阿司匹林联合氯吡格雷治疗急性心肌梗死的效果
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摘要
目的探讨阿司匹林联合氯吡格雷治疗急性心肌梗死的效果。方法选取2014年2月～2017年8月我院收治的88例急性心肌梗死患者作为研究对象,根据治疗的方法不同将其分为观察组(44例)和对照组(44例)。对照组患者单独采用阿司匹林治疗,观察组患者在对照组的基础上加用氯吡格雷治疗。比较两组患者治疗前后的凝血功能指标[活化部分凝血酶原时间(APTT)、凝血酶原时间(PT)、血小板(PLT)]及心功能指标[左室射血分数(LVEF)、左室收缩末内径(LVESD)、左室舒张末内径(LVEDD)]变化情况,并比较两组患者的心血管事件发生情况。结果两组患者治疗前的凝血功能指标比较,差异无统计学意义(P>0.05);两组患者治疗后的APTT、PT均长于治疗前,PLT低于治疗前,差异有统计学意义(P<0.05);两组患者治疗后的凝血功能指标比较,差异无统计学意义(P>0.05)。两组患者治疗前的心功能指标比较,差异无统计学意义(P>0.05);观察组患者治疗后的LVEF高于治疗前,LVESD、LVEDD低于治疗前,差异有统计学意义(P<0.05);对照组患者治疗后的LVEF高于治疗前,LVESD、LVEDD低于治疗前,但差异无统计学意义(P>0.05);观察组患者治疗后的LVEF高于对照组,LVESD、LVEDD低于对照组,差异有统计学意义(P<0.05)。观察组患者的复合终点、死亡、梗死后心绞痛、再发心肌梗死发生率均低于对照组,差异有统计学意义(P<0.05)。结论急性心肌梗死患者采用阿司匹林联合氯吡格雷治疗的临床效果显著,可推广应用。
Objective To investigate the effect of Aspirin combined with Clopidogrel in the treatment of acute myocardial infarction.Methods From February 2014 to August 2017,a total of 88 patients with acute myocardial infarction admitted to our hospital were selected as research objects and they were divided into the observation group(44 cases)and the control group(44 cases) according to different treatment methods.In the control group,Aspirin alone was used,while in the observation group,Clopidogrel was added on the basis of the control group.The coagulation function indicators(activated partial prothrombin time [APTT],prothrombin time [PT],platelet [PLT]) and cardiac function indicators(left ventricular ejection fraction [LVEF],left ventricle end systolic diameter [LVESD]),left ventricular end diastolic diameter [LVEDD]) before and after treatment and incidence of cardiovascular events between the two groups were compared.Results There were no significant differences in coagulation function indicators between the two groups before treatment(P>0.05).The APTT and PT after treatment in the two groups were longer than those before treatment,the PLT was lower than that before treatment,and the differences were statistically significant(P<0.05).There were no significant differences in coagulation function indicators between the two groups after treatment(P>0.05).There were no significant differences in cardiac function indicators between the two groups before treatment(P>0.05).The LVEF after treatment of the observation group was higher than that before treatment,the LVESD and LVEDD were lower than those before treatment,and the differences were statistically significant(P<0.05).The LVEF after treatment in the control group was higher than that before treatment,the LVESD and LVEDD were lower than those before treatment,but the differences weren′t statistically significant(P>0.05).The LVEF after treatment in the observation group was higher than that in the control group,the LVESD and LVEDD were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence rates of composite endpoint,death,post-infarction angina pectoris,and recurrent myocardial infarction in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The clinical effect of Aspirin combined with Clopidogrel in the treatment of patients with acute myocardial infarction is remarkable,and can be promoted and applied.
Objective To investigate the effect of Aspirin combined with Clopidogrel in the treatment of acute myocardial infarction.Methods From February 2014 to August 2017,a total of 88 patients with acute myocardial infarction admitted to our hospital were selected as research objects and they were divided into the observation group(44 cases)and the control group(44 cases) according to different treatment methods.In the control group,Aspirin alone was used,while in the observation group,Clopidogrel was added on the basis of the control group.The coagulation function indicators(activated partial prothrombin time [APTT],prothrombin time [PT],platelet [PLT]) and cardiac function indicators(left ventricular ejection fraction [LVEF],left ventricle end systolic diameter [LVESD]),left ventricular end diastolic diameter [LVEDD]) before and after treatment and incidence of cardiovascular events between the two groups were compared.Results There were no significant differences in coagulation function indicators between the two groups before treatment(P>0.05).The APTT and PT after treatment in the two groups were longer than those before treatment,the PLT was lower than that before treatment,and the differences were statistically significant(P<0.05).There were no significant differences in coagulation function indicators between the two groups after treatment(P>0.05).There were no significant differences in cardiac function indicators between the two groups before treatment(P>0.05).The LVEF after treatment of the observation group was higher than that before treatment,the LVESD and LVEDD were lower than those before treatment,and the differences were statistically significant(P<0.05).The LVEF after treatment in the control group was higher than that before treatment,the LVESD and LVEDD were lower than those before treatment,but the differences weren′t statistically significant(P>0.05).The LVEF after treatment in the observation group was higher than that in the control group,the LVESD and LVEDD were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence rates of composite endpoint,death,post-infarction angina pectoris,and recurrent myocardial infarction in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The clinical effect of Aspirin combined with Clopidogrel in the treatment of patients with acute myocardial infarction is remarkable,and can be promoted and applied.
引文
[1]牛少辉,张丽华,简立国.氯吡格雷联合阿司匹林治疗急性心肌梗死的疗效观察[J].中国临床医学,2014,21(2):151-153.
[2]陈洪云,刘玲,吴猛,等.参附注射液联合阿司匹林与氯吡格雷和低分子肝素治疗急性心肌梗死的急救体会[J].中国中西医结合急救杂志,2016,23(4):431-432.
[3]许明明,倪白云,夏加琴.阿司匹林联合氯吡格雷对急性缺血性脑卒中患者临床疗效及血清FIB Hcy水平的影响[J].河北医学,2017,23(4):558-560.
[4]郭爱红,王丙聚,韩晓芳.阿司匹林联合氯吡格雷治疗急性脑梗死并脑微出血的临床疗效[J].实用心脑肺血管病杂志,2017,25(5):109-111.
[5]王晓青.院前阿司匹林、氯吡格雷双联抗血小板药物治疗联合急诊抢救护理程序在急性心肌梗死患者中应用效果观察[J].中国生化药物杂志,2017,37(9):141-142,145.
[6]张红.阿司匹林与氯吡格雷联合治疗急性心肌梗死患者的凝血功能变化[J].血栓与止血学,2016,22(6):641-643.
[7]马中兴,李晨光.替罗非班、阿司匹林与氯吡格雷联合用于急性心肌梗死患者急诊经皮冠状动脉介入治疗的效果观察[J].中国医院用药评价与分析,2017,17(6):796-797,800.
[8]曾春艳,纪征,孙淑贤,等.不同程度冠状动脉病变ST段抬高型急性心肌梗死患者抗栓效果比较研究[J].中国全科医学,2018,21(12):1428-1431,1436.
[9]李坤,罗芳,黄素素,等.双联抗血小板联合质子泵抑制剂治疗急性心肌梗死对患者预后的影响[J].海南医学,2017,28(22):3637-3639.
[10]杨建军.阿司匹林与氯吡格雷联合治疗急性心肌梗死患者临床观察[J].血栓与止血学,2017,23(2):193-195.
[11]黄攀登,吴远慧,谷伟,等.麝香保心丸联合西药治疗老年急性心肌梗死的临床疗效[J].中国循证心血管医学杂志,2016,8(9):1096-1099.
[12]周伟伟,谷惠敏,吕晓蕾,等.氯吡格雷联合阿司匹林治疗老年急性心肌梗死的疗效分析[J].河北医药,2018,40(14):2186-2188,2192.
[13]唐世玲,张剑波,高志胜,等.替格瑞洛与氯吡格雷对急性心肌梗死患者经皮冠脉介入联合血栓抽吸术后炎症因子的影响[J].中国中西医结合急救杂志,2018,25(1):40-43.
[14]王宇.替格瑞洛与氯吡格雷对急性心肌梗死患者行急诊PCI的临床效果和安全性对比[J].检验医学与临床,2018,15(8):1128-1131.
[15]贾珠银,杨建敏.替格瑞洛联合阿司匹林治疗急性冠状动脉综合征的临床研究[J].中国临床药理学杂志,2016,32(14):1254-1256,1282.
[2]陈洪云,刘玲,吴猛,等.参附注射液联合阿司匹林与氯吡格雷和低分子肝素治疗急性心肌梗死的急救体会[J].中国中西医结合急救杂志,2016,23(4):431-432.
[3]许明明,倪白云,夏加琴.阿司匹林联合氯吡格雷对急性缺血性脑卒中患者临床疗效及血清FIB Hcy水平的影响[J].河北医学,2017,23(4):558-560.
[4]郭爱红,王丙聚,韩晓芳.阿司匹林联合氯吡格雷治疗急性脑梗死并脑微出血的临床疗效[J].实用心脑肺血管病杂志,2017,25(5):109-111.
[5]王晓青.院前阿司匹林、氯吡格雷双联抗血小板药物治疗联合急诊抢救护理程序在急性心肌梗死患者中应用效果观察[J].中国生化药物杂志,2017,37(9):141-142,145.
[6]张红.阿司匹林与氯吡格雷联合治疗急性心肌梗死患者的凝血功能变化[J].血栓与止血学,2016,22(6):641-643.
[7]马中兴,李晨光.替罗非班、阿司匹林与氯吡格雷联合用于急性心肌梗死患者急诊经皮冠状动脉介入治疗的效果观察[J].中国医院用药评价与分析,2017,17(6):796-797,800.
[8]曾春艳,纪征,孙淑贤,等.不同程度冠状动脉病变ST段抬高型急性心肌梗死患者抗栓效果比较研究[J].中国全科医学,2018,21(12):1428-1431,1436.
[9]李坤,罗芳,黄素素,等.双联抗血小板联合质子泵抑制剂治疗急性心肌梗死对患者预后的影响[J].海南医学,2017,28(22):3637-3639.
[10]杨建军.阿司匹林与氯吡格雷联合治疗急性心肌梗死患者临床观察[J].血栓与止血学,2017,23(2):193-195.
[11]黄攀登,吴远慧,谷伟,等.麝香保心丸联合西药治疗老年急性心肌梗死的临床疗效[J].中国循证心血管医学杂志,2016,8(9):1096-1099.
[12]周伟伟,谷惠敏,吕晓蕾,等.氯吡格雷联合阿司匹林治疗老年急性心肌梗死的疗效分析[J].河北医药,2018,40(14):2186-2188,2192.
[13]唐世玲,张剑波,高志胜,等.替格瑞洛与氯吡格雷对急性心肌梗死患者经皮冠脉介入联合血栓抽吸术后炎症因子的影响[J].中国中西医结合急救杂志,2018,25(1):40-43.
[14]王宇.替格瑞洛与氯吡格雷对急性心肌梗死患者行急诊PCI的临床效果和安全性对比[J].检验医学与临床,2018,15(8):1128-1131.
[15]贾珠银,杨建敏.替格瑞洛联合阿司匹林治疗急性冠状动脉综合征的临床研究[J].中国临床药理学杂志,2016,32(14):1254-1256,1282.