Cajal间质细胞与肠易激综合征脑肠轴相互作用关系
摘要
<正>Cajal间质细胞(interstitial cells of cajal,ICC)是连接胃肠道神经系统与平滑肌细胞的重要间质细胞,广泛分布于胃肠组织,是胃肠慢波电位的起搏者、传导者,在调控胃肠动力方面起重要作用。肠易激综合征(irritable bowel syndrome,IBS)是一种胃肠功能紊乱性疾病,发病机制至今仍未阐明。目前,研究认为,IBS存在ICC数量、形态、结构及功能的异
引文
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[9]李培彩,卢小芳,张声生,等.腹泻型肠易激综合征大鼠模型的评价研究[J].中国中西医结合消化杂志,2016,24(3):176-177.
[10] Zhu MH,Sung TS,Kurahashi M,et al.Na+-K+-Cl-cotransporter(NKCC)maintains the chloride gradient to sustain pacemaker activity in interstitial cells of Cajal[J].Am J Physiol Gastrointest Liver Physiol,2016,311(6):1037-1046.
[11]杨波,蓝程,周旭春.感染后肠易激综合征小鼠Cajal间质细胞改变对肠道动力和内脏敏感性的影响[J].上海交通大学学报(医学版),2014,34(7):978-983.
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[15] Ebner K,Sartori SB,Singewald N.Tachykinin receptors as therapeutic targets in stress-related disorders[J].Curr Pharm Des,2009,15(14):1647-1674.
[16]张虹玺.养荣润肠舒合剂对慢传输型便秘模型大鼠结肠中c-kit、SP与VIP的影响[J].中国药房,2015,26(25):3476-3478.
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[18] Munoz M,Covenas R.NK-1 receptor antagonists:a new paradigm in pharmacological therapy[J].Curr Med Chem,2011,18(12):1820-1831.
[19] Munoz M,Covenas R.Involvement of substance P and the NK-1 receptor in human pathology[J].Amino Acids,2014,46(7):1727-1750.
[20] Sohn W,Lee OY,Lee KN,et al.Mast cell number,substance P and vasoactive intestinal peptide in irritable bowel syndrome with diarrhea[J].Scand Gastroenterol,2014,49(1):43-51.
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[22]罗和生,梁文晶,梁列新,等.肠易激综合征患者肠黏膜CRGP、SP水平的变化与临床症状的关系[J].临床消化病杂志,2014,26(6):336-339.
[23]Chen FX,Yu YB,Yuan XM,et al.Brain-derive neurtrophic factor enhances the contraction of intestinal muscle strips induced by SP and CGRP in mice[J].Regul Pept,2012,178(1-3):86-94.
[24]Sama SK.Are interstitial cells of Cajal plurifunction cells in the gut[J].Am J Physiol Gastrointest Liver Physiol,2008,294(2):372-390.
[25] Sanders KM.A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract[J].Gastroenterology,1996,111(2):492-515.
[26]Tanahshi Y,Ichimura Y,Kimura K,et al.Cholinergic neuromuscular transmission mediated by interstitial cells of Cajal in myenteric layer in mouse ileal longitudinal smooth muscles[J].Naunyn Schmiedebergs Arch Pharmacol,2014,387(4):377-388.
[27] Sanders KM,Kito Y,Hwang SJ,et al.Regulation of gastrointestinal smooth muscle function by Interstitial Cells[J].Physiology(Bethesda),2016,31(5):316-326.
[28]Sanders KM,Ward SM,Koh SD.Interstitial cells:regulators of smooth muscle function[J].Physiol Rev,2014,96(3):859-907.
[29]仇莎,杨秀丽,司增顺,等.胃肠ICC网络中P物质的研究进展及重要干预现状[J].世界中西医结合杂志,2013,8(8):861-864.
[30]Vannucchi MG.Receptor in interstitial cells of Cajal:identification and possible physiological roles[J].Microse Res Tech,1999,47(5):325-335.
[31] Ohman L,Simren M.Pathogenesis of IBS:role of inflammation,immunity and neuroimmune interactions[J].Nat Rev Gastroenterol Hepatol,2010,7(3):163-173.
[32]王景杰,秦明,刘震雄,等.干细胞因子/c-kit在肠易激综合征中的作用和地位[J].新思维与探索,2012,33(8B):74-80.
[33]Lee H,Park JH,Park DI,et al.Mucosal Mast Cell Count Is Associated With Intestinal Permeability in Patients With Diarrhea Predominant Irritable Bowel Syndrome[J].Journal of Neurogastroenterology and Motility,2013,19(2):244-250.
[34]谭至柔,谭丽,黄雪,等.慢传输型便秘大鼠结肠内Cajal间质细胞的变化[J].实用医学杂志,2011,27(18):3290-3292.
[2] Roohafza H,Keshteli AH,Daghaghzadeh H,et al.Life stressors,coping strategies,and social supports in patients with irritable bowel syndrome[J].Adv Biomed Res,2016,5:158.
[3] Agarwal N,Spiegel B.The effect of irritable bowel syndrome n health-related quality of life and health care expenditures[J].Gastroenterol Clin North Am,2011,40(1):11-19.
[4] Longstreth GF,Thompson WG,Chey WD,et al.Functional bowel disorders[J].Gastroenterology,2006,130(5):1480-1491.
[5]Lovell RM,Ford AC.Global prevalence of and risk factors for irritable bowel syndrome:a meta-analysis[J].Clin Gastroenterol Hepatol,2012,10(7):712-721.
[6]何宛蓉,张法灿,梁列新.肠易激综合征流行病学研究现状与进展[J].胃肠病学和肝病学杂志,2012,21(1):83-88.
[7] Koloski NA,Jones M,Kalantar J,et al.The brain-gut pathway in functional gastrointestinal disorders is bidirectional:a 12-year prospective population-based study[J].Gut,2012,61(9):1284-1290.
[8] Neufeld K,Kang N,Bienenstock J,et al.Reduced anxietylike behavior and central neurochemical change in germfree mice[J].Neurogastroenterol Motil,2011,23(3):255-264.
[9]李培彩,卢小芳,张声生,等.腹泻型肠易激综合征大鼠模型的评价研究[J].中国中西医结合消化杂志,2016,24(3):176-177.
[10] Zhu MH,Sung TS,Kurahashi M,et al.Na+-K+-Cl-cotransporter(NKCC)maintains the chloride gradient to sustain pacemaker activity in interstitial cells of Cajal[J].Am J Physiol Gastrointest Liver Physiol,2016,311(6):1037-1046.
[11]杨波,蓝程,周旭春.感染后肠易激综合征小鼠Cajal间质细胞改变对肠道动力和内脏敏感性的影响[J].上海交通大学学报(医学版),2014,34(7):978-983.
[12] Wouters MM,Roeder JL,Tharayil VS,et al.Protein kinase C{gamma}mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B[J].J Biol Chem,2009,284(32):21177-21184.
[13]Tanahashi Y,Ichimura Y,Kimura K,et al.Cholinergic neuromuscular transmission mediated by interstitial cells of Cajal in the myenteric layer in mouse ileal longitudinal smooth muscles[J].Naunyn Schmiedebergs Arch Pharmacol,2014,387(4):377-388.
[14] Ahad Eshrghian MD,Hamed Eshraghian MD.Interstitial cells of Cajal:A novel hypothesis for the pathophysiology of irritable bowel syndrome[J].Can J Gastroenterol,2011,25(5):277-279.
[15] Ebner K,Sartori SB,Singewald N.Tachykinin receptors as therapeutic targets in stress-related disorders[J].Curr Pharm Des,2009,15(14):1647-1674.
[16]张虹玺.养荣润肠舒合剂对慢传输型便秘模型大鼠结肠中c-kit、SP与VIP的影响[J].中国药房,2015,26(25):3476-3478.
[17] Koon HW,Pothoulakis C.Immunomodulatory properties of substance P:the gastrointestinal system as a model[J].Ann NY Acad Sci,2006,1088(1):23-90.
[18] Munoz M,Covenas R.NK-1 receptor antagonists:a new paradigm in pharmacological therapy[J].Curr Med Chem,2011,18(12):1820-1831.
[19] Munoz M,Covenas R.Involvement of substance P and the NK-1 receptor in human pathology[J].Amino Acids,2014,46(7):1727-1750.
[20] Sohn W,Lee OY,Lee KN,et al.Mast cell number,substance P and vasoactive intestinal peptide in irritable bowel syndrome with diarrhea[J].Scand Gastroenterol,2014,49(1):43-51.
[21] Yin Y,Zhong L,Wang JW,et al.Tong Xie Yao Fang relieves irritable bowel syndrome in rats via mechanisms involving regulation of 5-hydroxytryptamine and substance P[J].World Gastroenterol,2015,21(15):4536-4546.
[22]罗和生,梁文晶,梁列新,等.肠易激综合征患者肠黏膜CRGP、SP水平的变化与临床症状的关系[J].临床消化病杂志,2014,26(6):336-339.
[23]Chen FX,Yu YB,Yuan XM,et al.Brain-derive neurtrophic factor enhances the contraction of intestinal muscle strips induced by SP and CGRP in mice[J].Regul Pept,2012,178(1-3):86-94.
[24]Sama SK.Are interstitial cells of Cajal plurifunction cells in the gut[J].Am J Physiol Gastrointest Liver Physiol,2008,294(2):372-390.
[25] Sanders KM.A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract[J].Gastroenterology,1996,111(2):492-515.
[26]Tanahshi Y,Ichimura Y,Kimura K,et al.Cholinergic neuromuscular transmission mediated by interstitial cells of Cajal in myenteric layer in mouse ileal longitudinal smooth muscles[J].Naunyn Schmiedebergs Arch Pharmacol,2014,387(4):377-388.
[27] Sanders KM,Kito Y,Hwang SJ,et al.Regulation of gastrointestinal smooth muscle function by Interstitial Cells[J].Physiology(Bethesda),2016,31(5):316-326.
[28]Sanders KM,Ward SM,Koh SD.Interstitial cells:regulators of smooth muscle function[J].Physiol Rev,2014,96(3):859-907.
[29]仇莎,杨秀丽,司增顺,等.胃肠ICC网络中P物质的研究进展及重要干预现状[J].世界中西医结合杂志,2013,8(8):861-864.
[30]Vannucchi MG.Receptor in interstitial cells of Cajal:identification and possible physiological roles[J].Microse Res Tech,1999,47(5):325-335.
[31] Ohman L,Simren M.Pathogenesis of IBS:role of inflammation,immunity and neuroimmune interactions[J].Nat Rev Gastroenterol Hepatol,2010,7(3):163-173.
[32]王景杰,秦明,刘震雄,等.干细胞因子/c-kit在肠易激综合征中的作用和地位[J].新思维与探索,2012,33(8B):74-80.
[33]Lee H,Park JH,Park DI,et al.Mucosal Mast Cell Count Is Associated With Intestinal Permeability in Patients With Diarrhea Predominant Irritable Bowel Syndrome[J].Journal of Neurogastroenterology and Motility,2013,19(2):244-250.
[34]谭至柔,谭丽,黄雪,等.慢传输型便秘大鼠结肠内Cajal间质细胞的变化[J].实用医学杂志,2011,27(18):3290-3292.