脑出血患者脑利钠肽前体和超敏肌钙蛋白的水平及意义
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摘要
目的:探讨脑利钠肽前体(NT-pro BNP)和超敏肌钙蛋白T(c Tn T)在急性脑出血患者血浆中的水平。方法:高血压脑出血患者60例,根据病历资料及治疗结果分为康复组和死亡组,用电化学发光法检测2组患者入院第1天时血浆NT-pro BNP和c Tn T水平,同时观察康复组患者入院后第7天和第14天时血浆NT-pro BNP和c Tn T水平。结果:与康复组比较,入院第1天时死亡组患者NT-pro BNP和c Tn T均显著升高,差异有统计学意义(P<0.05);康复组患者脑出血第7天时,NT-pro BNP和c Tn T显著高于第1天和第14天,差异有统计学意义(P<0.05)。结论:急性脑出血预后与发病时患者血浆NT-pro BNP和c Tn T水平有关,NT-pro BNP和c Tn T水平在发病后第7天最高。
Objective: To investigate plasma levels and its clinical significance of brain natriuretic peptide precursor( NT-pro BNP) and high sensitive cardiac troponin T( c Tn T) in intracerebral hemorrhage patients. Methods: According to medical reocrds and treatment results,60 patients with hypertensive cerebral hemorrhage were divided into rehabilitation group and death group. NT-pro BNP and c Tn T levels of death group on the first day after admission and rehabilitation group on the 1st,7thand14 thdays after admission were tested by electrochemiluminescence immunoassay. Results: Compared with rehabilitation group,NT-pro BNP and c Tn T levles of death group on the first day after admission were increased significantly( P < 0. 05). NT-pro BNP and c Tn T levels of patients in rehabilitation group on the seventh day were higher than those on the first day and the fourteenth day( P < 0. 05).Conclusions: Prognosis of patients with acute cerebral hemorrhage is correlated with NT-pro BNP and c Tn T levels,which reach the highest on the seventh day after disease incidence.
Objective: To investigate plasma levels and its clinical significance of brain natriuretic peptide precursor( NT-pro BNP) and high sensitive cardiac troponin T( c Tn T) in intracerebral hemorrhage patients. Methods: According to medical reocrds and treatment results,60 patients with hypertensive cerebral hemorrhage were divided into rehabilitation group and death group. NT-pro BNP and c Tn T levels of death group on the first day after admission and rehabilitation group on the 1st,7thand14 thdays after admission were tested by electrochemiluminescence immunoassay. Results: Compared with rehabilitation group,NT-pro BNP and c Tn T levles of death group on the first day after admission were increased significantly( P < 0. 05). NT-pro BNP and c Tn T levels of patients in rehabilitation group on the seventh day were higher than those on the first day and the fourteenth day( P < 0. 05).Conclusions: Prognosis of patients with acute cerebral hemorrhage is correlated with NT-pro BNP and c Tn T levels,which reach the highest on the seventh day after disease incidence.
引文
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[9]张芹,张拥波,李继梅.脑出血研究进展[J].神经损伤与功能重建,2013(6):455-458.
[10]Jensen JK,Kristensen SR,Bak S.Frequency and significance of troponin T elevation in acute ischemic stroke[J].American Journal of Cardiology,2007(1):108-112.
[11]刘华,袁强,孙一睿,等.颅脑损伤后氨基末端脑利钠肽前体的应用价值研究[J].中华神经外科疾病研究杂志,2011(5):392-395.
[12]任亦频,李玫.急性脑卒中后心电图及心肌酶谱异常的临床研究[J].贵州医药,2008(8):697-698.
[13]包广杰.hs-CRP、肌钙蛋白Ⅰ和心肌酶在急性脑血管病中的临床应用[J].中国实用神经疾病杂志,2011(17):40.
[2]郭翼华,项嘉亮,陈荣植.中风患者检测氨基末端脑钠肽前体的临床意义[J].中国基层医药,2009(6):991-992.
[3]孙瑞玥,黄巾,彭辉,等.高血压脑出血患者血清N末端前体脑钠肽和肌钙蛋白T的变化和意义[J].感染、炎症、修复,2013(3):166-168.
[4]关新,杨秀娟,赵森,等.急性脑血管疾病患者肌红蛋白、肌钙蛋白I和心肌酶谱检测结果分析[J].国际检验医学杂志,2012(18):2273-2274.
[5]姜雪菲,张新超.高血压与血脑利钠肽/N末端脑利钠肽前体的关系[J].心血管康复医学杂志,2012(2):213-215.
[6]Cleland JG,Taylor J,Freemantle N.Relationship between plasma concentrations of N-terminal pro brain natriuretic peptide and the characteristics and outcome of patients with a clinical diagnosis of diastolic heart failure:a report from the PEP-CHF study[J].European Journal of Heart Failure,2012(5):487-494.
[7]康峰,赖晓菁,易春,等.超敏肌钙蛋白Ⅰ和B型利钠肽联合检测对急性左心衰竭的预后判断价值[J].中国心血管研究,2013(11):876-880.
[8]刘兵,谭鹤龙,俞春娟,等.急性脑血管病患者血浆N端脑钠肽前体的检测及意义[J].医学临床研究,2010(2):249-250.
[9]张芹,张拥波,李继梅.脑出血研究进展[J].神经损伤与功能重建,2013(6):455-458.
[10]Jensen JK,Kristensen SR,Bak S.Frequency and significance of troponin T elevation in acute ischemic stroke[J].American Journal of Cardiology,2007(1):108-112.
[11]刘华,袁强,孙一睿,等.颅脑损伤后氨基末端脑利钠肽前体的应用价值研究[J].中华神经外科疾病研究杂志,2011(5):392-395.
[12]任亦频,李玫.急性脑卒中后心电图及心肌酶谱异常的临床研究[J].贵州医药,2008(8):697-698.
[13]包广杰.hs-CRP、肌钙蛋白Ⅰ和心肌酶在急性脑血管病中的临床应用[J].中国实用神经疾病杂志,2011(17):40.