苏拉明防治后囊膜混浊的实验研究
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摘要
目的探讨苏拉明复合黏弹剂与肝素眼内灌注对大鼠后发性白内障的影响。方法选用健康大鼠制作白内障大鼠模型,行超声乳化白内障吸除术,术中分别应用普通黏弹剂、浓度为300μg/ml苏拉明复合黏弹剂及浓度为25μ/ml肝素,观察术后大鼠后囊膜混浊情况。结果浓度为300μg/ml苏拉明复合黏弹剂及浓度为25μ/ml肝素均能对鼠眼后发性白内障起到抑制作用,但苏拉明的作用更确切、疗效更好,长期效果更明显(P<0.05)。结论苏拉明复合黏弹剂较肝素能更好地预防鼠眼后发性白内障。
Objective To investigate effect on rat posterior capsular opacification(PCO) from intraocular injections of suramin composite viscoelastic and heparin through animal experience. Method We choose healthy rats to make models of cataract and undergo phacoemulsification. General viscoelastic, suramin composite viscoelastic with 300 ug/ml concentration, and heparin with 25μ/ml concentration are applied separately in the operation. PCO of rats after operation is observed and analyzed. Result Suramin composite viscoelastic with 300μg/ml concentration and heparin with 25μ/ml concentration have an inhibitive effect on PCO of rats' eyes, and suramin has better curative effect and obvious long-term effect. Conclusion This experience proves that suramin composite viscoelastic has better prevention of PCO of rat eyes than heparin.
Objective To investigate effect on rat posterior capsular opacification(PCO) from intraocular injections of suramin composite viscoelastic and heparin through animal experience. Method We choose healthy rats to make models of cataract and undergo phacoemulsification. General viscoelastic, suramin composite viscoelastic with 300 ug/ml concentration, and heparin with 25μ/ml concentration are applied separately in the operation. PCO of rats after operation is observed and analyzed. Result Suramin composite viscoelastic with 300μg/ml concentration and heparin with 25μ/ml concentration have an inhibitive effect on PCO of rats' eyes, and suramin has better curative effect and obvious long-term effect. Conclusion This experience proves that suramin composite viscoelastic has better prevention of PCO of rat eyes than heparin.
引文
[1]邴寒,李淼,张继超,等.N d:Y A G激光治疗后发性白内障280例临床分析[J].中国医学装备,2012,9(4):67-69.
[2]张筠,孔文君,赵平.低分子肝素钠对兔后发性白内障的抑制作用及对房水中PDGF和EGF含量的影响[J].中华眼科医学杂志(电子版),2012,2(2):100-104.
[3]赵鹏涛.基层YAG治疗后发障的观察[J].中国伤残医学,2016,24(8):79-80.
[4]杨庆红,陈威,刘兵,等.Nd:YAG激光治疗后发性白内障对角膜内皮细胞的影响研究[J].临床军医杂志,2011,39(5):1013-1014.
[5]孙海燕,闫爱民,赵平.苏拉明对外伤性增生性玻璃体视网膜病变抑制作用的实验研究[J].中华眼外伤职业眼病杂志,2011,33(8):566-569.
[6]Wiese C,Nikolova T,Zahanich I,et al.Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin[J].Int J Cardiol,2011,147(1):95-111.
[7]Tayel A,Abd El Galil KH,Ebrahim MA,et al.Suramin inhibits hepatic tissue damage in hepatocellular carcinoma through deactivation of heparanase enzyme[J].Eur J Pharmacol,2014,728(2):151-160.
[8]El-Kik CZ,Fernandes FFA,Tomaz MA,et al.Neutralization of apismellifera bee venom activities by suramin[J].Toxicon,2013,67(3):55-62.
[9]谌金金,王平.药物防治后发性白内障的研究进展[J].海南医学,2014,25(22):3335-3357.
[10]朱红梅.老年性白内障超声乳化联合人工晶体植入术并发症分析[J].中国临床医生杂志,2007,35(6):47-49.
[11]刘亦苏,施玉英,李然,等.可调节人工晶状体植入术后调节效果的观察[J].中国临床医生杂志,2009,37(4):47-49.
[12]Abela-Formanek C,Amon M,Schild G,et al.Uveal and capsular biocompatibility of hydrophilic acrylic,hydrophobic acrylic,and silicone intraocular lenses[J].J Cataract Refract Surg,2002,28(1):50-61.
[13]Cheng CY,Yen MY Chen SJ,et al.Visual acuity and contrast sensitivity in different types of Posterior capsule opacification[J].J Catract Rifract Surg,2001,27(7):1055-1060.
[14]Aslam TM,Patton N.Methods of assessment of patients for Nd:YAG laser capsulotomy that correlate with final visual improvement[J].BMC ophthalmol,2004,4(1):6052-6066.
[15]Prajna NV,Ellwein LB,Selvaraj S,et al.The madurai intraocular lensstudyⅣ:posterior capsule opacification[J].A m J Ophthalmol,2000,130(3):304-309.
[2]张筠,孔文君,赵平.低分子肝素钠对兔后发性白内障的抑制作用及对房水中PDGF和EGF含量的影响[J].中华眼科医学杂志(电子版),2012,2(2):100-104.
[3]赵鹏涛.基层YAG治疗后发障的观察[J].中国伤残医学,2016,24(8):79-80.
[4]杨庆红,陈威,刘兵,等.Nd:YAG激光治疗后发性白内障对角膜内皮细胞的影响研究[J].临床军医杂志,2011,39(5):1013-1014.
[5]孙海燕,闫爱民,赵平.苏拉明对外伤性增生性玻璃体视网膜病变抑制作用的实验研究[J].中华眼外伤职业眼病杂志,2011,33(8):566-569.
[6]Wiese C,Nikolova T,Zahanich I,et al.Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin[J].Int J Cardiol,2011,147(1):95-111.
[7]Tayel A,Abd El Galil KH,Ebrahim MA,et al.Suramin inhibits hepatic tissue damage in hepatocellular carcinoma through deactivation of heparanase enzyme[J].Eur J Pharmacol,2014,728(2):151-160.
[8]El-Kik CZ,Fernandes FFA,Tomaz MA,et al.Neutralization of apismellifera bee venom activities by suramin[J].Toxicon,2013,67(3):55-62.
[9]谌金金,王平.药物防治后发性白内障的研究进展[J].海南医学,2014,25(22):3335-3357.
[10]朱红梅.老年性白内障超声乳化联合人工晶体植入术并发症分析[J].中国临床医生杂志,2007,35(6):47-49.
[11]刘亦苏,施玉英,李然,等.可调节人工晶状体植入术后调节效果的观察[J].中国临床医生杂志,2009,37(4):47-49.
[12]Abela-Formanek C,Amon M,Schild G,et al.Uveal and capsular biocompatibility of hydrophilic acrylic,hydrophobic acrylic,and silicone intraocular lenses[J].J Cataract Refract Surg,2002,28(1):50-61.
[13]Cheng CY,Yen MY Chen SJ,et al.Visual acuity and contrast sensitivity in different types of Posterior capsule opacification[J].J Catract Rifract Surg,2001,27(7):1055-1060.
[14]Aslam TM,Patton N.Methods of assessment of patients for Nd:YAG laser capsulotomy that correlate with final visual improvement[J].BMC ophthalmol,2004,4(1):6052-6066.
[15]Prajna NV,Ellwein LB,Selvaraj S,et al.The madurai intraocular lensstudyⅣ:posterior capsule opacification[J].A m J Ophthalmol,2000,130(3):304-309.