人T细胞白血病病毒1型/人嗜T细胞病毒1型(HTLV-1)及其与相关疾病关系的研究进展
摘要
人T细胞白血病病毒1型/人嗜T细胞病毒1型(HTLV-1),是一种和人类T淋巴细胞白血病及HTLV-1相关性脊髓病/热带痉挛性瘫痪(HAM/TSP)等疾病密切相关的逆转录病毒。以往对于该病毒的认识仅仅局限于其导致这两种常见疾病,近来发现越来越多的自身免疫性疾病与该病毒的感染有着密切的联系。同时,该病毒通常经过漫长的潜伏期后发病,一旦发病治疗往往收效甚微,明确病毒如何侵入机体、其致病机制、如何和机体的免疫系统相互作用在细胞内长期潜伏,以便采取有效的早期干预措施将是后续研究的重点方向。我们总结了该病毒导致的相关免疫性疾病、该病毒和免疫系统相互作用的致病机制及治疗方式。
引文
[1] Poiesz B J, Ruscetti F W, Gazdar A F, et al. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma[J]. Proc Natl Acad Sci U S A, 1980, 77(12): 7415-7419.
[2] Varandas C M N, da Silva J L S, Primo J R L, et al. Early juvenile human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP): Study of 25 patients[J]. Clin Infect Dis, 2018, 67: 1427-1433.
[3] Castro L S, Rezend G R, Fermandes F R P, et al. HTLV-1 infection among men who have sex with men in Central Brazil[J]. Braz J Infect Dis, 2018, 22(6): 472-476.
[4] Bangham C R M, Matsuoka M. Human T-cell leukaemia virus type1: parasitism and pathogenesis[J/OL]. Philos Trans R Soc Lond B Biol Sci, 2017, 372(1732): 20160272. DOI: 10.1098/rstb.2016.0272.
[5] Fonseca E P D, Sa K N, Nunes R F R, et al. Balance, functional mobility, and fall occurrence in patients with human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis: a cross-sectional study[J]. Rev Soc Bras Med Trop, 2018, 51(2): 162-167.
[6] Ohshima K, Miyoshi H, Yamada K. The microenvironment and immune status of peripheral T-cell lymphoma: focusing on AITL and ATLL[J/OL]. Rinsho Ketsueki, 2018, 59(5): 574-587.
[7] Yasuma-Mitobe K, Matsuoka M. The roles of coinhibitory receptors in pathogenesis of human retroviral infections [J/OL]. Front Immunol, 2018, 9: 2755. DOI: 10.3389/fimmu.2018.02755.
[8] Khan M Y, Khan I N, Farman M, et al. HTLV-1 associated neurological disorders[J]. Curr Top Med Chem, 2017, 17: 1320-1330.
[9] Quaresma J A, Yoshikawa G T, Koyama R V, et al. HTLV-1, Immune response and autoimmunity[J/OL]. Viruses, 2015, 8(1): E5. DOI: 10.3390/v8010005.
[10] Gomes R K S, Albers A C, Salussoglia A I P, et al. Prevalence of ischemic heart disease and associated factors in patients with rheumatoid arthritis in Southern Brazil[J/OL]. Rev Bras Reumatol Engl Ed, 2017, 57(5): 412-418.
[11] Ambrosi A, Wahren-Herlenius M. Update on the immunobiology of Sjogren’s syndrome[J]. Curr Opin Rheumatol, 2015, 27(5): 468-475.
[12] Yasuma K, Matsuzaki T, Yamano Y, et al. HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors[J]. J Neurovirol, 2016, 22(4): 416-430.
[13] Shukla S K, Singh G, Ahmad S, et al. Infections, genetic and environmental factors in pathogenesis of autoimmune thyroid diseases[J]. Microb Pathog, 2018, 116: 279-288.
[14] Tang Y, George A M, Petrechko O, et al. Pseudotyping of HIV-1 with human T-lymphotropic virus 1 (HTLV-1) envelope glycoprotein during HIV-1-HTLV-1 coinfection facilitates direct HIV-1 Infection of female genital epithelial cells: Implications for sexual transmission of HIV-1[J/OL]. mSphere, 2018, 3(2): e00038-18. DOI: 10.1128/mSphere.00038-18. Print 2018 Apr 25.
[15] Tezuka K, Okuma K, Kuramitsu M, et al. Control of human T-cell leukemia virus type 1 (HTLV-1)infection by eliminating envelope protein-positive cells with recombinant vesicular stomatitis viruses encoding HTLV-1 primary receptor[J/OL]. J Virol, 2018, 92(4): e01885-17. DOI: 10.1128/JVI.01885-17. Print 2018 Feb 15.
[16] Lima C M, Santos S, Dourado A, et al. Association of sicca syndrome with proviral load and proinflammatory cytokines in HTLV-1 infection[J/OL]. J Immunol Res, 2016, 2016: 8402059. DOI: 10.1155/2016/8402059.
[17] Gazon H, Barbeau B, Mesnard J M, et al. Hijacking of the AP-1 signaling pathway during development of ATL[J/OL]. Front Microbiol, 2018, 8: 2686. DOI: 10.3389/fmicb.2017.02686.
[18] Mahgoub M, Yasunaga J I, Iwami S, et al. Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells[J/OL]. Proc Natl Acad Sci U S A, 2018, 115(6): E1269-E1278.
[19] Percher F, Curis C, Peres E, et al. HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation[J/OL]. Nat Commun, 2017, 8: 15890. DOI: 10.1038/ncomms158900.
[20] Gross C, Wiesmann V, Millen S, et al. The Tax-inducible actin-bundling protein Fascin is crucial for release and cell-to-cell transmission of human T-cell leukemia virus type 1 (HTLV-1) [J/OL]. PLoS Pathog, 2016, 12(10): e1005916. DOI: 10.1371/journal.ppat.1005916.
[21] Mozhgani S H, Jahantigh H R, Rafatpanah H, et al. Interferon lambda family along with HTLV-1 proviral load, Tax, and HBZ implicated in the pathogenesis of myelopathy/tropical spastic paraparesis[J/OL]. Neurodegener Dis, 2018, 18(2/3): 150-155.
[22] Tanaka A, Matsuoka M. HTLV-1 alters T cells for viral persistence and transmission[J/OL]. Front Microbiol, 2018, 9: 461. DOI: 10.3389/fmicb.2018.00461.
[23] Baratella M, Forlani G, Accolla R S. HTLV-1 HBZ viral protein: A key player in HTLV-1 mediated diseases[J/OL]. Front Microbiol, 2017, 8: 2615. DOI: 10.3389/fmicb.2017.02615.eCollection 2017.
[24] Kogure Y, Kataoka K. Genetic analysis and its clinical implication in adult T-cell leukemia/lymphoma [J]. Rinsho Ketsueki, 2018, 59(10): 2127-2135.
[25] Furuta R, Yasunaga J I, Miura M, et al. Human T-cell leukemia virus type 1infects multiple lineage hematopoietic cells in vivo[J/OL]. PLoS Pathog, 2017, 13(11): e1006722. DOI: 10.1371/journal.ppat.1006722.
[26] Rushing A W, Hoang K, Polakowski N, et al. The human T-cell leukemia virus type 1 basic leucine zipper factor attenuates repair of double-stranded DNA breaks via nonhomologous end joining[J/OL]. J Virol, 2018, 92(15): e00672-18. DOI: 10.1128/JVI.00672-18. Print 2018 Aug 1.
[27] Kinosada H, Yasunaga J I, Shimura K, et al. Correction: HTLV-1 bZIP factor enhances T-cell proliferation by impeding the suppressive signaling of co-inhibitory receptors[J/OL]. PLoS Pathog, 2017, 13(2): e1006228. DOI: 10.1371/journal.ppat.1006228.
[28] Panfil A R, Dissinger N J, Howard C M, et al. Functional comparison of HBZ and the related APH-2 protein provides insight into human T-cell leukemia virus type 1 pathogenesis[J]. J Virol, 2016, 90(7): 3760-3772.
[29] Enose-Akahata Y, Vellucci A, Jacobson S, et al. Role of HTLV-1 Tax and HBZ in the pathogenesis of HAM/TSP[J/OL]. Front Microbiol, 2017, 8: 2563.DOI: 10.3389/fmicb.2017.02563.
[30] Mitobe Y, Yasunaga J, Furuta R, et al. HTLV-1 bZIP factor RNA and protein impart distinct functions on T-cell proliferation and survival[J/OL]. Cancer Res, 2015, 75(19): 4143-4152.
[31] Moudgil K D. Interplay among cytokines and T cell subsets in the progression and control of immune-mediated diseases[J]. Cytokine, 2015, 74(1): 1-4.
[32] Gross C, Thoma-Kress A K. Molecular mechanisms of HTLV-1 cell-to-cell transmission[J/OL]. Viruses, 2016, 8(3): 74. DOI: 10.3390/v8030074.
[33] 马玲玲, 郭志祥, 宋迪, 等. cGAS通过调控固有免疫应答抑制HTLV-1在HeLa细胞中复制[J].中华微生物与免疫学杂志, 2017, 37(11): 822-826. Ma L, Guo Z, Song D, et al. Cyclic GMP-AMP synthase (cGAS) inhibits the replication of human T cell leukemia virus type 1 (HTLV-1) in HeLa cells through regulating innate immune response[J]. Zhong Hua Wei Sheng Wu Yu Mian Yi Xue Za Zhi, 2017, 37(11): 822-826.
[34] Pasquier A, Alais S, Roux L, et al. How to control HTLV-1-associated diseases: Preventing de novo cellular infection using antiviral therapy[J/OL]. Front Microbiol, 2018, 9: 278. DOI: 10.3389/fmicb.2018.00278.
[35] Kansagra A, Dahiya S, Litzow M. Continuing challenges and current issues in acute lymphoblastic leukemia[J]. Leuk Lymphoma, 2018, 59(3): 526-541.
[36] Lepretre S, Graux C, Touzart A, et al. Adult T-type lymphoblastic lymphoma: Treatment advances and prognostic indicators[J/OL]. Exp Hematol, 2017, 51: 7-16.
[37] Berkowitz J L, Janik J E , Stewart D M, et al. Safety, efficacy, and pharmacokinetics /pharmacodynamics of daclizumab (anti-CD25)in patients with adult T-cell leukemia/lymphoma [J/OL]. Clin Immunol, 2014, 155(2): 176-187.
[38] Roswarski J, Roschewski M, Lucas A, et al. Phase Ⅰ dose escalation study of the anti-CD2 monoclonal antibody, siplizumab, with DA-EPOCH-R in aggressive peripheral T-cell lymphomas [J/OL]. Leuk Lymphoma, 2018, 59(6): 1466-1469.
[2] Varandas C M N, da Silva J L S, Primo J R L, et al. Early juvenile human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP): Study of 25 patients[J]. Clin Infect Dis, 2018, 67: 1427-1433.
[3] Castro L S, Rezend G R, Fermandes F R P, et al. HTLV-1 infection among men who have sex with men in Central Brazil[J]. Braz J Infect Dis, 2018, 22(6): 472-476.
[4] Bangham C R M, Matsuoka M. Human T-cell leukaemia virus type1: parasitism and pathogenesis[J/OL]. Philos Trans R Soc Lond B Biol Sci, 2017, 372(1732): 20160272. DOI: 10.1098/rstb.2016.0272.
[5] Fonseca E P D, Sa K N, Nunes R F R, et al. Balance, functional mobility, and fall occurrence in patients with human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis: a cross-sectional study[J]. Rev Soc Bras Med Trop, 2018, 51(2): 162-167.
[6] Ohshima K, Miyoshi H, Yamada K. The microenvironment and immune status of peripheral T-cell lymphoma: focusing on AITL and ATLL[J/OL]. Rinsho Ketsueki, 2018, 59(5): 574-587.
[7] Yasuma-Mitobe K, Matsuoka M. The roles of coinhibitory receptors in pathogenesis of human retroviral infections [J/OL]. Front Immunol, 2018, 9: 2755. DOI: 10.3389/fimmu.2018.02755.
[8] Khan M Y, Khan I N, Farman M, et al. HTLV-1 associated neurological disorders[J]. Curr Top Med Chem, 2017, 17: 1320-1330.
[9] Quaresma J A, Yoshikawa G T, Koyama R V, et al. HTLV-1, Immune response and autoimmunity[J/OL]. Viruses, 2015, 8(1): E5. DOI: 10.3390/v8010005.
[10] Gomes R K S, Albers A C, Salussoglia A I P, et al. Prevalence of ischemic heart disease and associated factors in patients with rheumatoid arthritis in Southern Brazil[J/OL]. Rev Bras Reumatol Engl Ed, 2017, 57(5): 412-418.
[11] Ambrosi A, Wahren-Herlenius M. Update on the immunobiology of Sjogren’s syndrome[J]. Curr Opin Rheumatol, 2015, 27(5): 468-475.
[12] Yasuma K, Matsuzaki T, Yamano Y, et al. HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors[J]. J Neurovirol, 2016, 22(4): 416-430.
[13] Shukla S K, Singh G, Ahmad S, et al. Infections, genetic and environmental factors in pathogenesis of autoimmune thyroid diseases[J]. Microb Pathog, 2018, 116: 279-288.
[14] Tang Y, George A M, Petrechko O, et al. Pseudotyping of HIV-1 with human T-lymphotropic virus 1 (HTLV-1) envelope glycoprotein during HIV-1-HTLV-1 coinfection facilitates direct HIV-1 Infection of female genital epithelial cells: Implications for sexual transmission of HIV-1[J/OL]. mSphere, 2018, 3(2): e00038-18. DOI: 10.1128/mSphere.00038-18. Print 2018 Apr 25.
[15] Tezuka K, Okuma K, Kuramitsu M, et al. Control of human T-cell leukemia virus type 1 (HTLV-1)infection by eliminating envelope protein-positive cells with recombinant vesicular stomatitis viruses encoding HTLV-1 primary receptor[J/OL]. J Virol, 2018, 92(4): e01885-17. DOI: 10.1128/JVI.01885-17. Print 2018 Feb 15.
[16] Lima C M, Santos S, Dourado A, et al. Association of sicca syndrome with proviral load and proinflammatory cytokines in HTLV-1 infection[J/OL]. J Immunol Res, 2016, 2016: 8402059. DOI: 10.1155/2016/8402059.
[17] Gazon H, Barbeau B, Mesnard J M, et al. Hijacking of the AP-1 signaling pathway during development of ATL[J/OL]. Front Microbiol, 2018, 8: 2686. DOI: 10.3389/fmicb.2017.02686.
[18] Mahgoub M, Yasunaga J I, Iwami S, et al. Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells[J/OL]. Proc Natl Acad Sci U S A, 2018, 115(6): E1269-E1278.
[19] Percher F, Curis C, Peres E, et al. HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation[J/OL]. Nat Commun, 2017, 8: 15890. DOI: 10.1038/ncomms158900.
[20] Gross C, Wiesmann V, Millen S, et al. The Tax-inducible actin-bundling protein Fascin is crucial for release and cell-to-cell transmission of human T-cell leukemia virus type 1 (HTLV-1) [J/OL]. PLoS Pathog, 2016, 12(10): e1005916. DOI: 10.1371/journal.ppat.1005916.
[21] Mozhgani S H, Jahantigh H R, Rafatpanah H, et al. Interferon lambda family along with HTLV-1 proviral load, Tax, and HBZ implicated in the pathogenesis of myelopathy/tropical spastic paraparesis[J/OL]. Neurodegener Dis, 2018, 18(2/3): 150-155.
[22] Tanaka A, Matsuoka M. HTLV-1 alters T cells for viral persistence and transmission[J/OL]. Front Microbiol, 2018, 9: 461. DOI: 10.3389/fmicb.2018.00461.
[23] Baratella M, Forlani G, Accolla R S. HTLV-1 HBZ viral protein: A key player in HTLV-1 mediated diseases[J/OL]. Front Microbiol, 2017, 8: 2615. DOI: 10.3389/fmicb.2017.02615.eCollection 2017.
[24] Kogure Y, Kataoka K. Genetic analysis and its clinical implication in adult T-cell leukemia/lymphoma [J]. Rinsho Ketsueki, 2018, 59(10): 2127-2135.
[25] Furuta R, Yasunaga J I, Miura M, et al. Human T-cell leukemia virus type 1infects multiple lineage hematopoietic cells in vivo[J/OL]. PLoS Pathog, 2017, 13(11): e1006722. DOI: 10.1371/journal.ppat.1006722.
[26] Rushing A W, Hoang K, Polakowski N, et al. The human T-cell leukemia virus type 1 basic leucine zipper factor attenuates repair of double-stranded DNA breaks via nonhomologous end joining[J/OL]. J Virol, 2018, 92(15): e00672-18. DOI: 10.1128/JVI.00672-18. Print 2018 Aug 1.
[27] Kinosada H, Yasunaga J I, Shimura K, et al. Correction: HTLV-1 bZIP factor enhances T-cell proliferation by impeding the suppressive signaling of co-inhibitory receptors[J/OL]. PLoS Pathog, 2017, 13(2): e1006228. DOI: 10.1371/journal.ppat.1006228.
[28] Panfil A R, Dissinger N J, Howard C M, et al. Functional comparison of HBZ and the related APH-2 protein provides insight into human T-cell leukemia virus type 1 pathogenesis[J]. J Virol, 2016, 90(7): 3760-3772.
[29] Enose-Akahata Y, Vellucci A, Jacobson S, et al. Role of HTLV-1 Tax and HBZ in the pathogenesis of HAM/TSP[J/OL]. Front Microbiol, 2017, 8: 2563.DOI: 10.3389/fmicb.2017.02563.
[30] Mitobe Y, Yasunaga J, Furuta R, et al. HTLV-1 bZIP factor RNA and protein impart distinct functions on T-cell proliferation and survival[J/OL]. Cancer Res, 2015, 75(19): 4143-4152.
[31] Moudgil K D. Interplay among cytokines and T cell subsets in the progression and control of immune-mediated diseases[J]. Cytokine, 2015, 74(1): 1-4.
[32] Gross C, Thoma-Kress A K. Molecular mechanisms of HTLV-1 cell-to-cell transmission[J/OL]. Viruses, 2016, 8(3): 74. DOI: 10.3390/v8030074.
[33] 马玲玲, 郭志祥, 宋迪, 等. cGAS通过调控固有免疫应答抑制HTLV-1在HeLa细胞中复制[J].中华微生物与免疫学杂志, 2017, 37(11): 822-826. Ma L, Guo Z, Song D, et al. Cyclic GMP-AMP synthase (cGAS) inhibits the replication of human T cell leukemia virus type 1 (HTLV-1) in HeLa cells through regulating innate immune response[J]. Zhong Hua Wei Sheng Wu Yu Mian Yi Xue Za Zhi, 2017, 37(11): 822-826.
[34] Pasquier A, Alais S, Roux L, et al. How to control HTLV-1-associated diseases: Preventing de novo cellular infection using antiviral therapy[J/OL]. Front Microbiol, 2018, 9: 278. DOI: 10.3389/fmicb.2018.00278.
[35] Kansagra A, Dahiya S, Litzow M. Continuing challenges and current issues in acute lymphoblastic leukemia[J]. Leuk Lymphoma, 2018, 59(3): 526-541.
[36] Lepretre S, Graux C, Touzart A, et al. Adult T-type lymphoblastic lymphoma: Treatment advances and prognostic indicators[J/OL]. Exp Hematol, 2017, 51: 7-16.
[37] Berkowitz J L, Janik J E , Stewart D M, et al. Safety, efficacy, and pharmacokinetics /pharmacodynamics of daclizumab (anti-CD25)in patients with adult T-cell leukemia/lymphoma [J/OL]. Clin Immunol, 2014, 155(2): 176-187.
[38] Roswarski J, Roschewski M, Lucas A, et al. Phase Ⅰ dose escalation study of the anti-CD2 monoclonal antibody, siplizumab, with DA-EPOCH-R in aggressive peripheral T-cell lymphomas [J/OL]. Leuk Lymphoma, 2018, 59(6): 1466-1469.