中国HIV-1感染者宿主HLA-B分型与艾滋病疾病进展间的关系
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摘要
宿主人类白细胞抗原(HLA)分型,与1型艾滋病病毒(HIV-1)感染者的疾病进展密切相关,针对中国不同人群感染HIV-1后疾病进展与宿主HLA分型间的相关关系已有众多报道,包括中部地区HIV-1感染者,北方汉族HIV-1感染者,北京男男同性恋HIV-1感染者,四川彝族HIV-1感染者等。在已报道的HLA分型中,有些HLA分型作用机制已明确,有些尚需要进一步研究。文章主要对目前报道的与中国HIV-1感染者疾病进展相关的HLA-B类分子分型进行综述,以期能更好地对与HIV-1感染者疾病进展相关的HLA分型进行研究提供依据和基础。
HLA typing is closely associated with AIDS disease progression.There are many reports about HLA typing of different populations infected with HIV-1 in China,such as HIV-1 infected populations in central China,the northern Han Chinese AIDS,Beijing MSM AIDS,and Sichuan Yi AIDS,etc.Here,we review the reports about the correlation between HLA-B typing and AIDS disease progression of HIV-1 infected individuals in China,so as to better understand the relationship between HLA-B typing and Chinese AIDS populations.
HLA typing is closely associated with AIDS disease progression.There are many reports about HLA typing of different populations infected with HIV-1 in China,such as HIV-1 infected populations in central China,the northern Han Chinese AIDS,Beijing MSM AIDS,and Sichuan Yi AIDS,etc.Here,we review the reports about the correlation between HLA-B typing and AIDS disease progression of HIV-1 infected individuals in China,so as to better understand the relationship between HLA-B typing and Chinese AIDS populations.
引文
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[11]Wei Z,Liu Y,Xu H,et al.Genome-Wide Association Studies of HIV-1Host Control in Ethnically Diverse Chinese Populations[J].Sci Rep,2015,5:10879.
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[13]MA Y,Chen Y,HaoJ,et al.Impact of HLA class I alleles on viral load in HIV-1B'infected individuals[J].China medical herald,2014,11(18):9-11.
[14]JIA,M-m,Hong K,Ren G,et al.Polymorphism of HLA class l alleles of HIV-infected individuals and its impact on HIV-1viral load in central China[J].Chin J microbiol immunol,2010,30(5):438-442.
[15]Jia M,Hong K,Chen J,et al.Preferential CTL targeting of Gag is associated with relative viral control in long-term surviving HIV-1infected former plasma donors from China[J].Cell Res,2012,22(5):903-914.
[16]Zhang H,Zhao B,Han X,et al.Associations of HLA class I antigen specificities and haplotypes with disease progression in HIV-1-infected Hans in Northern China[J].Hum Immunol,2013,74(12):1636-1642.
[17]Zhang H,Han X,Zhao B,et al.,Multilayered HIV-1gag-specific T-cell responses contribute to slow progression in HLA-A*30-B*13-C*06-positive patients[J].Aids,2015,29(9):993-1002.
[18]袁方,孙玉英,骆媛,等.我国汉族人群HLAⅠ类经典基因单倍型及连锁分析[J].中国实验血液学杂志,2007,15(5):1084-1089.
[19]Ammaranond P,Zaunders J,Satchell C,et al.A new variant cytotoxic T lymphocyte escape mutation in HLA-B27-positive individuals infected with HIV type 1[J].AIDS Res Hum Retroviruses,2005,21(5):395-397.
[20]Martin MP,Qi Y,Gao X,et al.Innate partnership of HLA-B and KIR3DL1subtypes against HIV-1[J].Nat Genet,2007,39(6):733-740.
[21]刘莹,刘小敏,李学云,等.HLA-B基因多态性与男男性接触者HIV/AIDS疾病进展研究[J].中国热带医学,2015,15(5):529-532.
[22]Zhang X,Huang X,Xia W,et al.HLA-B*44is associated with a lower viral set point and slow CD4decline in a cohort of Chinese homosexual men acutely infected with HIV-1[J].Clin Vaccine Immunol,2013,20(7):1048-1054.
[23]孙坚萍,孙焕芹,刘宁,等.中国北京男男同性恋艾滋病感染者HLA分型及与疾病进展分析[J].中国免疫学杂志,2016,32(8):1183-1186.
[24]Kawashima Y,Kuse N,Gatanaga H,et al.Long-term control of HIV-1in hemophiliacs carrying slow-progressing allele HLAB*5101[J].J Virol,2010,84(14):7151-7160.
[25]Carlson JM,Listgarten J,Pfeifer N,et al.Widespread impact of HLA restriction on immune control and escape pathways of HIV-1[J].J Virol,2012,86(9):5230-5243.
[26]Zhang Y,Peng Y,Yan H,et al.Multilayered defense in HLAB51-associated HIV viral control[J].J Immunol,2011,187(2):684-691.
[27]Sun J,Y Zhao,Peng Y,et al.Multiple T-cell responses are associated with better control of acute HIV-1infection:An observational study[J].Medicine(Baltimore),2016,95(30):e4429.
[28]Liu Y,Zhao Z,Li T,et al.High Resolution Human Leukocyte Antigen Class I Allele Frequencies and HIV-1Infection Associations in Chinese Han and Uyghur Cohorts[J].PLoS One,2012,7(12):e50656.
[29]Leslie AJ,Pfafferott KJ,Chetty,et al.HIV evolution:CTL escape mutation and reversion after transmission[J].Nat Med,2004,10(3):282-289.
[30]李星美,姚均,马名驹,等.四川凉山静脉吸毒人群HIV感染者中HLA-B*5701阳性率的研究[J].中国艾滋病性病,2011,17(4):404-406.
[31]Zhang H,Zhang T,Zhao H,et al.Low prevalence of human leukocyte antigen-B*5701in HIV-1-infected Chinese subjects:a prospective epidemiological investigation[J].AIDS Res Ther,2015,12:28.
[32]吴鹏.中国HIV感染长期不进展者与典型进展者遗传、免疫及HIV变异特点研究[D].北京:北京协和医学院,2011.
[33]Xu MY,Hong KX,Deng XL,et al.Association of HLA-B alleles with human immunodeficiency virus type 1infection in the Yi ethnic group in Sichuan province[J].Biomed Environ Sci,2004,17(2):203-208.
[34]Huang X,Ling H,Feng L,et al.Human leukocyte antigen profile in HIV-1infected individuals and AIDS patients from Chongqing,China[J].Microbiol Immunol,2009,53(9):512-523.
[35]Huang X,Ling H,Mao W,et al.Association of HLA-A,B,DRB1alleles and haplotypes with HIV-1infection in Chongqing,China[J].BMC Infect Dis,2009,9:201.
[36]Qing M,Li T,Han Y,et al.Accelerating effect of human leukocyte antigen-Bw6homozygosity on disease progression in Chinese HIV-1-infected patients[J].J Acquir Immune Defic Syndr,2006,41(2):137-139.
[37]赵彬,韩晓旭,代娣,等.中国人群HLA-B等位基因与HIV-1感染者疾病进程相关性研究[J].中国免疫学杂志,2008,24(5):430-433.
[2]Boulet S,Kleyman MJ,Kim Y,et al.A combined genotype of KIR3DL1high expressing alleles and HLA-B*57is associated with a reduced risk of HIV infection[J].Aids,2008,22(12):1487-1491.
[3]Migueles SA,Sabbaghian MS,Shupert WL,et al.HLA B*5701is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors[J].Proc Natl Acad Sci USA,2000,97(6):2709-2714.
[4]Hendel H,Caillat-Zucman S,Lebuanec H,et al.New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS[J].J Immunol,1999,162(11):6942-6946.
[5]Kiepiela P,Leslie AJ,Honeyborne I,et al.Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA[J].Nature,2004,432(7018):769-775.
[6]Goulder PJ,Walker BD.HIV and HLA class I:an evolving relationship[J].Immunity,2012,37(3):426-440.
[7]Antoni G,Guergnon J,Meaudre C,et al.MHC-driven HIV-1control on the long run is not systematically determined at early times post-HIV-1infection[J].Aids,2013,27(11):1707-1716.
[8]Honeyborne I,Prendergast A,Pereyra F,et al.Control of human immunodeficiency virus type 1is associated with HLA-B*13and targeting of multiple gag-specific CD8+T-cell epitopes[J].J Virol,2007,81(7):3667-3672.
[9]Prado JG,Honeyborne I,Brierley I,et al.Functional consequences of human immunodeficiency virus escape from an HLA-B*13-restricted CD8+T-cell epitope in p1Gag protein[J].J Virol,2009,83(2):1018-1025.
[10]Shahid A,Olvera A,Anmole G,et al.Consequences of HLA-B*13-Associated Escape Mutations on HIV-1Replication and Nef Function[J].J Virol,2015,89(22):11557-11571.
[11]Wei Z,Liu Y,Xu H,et al.Genome-Wide Association Studies of HIV-1Host Control in Ethnically Diverse Chinese Populations[J].Sci Rep,2015,5:10879.
[12]Li S,Jiao H,Yu X,et al.Human leukocyte antigen class I and class II allele frequencies and HIV-1infection associations in a Chinese cohort[J].J Acquir Immune Defic Syndr,2007,44(2):121-131.
[13]MA Y,Chen Y,HaoJ,et al.Impact of HLA class I alleles on viral load in HIV-1B'infected individuals[J].China medical herald,2014,11(18):9-11.
[14]JIA,M-m,Hong K,Ren G,et al.Polymorphism of HLA class l alleles of HIV-infected individuals and its impact on HIV-1viral load in central China[J].Chin J microbiol immunol,2010,30(5):438-442.
[15]Jia M,Hong K,Chen J,et al.Preferential CTL targeting of Gag is associated with relative viral control in long-term surviving HIV-1infected former plasma donors from China[J].Cell Res,2012,22(5):903-914.
[16]Zhang H,Zhao B,Han X,et al.Associations of HLA class I antigen specificities and haplotypes with disease progression in HIV-1-infected Hans in Northern China[J].Hum Immunol,2013,74(12):1636-1642.
[17]Zhang H,Han X,Zhao B,et al.,Multilayered HIV-1gag-specific T-cell responses contribute to slow progression in HLA-A*30-B*13-C*06-positive patients[J].Aids,2015,29(9):993-1002.
[18]袁方,孙玉英,骆媛,等.我国汉族人群HLAⅠ类经典基因单倍型及连锁分析[J].中国实验血液学杂志,2007,15(5):1084-1089.
[19]Ammaranond P,Zaunders J,Satchell C,et al.A new variant cytotoxic T lymphocyte escape mutation in HLA-B27-positive individuals infected with HIV type 1[J].AIDS Res Hum Retroviruses,2005,21(5):395-397.
[20]Martin MP,Qi Y,Gao X,et al.Innate partnership of HLA-B and KIR3DL1subtypes against HIV-1[J].Nat Genet,2007,39(6):733-740.
[21]刘莹,刘小敏,李学云,等.HLA-B基因多态性与男男性接触者HIV/AIDS疾病进展研究[J].中国热带医学,2015,15(5):529-532.
[22]Zhang X,Huang X,Xia W,et al.HLA-B*44is associated with a lower viral set point and slow CD4decline in a cohort of Chinese homosexual men acutely infected with HIV-1[J].Clin Vaccine Immunol,2013,20(7):1048-1054.
[23]孙坚萍,孙焕芹,刘宁,等.中国北京男男同性恋艾滋病感染者HLA分型及与疾病进展分析[J].中国免疫学杂志,2016,32(8):1183-1186.
[24]Kawashima Y,Kuse N,Gatanaga H,et al.Long-term control of HIV-1in hemophiliacs carrying slow-progressing allele HLAB*5101[J].J Virol,2010,84(14):7151-7160.
[25]Carlson JM,Listgarten J,Pfeifer N,et al.Widespread impact of HLA restriction on immune control and escape pathways of HIV-1[J].J Virol,2012,86(9):5230-5243.
[26]Zhang Y,Peng Y,Yan H,et al.Multilayered defense in HLAB51-associated HIV viral control[J].J Immunol,2011,187(2):684-691.
[27]Sun J,Y Zhao,Peng Y,et al.Multiple T-cell responses are associated with better control of acute HIV-1infection:An observational study[J].Medicine(Baltimore),2016,95(30):e4429.
[28]Liu Y,Zhao Z,Li T,et al.High Resolution Human Leukocyte Antigen Class I Allele Frequencies and HIV-1Infection Associations in Chinese Han and Uyghur Cohorts[J].PLoS One,2012,7(12):e50656.
[29]Leslie AJ,Pfafferott KJ,Chetty,et al.HIV evolution:CTL escape mutation and reversion after transmission[J].Nat Med,2004,10(3):282-289.
[30]李星美,姚均,马名驹,等.四川凉山静脉吸毒人群HIV感染者中HLA-B*5701阳性率的研究[J].中国艾滋病性病,2011,17(4):404-406.
[31]Zhang H,Zhang T,Zhao H,et al.Low prevalence of human leukocyte antigen-B*5701in HIV-1-infected Chinese subjects:a prospective epidemiological investigation[J].AIDS Res Ther,2015,12:28.
[32]吴鹏.中国HIV感染长期不进展者与典型进展者遗传、免疫及HIV变异特点研究[D].北京:北京协和医学院,2011.
[33]Xu MY,Hong KX,Deng XL,et al.Association of HLA-B alleles with human immunodeficiency virus type 1infection in the Yi ethnic group in Sichuan province[J].Biomed Environ Sci,2004,17(2):203-208.
[34]Huang X,Ling H,Feng L,et al.Human leukocyte antigen profile in HIV-1infected individuals and AIDS patients from Chongqing,China[J].Microbiol Immunol,2009,53(9):512-523.
[35]Huang X,Ling H,Mao W,et al.Association of HLA-A,B,DRB1alleles and haplotypes with HIV-1infection in Chongqing,China[J].BMC Infect Dis,2009,9:201.
[36]Qing M,Li T,Han Y,et al.Accelerating effect of human leukocyte antigen-Bw6homozygosity on disease progression in Chinese HIV-1-infected patients[J].J Acquir Immune Defic Syndr,2006,41(2):137-139.
[37]赵彬,韩晓旭,代娣,等.中国人群HLA-B等位基因与HIV-1感染者疾病进程相关性研究[J].中国免疫学杂志,2008,24(5):430-433.