巴戟天寡糖对阿霉素所致大鼠心肌损伤的影响
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摘要
目的探讨巴戟天寡糖对阿霉素所致大鼠心肌损伤的影响。方法雄性Wistar大鼠40只,随机均分为4组:阴性对照组、模型组以及2个巴戟天寡糖组(100、300 g·L~(-1)),通过腹腔注射阿霉素制作阿霉素所致心脏毒性模型,观察巴戟天寡糖干预后心肌组织中相关指标的变化。结果模型组超氧化物歧化酶(SOD)、过氧化氢酶(CAT)水平均低于阴性对照组,而丙二醛(MDA)、过氧化脂质(LPO)水平均高于阴性对照组(P均<0.05)。巴戟天寡糖100 g·L~(-1)组、巴戟天寡糖300 g·L~(-1)组SOD、CAT水平均高于模型组,而MDA、LPO水平均低于模型组(P均<0.05)。巴戟天寡糖组300 g·L~(-1)组SOD、CAT水平高于巴戟天寡糖100 g·L~(-1)组,而MDA、LPO水平低于巴戟天寡糖100 g·L~(-1)组(P均<0.05)。结论巴戟天寡糖对阿霉素所致心肌损伤具有保护作用,这可能与巴戟天寡糖的抗氧化作用有关。
Objective To investigate the effect of morinda officinalis oligosaccharide on myocardiun injury induced by doxorubicin in rats.Methods Forty male Wistar rats were randomly divided into 4 groups: the negative control group, the model group and 2 morinda officinalis oligosaccharide groups(100 and 300 g·L~(-1)). Adriamycin induced cardiotxicity model was made by intraperitoneal injection of doxorubicin, the changes of relevant indexes in myocardial tissue were observed after the intervention of doxorubicin.Results The superoxide dismutase(SOD) and catalase(CAT) levels in the model group were lower than those in the negative control group, while the malondialdehyde(MDA) and lipid peroxide(LPO) levels were higher than those in the negative control group(P<0.05). The SOD and CAT levels in the 100 g·L~(-1) morinda officinalis oligosaccharide group and the 300 g·L~(-1) morinda officinalis oligosaccharide group were higher than those in the model group, while the MDA and LPO levels were lower than those in the model group(P<0.05). The SOD and CAT levels in the 300 g·L~(-1) morinda officinalis oligosaccharide group were higher than those in the 100 g·L~(-1) morinda officinalis oligosaccharide group, while the MDA and LPO levels were lower than those in the 100 g·L~(-1) morinda officinalis oligosaccharide group(P<0.05).Conclusion Morinda officinalis oligosaccharide has protective effect on myocardium injury induced by doxorubicin, which may be related to the antioxidant effect of morinda officinalis oligosaccharide.
Objective To investigate the effect of morinda officinalis oligosaccharide on myocardiun injury induced by doxorubicin in rats.Methods Forty male Wistar rats were randomly divided into 4 groups: the negative control group, the model group and 2 morinda officinalis oligosaccharide groups(100 and 300 g·L~(-1)). Adriamycin induced cardiotxicity model was made by intraperitoneal injection of doxorubicin, the changes of relevant indexes in myocardial tissue were observed after the intervention of doxorubicin.Results The superoxide dismutase(SOD) and catalase(CAT) levels in the model group were lower than those in the negative control group, while the malondialdehyde(MDA) and lipid peroxide(LPO) levels were higher than those in the negative control group(P<0.05). The SOD and CAT levels in the 100 g·L~(-1) morinda officinalis oligosaccharide group and the 300 g·L~(-1) morinda officinalis oligosaccharide group were higher than those in the model group, while the MDA and LPO levels were lower than those in the model group(P<0.05). The SOD and CAT levels in the 300 g·L~(-1) morinda officinalis oligosaccharide group were higher than those in the 100 g·L~(-1) morinda officinalis oligosaccharide group, while the MDA and LPO levels were lower than those in the 100 g·L~(-1) morinda officinalis oligosaccharide group(P<0.05).Conclusion Morinda officinalis oligosaccharide has protective effect on myocardium injury induced by doxorubicin, which may be related to the antioxidant effect of morinda officinalis oligosaccharide.
引文
[1] 周儒兵,李伟,周双容.多西他赛注射剂联合吡柔比星注射剂治疗乳腺癌的临床研究[J].中国临床药理学杂志,2017,33(13):1194-1197.
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[8] 曾永君,赵新超,万梅绪,等.注射用益气复脉(冻干)对阿霉素诱导H9c2(2-1)心肌细胞毒性的保护作用[J].药物评价研究,2018,41(3):380-385.
[9] 曲震理,刘尚书,尚喜雨.辣木籽对阿霉素所致大鼠心脏毒性氧化损伤及心功能的影响[J].中国现代医药杂志,2019,21(5):38-39.
[10] 施洋,樊登峰,候宝林,等.阿霉素致心脏毒性的作用机制及其中药防治的研究进展[J].新疆中医药,2019,37(1):113-116.
[11] 郑素玉,陈健.巴戟天有效成分及其药理作用实验研究进展[J].世界中西医结合杂志,2012,7(9):823-825,828.
[12] 李鑫洁,李玲玲,鲁艺.巴戟天寡糖提纯工艺及药理作用研究进展[J].天然产物研究与开发,2019,31(2):345-353.
[2] 陆晨曦,韩跃虎,辛振龙,等.补骨脂酚对阿霉素心肌细胞损伤的保护作用及机制研究[J].西北大学学报(自然科学版),2018,48(6):769-775.
[3] 程亮星.巴戟天寡糖对大鼠子宫缺血再灌注损伤的抗氧化作用[J].中医研究,2018,31(7):68-70.
[4] 冯中亚.拓扑异构酶Ⅱa基因表达检测对乳腺癌多西他赛+阿霉素+环磷酰胺新辅助化疗方案疗效的预测作用[J].肿瘤基础与临床,2018,31(6):510-512.
[5] 杨冬梨,徐宗佩,李玉红,等.参麦注射液抗阿霉素心脏毒性及其协同放化疗抗肿瘤的作用[J].天津中医药大学学报,2018,37(6):445-448.
[6] 张珊,郝春华,葛一蒙,等.刺五加注射液改善阿霉素诱导大鼠心脏收缩功能下降的作用研究[J].中草药,2018,49(17):4071-4077.
[7] 顾冰,李超.参芪扶正注射液治疗含阿霉素方案心脏毒性的观察[J].肿瘤基础与临床,2011,24(5):438-439.
[8] 曾永君,赵新超,万梅绪,等.注射用益气复脉(冻干)对阿霉素诱导H9c2(2-1)心肌细胞毒性的保护作用[J].药物评价研究,2018,41(3):380-385.
[9] 曲震理,刘尚书,尚喜雨.辣木籽对阿霉素所致大鼠心脏毒性氧化损伤及心功能的影响[J].中国现代医药杂志,2019,21(5):38-39.
[10] 施洋,樊登峰,候宝林,等.阿霉素致心脏毒性的作用机制及其中药防治的研究进展[J].新疆中医药,2019,37(1):113-116.
[11] 郑素玉,陈健.巴戟天有效成分及其药理作用实验研究进展[J].世界中西医结合杂志,2012,7(9):823-825,828.
[12] 李鑫洁,李玲玲,鲁艺.巴戟天寡糖提纯工艺及药理作用研究进展[J].天然产物研究与开发,2019,31(2):345-353.