视网膜激光光凝术治疗对眼底病患者视神经功能的影响
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摘要
目的:探讨视网膜激光光凝术治疗眼底病的临床效果。方法:选取在医院治疗的94例(154眼)眼底病患者,根据治疗方案的不同将其分为观察组(50例87眼)和对照组(44例67眼),观察组给予视网膜激光光凝术治疗,对照组给予常规药物治疗。采用光学相干断层扫描(OCT)检测黄斑区视网膜厚度及黄斑中心凹容积;观察两组患者的治疗效果、视力改善情况及不良反应。结果:观察组治疗效果及视力改善明显好于对照组,其差异有统计学意义(x~2=0.364,P<0.05),其治疗总有效率和视力提高比例分别为87.36%和32.18%;观察组治疗后黄斑区视网膜厚度和中心凹容积分别为(311.24±18.87)m和(8.96±0.51)mm~3,明显高于对照组,其差异有统计学意义(x~2=0.342,P<0.05);对照组治疗前后黄斑区视网膜厚度和中心凹容积比较差异无统计学意义(x~2=0.918,P>0.05);观察组不良反应率为2.30%,明显低于对照组,其差异有统计学意义(x~2=8.399,P<0.05)。结论:视网膜激光光凝术治疗眼底病效果较好,能明显改善患者视力,且不良反应少,同时使黄斑区视网膜厚度及中心凹容积增加。
Objective: To investigate the clinical effect of retinal laser photocoagulation in treating fundus disease. Methods: 94 patients(154 eyes) with fundus diseases who received treatment in hospital were divided into observation group(50 cases, 87 eyes) and control group(44 cases, 67 eyes). The observation group was implemented retinal laser photocoagulation, while the control group was implemented conventional treatment. Optical coherence tomography(OCT) was used to detect retinal thickness of macular region and central fovea volume of macular region. And the therapeutic effect, the situation of visual acuity improvement and adverse reactions of the two groups were observed. Results: The therapeutic effect and situation of visual acuity improvement of observation group were significantly better than those of control group(x~2=0.364, P<0.05). And the total effective rate and the rate of visual acuity improvement of the observation group were 87.36% and 32.18%, respectively. The retinal thickness and central fovea volume of macular region of the observation group post treatment were(311.24±18.87) μm and(8.96±0.51) mm~3, respectively. And the two values of observation group were significantly higher than those of control group(x~2=0.342, P<0.05), respectively. On the other hand, the differences of retinal thickness and central fovea volume of macular region of control group between pre and post treatment were no significant(x~2=0.918, P>0.05). Besides, the adverse reaction rate of observation group(2.30%) was significantly lower than that of control group(x~2=8.399, P<0.05). Conclusion: Retinal laser photocoagulation is effective in treating fundus disease. It can significantly improve the visual acuity of patients, and it has less adverse reactions, and it can increase the retinal thickness and central fovea volume of macular region.
Objective: To investigate the clinical effect of retinal laser photocoagulation in treating fundus disease. Methods: 94 patients(154 eyes) with fundus diseases who received treatment in hospital were divided into observation group(50 cases, 87 eyes) and control group(44 cases, 67 eyes). The observation group was implemented retinal laser photocoagulation, while the control group was implemented conventional treatment. Optical coherence tomography(OCT) was used to detect retinal thickness of macular region and central fovea volume of macular region. And the therapeutic effect, the situation of visual acuity improvement and adverse reactions of the two groups were observed. Results: The therapeutic effect and situation of visual acuity improvement of observation group were significantly better than those of control group(x~2=0.364, P<0.05). And the total effective rate and the rate of visual acuity improvement of the observation group were 87.36% and 32.18%, respectively. The retinal thickness and central fovea volume of macular region of the observation group post treatment were(311.24±18.87) μm and(8.96±0.51) mm~3, respectively. And the two values of observation group were significantly higher than those of control group(x~2=0.342, P<0.05), respectively. On the other hand, the differences of retinal thickness and central fovea volume of macular region of control group between pre and post treatment were no significant(x~2=0.918, P>0.05). Besides, the adverse reaction rate of observation group(2.30%) was significantly lower than that of control group(x~2=8.399, P<0.05). Conclusion: Retinal laser photocoagulation is effective in treating fundus disease. It can significantly improve the visual acuity of patients, and it has less adverse reactions, and it can increase the retinal thickness and central fovea volume of macular region.
引文
[1]金佩瑶,彭金娟,邹海东,等.上海市新泾社区2型糖尿病居民5年随访的前瞻性调查研究1.糖尿病视网膜病变和糖尿病黄斑水肿的发病率及危险因素[J].中华实验眼科杂志,2016,34(4):363-367.
[2]苏玉英,王晶晶,夏智渝.糖尿病性视网膜病变发生发展的相关因素及中西医结合疗法的临床疗效[J].临床合理用药杂志,2016,9(9):134-136.
[3]夏伟,陈杨磊,孔祥蕴.全视网膜激光光凝术联合密蒙花方治疗重度非增殖性糖尿病视网膜病变的临床观察[J].河北中医,2016,38(7):992-994.
[4]孙文翠,贾亚丁,梁忠英,等.激光光凝眼底联合卵磷脂络合碘片治疗中心性浆液性脉络膜视网膜病变的临床研究[J].中国药物与临床,2015,15(8):1143-1145.
[5]贾绍友,丁明红,赵金亮.频域光学相干断层扫描观察早期小切口白内障摘除联合人工晶体植入术后黄斑区的形态变化[J].中国实用医药,2017,12(34):5-7.
[6]孙荻芳.糖尿病性视网膜病变玻璃体切除术后渗出性视网膜脱离相关因素分析[D].长春:吉林大学,2017.
[7]王中峰,杨雄里.谷氨酸受体在实验性青光眼视网膜细胞损伤中的作用[J].生理学报,2016,11(4):483-491.
[8]杨喆,相义会,付颖.单点多次和多点一次性完成视网膜激光光凝对非增生期糖尿病视网膜病变的临床疗效对比观察[J].临床和实验医学杂志,2016,15(12):1174-1177.
[9]韩林峰,柯根杰,王林,等.全视网膜激光光凝对增生型糖尿病视网膜病变视网膜前膜中环氧化酶-2、血管内皮生长因子表达的影响[J].中华眼底病杂志,2016,32(2):140-143.
[10]邱颖杰,郭秀华,相义会.抗血管内皮生长因子联合视网膜激光光凝术治疗视网膜分支静脉阻塞继发黄斑水肿的疗效观察[J].中国预防医学杂志,2016,11(9):715-717.
[11]刘艳琳.糖尿病视网膜病变激光光凝疗效的观察及评估[J].糖尿病新世界,2017,20(2):45-46.
[12]李士清,王志立,李萍,等.虹膜荧光血管造影联合眼底荧光血管造影在全视网膜激光光凝术后糖尿病视网膜病变患者中的应用研究[J].眼科新进展,2016,36(2):133-135.
[13]陶相宜,郭淑玲,董微丽.探讨视网膜激光光凝术治疗各种眼底病的临床疗效[J].河北医学,2017,23(2):238-240.
[14]薛春燕,蒋峰,闫峰,等.全视网膜激光光凝术后黄斑中心凹厚度的改变[J].中国激光医学杂志,2016,11(5):23-26.
[15]陈海军,沈白云.糖尿病视网膜病变行全视网膜激光光凝术后玻璃体视网膜的变化[J].广西医学,2016,38(2):277-279.
[2]苏玉英,王晶晶,夏智渝.糖尿病性视网膜病变发生发展的相关因素及中西医结合疗法的临床疗效[J].临床合理用药杂志,2016,9(9):134-136.
[3]夏伟,陈杨磊,孔祥蕴.全视网膜激光光凝术联合密蒙花方治疗重度非增殖性糖尿病视网膜病变的临床观察[J].河北中医,2016,38(7):992-994.
[4]孙文翠,贾亚丁,梁忠英,等.激光光凝眼底联合卵磷脂络合碘片治疗中心性浆液性脉络膜视网膜病变的临床研究[J].中国药物与临床,2015,15(8):1143-1145.
[5]贾绍友,丁明红,赵金亮.频域光学相干断层扫描观察早期小切口白内障摘除联合人工晶体植入术后黄斑区的形态变化[J].中国实用医药,2017,12(34):5-7.
[6]孙荻芳.糖尿病性视网膜病变玻璃体切除术后渗出性视网膜脱离相关因素分析[D].长春:吉林大学,2017.
[7]王中峰,杨雄里.谷氨酸受体在实验性青光眼视网膜细胞损伤中的作用[J].生理学报,2016,11(4):483-491.
[8]杨喆,相义会,付颖.单点多次和多点一次性完成视网膜激光光凝对非增生期糖尿病视网膜病变的临床疗效对比观察[J].临床和实验医学杂志,2016,15(12):1174-1177.
[9]韩林峰,柯根杰,王林,等.全视网膜激光光凝对增生型糖尿病视网膜病变视网膜前膜中环氧化酶-2、血管内皮生长因子表达的影响[J].中华眼底病杂志,2016,32(2):140-143.
[10]邱颖杰,郭秀华,相义会.抗血管内皮生长因子联合视网膜激光光凝术治疗视网膜分支静脉阻塞继发黄斑水肿的疗效观察[J].中国预防医学杂志,2016,11(9):715-717.
[11]刘艳琳.糖尿病视网膜病变激光光凝疗效的观察及评估[J].糖尿病新世界,2017,20(2):45-46.
[12]李士清,王志立,李萍,等.虹膜荧光血管造影联合眼底荧光血管造影在全视网膜激光光凝术后糖尿病视网膜病变患者中的应用研究[J].眼科新进展,2016,36(2):133-135.
[13]陶相宜,郭淑玲,董微丽.探讨视网膜激光光凝术治疗各种眼底病的临床疗效[J].河北医学,2017,23(2):238-240.
[14]薛春燕,蒋峰,闫峰,等.全视网膜激光光凝术后黄斑中心凹厚度的改变[J].中国激光医学杂志,2016,11(5):23-26.
[15]陈海军,沈白云.糖尿病视网膜病变行全视网膜激光光凝术后玻璃体视网膜的变化[J].广西医学,2016,38(2):277-279.