3):425-427.
[19] 刘秋红,张杰文,杨景瑞.老年卒中相关性肺炎患者外周血T淋巴细胞亚群及血清炎症因子变化的临床分析[J].中国实用神经疾病杂志,2016,19(8):34-35.
[20] 柳立岩,王春,张雪云.血清降钙素原、C反应蛋白及纤维蛋白原检测在脑卒中相关性肺炎中的临床意义[J].贵阳医学院学报,2016,41(7):826-828.
[2] 温德良,李智博,温艺超,等.重症监护病房脑卒中相关性肺炎多重耐药菌感染的危险因素及病原学分析[J].实用医学杂志,2016,32(13):2178-2181.
[3] 史凤磊,周震,孙丽双.芩芍颗粒雾化治疗卒中相关性肺炎疗效观察[J].中国急救医学,2016,36(1):191-192.
[4] 吕晶,刘昱材,赵志国.卒中相关性肺炎研究进展[J].湖南中医杂志,2017,33(2):147-152.
[5] 古柱亮,黄凡,陈天龙,等.背俞穴埋线治疗卒中相关性肺炎疗效观察[J].上海针灸杂志,2016,35(5):513-516.
[6] 李唯溱,王凌飞,赵颖.合用千金苇茎汤治疗脑卒中相关性肺感染32例[J].天津中医药,2017,34(6):398-399.
[7] 李亚宁.化痰通腑汤治疗卒中相关性肺炎疗效及对CRP、TNF-α及RAGE的影响[J].现代西医结合杂志,2017,26(20):2237-2240.
[8] 中华神经科学会中华神经外科学会.各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-381.
[9] 卒中相关性肺炎诊治中国专家共识组.卒中相关性肺炎诊治中国专家共识[J].中华内科杂志,2010,49(12):1075-1079
[10] 刘莉,吕银鹏,张丹琦.自拟降气化痰汤预防和治疗缺血性卒中相关性肺炎的临床观察[J].中医药信息,2016,33(2):95-96.
[11] 张淑霞,潘晓华,刘国荣,等.卒中相关性肺炎的发病机制及预测因素的研究进展[J].医学综述,2016,22(23):4637-4640.
[12] 王小亮,侯斌,姜远飞,等.补肾利咽饮干预卒中后假性延髓麻痹吞咽障碍对卒中相关性肺炎的影响[J].中国中医急症,2016,25(2):346-348.
[13] 季娟.老年卒中相关性肺炎临床分析[J].临床肺科杂志,2017,22(2):361-363.
[14] 黄璐,张月娟,廖若夷,等.中医药辅助治疗卒中相关性肺炎的Meta分析[J].湖南中医药大学学报,2016,36(1):81-84.
[15] 焦玉娟,孙培军,张连勇.自拟温阳化痰通络汤治疗卒中相关性肺炎(阳虚痰瘀阻络证)的临床观察[J].中国中医急症,2017,26(5):863-865.
[16] 李春华,樊红杰,王家玉.自拟清肺汤治疗卒中相关性肺炎疗效观察[J].现代中西医结合杂志,2016,25(24):2714-2716.
[17] 郭欢.半夏厚朴汤加减治疗卒中相关性肺炎的临床观察[J].中国中医急症,2016,25(7):1447-1449.
[18] 张丽娜,孙波.清金化痰汤对于卒中相关性肺炎的疗效、白细胞计数及C反应蛋白的影响[J].长春中医药大学学报,2017,33(3):425-427.
[19] 刘秋红,张杰文,杨景瑞.老年卒中相关性肺炎患者外周血T淋巴细胞亚群及血清炎症因子变化的临床分析[J].中国实用神经疾病杂志,2016,19(8):34-35.
[20] 柳立岩,王春,张雪云.血清降钙素原、C反应蛋白及纤维蛋白原检测在脑卒中相关性肺炎中的临床意义[J].贵阳医学院学报,2016,41(7):826-828.