C-反应蛋白与清蛋白比值对消化系统肿瘤预后评估的研究进展
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摘要
C-反应蛋白与清蛋白比值(CAR),是近年新发现的炎症相关标志物之一,可作为一系列肿瘤预后的预测因子。目前,CAR在肿瘤中的预测作用已成为研究的热点,该文旨在对CAR在消化系统肿瘤中作用的研究进展进行综述。
The ratio of C-reactive protein to albumin is one of the newly discovered markers related to inflammation in recent years.It can be used as a predictor of a series of tumor prognosis.At present,the predictive role of CAR in tumors has become a research hotspot.This paper reviews the research progress of CAR in digestive system tumors.
The ratio of C-reactive protein to albumin is one of the newly discovered markers related to inflammation in recent years.It can be used as a predictor of a series of tumor prognosis.At present,the predictive role of CAR in tumors has become a research hotspot.This paper reviews the research progress of CAR in digestive system tumors.
引文
[1]陈万青,孙可欣,郑荣寿,等.2014年中国分地区恶性肿瘤发病和死亡分析[J].中国肿瘤,2018,27(1):1-14.
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[7]SZKANDERA J,STOTZ M,ABSENGER G,et al.Validation of C-reactive protein levels as a prognostic indicator for survival in a large cohort of pancreatic cancer patients[J].Br J Cancer,2014,110(1):183-188.
[8]HU Q F,GOU Y C,SUN C Y,et al.The prognostic value of C-reactive protein in renal cell carcinoma:A systematic review and meta-analysis[J].Urol Oncol,2014,32(1):1-50.
[9]GUPTA D,LIS C G.Pretreatment serum albumin as a predictor of cancer survival:a systematic review of the epidemiological literature[J].Nutr J,2010,9(69):69.
[10]TAKAMORI S,TOYOKAWA G,SHIMOKAWA M A,et al.The C-Reactive protein/albumin ratio is a novel significant prognostic factor in patients with malignant pleural mesothelioma:a retrospective multi-institutional study[J].Ann Surg Oncol,2018,25(6):1555-1563.
[11]LIU Z Q,JIN K Z,GUO M,et al.Prognostic value of the CRP/Alb ratio,a novel Inflammation-Based score in pancreatic cancer[J].Ann Surg Oncol,2017,24(2):561-568.
[12]FAIRCLOUGH E,CAIRNS E,HAMILTON J,et al.E-valuation of a modified early warning system for acute medical admissions and comparison with C-reactive protein/albumin ratio as a predictor of patient outcome[J].Clin Med,2009,9(1):30-33.
[13]RANZANI O T,ZAMPIERI F G,FORTE D N,et al.C-reactive protein/albumin ratio predicts 90-day mortality of septic patients[J].PLoS One,2013,8(3):e59321.
[14]MAO M,WEI X,SHENG H,et al.C-reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer[J].Oncol Lett,2017,14(6):7417-7424.
[15]LIU Y B,CHEN S F,ZHENG C Y,et al.The prognostic value of the preoperative c-reactive protein/albumin ratio in ovarian cancer[J].BMC Cancer,2017,17(1):285.
[16]左婷婷,郑荣寿,曾红梅,等.中国胃癌流行病学现状[J].中国肿瘤临床,2017,44(1):52-58.
[17]WANG J,YU J C,KANG W M,et al.Treatment strategy for early gastric cancer[J].Surg Oncol,2012,21(2):119-123.
[18]SAITO H,KONO Y,MURAKAMI Y,et al.Prognostic significance of the preoperative ratio of C-Reactive protein to albumin and Neutrophil-Lymphocyte ratio in gastric cancer patients[J].World J Surg,2018,42(6):1819-1825.
[19]LIU X C,SUN X W,LIU J J,et al.Preoperative C-Reactive protein/albumin ratio predicts prognosis of patients after curative resection for gastric cancer[J].Transl Oncol,2015,8(4):339-345.
[20]SUN F,GE X L,LIU Z J,et al.Postoperative C-reactive protein/albumin ratio as a novel predictor for short-term complications following gastrectomy of gastric cancer[J].World J Surg Oncol,2017,15(1):191.
[21]SIEGEL R L,MILLER K D,JEMAL A.Cancer statistics,2015[J].CA Cancer J Clin,2015,65(1):5-29.
[22]WU M W,GUO J,GUO L H,et al.The C-reactive protein/albumin ratio predicts overall survival of patients with advanced pancreatic cancer[J].Tumor Biol,2016,37(9):12525-12533.
[23]HARUKI K,SHIBA H,SHIRAI Y,et al.The C-reactive Protein to Albumin Ratio Predicts Long-Term Outcomes in Patients with Pancreatic Cancer After Pancreatic Resection[J].World J Surg,2016,40(9):2254-2260.
[24]EDWARDS B K,NOONE A M,MARIOTTO A B,et al.Annual report to the nation on the status of cancer,1975-2010,featuring prevalence of comorbidity and impact on survival among persons with lung,colorectal,breast,or prostate cancer[J].Cancer,2014,120(9):1290-1314.
[25]SHIBUTANI M,MAEDA K,NAGAHARA H,et al.The significance of the C-reactive protein to albumin ratio as a marker for predicting survival and monitoring chemotherapeutic effectiveness in patients with unresectable metastatic colorectal cancer[J].Springerplus,2016,5(1):1798.
[26]SHIBUTANI M,MAEDA K,NAGAHARA H,et al.Prognostic significance of the preoperative ratio of C-Reactive protein to albumin in patients with colorectal cancer[J].Anticancer Res,2016,36(3):995-1001.
[27]HARUKI K,SHIBA H,HORIUCHI T,et al.Impact of the C-reactive protein to albumin ratio on long-term outcomes after hepatic resection for colorectal liver metastases[J].Am J Surg,2017,214(4):752-756.
[28]BRUIX J,GORES G J,MAZZAFERRO V.Hepatocellular carcinoma:clinical frontiers and perspectives[J].Gut,2014,63(5):844-855.
[29]KINOSHITA A,ONODA H,IMAI N,et al.The C-Reactive protein/albumin ratio,a novel Inflammation-Based prognostic score,predicts outcomes in patients with hepatocellular carcinoma[J].Ann Surg Oncol,2015,22(3):803-810.
[30]PANG S,ZHOU Z Q,YU X C,et al.The predictive value of integrated inflammation scores in the survival of patients with resected hepatocellular carcinoma:A Retrospective Cohort Study[J].Inter J Surg,2017,42(1):170-177.
[2]KUNIZAKI M,TOMINAGA T,WAKATA K,et al.Clinical significance of the C-reactive protein-to-albumin ratio for the prognosis of patients with esophageal squamous cell carcinoma[J].Mol Clin Oncol,2018,8(2):370-374.
[3]SHIMIZU T,ISHIZUKA M,SUZUKI T,et al.The value of the c-reactive protein-to-albumin ratio is useful for predicting survival of patients with child-pugh class a undergoing liver resection for hepatocellular carcinoma[J].World J Surg,2018,42(7):2218-2226.
[4]IBUKI Y,HAMAI Y,HIHARA J,et al.Role of postoperative C-Reactive protein levels in predicting prognosis after surgical treatment of esophageal cancer[J].World JSurg,2017,41(6):1558-1565.
[5]JANG J W,OH B S,KWON J H,et al.Serum interleukin-6and C-reactive protein as a prognostic indicator in hepatocellular carcinoma[J].Cytokine,2012,60(3):686-693.
[6]NAKATSU T,MOTOYAMA S,MARUYAMA K A,et al.Tumoral CRP expression in thoracic esophageal squamous cell cancers is associated with poor outcomes[J].Surg Today,2012,42(7):652-658.
[7]SZKANDERA J,STOTZ M,ABSENGER G,et al.Validation of C-reactive protein levels as a prognostic indicator for survival in a large cohort of pancreatic cancer patients[J].Br J Cancer,2014,110(1):183-188.
[8]HU Q F,GOU Y C,SUN C Y,et al.The prognostic value of C-reactive protein in renal cell carcinoma:A systematic review and meta-analysis[J].Urol Oncol,2014,32(1):1-50.
[9]GUPTA D,LIS C G.Pretreatment serum albumin as a predictor of cancer survival:a systematic review of the epidemiological literature[J].Nutr J,2010,9(69):69.
[10]TAKAMORI S,TOYOKAWA G,SHIMOKAWA M A,et al.The C-Reactive protein/albumin ratio is a novel significant prognostic factor in patients with malignant pleural mesothelioma:a retrospective multi-institutional study[J].Ann Surg Oncol,2018,25(6):1555-1563.
[11]LIU Z Q,JIN K Z,GUO M,et al.Prognostic value of the CRP/Alb ratio,a novel Inflammation-Based score in pancreatic cancer[J].Ann Surg Oncol,2017,24(2):561-568.
[12]FAIRCLOUGH E,CAIRNS E,HAMILTON J,et al.E-valuation of a modified early warning system for acute medical admissions and comparison with C-reactive protein/albumin ratio as a predictor of patient outcome[J].Clin Med,2009,9(1):30-33.
[13]RANZANI O T,ZAMPIERI F G,FORTE D N,et al.C-reactive protein/albumin ratio predicts 90-day mortality of septic patients[J].PLoS One,2013,8(3):e59321.
[14]MAO M,WEI X,SHENG H,et al.C-reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer[J].Oncol Lett,2017,14(6):7417-7424.
[15]LIU Y B,CHEN S F,ZHENG C Y,et al.The prognostic value of the preoperative c-reactive protein/albumin ratio in ovarian cancer[J].BMC Cancer,2017,17(1):285.
[16]左婷婷,郑荣寿,曾红梅,等.中国胃癌流行病学现状[J].中国肿瘤临床,2017,44(1):52-58.
[17]WANG J,YU J C,KANG W M,et al.Treatment strategy for early gastric cancer[J].Surg Oncol,2012,21(2):119-123.
[18]SAITO H,KONO Y,MURAKAMI Y,et al.Prognostic significance of the preoperative ratio of C-Reactive protein to albumin and Neutrophil-Lymphocyte ratio in gastric cancer patients[J].World J Surg,2018,42(6):1819-1825.
[19]LIU X C,SUN X W,LIU J J,et al.Preoperative C-Reactive protein/albumin ratio predicts prognosis of patients after curative resection for gastric cancer[J].Transl Oncol,2015,8(4):339-345.
[20]SUN F,GE X L,LIU Z J,et al.Postoperative C-reactive protein/albumin ratio as a novel predictor for short-term complications following gastrectomy of gastric cancer[J].World J Surg Oncol,2017,15(1):191.
[21]SIEGEL R L,MILLER K D,JEMAL A.Cancer statistics,2015[J].CA Cancer J Clin,2015,65(1):5-29.
[22]WU M W,GUO J,GUO L H,et al.The C-reactive protein/albumin ratio predicts overall survival of patients with advanced pancreatic cancer[J].Tumor Biol,2016,37(9):12525-12533.
[23]HARUKI K,SHIBA H,SHIRAI Y,et al.The C-reactive Protein to Albumin Ratio Predicts Long-Term Outcomes in Patients with Pancreatic Cancer After Pancreatic Resection[J].World J Surg,2016,40(9):2254-2260.
[24]EDWARDS B K,NOONE A M,MARIOTTO A B,et al.Annual report to the nation on the status of cancer,1975-2010,featuring prevalence of comorbidity and impact on survival among persons with lung,colorectal,breast,or prostate cancer[J].Cancer,2014,120(9):1290-1314.
[25]SHIBUTANI M,MAEDA K,NAGAHARA H,et al.The significance of the C-reactive protein to albumin ratio as a marker for predicting survival and monitoring chemotherapeutic effectiveness in patients with unresectable metastatic colorectal cancer[J].Springerplus,2016,5(1):1798.
[26]SHIBUTANI M,MAEDA K,NAGAHARA H,et al.Prognostic significance of the preoperative ratio of C-Reactive protein to albumin in patients with colorectal cancer[J].Anticancer Res,2016,36(3):995-1001.
[27]HARUKI K,SHIBA H,HORIUCHI T,et al.Impact of the C-reactive protein to albumin ratio on long-term outcomes after hepatic resection for colorectal liver metastases[J].Am J Surg,2017,214(4):752-756.
[28]BRUIX J,GORES G J,MAZZAFERRO V.Hepatocellular carcinoma:clinical frontiers and perspectives[J].Gut,2014,63(5):844-855.
[29]KINOSHITA A,ONODA H,IMAI N,et al.The C-Reactive protein/albumin ratio,a novel Inflammation-Based prognostic score,predicts outcomes in patients with hepatocellular carcinoma[J].Ann Surg Oncol,2015,22(3):803-810.
[30]PANG S,ZHOU Z Q,YU X C,et al.The predictive value of integrated inflammation scores in the survival of patients with resected hepatocellular carcinoma:A Retrospective Cohort Study[J].Inter J Surg,2017,42(1):170-177.