金银花提取物在围产期奶牛氧化应激及炎症中的应用前景
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摘要
围产期奶牛由于能量需求增加但干物质采食量减少会导致代谢和生理的改变,从而引发能量负平衡、氧化应激和炎症反应。氧化应激是机体炎症和免疫抑制的重要原因,可能会增加一系列围产期疾病的发病率。因此,加强围产期奶牛健康管理,对保证奶牛健康和发挥奶牛泌乳性能十分必要。以往研究显示,金银花提取物作为一种天然植物提取物,兼有药用和营养双重功效,且具有多种生理生化活性,如抗炎、抗氧化等。然而,目前金银花提取物在围产期奶牛上的应用还未见报道。因此,本文从围产期奶牛的氧化应激、炎症反应、免疫抑制以及金银花提取物在这些生理方面的作用进行了综述,以期为进一步探究金银花提取物在围产期奶牛上的作用效果提供参考。
During the perinatal period,the decreased dry matter intake and increased energy demand may induce some changes in metabolism and physiology,which leads to negative energy balance,oxidative stress and inflammatory reactions.Oxidative stress is an important cause of inflammation and immunosuppression and may increase the incidence of perinatal diseases.Therefore,it is necessary to strengthen the safety management of dairy cows in the perinatal period to ensure the health and production performance of the dairy cows.Previous studies have shown that as a natural plant,honeysuckle extract has both medicinal and nutritive effects,and has many physiological and biochemical activities,such as anti-inflammatory and anti-oxidation,etc.However,the application of honeysuckle extract to perinatal cows has not been reported yet.Therefore,this article summarized oxidative stress,inflammatory response,immunosuppression in perinatal dairy cows,and physiological and biochemical effects of using honeysuckle extract,which provided the reference for the further research of action effect of honeysuckle extract on perinatal cows.
During the perinatal period,the decreased dry matter intake and increased energy demand may induce some changes in metabolism and physiology,which leads to negative energy balance,oxidative stress and inflammatory reactions.Oxidative stress is an important cause of inflammation and immunosuppression and may increase the incidence of perinatal diseases.Therefore,it is necessary to strengthen the safety management of dairy cows in the perinatal period to ensure the health and production performance of the dairy cows.Previous studies have shown that as a natural plant,honeysuckle extract has both medicinal and nutritive effects,and has many physiological and biochemical activities,such as anti-inflammatory and anti-oxidation,etc.However,the application of honeysuckle extract to perinatal cows has not been reported yet.Therefore,this article summarized oxidative stress,inflammatory response,immunosuppression in perinatal dairy cows,and physiological and biochemical effects of using honeysuckle extract,which provided the reference for the further research of action effect of honeysuckle extract on perinatal cows.
引文
[1] DRACKLEY J K. Biology of dairy cows during the transition period:the final frontier?[J]. Journal of Dairy Science,1999,82(11):2259-2273.
[2]代迎春.围产期奶牛血清中抗氧化酶活性与铜锌锰镁含量变化规律的比较研究[D].硕士学位论文.呼和浩特:内蒙古农业大学,2007.
[3]魏清甜.粪肠球菌替代饲用抗生素对保育仔猪生产、免疫、肠道发育及肠道微生物的影响[D].硕士学位论文.南京:南京农业大学,2014.
[4] ZHOU,BULGARI O,VAILATI-RIBONI M,et al.Rumen-protected methionine compared w ith rumenprotected choline improves immunometabolic status in dairy cow s during the peripartal period[J]. Journal of Dairy Science,2016,99(11):8956-8969.
[5]海春旭.自由基医学[M].西安:第四军医大学出版社,2006.
[6] BENZ C C,YAU C. Ageing,oxidative stress and cancer:paradigms in parallax[J]. Nature Review s Cancer,2008,8(11):875-879.
[7] TREVISAN M,BROWNE R,RAM M,et al. Correlates of markers of oxidative status in the general population[J].American Journal of Epidemiology,2001,154(4):348-356.
[8]谷娟,张春刚,刘祯,等.氧化应激与奶牛围产期疾病的关系及其作用机制[J].中国奶牛,2015(10):31-36.
[9]熊桂林.硫辛酸对围产期奶牛的抗氧化作用研究[D].博士学位论文.扬州:扬州大学,2009.
[10] OSORIO J S,TREVISI E,LI C,et al. Supplementing Zn,M n,and Cu from amino acid complexes and Co from cobalt glucoheptonate during the peripartal period benefits postpartal cow performance and blood neutrophil function[J]. Journal of Dairy Science,2016,99(3):1868-1883.
[11] SORDILLO L M,AITKEN S L. Impact of oxidative stress on the health and immune function of dairy cattle[J]. Veterinary Immunology and Immunopathology,2009,128(1/2/3):104-109.
[12] HOGAN J S,SMITH K L,WEISS W P,et al. Relationships among vitamin E,selenium,and bovine blood neutrophils[J].Journal of Dairy Science,1990,73(9):2372-2378.
[13] POLITIS I,HIDIROGLOU N,WHITE J H,et al.Effects of vitamin E on mammary and blood leukocyte function,w ith emphasis on chemotaxis,in periparturient dairy cow s[J]. American Journal of Veterinary Research,1996,57(4):468-471.
[14] SORDILLO L M,CONTRERAS G A,AITKEN S L.M etabolic factors affecting the inflammatory response of periparturient dairy cow s[J]. Animal Health Research Review s,2009,10(1):53-63.
[15] BURVENICH C,BANNERMAN D D,LIPPOLIS J D,et al. Cumulative physiological events influence the inflammatory response of the bovine udder to Escherichia coli infections during the transition period[J].Journal of Dairy Science,2007,90(Suppl. 1):E39-E54.
[16] HILL A W.Factors influencing the outcome of Escherichia coli mastitis in the dairy cow[J]. Research in Veterinary Science,1981,31(1):107-112.
[17] SAGONE A L Jr,KAMPS S,CAMPBELL R. The effect of oxidant injury on the lymphoblastic transformation of human lymphocytes.[J]. Photochemistry and Photobiology,1978,28(4/5):909-915.
[18] METZGER Z,HOFFELD J T,OPPENHEIM J J.Macrophage-mediated supppression.Ⅰ. Evidence for participation of both hdyrogen peroxide and prostaglandins in suppression of murine lymphocyte proliferation[J].Journal of Immunology,1980,124(2):983-988.
[19] FISHER R I,BOSTICK-BRUTON F.Depressed T cell proliferative responses in Hodgkin’s disease:role of monocyte-mediated suppression via prostaglandins and hydrogen peroxide[J]. Journal of Immunology,1982,129(4):1770-1774.
[20] HADDAD J J E, SAFIEH-GARABEDIAN B,SAADE N E,et al. Chemioxyexcitation(Δp O2/ROS)-dependent release of IL-1β,IL-6 and TNF-α:evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium[J]. Cytokine,2001,13(3):138-147.
[21] KEHRLI M E Jr.,NONNECKE B J,ROTH J A. Alterations in bovine neutrophil function during the periparturient period[J]. American Journal of Veterinary Research,1989,50(2):207-214.
[22] GUIDRY A J,PAAPE M J,PEARSON R E. Effects of parturition and lactation on blood and milk cell concentrations,corticosteroids,and neutrophil phagocytosis in the cow[J].American Journal of Veterinary Research,1976,37(10):1195-1200.
[23] CAI T Q,WESTON P G,LUND L A,et al.Association betw een neutrophil functions and periparturient disorders in cow s[J]. American Journal of Veterinary Research,1994,55(7):934-943.
[24] BURTON J L,MADSEN S A,CHANG L C,et al.Gene expression signatures in neutrophils exposed to glucocorticoids:a new paradigm to help explain“neutrophil dysfunction”in parturient dairy cow s[J]. Veterinary Immunology and Immunopathology,2005,105(3/4):197-219.
[25] HUZZEY J M,MANN S,NYDAM D V,et al.Associations of peripartum markers of stress and inflammation w ith milk yield and reproductive performance in Holstein dairy cow s[J]. Preventive Veterinary M edicine,2015,120(3/4):291-297.
[26] WAGNER W L,HERBST D R,SOHMER S H.Colocasia[M]//M anual of the flow ering plants of Haw aii.Honolulu,Haw aii:University of Haw aii Press,1999:1356-1357.
[27]邢向伟.中药制剂中金银花与山银花的研究[D].硕士学位论文.郑州:河南中医药大学,2011.
[28]符运斌,黄涛,瞿明仁,等.金银花提取物对热应激肉牛血清激素及抗氧化指标的影响[J].动物营养学报,2016,28(3):926-931.
[29]宋小珍,符运斌,黄涛,等.金银花提取物对高温条件下肉牛抗氧化指标和骨骼肌肌纤维结构的影响[J].动物营养学报,2015,27(11):3534-3540.
[30]关炳峰,谭军,周志娣.金银花提取物的抗氧化作用与其绿原酸含量的相关性研究[J].食品工业科技,2007,28(10):127-129.
[31]李荣玮.金银花和蜂胶的抗氧化活性及其色谱分析研究[D].硕士学位论文.西安:西北大学,2008.
[32]胡宗福,于文利,赵亚平.绿原酸清除活性氧和抗脂质过氧化的研究[J].食品科学,2006,27(2):128-130.
[33] PALIKOVA I,VALENTOVA K,OBORNA I,et al.Protectivity of blue honeysuckle extract against oxidative human endothelial cells and rat hepatocyte damage[J]. Journal of Agricultural and Food Chemistry,2009,57(15):6584-6589.
[34]朱国栋,陈云波,潘凤,等.金银花中黄酮类化合物的研究进展[J].广东化工,2017,44(15):184-185.
[35]崔晓燕.金银花提取物的抗炎免疫作用研究[J].中国药房,2011,20(23):8-9.
[36]侯会娜.金银花提取物对小鼠T细胞行为的影响及脓毒症的免疫调节作用[D].硕士学位论文.广州:暨南大学,2008.
[37]刘蓓,刘玉红.金银花多糖对脾淋巴细胞的增殖作用[J].中国实用医药,2013,8(11):244-245.
[38] PARK K I,KANG S R,PARK H S,et al.Regulation of proinflammatory mediators via NF-κB and p38M APK-dependent mechanisms in RAW 264.7 macrophages by polyphenol components isolated from Korea Lonicera japonica Thunb[J]. Evidence-Based Complementary and Alternative M edicine,2012,2012:828521.
[39] KANG O H,CHOI J G,LEE J H,et al.Luteolin isolated from the flow ers of Lonicera japonica suppresses inflammatory mediator release by blocking NF-κB and M APKs activation pathw ays in HM C-1 cells[J].M olecules,2010,15(1):385-398.
[2]代迎春.围产期奶牛血清中抗氧化酶活性与铜锌锰镁含量变化规律的比较研究[D].硕士学位论文.呼和浩特:内蒙古农业大学,2007.
[3]魏清甜.粪肠球菌替代饲用抗生素对保育仔猪生产、免疫、肠道发育及肠道微生物的影响[D].硕士学位论文.南京:南京农业大学,2014.
[4] ZHOU,BULGARI O,VAILATI-RIBONI M,et al.Rumen-protected methionine compared w ith rumenprotected choline improves immunometabolic status in dairy cow s during the peripartal period[J]. Journal of Dairy Science,2016,99(11):8956-8969.
[5]海春旭.自由基医学[M].西安:第四军医大学出版社,2006.
[6] BENZ C C,YAU C. Ageing,oxidative stress and cancer:paradigms in parallax[J]. Nature Review s Cancer,2008,8(11):875-879.
[7] TREVISAN M,BROWNE R,RAM M,et al. Correlates of markers of oxidative status in the general population[J].American Journal of Epidemiology,2001,154(4):348-356.
[8]谷娟,张春刚,刘祯,等.氧化应激与奶牛围产期疾病的关系及其作用机制[J].中国奶牛,2015(10):31-36.
[9]熊桂林.硫辛酸对围产期奶牛的抗氧化作用研究[D].博士学位论文.扬州:扬州大学,2009.
[10] OSORIO J S,TREVISI E,LI C,et al. Supplementing Zn,M n,and Cu from amino acid complexes and Co from cobalt glucoheptonate during the peripartal period benefits postpartal cow performance and blood neutrophil function[J]. Journal of Dairy Science,2016,99(3):1868-1883.
[11] SORDILLO L M,AITKEN S L. Impact of oxidative stress on the health and immune function of dairy cattle[J]. Veterinary Immunology and Immunopathology,2009,128(1/2/3):104-109.
[12] HOGAN J S,SMITH K L,WEISS W P,et al. Relationships among vitamin E,selenium,and bovine blood neutrophils[J].Journal of Dairy Science,1990,73(9):2372-2378.
[13] POLITIS I,HIDIROGLOU N,WHITE J H,et al.Effects of vitamin E on mammary and blood leukocyte function,w ith emphasis on chemotaxis,in periparturient dairy cow s[J]. American Journal of Veterinary Research,1996,57(4):468-471.
[14] SORDILLO L M,CONTRERAS G A,AITKEN S L.M etabolic factors affecting the inflammatory response of periparturient dairy cow s[J]. Animal Health Research Review s,2009,10(1):53-63.
[15] BURVENICH C,BANNERMAN D D,LIPPOLIS J D,et al. Cumulative physiological events influence the inflammatory response of the bovine udder to Escherichia coli infections during the transition period[J].Journal of Dairy Science,2007,90(Suppl. 1):E39-E54.
[16] HILL A W.Factors influencing the outcome of Escherichia coli mastitis in the dairy cow[J]. Research in Veterinary Science,1981,31(1):107-112.
[17] SAGONE A L Jr,KAMPS S,CAMPBELL R. The effect of oxidant injury on the lymphoblastic transformation of human lymphocytes.[J]. Photochemistry and Photobiology,1978,28(4/5):909-915.
[18] METZGER Z,HOFFELD J T,OPPENHEIM J J.Macrophage-mediated supppression.Ⅰ. Evidence for participation of both hdyrogen peroxide and prostaglandins in suppression of murine lymphocyte proliferation[J].Journal of Immunology,1980,124(2):983-988.
[19] FISHER R I,BOSTICK-BRUTON F.Depressed T cell proliferative responses in Hodgkin’s disease:role of monocyte-mediated suppression via prostaglandins and hydrogen peroxide[J]. Journal of Immunology,1982,129(4):1770-1774.
[20] HADDAD J J E, SAFIEH-GARABEDIAN B,SAADE N E,et al. Chemioxyexcitation(Δp O2/ROS)-dependent release of IL-1β,IL-6 and TNF-α:evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium[J]. Cytokine,2001,13(3):138-147.
[21] KEHRLI M E Jr.,NONNECKE B J,ROTH J A. Alterations in bovine neutrophil function during the periparturient period[J]. American Journal of Veterinary Research,1989,50(2):207-214.
[22] GUIDRY A J,PAAPE M J,PEARSON R E. Effects of parturition and lactation on blood and milk cell concentrations,corticosteroids,and neutrophil phagocytosis in the cow[J].American Journal of Veterinary Research,1976,37(10):1195-1200.
[23] CAI T Q,WESTON P G,LUND L A,et al.Association betw een neutrophil functions and periparturient disorders in cow s[J]. American Journal of Veterinary Research,1994,55(7):934-943.
[24] BURTON J L,MADSEN S A,CHANG L C,et al.Gene expression signatures in neutrophils exposed to glucocorticoids:a new paradigm to help explain“neutrophil dysfunction”in parturient dairy cow s[J]. Veterinary Immunology and Immunopathology,2005,105(3/4):197-219.
[25] HUZZEY J M,MANN S,NYDAM D V,et al.Associations of peripartum markers of stress and inflammation w ith milk yield and reproductive performance in Holstein dairy cow s[J]. Preventive Veterinary M edicine,2015,120(3/4):291-297.
[26] WAGNER W L,HERBST D R,SOHMER S H.Colocasia[M]//M anual of the flow ering plants of Haw aii.Honolulu,Haw aii:University of Haw aii Press,1999:1356-1357.
[27]邢向伟.中药制剂中金银花与山银花的研究[D].硕士学位论文.郑州:河南中医药大学,2011.
[28]符运斌,黄涛,瞿明仁,等.金银花提取物对热应激肉牛血清激素及抗氧化指标的影响[J].动物营养学报,2016,28(3):926-931.
[29]宋小珍,符运斌,黄涛,等.金银花提取物对高温条件下肉牛抗氧化指标和骨骼肌肌纤维结构的影响[J].动物营养学报,2015,27(11):3534-3540.
[30]关炳峰,谭军,周志娣.金银花提取物的抗氧化作用与其绿原酸含量的相关性研究[J].食品工业科技,2007,28(10):127-129.
[31]李荣玮.金银花和蜂胶的抗氧化活性及其色谱分析研究[D].硕士学位论文.西安:西北大学,2008.
[32]胡宗福,于文利,赵亚平.绿原酸清除活性氧和抗脂质过氧化的研究[J].食品科学,2006,27(2):128-130.
[33] PALIKOVA I,VALENTOVA K,OBORNA I,et al.Protectivity of blue honeysuckle extract against oxidative human endothelial cells and rat hepatocyte damage[J]. Journal of Agricultural and Food Chemistry,2009,57(15):6584-6589.
[34]朱国栋,陈云波,潘凤,等.金银花中黄酮类化合物的研究进展[J].广东化工,2017,44(15):184-185.
[35]崔晓燕.金银花提取物的抗炎免疫作用研究[J].中国药房,2011,20(23):8-9.
[36]侯会娜.金银花提取物对小鼠T细胞行为的影响及脓毒症的免疫调节作用[D].硕士学位论文.广州:暨南大学,2008.
[37]刘蓓,刘玉红.金银花多糖对脾淋巴细胞的增殖作用[J].中国实用医药,2013,8(11):244-245.
[38] PARK K I,KANG S R,PARK H S,et al.Regulation of proinflammatory mediators via NF-κB and p38M APK-dependent mechanisms in RAW 264.7 macrophages by polyphenol components isolated from Korea Lonicera japonica Thunb[J]. Evidence-Based Complementary and Alternative M edicine,2012,2012:828521.
[39] KANG O H,CHOI J G,LEE J H,et al.Luteolin isolated from the flow ers of Lonicera japonica suppresses inflammatory mediator release by blocking NF-κB and M APKs activation pathw ays in HM C-1 cells[J].M olecules,2010,15(1):385-398.