中药材农药残留研究现状
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摘要
农药残留与中药材质量和安全密切相关,已引起国内外的普遍关注。该文通过总结近年研究成果,分析了目前中药材农药残留现状,总结了中药材农药残留的检测方法,并将国内外的中药材农药残留限量标准进行了对比,以期为中药材农药残留的检测和控制提供参考和依据。
The residue of the pesticides is closely related to the quality and safety of traditional Chinese medicines(TCMs) and has attracted widespread attention at home and abroad.This article analyzed the current status of pesticide residues in TCMs by summarizing the research results of recent years.At the same time,the methods for the detection of pesticide residues in TCMs were summarized,and the domestic and foreign pesticide residue limit standards for TCMs were compared,intending to provide reference and basis for the detection and control of pesticide residues in TCMs.
The residue of the pesticides is closely related to the quality and safety of traditional Chinese medicines(TCMs) and has attracted widespread attention at home and abroad.This article analyzed the current status of pesticide residues in TCMs by summarizing the research results of recent years.At the same time,the methods for the detection of pesticide residues in TCMs were summarized,and the domestic and foreign pesticide residue limit standards for TCMs were compared,intending to provide reference and basis for the detection and control of pesticide residues in TCMs.
引文
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[8]马雯,薛晓利,秦雪梅,等.中药材农药残留及脱除方法研究进展[J].中草药,2018(3):745.
[9]杨崇仁.中药农药现状与对策[J].中国现代中药,2013(8):633.
[10]何睿,张春玲,常育.中药材中7种拟除虫菊酯类农药残留的检测方法研究[J].西北药学杂志,2014(2):132.
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[19]陈一鑫,冯清胜,王晓中,等.离子液体-基质固相分散-超声雾化-固相萃取结合高效液相色谱法检测人参中三嗪类除草剂[J].分析化学,2016(7):1106.
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[21]Duan X,Tong L,Li D,et al.A Multiresidue Method for Simultaneous Determination of 116 Pesticides in Notoginseng Radix et Rhizoma using modified QuEChERS coupled with gas chromatography tandem mass spectrometry and census 180 batches of sample from Yunnan province[J].Chromatographia,2018,81(3):545.
[22]Qin Y,Chen L,Yang X,et al.Multi-residue method for determination of selected neonicotinoid insecticides in traditional Chinese medicine using modified dispersive solid-phase extraction combined with ultra-performance liquid chromatography tandem mass spectrometry[J].Anal Sci,2015,31(8):823.
[23]Qin Y,Chen L,Yang X,et al.Determination of 19 representative pesticides in traditional Chinese medicines by dispersive liquid-liquid microextraction and ultrahigh-performance liquid chromatography-tandem mass spectrometry[J].Chromatographia,2016,79(13/14):875.
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[25]吴飞,黄力,李月侠,等.不同产地黄芪中有机氯类农药残留量的比较研究[J].广东化工,2017(11):111.
[26]曾鸿超,张文斌,孙玉琴,等.三七中五氯硝基苯残留现状调查[J].人参研究,2015(4):48.
[27]何清彦,皮胜玲,谢嘉驰,等.GC-ECD测定当归等10种药食两用中药材中有机氯残留量[J].中国当代医药,2016(10):4.
[28]顾炎,薛健,金红宇,等.金银花中有机磷类农药测定方法建立及残留状况调查[J].中国现代中药,2016(9):1148.
[29]李家春,伍静玲,秦建平,等.基于QuEChERS法-超高效液相色谱-串联质谱法的5种中药材中35种有机磷农药残留量的快速分析[J].药物分析杂志,2016(1):122.
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[31]李嘉欣,石上梅,薛健.禁限用有机氯及拟除虫菊酯类农药在金银花中残留状况调查[J].中药材,2018(4):790.
[32]王莹,金红宇,隋海霞,等.枸杞中拟除虫菊酯类农药残留水平及累积暴露评估[J].中国食品卫生杂志,2017(5):616
[33]张艳,苟春林,姜瑞,等.宁夏枸杞中拟除虫菊酯类农药残留风险评估[J].新疆农业科学,2015(12):2273.
[34]靳敏,梁青青,张丽萍,等.蒙古黄芪种植土壤及药材中重金属和农药残留分析[J].中药材,2015(3):454.
[35]王莹,魏赫,乔菲,等.气相色谱-串联质谱法快速筛查人参中192种农药残留[J].中国实验方剂学杂志,2018(15):83.
[36]黄绍军,李超,马成章,等.气相色谱-串联质谱法测定玉龙县人参中农药残留量[J].分析试验室,2017(4):423.
[37]赵春杰,侯哲,袁丽华,等.气相色谱法同时测定西洋参药材根中12种农药残留的含量[J].沈阳大学学报:自然科学版,2014(3):193.
[38]刘洁,佟玲,孟文婷,等.固相萃取-超快速液相色谱-串联质谱法测定当归中135种农药及其代谢物残留[J].色谱,2015(12):1257.
[39]周卿,张艳,杨鑫.分散液相微萃取-液质联用法快速测定党参中有机磷农药残留[J].湖北农业科学,2018(15):81.
[40]余磊,王兴宁.固相萃取/在线凝胶色谱净化-气相色谱质谱法测定党参中18种农药残留量[J].贵阳学院学报:自然科学版,2015(2):36.
[41]余磊,王兴宁.加速溶剂萃取-气相色谱-串联质谱法测定党参中69种农药残留量[J].理化检验:化学分册,2014(10):1232.
[42]刘知远.石英毛细管气相色谱法测定柘荣太子参中联苯菊酯、毒死蜱的农药残留量[J].药物分析杂志,2013(2):271.
[43]林祥群,卢春霞,罗小玲,等.气相色谱-质谱法测定枸杞中28种农药残留[J].江苏农业科学,2016(1):285.
[44]吴梅青.不同产地莲子和莲子心中有机氯农药残留分析[J].安徽农业科学,2014(19):6233.
[45]李嘉欣,石上梅,薛健.有机磷类禁限用农药在金银花中的残留状况及风险评估[J].中国中药杂志,2018,43(11):2333.
[46]吕盼,费毅琴,聂晶,等.不同产区菊花药材的农药残留与重金属元素检测分析[J].时珍国医国药,2018(6):1466.
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[2]魏建和,屠鹏飞,李刚,等.我国中药农业现状分析与发展趋势思考[J].中国现代中药,2015(2):94.
[3]杨银慧,豆小文,孔维军,等.我国中药材中农药登记现状及污染分析[J].中国中药杂志,2013,38(24):4238.
[4]Shaban N S,Abdou K A,Hassan N E Y.Impact of toxic heavy metals and pesticide residues in herbal products[J].Beni-Suef Univ Basic Appl Sci,2016,5(1):102.
[5]何曼莉,谢建军,陈捷,等.凝胶渗透色谱-固相萃取-气相色谱法同时测定药食两用中药材中17种有机氯类农药残留量[J].食品安全质量检测学报,2015(3):893.
[6]苗青,孔维军,魏建和,等.中药材中农药残留现状及控制措施评析[J].农药学学报,2012(4):363.
[7]康传志,郭兰萍,周涛,等.中药材农残研究现状的探讨[J].中国中药杂志,2016,41(2):155.
[8]马雯,薛晓利,秦雪梅,等.中药材农药残留及脱除方法研究进展[J].中草药,2018(3):745.
[9]杨崇仁.中药农药现状与对策[J].中国现代中药,2013(8):633.
[10]何睿,张春玲,常育.中药材中7种拟除虫菊酯类农药残留的检测方法研究[J].西北药学杂志,2014(2):132.
[11]秦立新,魏进,陈才俊,等.中药材中拟除虫菊酯类农药残留检测研究进展[J].贵州农业科学,2014(3):71.
[12]程寿峰,张明时,夏品华,等.黔产中药材饮片中拟除虫菊酯农药残留量分析[J].湖北大学学报:自然科学版,2013(2):197.
[13]胡一晨,万丽,杨芳,等.中药中农药残留的限量标准及相关研究现状[J].中药与临床,2012(1):48.
[14]傅巧真,路俊仙,王萌,等.中药材农药残留原因及防治措施的研究进展[J].时珍国医国药,2014(4):925.
[15]吴梅青.中药材中农药残留、重金属检测技术研究进展[J].中国药物评价,2013(6):324.
[16]中国药典.四部[S].2015.
[17]Zhao X,Kong W,Wei J,et al.Gas chromatography with flame photometric detection of 31 organophosphorus pesticide residues in Alpinia oxyphylla dried fruits[J].Food Chem,2014,162:270.
[18]Liu H,Kong W,Gong B,et al.Rapid analysis of multi-pesticides in Morinda officinalis by GC-ECD with accelerated solvent extraction assisted matrix solid phase dispersion and positive confirmation by GC-MS[J].J Chromatogr B,2015,974:65.
[19]陈一鑫,冯清胜,王晓中,等.离子液体-基质固相分散-超声雾化-固相萃取结合高效液相色谱法检测人参中三嗪类除草剂[J].分析化学,2016(7):1106.
[20]刘志风,徐靖,李建淼,等.GC-MS与GC-MS/MS在灵芝农药残留分析中的应用[J].现代中药研究与实践,2015(5):20.
[21]Duan X,Tong L,Li D,et al.A Multiresidue Method for Simultaneous Determination of 116 Pesticides in Notoginseng Radix et Rhizoma using modified QuEChERS coupled with gas chromatography tandem mass spectrometry and census 180 batches of sample from Yunnan province[J].Chromatographia,2018,81(3):545.
[22]Qin Y,Chen L,Yang X,et al.Multi-residue method for determination of selected neonicotinoid insecticides in traditional Chinese medicine using modified dispersive solid-phase extraction combined with ultra-performance liquid chromatography tandem mass spectrometry[J].Anal Sci,2015,31(8):823.
[23]Qin Y,Chen L,Yang X,et al.Determination of 19 representative pesticides in traditional Chinese medicines by dispersive liquid-liquid microextraction and ultrahigh-performance liquid chromatography-tandem mass spectrometry[J].Chromatographia,2016,79(13/14):875.
[24]杨婉珍,康传志,纪瑞锋,等.中药材残留农药情况分析及其标准研制的思考[J].中国中药杂志,2017,42(12):2284.
[25]吴飞,黄力,李月侠,等.不同产地黄芪中有机氯类农药残留量的比较研究[J].广东化工,2017(11):111.
[26]曾鸿超,张文斌,孙玉琴,等.三七中五氯硝基苯残留现状调查[J].人参研究,2015(4):48.
[27]何清彦,皮胜玲,谢嘉驰,等.GC-ECD测定当归等10种药食两用中药材中有机氯残留量[J].中国当代医药,2016(10):4.
[28]顾炎,薛健,金红宇,等.金银花中有机磷类农药测定方法建立及残留状况调查[J].中国现代中药,2016(9):1148.
[29]李家春,伍静玲,秦建平,等.基于QuEChERS法-超高效液相色谱-串联质谱法的5种中药材中35种有机磷农药残留量的快速分析[J].药物分析杂志,2016(1):122.
[30]郑双双,高新花,刘珂.金银花等3种中药材中有机磷农药残留量的测定[J].烟台大学学报:自然科学与工程版,2013(1):69.
[31]李嘉欣,石上梅,薛健.禁限用有机氯及拟除虫菊酯类农药在金银花中残留状况调查[J].中药材,2018(4):790.
[32]王莹,金红宇,隋海霞,等.枸杞中拟除虫菊酯类农药残留水平及累积暴露评估[J].中国食品卫生杂志,2017(5):616
[33]张艳,苟春林,姜瑞,等.宁夏枸杞中拟除虫菊酯类农药残留风险评估[J].新疆农业科学,2015(12):2273.
[34]靳敏,梁青青,张丽萍,等.蒙古黄芪种植土壤及药材中重金属和农药残留分析[J].中药材,2015(3):454.
[35]王莹,魏赫,乔菲,等.气相色谱-串联质谱法快速筛查人参中192种农药残留[J].中国实验方剂学杂志,2018(15):83.
[36]黄绍军,李超,马成章,等.气相色谱-串联质谱法测定玉龙县人参中农药残留量[J].分析试验室,2017(4):423.
[37]赵春杰,侯哲,袁丽华,等.气相色谱法同时测定西洋参药材根中12种农药残留的含量[J].沈阳大学学报:自然科学版,2014(3):193.
[38]刘洁,佟玲,孟文婷,等.固相萃取-超快速液相色谱-串联质谱法测定当归中135种农药及其代谢物残留[J].色谱,2015(12):1257.
[39]周卿,张艳,杨鑫.分散液相微萃取-液质联用法快速测定党参中有机磷农药残留[J].湖北农业科学,2018(15):81.
[40]余磊,王兴宁.固相萃取/在线凝胶色谱净化-气相色谱质谱法测定党参中18种农药残留量[J].贵阳学院学报:自然科学版,2015(2):36.
[41]余磊,王兴宁.加速溶剂萃取-气相色谱-串联质谱法测定党参中69种农药残留量[J].理化检验:化学分册,2014(10):1232.
[42]刘知远.石英毛细管气相色谱法测定柘荣太子参中联苯菊酯、毒死蜱的农药残留量[J].药物分析杂志,2013(2):271.
[43]林祥群,卢春霞,罗小玲,等.气相色谱-质谱法测定枸杞中28种农药残留[J].江苏农业科学,2016(1):285.
[44]吴梅青.不同产地莲子和莲子心中有机氯农药残留分析[J].安徽农业科学,2014(19):6233.
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