人参米抗疲劳和抗氧化活性研究
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摘要
目的:研究人参米对小鼠的抗疲劳和抗氧化活性。方法:除对照组外,小鼠饲喂以人参米为主要成分的饲料,6周后测定小鼠体重变化、负重游泳力竭时间、肝糖原、血乳酸、血清尿素氮(BUN)、超氧化物歧化酶(SOD)及丙二醛(MDA)的含量。结果:人参米对小鼠体重增长无显著影响,但能延长小鼠负重游泳时间,增强小鼠血清SOD活性,提高肝糖原含量,降低血清MDA、BUN及血乳酸含量。结论:人参米具有抗疲劳和抗氧化作用。
Objective: To explore the effects of ginseng rice on anti-fatigue and anti-oxidation in mice. Methods:The fodder which mainly consists of ginseng rice were administrated to the mice for 6 consecutive weeks. After 6 weeks of experiment, the bodyweight of mice, loaded swimming time, the content of liver glycogen, blood lactic acid, urea nitrogen, MDA and SOD were measured. Results: Ginseng rice has no significant effect on body weight of the mice between control group and experimental group.Compared with the control group, the loaded swimming survival time of the mice which administrated to ginseng rice was prolonged, at the same time, ginseng rice enhanced the SOD activities of mice blood,increased the content of liver glycogen, decreased the MDA content of mice blood, urea nitrogen and blood lactic acid in mice.Conclusion: Ginseng rice possesses anti-fatigue and anti-oxidation activities.
Objective: To explore the effects of ginseng rice on anti-fatigue and anti-oxidation in mice. Methods:The fodder which mainly consists of ginseng rice were administrated to the mice for 6 consecutive weeks. After 6 weeks of experiment, the bodyweight of mice, loaded swimming time, the content of liver glycogen, blood lactic acid, urea nitrogen, MDA and SOD were measured. Results: Ginseng rice has no significant effect on body weight of the mice between control group and experimental group.Compared with the control group, the loaded swimming survival time of the mice which administrated to ginseng rice was prolonged, at the same time, ginseng rice enhanced the SOD activities of mice blood,increased the content of liver glycogen, decreased the MDA content of mice blood, urea nitrogen and blood lactic acid in mice.Conclusion: Ginseng rice possesses anti-fatigue and anti-oxidation activities.
引文
[1]Daisy Dai,Chun-Feng Zhang,Stephanie Williams,Chun-Su Yuan,Chong-zhi Wang.Ginseng on Cancer:Potential Role in Modulating Inflammation-Mediated Angiogenesis[J].The American Journal of Chinese Medicine,2017,45(1):1~10.
[2]Jinghui Sun,Chuanxin Jiao,Yue Ma,Jianguang Chen,Wei Wu,Shuying Liu.Anti-ageing effect of red ginseng revealed by urinary metabonomics using RRLCQ-TOF-MS[J].Phytochemical Analysis,2018:1~11.
[3]Hyeong-Geug Kim1,Jung-Hyo Cho1,Sa-Ra Yoo,Jin-Seok Lee,Jong-Min Han,Nam-Hun Lee,Yo-Chan Ahn,Chang-Gue Son.Antifatigue Effects of Panax ginseng C.A.Meyer:A Randomised,Double-Blind,Placebo-Controlled Trial[J].Plos One,2013,8(4):e61271.
[4]Yeonju Lee,Seikwan Oh.Administration of red ginseng ameliorates memory decline in aged mice[J].Journal of Ginseng Research,2015,39(3):250~256.
[5]Yao Wang,Yi Liu,Xiao-Yu Zhang,Li-Hui Xu,Dong-Yun Ouyang,Kun-Peng Liu,Hao Pan,Jian He,Xian-Hui He.Ginsenoside Rg1 regulates innate immune responses in macrophages through differentially modulating the NF-κB and PI3K/Akt/m TOR pathways[J].International Immunopharmacology,2014,23(1):77~84.
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[9]Aiping Chi,Hong Li,Chenzhe Kang,Huanhuan Guo,Yimin Wang,Fei Guo,Liang Tang.Anti-fatigue activity of a novel polysaccharide conjugates from Ziyang green tea[J].International Journal of Biological Macromolecules,2015,80:566~572.
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[11]Bo Qi,Lan Zhang,Zhiqun Zhang,Jiangqiong Ouyang,and Hui Huang.Effects of ginsenosides-Rb1 on exercise-induced oxidative stress in forced swimming mice[J].Pharmacognosy Magazine,2014,10(40):458~463.
[12]Wenyan Tang,Yi Zhang,Jing Gao,Xueying Ding,Shen Gao.The Anti-fatigue Effect of 20(R)-Ginsenoside Rg3 in Mice by Intranasally Administration[J].Biological&Pharmaceutical Bulletin,2008,31(11):2024~2027.
[13]Yuxia Xu,Peng Zhang,Chu Wang,Ye Shan,Dandan Wang,Fenglei Qian,Mengwei Sun,Cuiqing Zhu.Effect of ginsenoside Rg3 on tyrosine hydroxylase and related mechanisms in the forced swimming-induced fatigue rats[J].Journal of Ethnopharmacology,2013,150(1):138~147.
[14]Hyun A Oh,Dae-Eung Kim,Hyuck Jai Choi,Nam Jae Kim,Dong-Hyun Kim.Anti-fatigue Effects of20(S)-Protopanaxadiol and 20(S)-Protopanaxatriol in Mice[J].Biological&Pharmaceutical Bulletin,2015,38(9):1415~1419.
[15]Han Gao,Wencheng Zhang,Bingsong Wang,Ailing Hui,Biao Du,Tingting Wang,Ling Meng,Huixi Bian,Zeyu Wu.Purification,characterization and antifatigue activity of polysaccharide fractions from okra(Abelmoschus esculentus(L.)Moench)[J].Food&Function,2018,9:1088~1101.
[16]王璟,秦雪,仝令印,孙海基.黄酒对小鼠抗疲劳能力和衰老小鼠免疫器官的影响[J].食品科学,2016,37(21):224~228.
[17]王云,管国倩,曹俊平,易理伟,刘超.高原舒颗粒对小鼠抗疲劳作用的实验研究[J].西北药学杂志,2016,31(1):61~64.
[18]Lei Bao,Xiaxia Cai,Junbo Wang,Yuan Zhang,Bin Sun,Yong Li.Anti-Fatigue Effects of Small Molecule Oligopeptides Isolated from Panax ginseng C.A.Meyer in Mice[J].Nutrients,2016,8(12):807.
[19]T.Anand,G.Phani Kumar,M.D.Pandareesh,M.S.L.Swamy,Farhath Khanum,A.S.Bawa.Effect of Bacoside Extract from Bacopa monniera on Physical Fatigue Induced by Forced Swimming[J].Phytotherapy Research,2012,26(4):587~593.
[20]李吉萍,孙婷婷,胡天骄,刘墨祥.板蓝根活性组分对小鼠耐缺氧及抗疲劳作用的实验研究[J].中国药理学通报,2016,32(5):712~715.
[21]Weimin Tang,Lu Jin,Lianghua Xie,Juqing Huang,Nan Wang,Bingquan Chu,Xulin Dai,Yu Liu,Rui Wang,Ying Zhang.Structural Characterization and Antifatigue Effect In Vivo of Maca(Lepidium meyenii Walp)Polysaccharide[J].Journal of Food Science,2017,82(3):757~764.
[2]Jinghui Sun,Chuanxin Jiao,Yue Ma,Jianguang Chen,Wei Wu,Shuying Liu.Anti-ageing effect of red ginseng revealed by urinary metabonomics using RRLCQ-TOF-MS[J].Phytochemical Analysis,2018:1~11.
[3]Hyeong-Geug Kim1,Jung-Hyo Cho1,Sa-Ra Yoo,Jin-Seok Lee,Jong-Min Han,Nam-Hun Lee,Yo-Chan Ahn,Chang-Gue Son.Antifatigue Effects of Panax ginseng C.A.Meyer:A Randomised,Double-Blind,Placebo-Controlled Trial[J].Plos One,2013,8(4):e61271.
[4]Yeonju Lee,Seikwan Oh.Administration of red ginseng ameliorates memory decline in aged mice[J].Journal of Ginseng Research,2015,39(3):250~256.
[5]Yao Wang,Yi Liu,Xiao-Yu Zhang,Li-Hui Xu,Dong-Yun Ouyang,Kun-Peng Liu,Hao Pan,Jian He,Xian-Hui He.Ginsenoside Rg1 regulates innate immune responses in macrophages through differentially modulating the NF-κB and PI3K/Akt/m TOR pathways[J].International Immunopharmacology,2014,23(1):77~84.
[6]中华人民共和国卫生部.关于批准人参(人工种植)为新资源食品的公告[R].北京:中华人民共和国卫生部,2016.
[7]Bin Qi,Li Liu,He Zhang,Guang-xin Zhou,Shan Wang,Xiao-zheng Duan,Xue-yuan Bai,Si-ming Wang,Da-qing Zhao.Anti-fatigue effects of proteins isolated from Panax quinquefolium[J].Journal of Ethnopharmacology,2014,153(2):430~434.
[8]刘冲,刘荫贞,乐智勇,林伟雄,梁生旺.人参枸杞复方颗粒抗疲劳作用研究[J].中南药学,2017,15(7):924~927.
[9]Aiping Chi,Hong Li,Chenzhe Kang,Huanhuan Guo,Yimin Wang,Fei Guo,Liang Tang.Anti-fatigue activity of a novel polysaccharide conjugates from Ziyang green tea[J].International Journal of Biological Macromolecules,2015,80:566~572.
[10]Jia Wang,Shanshan Li,Yuying Fan,et al.Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C.A.Meyer[J].Journal of Ethnopharmacology,2010,130(2):421~423.
[11]Bo Qi,Lan Zhang,Zhiqun Zhang,Jiangqiong Ouyang,and Hui Huang.Effects of ginsenosides-Rb1 on exercise-induced oxidative stress in forced swimming mice[J].Pharmacognosy Magazine,2014,10(40):458~463.
[12]Wenyan Tang,Yi Zhang,Jing Gao,Xueying Ding,Shen Gao.The Anti-fatigue Effect of 20(R)-Ginsenoside Rg3 in Mice by Intranasally Administration[J].Biological&Pharmaceutical Bulletin,2008,31(11):2024~2027.
[13]Yuxia Xu,Peng Zhang,Chu Wang,Ye Shan,Dandan Wang,Fenglei Qian,Mengwei Sun,Cuiqing Zhu.Effect of ginsenoside Rg3 on tyrosine hydroxylase and related mechanisms in the forced swimming-induced fatigue rats[J].Journal of Ethnopharmacology,2013,150(1):138~147.
[14]Hyun A Oh,Dae-Eung Kim,Hyuck Jai Choi,Nam Jae Kim,Dong-Hyun Kim.Anti-fatigue Effects of20(S)-Protopanaxadiol and 20(S)-Protopanaxatriol in Mice[J].Biological&Pharmaceutical Bulletin,2015,38(9):1415~1419.
[15]Han Gao,Wencheng Zhang,Bingsong Wang,Ailing Hui,Biao Du,Tingting Wang,Ling Meng,Huixi Bian,Zeyu Wu.Purification,characterization and antifatigue activity of polysaccharide fractions from okra(Abelmoschus esculentus(L.)Moench)[J].Food&Function,2018,9:1088~1101.
[16]王璟,秦雪,仝令印,孙海基.黄酒对小鼠抗疲劳能力和衰老小鼠免疫器官的影响[J].食品科学,2016,37(21):224~228.
[17]王云,管国倩,曹俊平,易理伟,刘超.高原舒颗粒对小鼠抗疲劳作用的实验研究[J].西北药学杂志,2016,31(1):61~64.
[18]Lei Bao,Xiaxia Cai,Junbo Wang,Yuan Zhang,Bin Sun,Yong Li.Anti-Fatigue Effects of Small Molecule Oligopeptides Isolated from Panax ginseng C.A.Meyer in Mice[J].Nutrients,2016,8(12):807.
[19]T.Anand,G.Phani Kumar,M.D.Pandareesh,M.S.L.Swamy,Farhath Khanum,A.S.Bawa.Effect of Bacoside Extract from Bacopa monniera on Physical Fatigue Induced by Forced Swimming[J].Phytotherapy Research,2012,26(4):587~593.
[20]李吉萍,孙婷婷,胡天骄,刘墨祥.板蓝根活性组分对小鼠耐缺氧及抗疲劳作用的实验研究[J].中国药理学通报,2016,32(5):712~715.
[21]Weimin Tang,Lu Jin,Lianghua Xie,Juqing Huang,Nan Wang,Bingquan Chu,Xulin Dai,Yu Liu,Rui Wang,Ying Zhang.Structural Characterization and Antifatigue Effect In Vivo of Maca(Lepidium meyenii Walp)Polysaccharide[J].Journal of Food Science,2017,82(3):757~764.