影响早期舌鳞状细胞癌患者手术效果及预后的相关因素分析
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摘要
目的探究影响早期舌鳞状细胞癌患者手术效果及预后的相关因素。方法回顾性分析本院2010年2月～2013年8月收治的161例早期舌鳞癌患者资料,根据患者是否出现复发进行分组,分析复发情况与年龄、临床分期、病理分级、综合治疗、颈部淋巴结清扫等因素的相关性,采用Kaplan-Meier法计算患者的生存率,并统计3年、5年生存率与年龄、性别、临床分期、颈部淋巴结清扫、综合治疗、复发、病理分级、吸烟喝酒等因素的相关性,对各因素先进行单因素分析,之后进一步纳入logistics回归模型进行多因素分析。结果临床分期、病理分级、综合治疗、颈部淋巴结清扫是影响早期舌鳞癌患者复发的主要因素(P <0.05),进一步行logistics分析结果显示,综合治疗、颈部淋巴结清扫是影响早期舌鳞癌患者复发的独立因素(P <0.05);年龄、综合治疗、复发、颈部淋巴结清扫是影响早期舌鳞癌患者生存率的主要因素(P <0.05),进一步行logistics分析结果显示,年龄、复发是影响早期舌鳞癌患者生存率的独立因素(P <0.05)。结论综合治疗、颈部淋巴结清扫是影响早期舌鳞癌患者复发的独立因素,而年龄、复发则是影响早期舌鳞癌患者生存率的独立因素,建议重视患者的颈部淋巴结清扫及术后的综合治疗,降低复发率,提高患者的生存率。
Objective To investigate the factors affecting the surgical outcome and prognosis of patients with early tongue squamous cell carcinoma. Methods A retrospective analysis of 161 patients with early squamous cell carcinoma of the tongue admitted to our hospital from February 2010 to August 2013 was conducted. The patients were divided according to whether they had recurrence. The recurrence and age, clinical analysis, pathological grading, comprehensive treatment and neck were analyzed. The correlation of factors such as lymph node dissection was calculated by Kaplan-Meier method, and the 3-year and 5-year survival rates were compared with age, gender, clinical stage, cervical lymph node dissection, comprehensive treatment, recurrence, pathological grading, The correlation between smoking and drinking factors, the single factor analysis of each factor, and then further into the logistic regression model for multi-factor analysis. Results Clinical stage, pathological grade, comprehensive treatment, and cervical lymph node dissection were the main factors affecting the recurrence of early tongue squamous cell carcinoma(P < 0.05). Further logistic analysis showed that comprehensive treatment and cervical lymph node dissection were the early effects of tongue scale. Independent factors of recurrence of cancer patients(P < 0.05); age, comprehensive treatment, recurrence, and cervical lymph node dissection were the main factors affecting the survival rate of patients with early tongue squamous cell carcinoma(P<0.05). Further logistic analysis showed that age, Recurrence was an independent factor affecting the survival rate of patients with early tongue squamous cell carcinoma(P < 0.05). ConclusionsComprehensive treatment and cervical lymph node dissection are independent factors affecting the recurrence of early tongue squamous cell carcinoma, and age and recurrence are independent factors affecting the survival rate of patients with early tongue squamous cell carcinoma. It is recommended to pay attention to the patient's cervical lymph node dissection and postoperative comprehensive treatment, reduce the recurrence rate and improve the survival rate of patients.
Objective To investigate the factors affecting the surgical outcome and prognosis of patients with early tongue squamous cell carcinoma. Methods A retrospective analysis of 161 patients with early squamous cell carcinoma of the tongue admitted to our hospital from February 2010 to August 2013 was conducted. The patients were divided according to whether they had recurrence. The recurrence and age, clinical analysis, pathological grading, comprehensive treatment and neck were analyzed. The correlation of factors such as lymph node dissection was calculated by Kaplan-Meier method, and the 3-year and 5-year survival rates were compared with age, gender, clinical stage, cervical lymph node dissection, comprehensive treatment, recurrence, pathological grading, The correlation between smoking and drinking factors, the single factor analysis of each factor, and then further into the logistic regression model for multi-factor analysis. Results Clinical stage, pathological grade, comprehensive treatment, and cervical lymph node dissection were the main factors affecting the recurrence of early tongue squamous cell carcinoma(P < 0.05). Further logistic analysis showed that comprehensive treatment and cervical lymph node dissection were the early effects of tongue scale. Independent factors of recurrence of cancer patients(P < 0.05); age, comprehensive treatment, recurrence, and cervical lymph node dissection were the main factors affecting the survival rate of patients with early tongue squamous cell carcinoma(P<0.05). Further logistic analysis showed that age, Recurrence was an independent factor affecting the survival rate of patients with early tongue squamous cell carcinoma(P < 0.05). ConclusionsComprehensive treatment and cervical lymph node dissection are independent factors affecting the recurrence of early tongue squamous cell carcinoma, and age and recurrence are independent factors affecting the survival rate of patients with early tongue squamous cell carcinoma. It is recommended to pay attention to the patient's cervical lymph node dissection and postoperative comprehensive treatment, reduce the recurrence rate and improve the survival rate of patients.
引文
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