温针灸配合益肾化瘀方治疗良性前列腺增生的疗效观察
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摘要
目的观察三阴交穴温针灸配合益肾化瘀方对良性前列腺增生(BPH)患者排尿功能、性激素水平及前列腺体积变化的影响。方法将74例BPH患者随机分成治疗组和对照组,每组37例。对照组给予益肾化瘀方治疗,治疗组给予三阴交穴温针灸配合益肾化瘀方治疗。观察两组治疗前后排尿功能、性激素水平及前列腺体积变化及不良反应情况,并比较两组临床疗效。结果治疗组总有效率为91.9%,对照组为70.3%,两组比较差异具有统计学意义(P<0.05)。两组治疗后排尿功能各项指标(Qmax、Qave及PVR)、各项性激素水平(T、E2、E2/T)及前列腺体积与同组治疗前比较,差异均具有统计学意义(P<0.05)。治疗组治疗后排尿功能各项指标、各项性激素水平及前列腺体积与对照组比较,差异具有统计学意义(P<0.05)。结论三阴交穴温针灸配合益肾化瘀方治疗BPH可显著提高临床疗效,改善排尿功能,恢复性激素水平平衡,促进前列腺体积缩小。
Objective To investigate the effect of point Sanyinjiao(SP6) warm needling moxibustion plus kidneyreinforcing and stasis-resolving prescription on urinary voiding function, sex hormone levels and prostate volume in patients with benign prostatic hyperplasia(BPH). Method Seventy-four BPH patients were randomized to treatment and control groups, 37 cases each. The control group received treatment with kidney-reinforcing and stasis-resolving prescription and the treatment group, warm needling moxibustion at point Sanyinjiao(SP6) in addition. In the two groups, urinary voiding function, sex hormone levels and prostate volume were examined before and after treatment and adverse reactions were observed after treatment. The clinical therapeutic effects were compared between the two groups. Result The total efficacy rate was 91.9% in the treatment group and 70.3% in the control group with a statistically significant difference between the two groups(P<0.05). There were statistically significant pre-/posttreatment differences in urinary voiding function item indicators(Qmax、Qave and PVR), sex hormone(T, E2 and E2/T) levels and prostate volume in the two groups(P<0.05). There were statistically significant post-treatment differences in urinary voiding function item indicators, sex hormone levels and prostate volume between the treatment and control groups(P<0.05). Conclusion Point Sanyinjiao(SP6) warm needling moxibustion plus kidney-reinforcing and stasisresolving prescription can significantly enhance the clinical therapeutic effect on BPH, improve urinary voiding function, restore sex hormone balance and help to reduce prostate volume.
Objective To investigate the effect of point Sanyinjiao(SP6) warm needling moxibustion plus kidneyreinforcing and stasis-resolving prescription on urinary voiding function, sex hormone levels and prostate volume in patients with benign prostatic hyperplasia(BPH). Method Seventy-four BPH patients were randomized to treatment and control groups, 37 cases each. The control group received treatment with kidney-reinforcing and stasis-resolving prescription and the treatment group, warm needling moxibustion at point Sanyinjiao(SP6) in addition. In the two groups, urinary voiding function, sex hormone levels and prostate volume were examined before and after treatment and adverse reactions were observed after treatment. The clinical therapeutic effects were compared between the two groups. Result The total efficacy rate was 91.9% in the treatment group and 70.3% in the control group with a statistically significant difference between the two groups(P<0.05). There were statistically significant pre-/posttreatment differences in urinary voiding function item indicators(Qmax、Qave and PVR), sex hormone(T, E2 and E2/T) levels and prostate volume in the two groups(P<0.05). There were statistically significant post-treatment differences in urinary voiding function item indicators, sex hormone levels and prostate volume between the treatment and control groups(P<0.05). Conclusion Point Sanyinjiao(SP6) warm needling moxibustion plus kidney-reinforcing and stasisresolving prescription can significantly enhance the clinical therapeutic effect on BPH, improve urinary voiding function, restore sex hormone balance and help to reduce prostate volume.
引文
[1]刘龙,旷建刚.经尿道前列腺汽化电切术联合钬激光碎石术同期治疗良性前列腺增生症合并膀胱结石的临床效果[J].中国医药导报,2016,13(27):95-98.
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[4]陈浩,张瑞,黄兴儒,等.中西药联合治疗良性前列腺增生症的优化方案研究[J].世界中西医结合杂志,2016,11(4):510-513.
[5]姜磊,陈英华,杜文秀,等.针刺配合艾灸治疗前列腺增生临床观察[J].上海针灸杂志,2015,34(2):139-140.
[6]那彦群,叶章群,孙光.中国泌尿外科疾病诊断治疗指南[M].北京:人民卫生出版社,2011:122.
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[8]Basha SZ,Mohamed GA,Abdel-Naim AB,et al.Cucurbitacin E glucoside from Citrullus colocynthis inhibits testosterone-induced benign prostatic hyperplasia in mice[J].Drug Chem Toxicol,2019,12:1-11.
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[10]Vasilyeva IN,Bespalov VG,Von JD,et al.Cell-Free DNAPlasma Levels Differ in Age-Specific Pattern in Healthy Rats and Castrates with Testosterone-Induced Benign Prostatic Hyperplasia[J].Int J Genomics,2019,2019:8173630.
[11]汪青,肖东,吕雁,等.益肾化瘀方含药血清对NRK52E转分化过程中TGF-?_1、BMP-7表达的影响[J].中国中西医结合肾病杂志,2016,17(1):18-21.
[12]Nasr El-Din WA,Abdel Fattah IO.The potential curative and preventive effects of garlic on testosterone-induced benign prostatic hyperplasia in orchiectomized rats[J].Rom J Morphol Embryol,2019,60(1):145-158.
[13]Khanduri S,Imam T,Khan M,et al.Rare Variant of Carcinoma Prostate Masquerading as Benign Prostatic Hyperplasia[J].Cureus,2019,11(4):e4504.
[14]郑玲,库宝庆,王月.健脾益肾化瘀方对肾衰竭患者免疫功能及微炎症的影响[J].现代中西医结合杂志,2017,26(26):2901-2903.
[15]李晨.火针治疗前列腺增生症临床观察[J].上海针灸杂志,2016,35(12):1445-1447.
[16]耿旭强,李伟红,李欣珂,等.神阙穴隔盐灸联合三阴交温针灸治疗痰湿中阻型失眠的临床观察[J].海军医学杂志,2017,38(5):429-431,458.
[17]凌圣,薛学义.前列腺按摩配合针灸治疗前列腺增生症的临床疗效分析[J].针灸临床杂志,2016,32(11):11-13.
[18]李伟红,凌昌全.神阙穴隔盐灸配合三阴交穴温针灸治疗虚证良性前列腺增生症[J].第二军医大学学报,2015,36(12):1382-1384.
[19]王锦涛,于月青,陈文峰,等.中西医结合治疗前列腺增生尿潴留疗效及对相关因子的影响[J].现代中西医结合杂志,2017,26(33):3703-3705.
[20]Zhang W,Ma L,Bauer BA,et al.Acupuncture for benign prostatic hyperplasia:A systematic review and metaanalysis[J].PloS One,2017,12(4):e174586.
[21]罗慧麟,罗青锋,付贵平,等.热敏灸结合电针治疗良性前列腺增生症的临床疗效观察[J].针灸临床杂志,2016,32(4):1-3.
[22]丁青.“行气利水,补气固摄”针刺方法调理治疗前列腺增生的临床观察[J].中国组织工程研究,2014,18(12):82.
[23]孙洁,李滢,彭彦霞,等.艾灸结合功能性电刺激治疗良性前列腺增生症排尿功能障碍的临床疗效评价[J].北京中医药,2017,36(3):261-265.
[24]徐辉,王志勇,常辉,等.性激素、前列腺特异性抗原及其相关参数对前列腺癌的诊断价值[J].中国医药导报,2017,14(15):76-79.
[25]郑入文,胡慧.电针治疗良性前列腺增生及对患者雌雄激素水平的影响[J].中国针灸,2017,37(6):599-602.
[26]高燕,刘波,贾松松,等.温阳化气法穴位埋线联合温针灸治疗良性前列腺增生症临床观察[J].山东中医杂志,2016,35(10):883-885.
[2]Wang MQ,Guo LP,Duan F,et al.Prostatic arterial embolization for the treatment of lower urinary tract symptoms caused by benign prostatic hyperplasia:a comparative study of medium-and large-volume prostates[J].BJU Internat,2016,117(1):155-164.
[3]陈其华,赵丹,王大进,等.自拟方药益肾通癃胶囊治疗前列腺增生症疗效观察[J].中国性科学,2016,25(2):90-92.
[4]陈浩,张瑞,黄兴儒,等.中西药联合治疗良性前列腺增生症的优化方案研究[J].世界中西医结合杂志,2016,11(4):510-513.
[5]姜磊,陈英华,杜文秀,等.针刺配合艾灸治疗前列腺增生临床观察[J].上海针灸杂志,2015,34(2):139-140.
[6]那彦群,叶章群,孙光.中国泌尿外科疾病诊断治疗指南[M].北京:人民卫生出版社,2011:122.
[7]郑筱萸.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002:153-154.
[8]Basha SZ,Mohamed GA,Abdel-Naim AB,et al.Cucurbitacin E glucoside from Citrullus colocynthis inhibits testosterone-induced benign prostatic hyperplasia in mice[J].Drug Chem Toxicol,2019,12:1-11.
[9]Thomas D,Zorn KC,Zaidi N,et al.Does urodynamics predict voiding after benign prostatic hyperplasia surgery in patients with detrusor underactivity?[J].Asian J Urol,2019,6(3):264-269.
[10]Vasilyeva IN,Bespalov VG,Von JD,et al.Cell-Free DNAPlasma Levels Differ in Age-Specific Pattern in Healthy Rats and Castrates with Testosterone-Induced Benign Prostatic Hyperplasia[J].Int J Genomics,2019,2019:8173630.
[11]汪青,肖东,吕雁,等.益肾化瘀方含药血清对NRK52E转分化过程中TGF-?_1、BMP-7表达的影响[J].中国中西医结合肾病杂志,2016,17(1):18-21.
[12]Nasr El-Din WA,Abdel Fattah IO.The potential curative and preventive effects of garlic on testosterone-induced benign prostatic hyperplasia in orchiectomized rats[J].Rom J Morphol Embryol,2019,60(1):145-158.
[13]Khanduri S,Imam T,Khan M,et al.Rare Variant of Carcinoma Prostate Masquerading as Benign Prostatic Hyperplasia[J].Cureus,2019,11(4):e4504.
[14]郑玲,库宝庆,王月.健脾益肾化瘀方对肾衰竭患者免疫功能及微炎症的影响[J].现代中西医结合杂志,2017,26(26):2901-2903.
[15]李晨.火针治疗前列腺增生症临床观察[J].上海针灸杂志,2016,35(12):1445-1447.
[16]耿旭强,李伟红,李欣珂,等.神阙穴隔盐灸联合三阴交温针灸治疗痰湿中阻型失眠的临床观察[J].海军医学杂志,2017,38(5):429-431,458.
[17]凌圣,薛学义.前列腺按摩配合针灸治疗前列腺增生症的临床疗效分析[J].针灸临床杂志,2016,32(11):11-13.
[18]李伟红,凌昌全.神阙穴隔盐灸配合三阴交穴温针灸治疗虚证良性前列腺增生症[J].第二军医大学学报,2015,36(12):1382-1384.
[19]王锦涛,于月青,陈文峰,等.中西医结合治疗前列腺增生尿潴留疗效及对相关因子的影响[J].现代中西医结合杂志,2017,26(33):3703-3705.
[20]Zhang W,Ma L,Bauer BA,et al.Acupuncture for benign prostatic hyperplasia:A systematic review and metaanalysis[J].PloS One,2017,12(4):e174586.
[21]罗慧麟,罗青锋,付贵平,等.热敏灸结合电针治疗良性前列腺增生症的临床疗效观察[J].针灸临床杂志,2016,32(4):1-3.
[22]丁青.“行气利水,补气固摄”针刺方法调理治疗前列腺增生的临床观察[J].中国组织工程研究,2014,18(12):82.
[23]孙洁,李滢,彭彦霞,等.艾灸结合功能性电刺激治疗良性前列腺增生症排尿功能障碍的临床疗效评价[J].北京中医药,2017,36(3):261-265.
[24]徐辉,王志勇,常辉,等.性激素、前列腺特异性抗原及其相关参数对前列腺癌的诊断价值[J].中国医药导报,2017,14(15):76-79.
[25]郑入文,胡慧.电针治疗良性前列腺增生及对患者雌雄激素水平的影响[J].中国针灸,2017,37(6):599-602.
[26]高燕,刘波,贾松松,等.温阳化气法穴位埋线联合温针灸治疗良性前列腺增生症临床观察[J].山东中医杂志,2016,35(10):883-885.