食药用菌抗神经炎症的研究进展
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摘要
神经胶质细胞和神经元是神经系统两大细胞种类,其中神经胶质细胞占神经系统细胞总数的70%。越来越多的研究证明,由神经胶质细胞介导的神经炎症是神经退行性疾病如阿茨海默症发病的重要因素之一,因而抑制脑部神经炎症,有益于神经退行性疾病的预防与治疗。近年来的一些研究表明源于食药用菌的多糖、核苷、甾醇、萜类等活性物质,能够通过抑制脑内胶质细胞激活,表现出良好的抗神经炎的活性,其活性作用机制涉及到抑制TNF-α和IL-1β等促炎性细胞因子释放,增加IL-10等抗炎症因子的产生等。根据近年的文献报道,本文总结了食药用菌在抗神经炎症的活性成分及作用机制等方面的研究进展,为从食药用菌中筛选出抗神经炎症和治疗神经退行性疾病的大健康产品提供参考。
Neuroglia cells and neurons are most predominant cells in the neural system,in which neuroglia cells amount up to 70% of the total cells in the neural system.More and more evidences showed that neuroglia cell mediated neuroinflammation is one of the most important trigger of neurodegenerative diseases.Therefore,inhibition of neuroinflammation is beneficial for prevention and treatment of neurodegenerative diseases.Recent evidences showed that some polysaccharides and terpenoids from edible and medicinal mushroom displayed good anti-neuroinflammation activity through inhibition on neuroglia cell activation.The inhibition mechanism involved inhibition on the release of pro-inflammatory factors such as TNF-αand IL-1β,and stimulation on the production of anti-inflammation factors such as IL-10.Active compounds from edible and medicinal mushrooms with anti-neuroinflammation activities were reviewed,lending insights for the development of therapeutics for neurodegenerative diseases.
Neuroglia cells and neurons are most predominant cells in the neural system,in which neuroglia cells amount up to 70% of the total cells in the neural system.More and more evidences showed that neuroglia cell mediated neuroinflammation is one of the most important trigger of neurodegenerative diseases.Therefore,inhibition of neuroinflammation is beneficial for prevention and treatment of neurodegenerative diseases.Recent evidences showed that some polysaccharides and terpenoids from edible and medicinal mushroom displayed good anti-neuroinflammation activity through inhibition on neuroglia cell activation.The inhibition mechanism involved inhibition on the release of pro-inflammatory factors such as TNF-αand IL-1β,and stimulation on the production of anti-inflammation factors such as IL-10.Active compounds from edible and medicinal mushrooms with anti-neuroinflammation activities were reviewed,lending insights for the development of therapeutics for neurodegenerative diseases.
引文
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[3]GLASS CK,SAIJO K.Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells[J].Nature Reviews Immunology,2010,10(5):365-376.
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[7]BELLUCCI A,BUGIANI O,GHETTI B,et al.Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301Smutation[J].Neurodegenerative Diseases,2011,8(4):221-229.
[8]傅文垚.三种神经退行性疾病相关基因互作网络和药物靶点的比较分析[D].合肥:合肥工业大学,2017.
[9]李昂.2010-2050年中国老年痴呆的预测研究[D].苏州:苏州大学,2015.
[10]刘疏影,陈彪.帕金森病流行现状[J].中国现代神经疾病杂志,2016,16(2):98-101.
[11]王越,王士博,于晓雯,等.阿司匹林对Aβ25-35诱导神经元炎性损伤的保护作用研究[J].中华老年多器官疾病杂志,2016,15(5):382-386.
[12]汤仕龙.非甾体抗炎药与上消化道出血关系的探究[J].实用中西医结合临床,2016,16(3):42-43.
[13]GUNAWARDENA D,SHANMUGAM K,LOW M,et al.Determination of anti-inflammatory activities of standardised preparations of plant-and mushroom-based foods[J].European Journal of Nutrition,2014,53(1):335-343.
[14]GENG Y,ZHU S,LU Z,et al.Anti-inflammatory activity of mycelial extracts from medicinal mushrooms[J].International Journal of Medicinal Mushrooms,2014,16(4):319.
[15]PHAN C W,DAVID P,NAIDU M,et al.Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases:diversity,metabolite,and mechanism[J].Critical Reviews in Biotechnology,2014,35(3):355.
[16]XU T,BEELMAN RB.The bioactive compounds in medicinal mushrooms have potential protective effects against neurodegenerative diseases[J].Advances in Food Technology and Nutritional Sciences,2015,1(2):62-65.
[17]陈世通,白建波,李梦杰,等.食药用菌多糖的药理作用及开发利用研究[J].北方园艺,2012,36(17):195-198.
[18]HUANG X,NIE S.The structure of mushroom polysaccharides and their beneficial role in health[J].Food&Function,2015,6(10):3205.
[19]CAI Q,LI Y,GANG P.Polysaccharides from Ganoderma lucidum,attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response[J].Journal of Neuroinflammation,2017,14(1):63.
[20]JAYASOORIYA RG,KANG CH,SEO MJ,et al.Exopolysaccharide of Laetiporus sulphureus var.miniatus downregulates LPS-induced production of NO,PGE2,and TNF-αin BV2 microglia cells via suppression of the NF-κB pathway[J].Food&Chemical Toxicology,2011,49(11):2758-64.
[21]汪保华,袁华,吕志华,等.灵芝多糖对模拟AD学习记忆障碍大鼠海马白细胞介素-6表达的影响[J].卒中与神经疾病,2017,14(4):206-209.
[22]ZHOU ZY,TANG YP,XIANG J,et al.Neuroprotective effects of water-soluble Ganoderma lucidum polysaccharides on cerebral ischemic injury in rats[J].Journal of Ethnopharmacology,2010,131(1):154-164.
[23]北京绿源求证科技发展有限责任公司.一种治疗糖尿病性末梢神经炎的中药:中国,200810103596.2[P].2009-10-14.
[24]邵连亭.面神经炎康复散中药配方:中国,201210327175.4[P].2014-03-05.
[25]刘瑜.新型倍半萜类化合物Myrrhterpenoid A对小胶质细胞的抑制作用及机制研究[D].天津:南开大学,2013.
[26]魏仁平,孙芳玲,艾厚喜,等.龙胆苦苷抗炎症作用和机制研究进展[C]//第十六届全国神经精神药理学学术会议论文集.温州:中国药理学会,2014:678-679.
[27]PAREEK TK,BELKADI A,KESAVAPANY S,et al.Triterpenoid modulation of IL-17and Nrf-2expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis[J].Scientific Reports,2011,1(51):201.
[28]ZHOU Y,QU ZQ,ZENG YS,et al.Neuroprotective effect of preadministration with Ganoderma lucidum spore on rat hippocampus[J].Experimental and Toxicologic Pathology,2012,64(7-8):673-680.
[29]黄勇攀,刘丙进,喻南慧,等.灵芝三萜类化合物对AD模型大鼠脑组织保护作用的研究[J].贵阳医学院学报,2008,33(6):662-664.
[30]LAI CS,YU MS,YUEN WH,et al.Antagonizing beta-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum[J].Brain Research.2008,1190:215-224.
[31]LIU DZ,LIANG HJ,CHEN CH,et al.Comparative anti-inflammatory characterization of wild fruiting body,liquid-state fermentation,and solid-state culture of Taiwanofungus camphoratus,in microglia and the mechanism of its action[J].Journal of Ethnopharmacology,2007,113(1):45-53.
[32]MADAMANCHI G,YEW-MIM T.Review of Pharmacological effects of Antrodia camphorataandits bioactive compounds[J].Evidence-Based Complementray and Alternative Medicine,2011,(2010-09-15),2010,2011(1741-427X):212641.
[33]HSEU YC,WU FY,WU JJ,et al.Anti-inflammatory potential of Antrodia Camphorata through inhibition of iNOS,COX-2and cytokines via the NF-kappaB pathway[J].International Immunopharmacology,2005,5(13):1914-1925.
[34]JIAO Y,XIE T,ZOU LH,et al.Lanostane triterpenoids from Ganoderma curtisii,and their NO production inhibitory activities of LPS-induced microglia[J].Bioorganic&Medicinal Chemistry Letters,2016,26(15):3556-3561.
[35]张静,张家臣,高智席,等.猴头菇活性成分研究进展[J].南方农业,2016,10(12):186-188.
[36]樊慧婷,林洪生.蛹虫草化学成分及药理作用研究进展[J].中国中药杂志,2013,38(15):2549-2552.
[37]赵友兴,吴兴亮,黄圣卓.中国药用菌物化学成分与生物活性研究进展[J].贵州科学,2013,31(1):18-27.
[38]NALLATHAMBY N,GUAN-SERM L,VIDYADARAN S,et al.Ergosterol of Cordyceps militaris attenuates lps induced inflammation in BV2microglia cells[J].Natural Product Communications,2015,10(6):885-886.
[39]都兴范,李军,王林美.蛹虫草中虫草素的研究进展[J].食用菌,2012,34(6):3-5.
[40]张慧,罗帷.蛹虫草中虫草素的研究与开发进展[J].现代农业科技,2016(9):292-292.
[41]邓昌,欧阳波,陶然,等.虫草素对小鼠脑缺血再灌注损伤的神经保护作用及炎症调节[J].中国老年学杂志,2014,34(3):687-690.
[42]孟雪莲,陈长兰,孔维娟,等.虫草素抑制脂多糖诱导的小胶质细胞活化及神经保护作用[J].食品科学,2014,35(19):224-230.
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