右美托咪定对结直肠癌根治术围术期血流动力学及麻醉复苏期质量的影响
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摘要
为观察右美托咪定对结直肠癌根治术围术期患者血流动力学及麻醉复苏期质量的影响,选择2017年10月至2018年9月于我院行结直肠癌根治术的104例患者,应用随机数字表法分为对照组和观察组,各52例。2组患者均接受全身麻醉,方法相同,观察组患者气管内插管后先予右美托咪定0.4μg/kg,10min内输注完毕,然后以0.4μg/(kg·h)的速度持续泵注至手术结束前30min,对照组予等量0.9%氯化钠注射液。对比观察2组患者围术期不同时点平均动脉压(MAP)、心率(HR)波动情况,以及术后麻醉复苏期质量。结果显示,2组仅拔管前(T5)和拔管后即刻(T6)MAP、HR比较差异显著,观察组低于对照组,P <0.05;麻醉诱导前(T1)、术前(T2)、手术开始后30min(T3)和手术结束时(T4),2组MAP、HR比较差异均无统计学意义,P>0.05。观察组患者麻醉复苏期认知功能障碍及躁动发生率均明显低于对照组,P <0.05。结果表明,右美托咪定应用于结直肠癌根治术可维持患者围术期血流动力学稳定,减少麻醉复苏期认知障碍及躁动的发生,提高麻醉复苏期质量。
This study was to investigate the influence of Dexmedetomidine on the hemodynamics at perioperation of radical procedure for colorectal cancer,and on the quality at anesthestic resuscitation,enrolled104 patients to be subject to radical surgery for colorectal cancer in author's hospital from 2017-10 to 2018-09,randomly divided them into control group and observation one,52 cases for each group,both groups all received general anesthesia in same method,but in observation group,after patients were given with endotracheal intubation,firstly injected with Dexmedetomidine(in 0.4μg/kg,for 10 min),then at the velocity of0.4μg/(kg·h)continously pump-injecting this drug till 30 min before the end of surgery,while in control group patients were given with equal volume of 0.9% NaCl injection same as observation group's one;then both groups' MAP and HR ranging at different time-points of perioperation,as well the quality of anesthestic resuscitation after surgery were compared between the two groups.As results,at once after extubation(T6)and before extubation(T5)the MAP and HR of observation group were all significantly lower than that of control group(P <0.05),but at T1(before induction of anesthesia),T2(before operation),T3(30 min later after operation),and T4(at the end of operation)there were all no statistical difference(P >0.05);in patients' cognitive disorder and agitation incidence observation group was significantly lower than control group(P <0.05).Results show that in colorectal cancer radical surgery Dexmedetomidine can maintain patient's hemodynamics stable at perioperation,reduce onset of their cognitive disorder and agitation at anesthestic resuscitation thus enhancing the quality of this period.
This study was to investigate the influence of Dexmedetomidine on the hemodynamics at perioperation of radical procedure for colorectal cancer,and on the quality at anesthestic resuscitation,enrolled104 patients to be subject to radical surgery for colorectal cancer in author's hospital from 2017-10 to 2018-09,randomly divided them into control group and observation one,52 cases for each group,both groups all received general anesthesia in same method,but in observation group,after patients were given with endotracheal intubation,firstly injected with Dexmedetomidine(in 0.4μg/kg,for 10 min),then at the velocity of0.4μg/(kg·h)continously pump-injecting this drug till 30 min before the end of surgery,while in control group patients were given with equal volume of 0.9% NaCl injection same as observation group's one;then both groups' MAP and HR ranging at different time-points of perioperation,as well the quality of anesthestic resuscitation after surgery were compared between the two groups.As results,at once after extubation(T6)and before extubation(T5)the MAP and HR of observation group were all significantly lower than that of control group(P <0.05),but at T1(before induction of anesthesia),T2(before operation),T3(30 min later after operation),and T4(at the end of operation)there were all no statistical difference(P >0.05);in patients' cognitive disorder and agitation incidence observation group was significantly lower than control group(P <0.05).Results show that in colorectal cancer radical surgery Dexmedetomidine can maintain patient's hemodynamics stable at perioperation,reduce onset of their cognitive disorder and agitation at anesthestic resuscitation thus enhancing the quality of this period.
引文
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