两种三联疗法治疗幽门螺杆菌感染胃溃疡的临床疗效比较
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摘要
目的探讨两种三联疗法治疗幽门螺杆菌(Hp)感染胃溃疡的临床疗效。方法 53例幽门螺杆菌感染胃溃疡患者,随机分为观察组(27例)和对照组(26例)。观察组给予奥美拉唑、阿莫西林、克拉霉素联合治疗,对照组给予奥美拉唑、阿莫西林、甲硝唑联合治疗。对比两组的治疗效果。结果观察组治疗总有效率为96.30%,对照组治疗总有效率为69.23%,观察组治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。观察组的幽门螺杆菌根除率为88.89%、不良反应发生率为18.52%,对照组的幽门螺杆菌根除率为65.38%、不良反应发生率为23.08%,观察组幽门螺杆菌根除率高于对照组,差异具有统计学意义(P<0.05),两组不良反应发生率比较差异无统计学意义(P>0.05)。结论奥美拉唑、阿莫西林、克拉霉素三种药物联合治疗能显著提高幽门螺杆菌感染胃溃疡患者的幽门螺杆菌清除率,促进疾病好转,适用于在临床上广泛推广。
Objective To discuss the clinical efficacy of two kinds of triple therapy in the treatment of Helicobacter pylori(Hp) infection and gastric ulcer. Methods A total of 53 gastric ulcer patients with Helicobacter pylori infection were randomly divided into observation group(27 cases) and control group(26 cases). The observation group was treated with combined therapy of omeprazole, amoxicillin and clarithromycin, and the control group was treated with combined therapy of omeprazole, amoxicillin and metronidazole. The treatment effect in two groups was compared. Results The observation group had total treatment effective rate as 96.30%, which was 69.23% in the control group. The observation group had higher total treatment effective rate than the control group, and the difference was statistically significant(P<0.05). The observation group had Helicobacter pylori eradication rate as 88.89% and incidence of adverse reactions as 18.52%, which were 65.38% and 23.08% in the control group. The observation group had higher Helicobacter pylori eradication rate than the control group, and the difference was statistically significant(P<0.05). Both groups had no statistically significant difference in incidence of adverse reactions(P>0.05). Conclusion Combined therapy of omeprazole, amoxicillin and clarithromycin can significantly improve the Helicobacter pylori eradication rate of gastric ulcer patients with Helicobacter pylori infection, and promote the improvement of the disease. It can be widely promoted in clinic.
Objective To discuss the clinical efficacy of two kinds of triple therapy in the treatment of Helicobacter pylori(Hp) infection and gastric ulcer. Methods A total of 53 gastric ulcer patients with Helicobacter pylori infection were randomly divided into observation group(27 cases) and control group(26 cases). The observation group was treated with combined therapy of omeprazole, amoxicillin and clarithromycin, and the control group was treated with combined therapy of omeprazole, amoxicillin and metronidazole. The treatment effect in two groups was compared. Results The observation group had total treatment effective rate as 96.30%, which was 69.23% in the control group. The observation group had higher total treatment effective rate than the control group, and the difference was statistically significant(P<0.05). The observation group had Helicobacter pylori eradication rate as 88.89% and incidence of adverse reactions as 18.52%, which were 65.38% and 23.08% in the control group. The observation group had higher Helicobacter pylori eradication rate than the control group, and the difference was statistically significant(P<0.05). Both groups had no statistically significant difference in incidence of adverse reactions(P>0.05). Conclusion Combined therapy of omeprazole, amoxicillin and clarithromycin can significantly improve the Helicobacter pylori eradication rate of gastric ulcer patients with Helicobacter pylori infection, and promote the improvement of the disease. It can be widely promoted in clinic.
引文
[1]张耀蓉.种三联疗法根除幽门螺杆菌感染胃溃疡临床疗效比较.健康必读旬刊,2013,12(4):260-261.
[2]于礼心.不同三联疗法根除幽门螺杆菌感染胃溃疡的临床疗效对比分析.中国现代药物应用,2016,10(5):159-160.
[3]李宏,江云龙.分析三联疗法治疗幽门螺杆菌感染胃溃疡的临床疗效.医药前沿,2016,6(18):103-104.
[4]刘二云.三联疗法根除幽门螺杆菌感染胃溃疡临床疗效观察.临床合理用药杂志,2012,5(7):64.
[5]王泽.三联疗法应用于幽门螺杆菌感染胃溃疡的临床疗效观察.健康必读旬刊,2012,11(5):200.
[6]马艳华.观察两种三联疗法根除幽门螺杆菌感染胃溃疡的疗效.临床医药文献电子杂志,2015(22):4600-4601.
[7]邵安健.两种三联疗法治疗幽门螺旋杆菌相关性胃溃疡的临床研究.中国基层医药,2008,15(7):1161.
[8]余晓,杨俊.两种三联疗法治疗幽门螺杆菌感染的消化性溃疡效果比较.中国乡村医药,2013(7):10.
[9]龚秋.不同的三联疗法治疗幽门螺旋杆菌感染胃溃疡的临床治疗.健康必读旬刊,2013,12(6):395.
[10]王能民.两种三联疗法对幽门螺旋杆菌相关性胃溃疡的对比研究.四川医学,2013,34(3):401-402.
[2]于礼心.不同三联疗法根除幽门螺杆菌感染胃溃疡的临床疗效对比分析.中国现代药物应用,2016,10(5):159-160.
[3]李宏,江云龙.分析三联疗法治疗幽门螺杆菌感染胃溃疡的临床疗效.医药前沿,2016,6(18):103-104.
[4]刘二云.三联疗法根除幽门螺杆菌感染胃溃疡临床疗效观察.临床合理用药杂志,2012,5(7):64.
[5]王泽.三联疗法应用于幽门螺杆菌感染胃溃疡的临床疗效观察.健康必读旬刊,2012,11(5):200.
[6]马艳华.观察两种三联疗法根除幽门螺杆菌感染胃溃疡的疗效.临床医药文献电子杂志,2015(22):4600-4601.
[7]邵安健.两种三联疗法治疗幽门螺旋杆菌相关性胃溃疡的临床研究.中国基层医药,2008,15(7):1161.
[8]余晓,杨俊.两种三联疗法治疗幽门螺杆菌感染的消化性溃疡效果比较.中国乡村医药,2013(7):10.
[9]龚秋.不同的三联疗法治疗幽门螺旋杆菌感染胃溃疡的临床治疗.健康必读旬刊,2013,12(6):395.
[10]王能民.两种三联疗法对幽门螺旋杆菌相关性胃溃疡的对比研究.四川医学,2013,34(3):401-402.