细胞免疫功能检测在乳腺癌临床分期及预后评估中的价值分析
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摘要
目的探讨细胞免疫功能检测在乳腺癌临床分期及预后评估中的应用价值。方法将2015年7月～2018年8月接收的80例女性乳腺癌患者作为观察组,另选取同时期乳腺正常的80例女性对象作为对照组,比较两组对象的外周血T淋巴细胞亚群免疫功能的检测结果。结果观察组患者CD3~+均低于对照组,差异有统计学意义(P<0.05);乳腺癌Ⅲ、Ⅳ期患者CD8~+明显高于Ⅰ、Ⅱ期患者及对照组,差异有统计学意义(P<0.05);乳腺癌Ⅲ、Ⅳ期患者CD3~+、CD4~+、CD4~+/CD8~+低于Ⅰ、Ⅱ期患者及对照组,差异有统计学意义(P<0.05)。结论细胞免疫功能检测在乳腺癌分期及预后评估中具有较好的应用价值,值得应用并推广。
Objective To investigate the application value of cellular immune function test in clinical staging and prognosis evaluation of breast cancer. Methods 80 female breast cancer patients received from July 2015 to August 2018 were enrolled in the study. Another 80 female subjects with normal breasts were selected as the control group. The test results of immune function of the peripheral blood T lymphocyte subsets of the two groups were compared. Results The data showed that the CD3~+ of breast cancer patients was lower than that of the control group, and the difference was statistically different(P<0.05). The CD8~+ of patients with stage Ⅲ and Ⅳ breast cancer was significantly higher than that of patients with stage Ⅰ and Ⅱ and the control group. There were statistical differences between two data sets(P<0.05). CD3~+, CD4~+, CD4~+/CD8~+ in patients with stage Ⅲ and Ⅳ breast cancer was lower than that in stage Ⅰ and Ⅱpatients and the control group, and the data were statistically different(P<0.05). Conclusion The detection of cellular immune function has a good application value in the staging and prognosis evaluation of breast cancer, which is worthy of application and promotion.
Objective To investigate the application value of cellular immune function test in clinical staging and prognosis evaluation of breast cancer. Methods 80 female breast cancer patients received from July 2015 to August 2018 were enrolled in the study. Another 80 female subjects with normal breasts were selected as the control group. The test results of immune function of the peripheral blood T lymphocyte subsets of the two groups were compared. Results The data showed that the CD3~+ of breast cancer patients was lower than that of the control group, and the difference was statistically different(P<0.05). The CD8~+ of patients with stage Ⅲ and Ⅳ breast cancer was significantly higher than that of patients with stage Ⅰ and Ⅱ and the control group. There were statistical differences between two data sets(P<0.05). CD3~+, CD4~+, CD4~+/CD8~+ in patients with stage Ⅲ and Ⅳ breast cancer was lower than that in stage Ⅰ and Ⅱpatients and the control group, and the data were statistically different(P<0.05). Conclusion The detection of cellular immune function has a good application value in the staging and prognosis evaluation of breast cancer, which is worthy of application and promotion.
引文
[1]中国抗癌协会乳腺癌专业委员会.中国抗癌协会乳腺癌诊治指南与规范(2015版)[J].中国癌症杂志,2015,25(9):692-754.
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[3]Yuan C,Wang Q.Comparative analysis of the effect of different radiotherapy regimes on lymphocyte and its subpopulations in breast cancer patients[J].Clinical&Translational Oncology:Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico,2018,20(9):1219-1225.
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[8]周颖,常瑜,王一.三阴乳腺癌患者血清维生素D水平与T细胞免疫功能关系的研究[J].现代检验医学杂志,2018,33(4):47-50.
[9]李冉冉,张鹏飞,袁冰,等.乳腺癌MCF-7细胞分泌的血管内皮生长因子诱导血管内皮细胞免疫功能抑制[J].山东大学学报(医学版),2016,54(2):38-43.
[10]Savas P,Virassamy B,Ye C,et al.Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis[J].Nature Medicine,2018,24(7):986-993.
[11]杨辉,江皓.新辅助TAC化疗对早期乳腺癌患者疗效、细胞免疫功能和Ki-67的影响[J].中华全科医学,2017,15(4):555-557,671.
[12]王文慧,李海滨,李景生,等.乳腺癌患者荷瘤状态T淋巴细胞亚群检测及其临床意义[J].中国老年学杂志,2016,36(8):1873-1874.
[13]Wang L,Zhou D,Ren H,et al.Effects of modified FOL-FOX-6 chemotherapy on cellular immune function in patients with gastric cancer[J].Oncology Letters,2018,11(1):124-127.
[14]Larry M,Liisa L,Markus L.The effect of bifidobacterium animalis ssp.lactis HN019 on cellular immune Function in healthy elderly subjects:Systematic review and metaanalysis[J].Nutrients,2017,9(3):191-194.
[15]En-Lin Z.Effect of immunotherapy combined with intravenous chemotherapy on the tumor load,immune function and cancer cell proliferation activity in patients with advanced colon cancer[J].Journal of Hainan Medical U-niversity,2017,23(18):1123-1127.
[2]靳颖,高庆双.乳腺癌患者外周血T淋巴细胞亚群的变化及其检测的意义[J].世界最新医学信息文摘(连续型电子期刊),2016,16(83):107-107.
[3]Yuan C,Wang Q.Comparative analysis of the effect of different radiotherapy regimes on lymphocyte and its subpopulations in breast cancer patients[J].Clinical&Translational Oncology:Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico,2018,20(9):1219-1225.
[4]孟淑萍,张正平,王霈,等.CT、超声、X线钼靶在乳腺癌诊断中的应用价值研究[J].中国CT和MRI杂志,2014,12(7):33-35.
[5]戴东.国产乳腺专用PET(PEM)对乳腺癌诊断价值的临床研究[D].天津医科大学,2016.
[6]王文慧,李海滨,宋玉国,等.乳腺癌患者细胞免疫指标的检测及意义[J].北华大学学报(自然科学版),2017,18(1):53-56.
[7]吕松林.细胞免疫功能检测对乳腺癌临床分期及预后的评估价值[J].中国现代药物应用,2016,10(1):29-30.
[8]周颖,常瑜,王一.三阴乳腺癌患者血清维生素D水平与T细胞免疫功能关系的研究[J].现代检验医学杂志,2018,33(4):47-50.
[9]李冉冉,张鹏飞,袁冰,等.乳腺癌MCF-7细胞分泌的血管内皮生长因子诱导血管内皮细胞免疫功能抑制[J].山东大学学报(医学版),2016,54(2):38-43.
[10]Savas P,Virassamy B,Ye C,et al.Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis[J].Nature Medicine,2018,24(7):986-993.
[11]杨辉,江皓.新辅助TAC化疗对早期乳腺癌患者疗效、细胞免疫功能和Ki-67的影响[J].中华全科医学,2017,15(4):555-557,671.
[12]王文慧,李海滨,李景生,等.乳腺癌患者荷瘤状态T淋巴细胞亚群检测及其临床意义[J].中国老年学杂志,2016,36(8):1873-1874.
[13]Wang L,Zhou D,Ren H,et al.Effects of modified FOL-FOX-6 chemotherapy on cellular immune function in patients with gastric cancer[J].Oncology Letters,2018,11(1):124-127.
[14]Larry M,Liisa L,Markus L.The effect of bifidobacterium animalis ssp.lactis HN019 on cellular immune Function in healthy elderly subjects:Systematic review and metaanalysis[J].Nutrients,2017,9(3):191-194.
[15]En-Lin Z.Effect of immunotherapy combined with intravenous chemotherapy on the tumor load,immune function and cancer cell proliferation activity in patients with advanced colon cancer[J].Journal of Hainan Medical U-niversity,2017,23(18):1123-1127.