组蛋白乙酰化在慢性牙周炎来源牙周膜干细胞成骨分化中的作用
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摘要
表观遗传是指基因序列不发生改变的前提下,基因表达却发生改变,且这种改变能够遗传至后代。其中,组蛋白乙酰化属于表观遗传范畴中重要的一种类型。现有的研究表明慢性牙周炎的发生与表观遗传修饰具有一定的关系。结合已有研究,本文对组蛋白乙酰化在慢性牙周炎来源牙周膜干细胞成骨分化中的作用作一综述。
Epigenetics is defined as a change in gene expression without the alteration of the genetic sequence.Such a change would be inherited by offspring.Histone acetylation is a type of epigenetics.Existing studies proposed that chronic periodontitis is related to epigenetic modification.In this review,we summarised the influence of chronic periodontitis on periodontal ligament stem cells by histone acetylation.
Epigenetics is defined as a change in gene expression without the alteration of the genetic sequence.Such a change would be inherited by offspring.Histone acetylation is a type of epigenetics.Existing studies proposed that chronic periodontitis is related to epigenetic modification.In this review,we summarised the influence of chronic periodontitis on periodontal ligament stem cells by histone acetylation.
引文
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[12]Sun J,Dong Z,Zhang Y,et al.Osthole improves function of periodontitis periodontal ligament stem cells via epigenetic modification in cell sheets engineering[J].Sci Rep,2017,7(1):5254.
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[15]Manjunath BC,Praveen K,Chandrashekar BR,et al.Periodontal infections:a risk factor for various systemic diseases[J].Natl Med J India,2011,24(4):214-219.
[16]Xu Q,Li B,Yuan L,et al.Combination of platelet-rich plasma within periodontal ligament stemcell sheets enhances cell differentiation and matrix production[J].J Tissue Eng Regen Med,2017,11(3):627-636.
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[18]Ohlstein B,Kai T,Decotto E,et al.The stem cell niche:theme and variations[J].Curr Opin Cell Biol,2004,16(6):693-699.
[19]孔祥伟,叶瑞东,刘文佳,等.炎症微环境中经典Wnt信号通路对牙周膜干细胞成骨分化的调控作用[J].口腔生物医学,2015,6(3):129-136.Kong XW,Ye RD,Liu WJ,et al.Wnt/β-cateninsignaling pathway mediates the impaired osteogenic differentiation of periodontal ligament stem cells in inflammatory microenvironment[J].Oral Biomed,2015,6(3):129-136.
[20]刘娜,石海刚,张维,等.炎症微环境作用下经典及非经典Wnt通路平衡对牙周膜干细胞成骨分化的调控作用[J].中华口腔医学杂志,2016,51(11):673-679.Liu N,Shi HG,Zhang W,et al.The crosstalk between canonical and noncanonicai Wnt signaling pathway in osteoblast differentiation of periodontal ligament stem cells in inflammatory microenvironments[J].Chin J Stomatol,2016,51(11):673-679.
[21]Tan J,Zhou LH,Xue P,et al.Tumor necrosis factor-alpha attenuates the osteogenic differentiation capacity of periodontal ligament stem cells by activating protein kinase like endoplasmic reticulum kinase signaling[J].J Periodontol,2016,87(8):e159-e171.
[22]白林,辛月娇,段丁瑜,等.巨噬细胞功能和炎症消退机制及与牙周炎关系研究进展[J].华西口腔医学杂志,2017,35(4):427-432.Bai L,Xin YJ,Duan DY,et al.Advances in macrophage function and its anti-inflammatory and proresolving activity and role in periodontitis development[J].West Chin J Stomatol,2017,35(4):427-432.
[23]Van Dyke TE.The management of inflammation in periodontal disease[J].J Periodontol,2008,79(8):1601-1608.
[24]Ye L,Fan Z,Yu B,et al.Histone demethylases KDM4Band KDM6B promote osteogenic differentiation of human MSCs[J].Cell Stem Cell,2018,23(6):898-899.
[25]Gomez RS,Dutra WO,Moreira PR.Epigenetics and periodontal disease:future perspectives[J].Inflamm Res,2009,58(10):625-629.
[26]袁林,孙晋,杨征毅,等.乙酰基转移酶KAT2A调控牙周膜干细胞成骨分化的研究[J].口腔生物医学,2015,6(3):155-159.Yuan L,Sun J,Yang ZY,et al.Study of acetyltransferase KAT2A regulating osteogenic differentiation potential of periodontal ligament stem cells[J].Oral Biomed,2015,6(3):155-159.
[27]Xue P,Li B,An Y,et al.Decreased MORF leads to prolonged endoplasmic reticulum stress in periodontitis-associated chronic inflammation[J].Cell Death Differ,2016,23(11):1862-1872.
[28]杨倩娟.miR-17~92家族介导的HDAC9炎症牙周膜干细胞成骨分化能力的影响[D].西安:第四军医大学,2016.Yang QJ.miR-17-92 cluster mediated HDAC9 effects on the osteogenetic capability of the inflammatory PDLSCs[D].Xi’an:The Fourth Military Medical University,2016.
[2]袁林,孙晋,程峰,等.牙周膜干细胞中乙酰基转移酶MORF调控成骨的研究[J].实用口腔医学杂志,2016,32(6):778-782.Yuan L,Sun J,Cheng F,et al.Acetyltransferase MORF regulates osteogenic differentiation potential of periodontal ligament stem cells[J].J Pract Stomatol,2016,32(6):778-782.
[3]Roberfroid S,Vanderleyden J,Steenackers H.Gene expression variability in clonal populations:causes and consequences[J].Crit Rev Microbiol,2016,42(6):969-984.
[4]van Dijk PJ,Ellis TH.The full breadth of Mendel’s genetics[J].Genetics,2016,204(4):1327-1336.
[5]Holliday R.DNA methylation and epigenetic defects in carcinogenesis[J].Mutat Res,1987,181(2):215-217.
[6]雷丹,姜苏,吴亚菲,等.表观遗传修饰和牙周病的相关性[J].国际口腔医学杂志,2012,39(2):257-259.Lei D,Jiang S,Wu YF,et al.Association between epigenetic modification and periodontal diseases[J].Int J Stomatol,2012,39(2):257-259.
[7]Li B,Sun J,Dong Z,et al.GCN5 modulates osteogenic differentiation of periodontal ligament stem cells through DKK1acetylation in inflammatory microenvironment[J].Sci Rep,2016,6:26542.
[8]Timmermann S,Lehrmann H,Polesskaya A,et al.Histone acetylation and disease[J].Cell Mol Life Sci,2001,58(5/6):728-736.
[9]Lavu V,Venkatesan V,Rao SR.The epigenetic paradigm in periodontitis pathogenesis[J].J Indian Soc Periodontol,2015,19(2):142-149.
[10]Ari G,Cherukuri S,Namasivayam A.Epigenetics and periodontitis:a contemporary review[J].J Clin Diagn Res,2016,10(11):ZE07-ZE09.
[11]Lindroth AM,Park YJ.Epigenetic biomarkers:a step forward for understanding periodontitis[J].J Periodontal Implant Sci,2013,43(3):111-120.
[12]Sun J,Dong Z,Zhang Y,et al.Osthole improves function of periodontitis periodontal ligament stem cells via epigenetic modification in cell sheets engineering[J].Sci Rep,2017,7(1):5254.
[13]Pihlstrom BL,Michalowicz BS,Johnson NW.Periodontal diseases[J].Lancet,2005,366(9499):1809-1820.
[14]Lindemann RA,Economou JS,Rothermel H.Production of interleukin-1 and tumor necrosis factor by human peripheral monocytes activated by periodontal bacteria and extracted lipopolysaccharides[J].J Dent Res,1988,67(8):1131-1135.
[15]Manjunath BC,Praveen K,Chandrashekar BR,et al.Periodontal infections:a risk factor for various systemic diseases[J].Natl Med J India,2011,24(4):214-219.
[16]Xu Q,Li B,Yuan L,et al.Combination of platelet-rich plasma within periodontal ligament stemcell sheets enhances cell differentiation and matrix production[J].J Tissue Eng Regen Med,2017,11(3):627-636.
[17]Seo BM,Miura M,Gronthos S,et al.Investigation of multipotent postnatal stem cells from human periodontal ligament[J].Lancet,2004,364(9429):149-155.
[18]Ohlstein B,Kai T,Decotto E,et al.The stem cell niche:theme and variations[J].Curr Opin Cell Biol,2004,16(6):693-699.
[19]孔祥伟,叶瑞东,刘文佳,等.炎症微环境中经典Wnt信号通路对牙周膜干细胞成骨分化的调控作用[J].口腔生物医学,2015,6(3):129-136.Kong XW,Ye RD,Liu WJ,et al.Wnt/β-cateninsignaling pathway mediates the impaired osteogenic differentiation of periodontal ligament stem cells in inflammatory microenvironment[J].Oral Biomed,2015,6(3):129-136.
[20]刘娜,石海刚,张维,等.炎症微环境作用下经典及非经典Wnt通路平衡对牙周膜干细胞成骨分化的调控作用[J].中华口腔医学杂志,2016,51(11):673-679.Liu N,Shi HG,Zhang W,et al.The crosstalk between canonical and noncanonicai Wnt signaling pathway in osteoblast differentiation of periodontal ligament stem cells in inflammatory microenvironments[J].Chin J Stomatol,2016,51(11):673-679.
[21]Tan J,Zhou LH,Xue P,et al.Tumor necrosis factor-alpha attenuates the osteogenic differentiation capacity of periodontal ligament stem cells by activating protein kinase like endoplasmic reticulum kinase signaling[J].J Periodontol,2016,87(8):e159-e171.
[22]白林,辛月娇,段丁瑜,等.巨噬细胞功能和炎症消退机制及与牙周炎关系研究进展[J].华西口腔医学杂志,2017,35(4):427-432.Bai L,Xin YJ,Duan DY,et al.Advances in macrophage function and its anti-inflammatory and proresolving activity and role in periodontitis development[J].West Chin J Stomatol,2017,35(4):427-432.
[23]Van Dyke TE.The management of inflammation in periodontal disease[J].J Periodontol,2008,79(8):1601-1608.
[24]Ye L,Fan Z,Yu B,et al.Histone demethylases KDM4Band KDM6B promote osteogenic differentiation of human MSCs[J].Cell Stem Cell,2018,23(6):898-899.
[25]Gomez RS,Dutra WO,Moreira PR.Epigenetics and periodontal disease:future perspectives[J].Inflamm Res,2009,58(10):625-629.
[26]袁林,孙晋,杨征毅,等.乙酰基转移酶KAT2A调控牙周膜干细胞成骨分化的研究[J].口腔生物医学,2015,6(3):155-159.Yuan L,Sun J,Yang ZY,et al.Study of acetyltransferase KAT2A regulating osteogenic differentiation potential of periodontal ligament stem cells[J].Oral Biomed,2015,6(3):155-159.
[27]Xue P,Li B,An Y,et al.Decreased MORF leads to prolonged endoplasmic reticulum stress in periodontitis-associated chronic inflammation[J].Cell Death Differ,2016,23(11):1862-1872.
[28]杨倩娟.miR-17~92家族介导的HDAC9炎症牙周膜干细胞成骨分化能力的影响[D].西安:第四军医大学,2016.Yang QJ.miR-17-92 cluster mediated HDAC9 effects on the osteogenetic capability of the inflammatory PDLSCs[D].Xi’an:The Fourth Military Medical University,2016.