中西医结合治疗对婴儿肝炎综合征血小板参数及血清、胆汁疾病相关指标的影响研究
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摘要
目的研究中西医结合治疗对婴儿肝炎综合征血小板参数及血清、胆汁疾病相关指标的影响。方法选取2014年10月~2016年4月期间于本院进行诊治的56例婴儿肝炎综合征为研究对象,将56例患儿根据随机数字表法分为对照组28例和治疗组28例,对照组进行常规婴儿肝炎综合征西医治疗,治疗组则采用中西医结合治疗的方式进行治疗,然后将两组患儿治疗前和治疗后不同时间的血小板参数及血清、胆汁疾病相关指标进行检测与比较。结果治疗前两组的血小板参数及血清、胆汁疾病相关指标差异均无统计学意义(P>0.05),而治疗后不同时间两组的血小板参数及血清、胆汁疾病相关指标均持续改善,且治疗组的检测结果均显著地好于对照组同时间的检测结果,差异均有统计学意义(P<0.05)。结论中西医结合治疗对婴儿肝炎综合征血小板参数及血清、胆汁疾病相关指标的影响更好,因此本治疗方案更为适用于肝炎综合征患儿。
Objective To study the impacts of integrated Chinese and western medicine on the platelet parameters and the relevant indexes of serum and bile disorders in infantile hepatitis. Methods From October 2014 to April 2016,56 cases of infantile hepatitis syndrome treated in the hospital were selected as the subjects. According to the random number table,56 cases were divided into a control group( 28 cases) and a treatment group( 28 cases). In the control group,the routine western medicine treatment was applied. In the treatment group,the integrated Chinese and western medicine was adopted. The platelet parameters and the relevant indexes of serum and bile disorders were detected and compared before treatment and the different time points after treatment in the two groups separately. Results The differences were not significant in the platelet parameters and the relevant indexes of serum and bile disorders between the two groups( P > 0. 05) and those were constantly improved at the different time points after treatment. The results in the treatment group were significantly better than those in the control group at the same time point,indicating the significant differences( P < 0. 05). Conclusion The integrated Chinese and western medicine much better affects the platelet parameters and the relevant indexes of serum and bile disorders. This scheme is considerably suitable for the treatment of infantile hepatitis syndrome.
Objective To study the impacts of integrated Chinese and western medicine on the platelet parameters and the relevant indexes of serum and bile disorders in infantile hepatitis. Methods From October 2014 to April 2016,56 cases of infantile hepatitis syndrome treated in the hospital were selected as the subjects. According to the random number table,56 cases were divided into a control group( 28 cases) and a treatment group( 28 cases). In the control group,the routine western medicine treatment was applied. In the treatment group,the integrated Chinese and western medicine was adopted. The platelet parameters and the relevant indexes of serum and bile disorders were detected and compared before treatment and the different time points after treatment in the two groups separately. Results The differences were not significant in the platelet parameters and the relevant indexes of serum and bile disorders between the two groups( P > 0. 05) and those were constantly improved at the different time points after treatment. The results in the treatment group were significantly better than those in the control group at the same time point,indicating the significant differences( P < 0. 05). Conclusion The integrated Chinese and western medicine much better affects the platelet parameters and the relevant indexes of serum and bile disorders. This scheme is considerably suitable for the treatment of infantile hepatitis syndrome.
引文
[1]夏毅如,陈振华.联合应用还原型谷胱甘肽和促肝细胞生长素治疗婴儿肝炎综合征疗效研究[J].中国现代药物应用,2016,10(9):175-176.
[2]高明,任章平.熊去氧胆酸联合护肝药物对婴儿肝炎综合征生化指标的影响[J].肝脏,2016,21(2):123-125.
[3]崔俊,黄英,王大佳,等.胆道闭锁与婴儿肝炎综合征的诊断和鉴别指标的分析[J].国际儿科学杂志,2014,41(6):652-655.
[4]黄丽,王琳琳.612例婴儿肝炎综合征病因及预后分析[J].广西医科大学学报,2015,32(5):795-797.
[5]朱利君,文化日.婴儿肝炎综合征中医治疗临床分析[J].世界中医药,2015,10(A01):83.
[6]刘燕琼,秦雪,彭契六,等.人巨细胞病毒感染与婴儿肝炎综合征及肝功能损害的相关性研究[J].重庆医学,2014,43(36):4903-4905.
[7]申静,宁沛,秦丽娜,等.清热凉血化瘀方口服联合灌肠治疗婴儿肝炎综合征的临床研究[J].河北中医,2014,36(11):1616-1618.
[8]Wang X,Qian L,Jia L,et al.Utility of Shear Wave Elastography for Differentiating Biliary Atresia From Infantile Hepatitis Syndrome[J].J Ultrasound Med,2016,35(7):1475-1479.
[9]Cho HH,Kim WS,Choi YH,et al.Ultrasonography evaluation of infants with Alagille syndrome:In comparison with biliary atresia and neonatal hepatitis[J].Eur J Radiol,2016,85(6):1045-1052.
[10]胡丽敏,平莉莉,刘秀霞,等.血清标志蛋白对婴儿肝炎综合征诊断及病情评定价值[J].临床合理用药杂志,2014,7(25):139-140.
[11]桂赛珠,夏萍,蒋颖颖,等.茵栀黄口服液治疗黄疸型婴儿肝炎综合征疗效观察及安全性评估[J].中国现代医生,2012,50(36):83-84.
[12]李宁,张博.中药直肠滴入联合西药对婴儿肝炎综合征患儿血生化指标的影响[J].世界华人消化杂志,2015,23(28):4568-4573.
[13]邓文林,熊慧,王玲玲,等.婴儿肝炎综合征血清纤维化标志物临床价值研究[J].中国当代儿科杂志,2014,16(10):1029-1032.
[14]彭娜,王武明,谭静.婴儿肝炎综合征患儿血清肝纤维化指标及与肝功能相关性研究[J].肝脏,2016,21(4):296-298.
[15]江治霞,熊小丽,鄢素琪.中西医结合治疗巨细胞病毒感染婴儿肝炎综合征的临床观察[J].湖北中医杂志,2013,35(1):11-12.
[16]梁嘉仪,吴莉莉,任杰,等.肝门部胆管声像在鉴别婴儿肝炎综合征与胆道闭锁中的应用价值[J].广东医学,2015,36(19):2976-2978.
[17]王玉梅.布拉氏酵母菌散联合熊去氧胆酸治疗婴儿肝炎综合征的疗效观察[J].医学理论与实践,2015,28(17):2366-2367.
[18]王丽,钱继红,张拥军,等.人巨细胞病毒肝炎综合征婴儿外周血宿主microRNA表达的变化[J].中华实用儿科临床杂志,2013,28(10):737-740.
[19]肖波.更昔洛韦联合熊去氧胆酸对先天性巨细胞病毒感染致新生儿肝炎综合征的疗效观察[J].肝脏,2015,20(6):497-498.
[20]胡彩红.西宁地区婴儿肝炎综合征与巨细胞病毒感染的临床分析[J].青海医药杂志,2013,43(4):20.
[21]李晓军,李晓岚.促肝细胞生长素联合更昔洛韦治疗婴儿巨细胞病毒肝炎的疗效观察[J].国际儿科学杂志,2015,42(5):575-577.
[22]林莉,晏晓敏,黄志华.婴儿肝炎综合征应用微生态调节剂后肠道菌群及胆汁成分的随机双盲对照临床研究[J].中国实用儿科杂志,2010,25(7):520-523.
[23]唐丽英,卿文衡.婴幼儿肝炎综合征诊疗中血清总胆汁酸测定的临床意义[J].中国中医药咨讯,2010,2(29):4-5.
[2]高明,任章平.熊去氧胆酸联合护肝药物对婴儿肝炎综合征生化指标的影响[J].肝脏,2016,21(2):123-125.
[3]崔俊,黄英,王大佳,等.胆道闭锁与婴儿肝炎综合征的诊断和鉴别指标的分析[J].国际儿科学杂志,2014,41(6):652-655.
[4]黄丽,王琳琳.612例婴儿肝炎综合征病因及预后分析[J].广西医科大学学报,2015,32(5):795-797.
[5]朱利君,文化日.婴儿肝炎综合征中医治疗临床分析[J].世界中医药,2015,10(A01):83.
[6]刘燕琼,秦雪,彭契六,等.人巨细胞病毒感染与婴儿肝炎综合征及肝功能损害的相关性研究[J].重庆医学,2014,43(36):4903-4905.
[7]申静,宁沛,秦丽娜,等.清热凉血化瘀方口服联合灌肠治疗婴儿肝炎综合征的临床研究[J].河北中医,2014,36(11):1616-1618.
[8]Wang X,Qian L,Jia L,et al.Utility of Shear Wave Elastography for Differentiating Biliary Atresia From Infantile Hepatitis Syndrome[J].J Ultrasound Med,2016,35(7):1475-1479.
[9]Cho HH,Kim WS,Choi YH,et al.Ultrasonography evaluation of infants with Alagille syndrome:In comparison with biliary atresia and neonatal hepatitis[J].Eur J Radiol,2016,85(6):1045-1052.
[10]胡丽敏,平莉莉,刘秀霞,等.血清标志蛋白对婴儿肝炎综合征诊断及病情评定价值[J].临床合理用药杂志,2014,7(25):139-140.
[11]桂赛珠,夏萍,蒋颖颖,等.茵栀黄口服液治疗黄疸型婴儿肝炎综合征疗效观察及安全性评估[J].中国现代医生,2012,50(36):83-84.
[12]李宁,张博.中药直肠滴入联合西药对婴儿肝炎综合征患儿血生化指标的影响[J].世界华人消化杂志,2015,23(28):4568-4573.
[13]邓文林,熊慧,王玲玲,等.婴儿肝炎综合征血清纤维化标志物临床价值研究[J].中国当代儿科杂志,2014,16(10):1029-1032.
[14]彭娜,王武明,谭静.婴儿肝炎综合征患儿血清肝纤维化指标及与肝功能相关性研究[J].肝脏,2016,21(4):296-298.
[15]江治霞,熊小丽,鄢素琪.中西医结合治疗巨细胞病毒感染婴儿肝炎综合征的临床观察[J].湖北中医杂志,2013,35(1):11-12.
[16]梁嘉仪,吴莉莉,任杰,等.肝门部胆管声像在鉴别婴儿肝炎综合征与胆道闭锁中的应用价值[J].广东医学,2015,36(19):2976-2978.
[17]王玉梅.布拉氏酵母菌散联合熊去氧胆酸治疗婴儿肝炎综合征的疗效观察[J].医学理论与实践,2015,28(17):2366-2367.
[18]王丽,钱继红,张拥军,等.人巨细胞病毒肝炎综合征婴儿外周血宿主microRNA表达的变化[J].中华实用儿科临床杂志,2013,28(10):737-740.
[19]肖波.更昔洛韦联合熊去氧胆酸对先天性巨细胞病毒感染致新生儿肝炎综合征的疗效观察[J].肝脏,2015,20(6):497-498.
[20]胡彩红.西宁地区婴儿肝炎综合征与巨细胞病毒感染的临床分析[J].青海医药杂志,2013,43(4):20.
[21]李晓军,李晓岚.促肝细胞生长素联合更昔洛韦治疗婴儿巨细胞病毒肝炎的疗效观察[J].国际儿科学杂志,2015,42(5):575-577.
[22]林莉,晏晓敏,黄志华.婴儿肝炎综合征应用微生态调节剂后肠道菌群及胆汁成分的随机双盲对照临床研究[J].中国实用儿科杂志,2010,25(7):520-523.
[23]唐丽英,卿文衡.婴幼儿肝炎综合征诊疗中血清总胆汁酸测定的临床意义[J].中国中医药咨讯,2010,2(29):4-5.