早期CRRT在急性重症胰腺炎治疗中的临床应用
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摘要
目的研究探讨早期CRRT在急性重症胰腺炎治疗中的临床应用效果。方法该实验于2012年11月—2018年6月在该院进行,以此时段内方便选取收治的80例急性重症胰腺炎患者为研究对象,随机均分两组各40例,以传统治疗为对照组,以早期CRRT治疗为观察组,分析早期CRRT治疗的价值所在,并对比两组的疗效、不良反应、细胞因子水平。结果观察组的有效率为92.5%,对照组的为80.0%,差异有统计学意义(χ~2=9.125,P<0.05);观察组疗效较对照组高,不良反应少于对照组,细胞因子水平优于对照组,两组比较,差异有统计学意义(P<0.05)。结论对于急性重症胰腺炎的患者,采取早期CRRT治疗,效果显著,可以增强疗效,改善实验室指标,提高生存质量,值得在今后的治疗中应用。
Objective To study the clinical effect of early CRRT in the treatment of severe acute pancreatitis. Methods The experiment was carried out in our hospital from November 2012 to June 2018. Convenient select 80 patients with severe acute pancreatitis were randomly divided into two groups, 40 cases in each group. The control group was treated with traditional therapy and the observation group was treated with early CRRT. Adverse reactions and cytokines levels. Results The effective rate of the observation group was 92.5%, the control group was 80.0%, and the difference was statistically significant(χ~2=9.125,P=0.05). The curative effect of the observation group was higher than that of the control group, the adverse reactions were less than that of the control group, and the level of cytokines was higher than that of the control group,the difference was statistically significant(P<0.05). Conclusion Early CRRT is effective in the treatment of severe acute pancreatitis. It can enhance the curative effect, improve the laboratory indexes and improve the quality of life. It is worth applying in the future.
Objective To study the clinical effect of early CRRT in the treatment of severe acute pancreatitis. Methods The experiment was carried out in our hospital from November 2012 to June 2018. Convenient select 80 patients with severe acute pancreatitis were randomly divided into two groups, 40 cases in each group. The control group was treated with traditional therapy and the observation group was treated with early CRRT. Adverse reactions and cytokines levels. Results The effective rate of the observation group was 92.5%, the control group was 80.0%, and the difference was statistically significant(χ~2=9.125,P=0.05). The curative effect of the observation group was higher than that of the control group, the adverse reactions were less than that of the control group, and the level of cytokines was higher than that of the control group,the difference was statistically significant(P<0.05). Conclusion Early CRRT is effective in the treatment of severe acute pancreatitis. It can enhance the curative effect, improve the laboratory indexes and improve the quality of life. It is worth applying in the future.
引文
[1]刘光灿.急性重症胰腺炎患者应用早期CRRT与血液灌流治疗对其氧合指数的影响[J].中国社区医师,2018,34(22):26,28.
[2] Luan ZG,Zhang J,Yin XH, et al.Ethyl pyruvate signif-icantly inhibits tumour necrosis factor-α, interleukin-1βand high mobility group box 1 releasing and attenuates sodium taurocholate-induced severe acute pancreatitis associated with acute lung injury[J]. Clinical and Exper-imental Immunology:An Official Journal of the British Society for Immunology,2013,172(3):417-426.
[3]彭艳,文刚,彭雪刚,等.重症胰腺炎患者血淀粉酶、TNF-α、IL-1β和PCT在CRRT治疗后的变化和意义[J].标记免疫分析与临床,2017,24(9):1011-1014.
[4]李昌,母珍珍,王磊,等.诱导型一氧化氮合酶(iNOS)对重症急性胰腺炎时胰岛内分泌功能的影响[J].中外医疗,2017,36(17):42-43,46.
[5]钟璇,肖先华.连续性肾脏替代疗法对重症胰腺炎患者肝肾功能的保护作用研究[J].解放军医药杂志,2017,29(4):99-102.
[6]闫静静.1例CRRT结合腹膜后穿刺引流治疗急性重症胰腺炎的护理体会[J].当代护士,2016(9下旬刊):129-130.
[7]竺添雨,帅颖丽,孔弘伟.生长抑素、加贝酯联合乌司他丁治疗急性胰腺炎的临床疗效分析[J].中外医疗,2017,36(30):109-110,113.
[8]徐玮炜.CRRT在重症急性胰腺炎患者临床治疗中的价值与效果研究[J].检验医学与临床,2016,13(6):800-802.
[9]吴寿坤,邝玉群,罗文晓,等.CRRT治疗老年重症急性胰腺炎患者的临床疗效观察[J].中国医药指南,2015,13(15):98-99.
[10]余栋栽,黄妙婷,谭家香,等.内科常规治疗联合床旁连续性肾脏替代疗法治疗急性重症胰腺炎的效果观察[J].右江民族医学院学报,2015,37(1):26-28.
[11] Koyasu S,Isoda H,Tsuji Y,et al.Hepatic arterial perfusion increases in the early stage of severe acute pancreatitis patients:Evaluation by perfusion computed tomography[J].European Journal of Radiology,2012,81(1):43-46.
[12]黄美英,王洁,黄鹏,等.血液灌流联合CRRT治疗重症急性胰腺炎合并急性肾损伤的临床疗效分析[J].中外医疗,2016,35(24):69-71.
[2] Luan ZG,Zhang J,Yin XH, et al.Ethyl pyruvate signif-icantly inhibits tumour necrosis factor-α, interleukin-1βand high mobility group box 1 releasing and attenuates sodium taurocholate-induced severe acute pancreatitis associated with acute lung injury[J]. Clinical and Exper-imental Immunology:An Official Journal of the British Society for Immunology,2013,172(3):417-426.
[3]彭艳,文刚,彭雪刚,等.重症胰腺炎患者血淀粉酶、TNF-α、IL-1β和PCT在CRRT治疗后的变化和意义[J].标记免疫分析与临床,2017,24(9):1011-1014.
[4]李昌,母珍珍,王磊,等.诱导型一氧化氮合酶(iNOS)对重症急性胰腺炎时胰岛内分泌功能的影响[J].中外医疗,2017,36(17):42-43,46.
[5]钟璇,肖先华.连续性肾脏替代疗法对重症胰腺炎患者肝肾功能的保护作用研究[J].解放军医药杂志,2017,29(4):99-102.
[6]闫静静.1例CRRT结合腹膜后穿刺引流治疗急性重症胰腺炎的护理体会[J].当代护士,2016(9下旬刊):129-130.
[7]竺添雨,帅颖丽,孔弘伟.生长抑素、加贝酯联合乌司他丁治疗急性胰腺炎的临床疗效分析[J].中外医疗,2017,36(30):109-110,113.
[8]徐玮炜.CRRT在重症急性胰腺炎患者临床治疗中的价值与效果研究[J].检验医学与临床,2016,13(6):800-802.
[9]吴寿坤,邝玉群,罗文晓,等.CRRT治疗老年重症急性胰腺炎患者的临床疗效观察[J].中国医药指南,2015,13(15):98-99.
[10]余栋栽,黄妙婷,谭家香,等.内科常规治疗联合床旁连续性肾脏替代疗法治疗急性重症胰腺炎的效果观察[J].右江民族医学院学报,2015,37(1):26-28.
[11] Koyasu S,Isoda H,Tsuji Y,et al.Hepatic arterial perfusion increases in the early stage of severe acute pancreatitis patients:Evaluation by perfusion computed tomography[J].European Journal of Radiology,2012,81(1):43-46.
[12]黄美英,王洁,黄鹏,等.血液灌流联合CRRT治疗重症急性胰腺炎合并急性肾损伤的临床疗效分析[J].中外医疗,2016,35(24):69-71.