HPV联合细胞DNA定量检查及血清SCC在宫颈癌筛查及预后中的意义
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摘要
目的:探究HPV联合细胞DNA定量检查及血清SCC在宫颈癌筛查及预后中的意义。方法:选取2012年12月-2017年12月本院收治的98例宫颈癌患者为A组,同时期的98例高度鳞状上皮内病变(high-grade squamous intraepithelial lesion,HSIL)患者为B组,98例低度鳞状上皮内病变(lowgrade squamous intraepithelial lesion,LSIL)患者为C组,98例体检健康妇女为D组。比较四组HPV、细胞DNA定量检查及血清SCC阳性率,同时比较A组中不同分期与分化程度宫颈癌患者的阳性率。结果:A组与B组HPV、细胞DNA定量检查比较,差异均无统计学意义(P>0.05),但均高于C组和D组,A组血清SCC阳性率高于其他三组,差异有统计学意义(P<0.05),但A组中不同分期与分化程度宫颈癌患者HPV、细胞DNA定量检查比较,差异均无统计学意义(P>0.05),但血清SCC阳性率比较,差异有统计学意义(P<0.05)。结论:宫颈癌患者的HPV、细胞DNA定量检查及血清SCC结果明显异常,但对疾病分期与分化程度无明显意义。
Objective:To investigate the significance of HPV combined with cellular DNA quantitative examination and serum SCC in the screening and prognosis of cervical cancer.Method:98 patients with cervical cancer from December 2012 to December 2017 were chosen as group A,98 patients with high-grade squamous intraepithelial lesion(HSIL)at the same time were chosen as group B,98 patients with low-grade squamous intraepithelial lesion(LSIL)were chosen as group C,98 healthy women were chosen as group D.Then the positive rates of HPV,cellular DNA quantitative examination and serum SCC of four groups were compared,then the positive rates of group A with different stages and differentiation of cervical cancer were compared.Result:The HPV and cellular DNA quantitative examination of group A and group B were compared,there were no statistically significant differences(P>0.05),they were higher than those of group C and group D,the serum SCC positive rates of group A were higher than those of three groups,there were all statistically significant differences(P<0.05),while the HPV and cellular DNA quantitative examination of group A with different stages and differentiation of cervical cancer were compared,there were no statistically significant differences(P>0.05),and the serum SCC positive rates were compared,there were all statistically significant differences(P<0.05).Conclusion:The HPV,cellular DNA quantitative examination and serum SCC of patients with cervical cancer are significantly abnormal,while the significance for the disease stages and differentiation are not obvious.
Objective:To investigate the significance of HPV combined with cellular DNA quantitative examination and serum SCC in the screening and prognosis of cervical cancer.Method:98 patients with cervical cancer from December 2012 to December 2017 were chosen as group A,98 patients with high-grade squamous intraepithelial lesion(HSIL)at the same time were chosen as group B,98 patients with low-grade squamous intraepithelial lesion(LSIL)were chosen as group C,98 healthy women were chosen as group D.Then the positive rates of HPV,cellular DNA quantitative examination and serum SCC of four groups were compared,then the positive rates of group A with different stages and differentiation of cervical cancer were compared.Result:The HPV and cellular DNA quantitative examination of group A and group B were compared,there were no statistically significant differences(P>0.05),they were higher than those of group C and group D,the serum SCC positive rates of group A were higher than those of three groups,there were all statistically significant differences(P<0.05),while the HPV and cellular DNA quantitative examination of group A with different stages and differentiation of cervical cancer were compared,there were no statistically significant differences(P>0.05),and the serum SCC positive rates were compared,there were all statistically significant differences(P<0.05).Conclusion:The HPV,cellular DNA quantitative examination and serum SCC of patients with cervical cancer are significantly abnormal,while the significance for the disease stages and differentiation are not obvious.
引文
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[13]Lesley A Anderson,Michael A O’Rorke,Robbie Wilson,et al.HPV prevalence and type-distribution in cervical cancer and premalignant lesions of the cervix:A population-based study from Northern Ireland[J].J Med Virol,2016,88(7):1262-1270.
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[16]杨正浩,魏珍,刘涛.细胞DNA定量分析法和液基薄层细胞学检测技术在宫颈癌早期诊断中的应用对比[J].昆明医科大学学报,2015,36(6):59-61.
[17]吕晓杰,曹冬如,蒋红清,等.高危型人乳头瘤病毒负荷量与宫颈细胞DNA倍体定量关系的探讨[J].中国妇幼保健,2015,30(22):3781-3783.
[18]代黎,叶佳.宫颈细胞DNA定量及高危型HPV检测在宫颈癌筛查中的应用[J].深圳中西医结合杂志,2017,27(4):54-55.
[19]王昱.细胞DNA定量分析法在宫颈癌及癌前病变筛查及诊断中的应用价值[J].山西医药杂志,2017,46(4):472-473.
[20]莫伟杰,赵仁峰,李伟,等.宫颈细胞DNA倍体测定联合人乳头瘤病毒感染检测筛查宫颈癌的价值[J].广西医学,2016,38(1):105-107.
[2]王飞霞,杨瑞利,韩双.细胞DNA定量分析联合HR-HPV、SCCA、CYFRA21-1检测在早期宫颈癌筛查中的价值[J].肿瘤学杂志,2018,24(3):281-284.
[3]王双双,李惠,唐福婷,等.细胞DNA定量分析及高危型HPV-DNA检测在宫颈病变筛查中的应用[J].临床与病理杂志,2017,37(4):791-795.
[4]谭景浪,陈琼,乔莎莎,等.细胞DNA定量分析联合液基细胞学在宫颈癌筛查中的临床应用研究[J].河北医学,2016,22(2):261-264.
[5]张喆,孔令婷,孙寒雪,等.细胞DNA定量分析在宫颈病变筛查中的应用价值[J].中国医科大学学报,2017,46(11):1013-1018.
[6]闻明,田德明,杨小苗,等.宫颈细胞DNA定量分析在宫颈癌筛查中的应用价值[J].皖南医学院学报,2016,35(4):371-373.
[7]项艳,杜晓东,徐凤秋.细胞DNA定量分析技术在宫颈癌筛查中的应用价值[J].中国妇幼保健,2017,32(22):5751-5752.
[8]罗丽丽,王莹,罗小婉,等.细胞DNA倍体分析对宫颈高度鳞状上皮内病变诊断及随访价值研究[J].中国优生与遗传杂志,2017,25(9):22-24.
[9]林娜,吴春林.细胞DNA倍体分析联合高危HPV DNA核酸检测在子宫颈鳞状上皮高级别内病变筛查中的应用研究[J].中外医学研究,2017,15(31):76-78.
[10]陈涝彧.细胞DNA定量分析技术在宫颈癌筛查中的应用[J].现代肿瘤医学,2015,23(8):1116-1118.
[11]Elena Wüstenhagen,Fatima Boukhallouk,Inka Negwer,et al.Rational design for cervical cancer therapeutics:cellular and non-cellular based strategies on the horizon for recurrent,metastatic or refractory cervical cancer[J].Expert Opin Drug Dis,2018,13(5):445-457.
[12]Mehta K,Laimonis L.Human Papillomaviruses Preferentially Recruit DNA Repair Factors to Viral Genomes for Rapid Repair and Amplification[J].MBio,2018,9(1):25-26.
[13]Lesley A Anderson,Michael A O’Rorke,Robbie Wilson,et al.HPV prevalence and type-distribution in cervical cancer and premalignant lesions of the cervix:A population-based study from Northern Ireland[J].J Med Virol,2016,88(7):1262-1270.
[14]Anco Molijn,David Jenkins,Wen Chen,et al.The complex relationship between human papillomavirus and cervical adenocarcinoma[J].Int J Cancer,2016,138(2):409-416.
[15]闻明,王琳,田德明,等.DNA定量分析在宫颈早期病变诊断中的应用及其对细胞学ASCUS的临床意义[J].蚌埠医学院学报,2018,43(6):713-716.
[16]杨正浩,魏珍,刘涛.细胞DNA定量分析法和液基薄层细胞学检测技术在宫颈癌早期诊断中的应用对比[J].昆明医科大学学报,2015,36(6):59-61.
[17]吕晓杰,曹冬如,蒋红清,等.高危型人乳头瘤病毒负荷量与宫颈细胞DNA倍体定量关系的探讨[J].中国妇幼保健,2015,30(22):3781-3783.
[18]代黎,叶佳.宫颈细胞DNA定量及高危型HPV检测在宫颈癌筛查中的应用[J].深圳中西医结合杂志,2017,27(4):54-55.
[19]王昱.细胞DNA定量分析法在宫颈癌及癌前病变筛查及诊断中的应用价值[J].山西医药杂志,2017,46(4):472-473.
[20]莫伟杰,赵仁峰,李伟,等.宫颈细胞DNA倍体测定联合人乳头瘤病毒感染检测筛查宫颈癌的价值[J].广西医学,2016,38(1):105-107.