摘要
目的探讨前列腺活检患者血清高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)对前列腺穿刺阳性率的影响。方法选取2013年5月至2017年5月住院的行前列腺穿刺活检的230例患者作为研究对象,经病理确诊为前列腺癌(prostatic cancer,PCa)患者80例,良性前列腺增生(benign prostatic hyperplasia,BPH)患者150例。采用多元Logistic回归分析hs-CRP等因素对前列腺穿刺阳性率的影响。结果 (1) PCa患者hs-CRP水平明显高于BPH患者(P<0. 05);(2) hs-CRP>3 mg/L者76例,其中PCa患者42例,穿刺阳性率为55. 26%(42/76); hsCRP≤3 mg/L者154例,其中PCa患者38例,穿刺阳性率为24. 68%(38/154)。hs-CRP> 3 mg/L者前列腺穿刺阳性率明显高于hs-CRP≤3 mg/L者(P<0. 05);(3)经多元Logistic回归分析,hs-CRP是影响前列腺穿刺阳性率的独立危险因素。结论 hs-CRP是影响前列腺穿刺阳性率的一个独立危险因素,当血清之中的该指标水平上升时,前列腺穿刺阳性率随之而显著升高,对于疾病的临床诊断具有提示意义。
Objective To investigate the effects of serum high-sensitivity C-reactive protein( hs-CRP) value on positive rate of prostate puncture in patients with prostate biopsy. Methods In this study,we selected 230 patients who underwent prostate biopsy in our hospital from May 2013 to May 2017 as subjects,and 150 patients with benign prostatic hyperplasia( BPH) were diagnosed as prostate cancer( PCa) in 80 cases. The effects of hs-CRP and other factors on the positive rate of prostate puncture were analyzed by multivariate logistic regression. Results( 1) The hs-CRP level of PCA patients was significantly higher than that in BPH patients( P <0. 05).( 2) In 76 cases of hs-CRP >3 mg/L,the number of PCA was 42 cases,and the positive rate of puncture was 55. 26%( 42/76). In 154 cases,the number of PCA patients was 38 cases,and the positive rate of puncture was 24. 68%( 38/154) hs-CRP≤3 mg/L. The positive rate of prostate puncture in hs-CRP > 3 mg/L was significantly higher than that of hs-CRP≤3mg/L( P < 0. 05).( 3) By multivariate logistic regression analysis,hs-CRP is an independent risk factor affecting the positive rate of prostate puncture. Conclusion hs-CRP is an independent risk factor affecting the positive rate of prostate puncture,the positive rate of prostate puncture increases significantly when the level of serum is increased,which has significance in the clinical diagnosis of the disease.
引文
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