干扰素治疗复发性小儿喉乳头状瘤的临床效果
|
摘要
目的探讨干扰素治疗复发性小儿喉乳头状瘤的临床效果。方法选择2014年3月—2017年9月本院收治的小儿喉乳头状瘤患者80例,按照随机数字法分为两组,各40例。对照组实施支撑喉镜下CO_2激光治疗,观察组联合使用干扰素α-2a,治疗后随访1年,比较两组复发次数及复发时间,两组治疗后炎症相关因子,如:TNF-α、IL-1和hs-CRP水平变化,统计两组整体临床治疗效果,计算有效率。结果观察组复发次数少于对照组(P <0.05),复发时间长于对照组(P<0.05),治疗后观察组炎症相关因子中:TNF-α、IL-1和hs-CRP水平低于对照组(P <0.05),观察组有效率为70.0%,高于对照组的42.5%。结论针对复发性小儿喉乳头状瘤在实施支撑喉镜治疗同时联合使用干扰素治疗,能显著减少复发次数,避免术后复发,调节机体炎症反应,提高整体临床治疗效果。
Objective To investigate the clinical effect of interferon for recurrent papillary papilloma in children. Methods 80 cases with laryngeal papilloma admitted to our hospital from March 2014 to September 2017 were enrolled. According to the random number method, they were divided into two groups, 40 cases in each group. The control group was given CO_2 laser treatment under the support laryngoscope. The observation group was treated with interferon α-2 a. The patients were followed up for 1 year after treatment. The number of relapses and time of recurrence were compared between the two groups. The inflammation-related factors such as TNF-α were treated in the two groups. The levels of IL-1 and hs-CRP were changed, and the overall clinical treatment effect of the two groups was counted, and the calculation efficiency was calculated. Results The number of relapses in the observation group was lower than that in the control group(P < 0.05), and the recurrence time was longer than that in the control group(P < 0.05). The levels of TNF-α, IL-1 and hs-CRP in the observation group were lower than those in the control group. The control group(P < 0.05), the effective rate of the observation group was 70.0%, which was significantly higher than that of the control group(42.5%). Conclusion In the treatment of recurrent pediatric laryngeal papilloma with support laryngoscopy combined with interferon therapy, it can significantly reduce the number of relapses, avoid postoperative recurrence, regulate the body's inflammatory response, and improve the overall clinical treatment effect.
Objective To investigate the clinical effect of interferon for recurrent papillary papilloma in children. Methods 80 cases with laryngeal papilloma admitted to our hospital from March 2014 to September 2017 were enrolled. According to the random number method, they were divided into two groups, 40 cases in each group. The control group was given CO_2 laser treatment under the support laryngoscope. The observation group was treated with interferon α-2 a. The patients were followed up for 1 year after treatment. The number of relapses and time of recurrence were compared between the two groups. The inflammation-related factors such as TNF-α were treated in the two groups. The levels of IL-1 and hs-CRP were changed, and the overall clinical treatment effect of the two groups was counted, and the calculation efficiency was calculated. Results The number of relapses in the observation group was lower than that in the control group(P < 0.05), and the recurrence time was longer than that in the control group(P < 0.05). The levels of TNF-α, IL-1 and hs-CRP in the observation group were lower than those in the control group. The control group(P < 0.05), the effective rate of the observation group was 70.0%, which was significantly higher than that of the control group(42.5%). Conclusion In the treatment of recurrent pediatric laryngeal papilloma with support laryngoscopy combined with interferon therapy, it can significantly reduce the number of relapses, avoid postoperative recurrence, regulate the body's inflammatory response, and improve the overall clinical treatment effect.
引文
[1]岑瑞祥,万浪,彭聪,等.低温等离子刀联合匹多莫德治疗复发性小儿喉乳头状瘤的疗效分析[J].河北医科大学学报,2015,36(4):779-782.
[2]李姬梅,焦海花,游金华.宫颈LEEP锥切术后用重组人干扰素-α2b凝胶对人乳头状瘤病毒感染的宫颈上皮内瘤变患者的疗效评价[J].抗感染药学,2017,14(1):172-174.
[3]汤荣兴,王晓军,徐连生.右美托咪定复合七氟烷全麻对小儿喉乳头状瘤切除术麻醉苏醒期躁动的影响[J].现代肿瘤医学,2018,26(18):2938-2941.
[4]李铮,马丽丽,王旭.重组人干扰素不同制剂联合高频电刀治疗女性生殖道尖锐湿疣96例效果分析[J].潍坊医学院学报,2017,39(2):117-119.
[5]邱昌慧.重组人干扰素α-2b凝胶在慢性宫颈炎合并高危型人乳头状瘤病毒感染治疗中的临床效果[J].中国当代医药,2017,24(7):127-129.
[6]岑瑞祥,万浪,彭聪,等.低温等离子刀联合匹多莫德治疗小儿喉乳头状瘤的疗效分析[J].河北医科大学学报,2015,36(4):416-418.
[7]韦舟雄,何江,吴铖林,等.显微喉镜下CO2激光手术治疗复发性小儿喉乳头状瘤临床疗效[J].右江民族医学院学报,2017,39(3):201-202,210.
[8]马红英,耿智隆,王翻丽,等.重度气道梗阻小儿喉乳头状瘤围术期麻醉体会[J].西北国防医学杂志,2017,38(12):815-818.
[9]凡尔克·艾合买提江,美力班·吐尔逊,郭文涛,等.宫颈癌组织中Toll样受体9和干扰素调节因子7蛋白表达与人乳头状瘤病毒感染的关系[J].新疆医科大学学报,2018,41(5):539-542,547.
[10]刘金兰.干扰素栓剂配合宫颈电热圈环切术治疗宫颈人乳头状瘤病毒感染的可行性[J].中国当代医药,2018,25(2):74-76.
[11]刘春阳.局部注射干扰素结合CO2激光治疗尖锐湿疣的效果观察[J].黑龙江医药科学,2018,41(3):141-142.
[12]周兴雯,赵皓森,周文瑞,等. 5-氨基酮戊酸光动力疗法联合重组人干扰素α-2b凝胶治疗尖锐湿疣的疗效及性生活满意度调查[J].中国性科学,2018,27(2):73-75.
[2]李姬梅,焦海花,游金华.宫颈LEEP锥切术后用重组人干扰素-α2b凝胶对人乳头状瘤病毒感染的宫颈上皮内瘤变患者的疗效评价[J].抗感染药学,2017,14(1):172-174.
[3]汤荣兴,王晓军,徐连生.右美托咪定复合七氟烷全麻对小儿喉乳头状瘤切除术麻醉苏醒期躁动的影响[J].现代肿瘤医学,2018,26(18):2938-2941.
[4]李铮,马丽丽,王旭.重组人干扰素不同制剂联合高频电刀治疗女性生殖道尖锐湿疣96例效果分析[J].潍坊医学院学报,2017,39(2):117-119.
[5]邱昌慧.重组人干扰素α-2b凝胶在慢性宫颈炎合并高危型人乳头状瘤病毒感染治疗中的临床效果[J].中国当代医药,2017,24(7):127-129.
[6]岑瑞祥,万浪,彭聪,等.低温等离子刀联合匹多莫德治疗小儿喉乳头状瘤的疗效分析[J].河北医科大学学报,2015,36(4):416-418.
[7]韦舟雄,何江,吴铖林,等.显微喉镜下CO2激光手术治疗复发性小儿喉乳头状瘤临床疗效[J].右江民族医学院学报,2017,39(3):201-202,210.
[8]马红英,耿智隆,王翻丽,等.重度气道梗阻小儿喉乳头状瘤围术期麻醉体会[J].西北国防医学杂志,2017,38(12):815-818.
[9]凡尔克·艾合买提江,美力班·吐尔逊,郭文涛,等.宫颈癌组织中Toll样受体9和干扰素调节因子7蛋白表达与人乳头状瘤病毒感染的关系[J].新疆医科大学学报,2018,41(5):539-542,547.
[10]刘金兰.干扰素栓剂配合宫颈电热圈环切术治疗宫颈人乳头状瘤病毒感染的可行性[J].中国当代医药,2018,25(2):74-76.
[11]刘春阳.局部注射干扰素结合CO2激光治疗尖锐湿疣的效果观察[J].黑龙江医药科学,2018,41(3):141-142.
[12]周兴雯,赵皓森,周文瑞,等. 5-氨基酮戊酸光动力疗法联合重组人干扰素α-2b凝胶治疗尖锐湿疣的疗效及性生活满意度调查[J].中国性科学,2018,27(2):73-75.