某高校6230名新生HBV感染情况分析
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摘要
目的检测襄阳市某高校新生乙肝三系检测项目,了解该校新生乙肝病毒携带情况,为高校做好在校学生乙肝的防治工作提供相关资料。方法通过酶联免疫吸附试验(ELISA)检测2017年6 230名新生乙肝三系检测项目,对阳性结果进行分类分析。结果 6 230名新生中HBsAg阳性率为1.79%(112/6230),其中男生为2.30%(66/2868)、女生为1.37%(46/3362),差异有统计学意义;在112例HBsAg阳性者中,HBsAg、HBeAg、HBcAb均阳性(大三阳)占41.07%(46/112),HBsAg、HBeAb、HBcAb均阳性(小三阳)占46.42%(52/112),HBsAg和HBsAb阳性3例,占比2.67%,HBsAg和HBcAb阳性9例,HBsAg和HBeAb阳性1例,单纯HBsAg阳性2例,差异有统计学意义;大三阳男生高于女生,小三阳男女生差异不大。结论 HBsAg阳性率男生高于女性,且HBsAg阳性者中大三阳和小三阳显著高于其它类型,有强感染性的类型也高于感染性低的类型。因此,应该加强对高校新生进行乙肝知识的宣传教育。
Objective To understand the hepatitis B virus(HBV) carrying status of freshmen in a university through detecting 3 systems of hepatitis-B, and to provide relevant information for the prevention and treatment of HBV among freshmen. Methods 6230 freshmen with hepatitis B were tested by enzyme linked immunosorbent assay(ELISA) in 2017, and the positive results were classified and analyzed. Results The positive rate of HBsAg in 6230 freshmen was 1.79%(112/6230), 2.30%(66/2868) for boys and 1.37%(46/3362) for girls. The difference was statistically significant. Among 112 HBsAg positive students, 41.07%(46/112) were HBsAg,HBeAg and HBcAb positive(great three positive), 46.42%(52/112) were HBsAg, HBeAb and HBcAb positive(small three positive), 3 cases were HBsAg and HBsAb positive(2.67%, HBsA). HBsAg and HBcAb were positive in 9 cases, HBsAg and HBeAb positive in 1 case, and HBsAg-positive in 2 cases, the difference was statistically significant The boy students in "great three positive"(29.9) were higher than the female students(17.52), while the girl students in small "small three positive"had no significant difference. Conclusion The positive rate of HBsAg is higher in boys than in girls, and among the HBsAg-positive ones, "great three positive"and "small three positive"are significantly higher than other types, and the type of strong infection is also higher than that of low infection. Therefore, it is necessary to strengthen the education of hepatitis B knowledge among freshmen in colleges and universities.
Objective To understand the hepatitis B virus(HBV) carrying status of freshmen in a university through detecting 3 systems of hepatitis-B, and to provide relevant information for the prevention and treatment of HBV among freshmen. Methods 6230 freshmen with hepatitis B were tested by enzyme linked immunosorbent assay(ELISA) in 2017, and the positive results were classified and analyzed. Results The positive rate of HBsAg in 6230 freshmen was 1.79%(112/6230), 2.30%(66/2868) for boys and 1.37%(46/3362) for girls. The difference was statistically significant. Among 112 HBsAg positive students, 41.07%(46/112) were HBsAg,HBeAg and HBcAb positive(great three positive), 46.42%(52/112) were HBsAg, HBeAb and HBcAb positive(small three positive), 3 cases were HBsAg and HBsAb positive(2.67%, HBsA). HBsAg and HBcAb were positive in 9 cases, HBsAg and HBeAb positive in 1 case, and HBsAg-positive in 2 cases, the difference was statistically significant The boy students in "great three positive"(29.9) were higher than the female students(17.52), while the girl students in small "small three positive"had no significant difference. Conclusion The positive rate of HBsAg is higher in boys than in girls, and among the HBsAg-positive ones, "great three positive"and "small three positive"are significantly higher than other types, and the type of strong infection is also higher than that of low infection. Therefore, it is necessary to strengthen the education of hepatitis B knowledge among freshmen in colleges and universities.
引文
[1]许正敏.病原生物与免疫学(第2版)[M].北京:人民卫生出版社,2011:197.
[2]中华人民共和国卫生部办公厅.卫生部公布全国人群乙肝血清流行病学调查结果[EB/OL].(2008-04-21)[2018-07-22].http://winhbv.com/news.asp?id=1.
[3]张秋红,张信,崔淑兰.某高校4届21183名新生HBV感染状况及ALT检测结果调查分析[J].实用医学杂志,2011(11):2065-2067.
[4]许正敏,李星军,卢恩昌,等.2003-2009年某校新生HBV感染及ALT检测结果分析[J].中国病原生物学杂志,2013(7):633-635.
[5]黄静,王秀梅.某高校5届新生HBsAg和ALT检测结果分析[J].保健医学研究与实践,2009(1):10-12.
[6]吕霞霞,李福辉.某高校新生HBsAg及ALT检测结果分析[J].中国学校卫生,2009(11):1038-1039.
[7]黄鹤,聂庆东,朱奎轩.某高校新生体检者ALT及HBsAg检测结果分析[J].中国肝脏病杂志,2012(2):25-27.
[8]孙莉,许正敏,卢恩昌,等.襄阳市某高校2003-2009年新生HBV感染情况分析[J].湖北民族学院学报,2013(2):66-67.
[9]汤建中,徐文锦,刘宏鹏,等.某高校新生血清HBV五项检测及其乙肝知识掌握情况调查报告[J].中国卫生统计,2012(3):402-403.
[2]中华人民共和国卫生部办公厅.卫生部公布全国人群乙肝血清流行病学调查结果[EB/OL].(2008-04-21)[2018-07-22].http://winhbv.com/news.asp?id=1.
[3]张秋红,张信,崔淑兰.某高校4届21183名新生HBV感染状况及ALT检测结果调查分析[J].实用医学杂志,2011(11):2065-2067.
[4]许正敏,李星军,卢恩昌,等.2003-2009年某校新生HBV感染及ALT检测结果分析[J].中国病原生物学杂志,2013(7):633-635.
[5]黄静,王秀梅.某高校5届新生HBsAg和ALT检测结果分析[J].保健医学研究与实践,2009(1):10-12.
[6]吕霞霞,李福辉.某高校新生HBsAg及ALT检测结果分析[J].中国学校卫生,2009(11):1038-1039.
[7]黄鹤,聂庆东,朱奎轩.某高校新生体检者ALT及HBsAg检测结果分析[J].中国肝脏病杂志,2012(2):25-27.
[8]孙莉,许正敏,卢恩昌,等.襄阳市某高校2003-2009年新生HBV感染情况分析[J].湖北民族学院学报,2013(2):66-67.
[9]汤建中,徐文锦,刘宏鹏,等.某高校新生血清HBV五项检测及其乙肝知识掌握情况调查报告[J].中国卫生统计,2012(3):402-403.