联合检测慢性阻塞性肺病患者血清脑钠肽及肌钙蛋白水平的价值研究
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摘要
目的探究慢性阻塞性肺疾病(COPD)稳定期及急性加重期(AECOPD)患者行血清脑钠肽(BNP)联合肌钙蛋白(cTnI)检测在临床中的价值。方法本研究于2016年9月至2018年5月在我院内科收集160例COPD患者,其中包括COPD稳定期患者60例,AECOPD患者100例。两组患者均分别检测BNP以及cTnI,对其相关性进行分析。结果 AECOPD患者的BNP以及cTnI水平相比稳定期患者更高,差异有统计学意义(P<0.05);在AECOPD患者中,重度患者两项指标检测水平显著高于中度和轻度患者,中度患者两项指标检测水平显著高于轻度患者,差异均存在统计学意义(P<0.05);单独检测BNP与cTnI对AECOPD的诊断效果与两项指标联合检测效果无统计学差异(P>0.05)。结论 BNP及cTnI水平能够有效反映AECOPD患者的病情严重程度,且二者联合检测对AECOPD的诊断效果良好。
Objective To explore the clinical value of serum brain natriuretic peptide(BNP)combined with troponin(cTnI)in patients with chronic obstructive pulmonary disease(COPD)and acute exacerbation(AECOPD).Methods In this study,160 cases of COPD patients were collected from September 2016 to May 2018 in our hospital,including 60 patients in the stable period of COPD and 100 cases of AECOPD patients.Two groups of patients were detected BNP and cTnI respectively,and their correlation was analyzed.Results The BNP and cTnI levels of patients with AECOPD were higher than those in the stable period,and the difference of data was statistically significant(P<0.05).In the patients with AECOPD,the level of detection of two indexes was significantly higher than that of moderate and mild patients,and the level of two indexes in moderate patients was significantly higher than those of light patients.The significance of the study was(P<0.05);there was no significant difference in the statistical difference between the diagnosis effect of BNP and cTnI on the diagnosis of AECOPD and the combined detection of two indexes(P>0.05).Conclusion The level of BNP and cTnI can effectively reflect the severity of AECOPD patients,and the combined detection of the two is effective in the diagnosis of AECOPD.
Objective To explore the clinical value of serum brain natriuretic peptide(BNP)combined with troponin(cTnI)in patients with chronic obstructive pulmonary disease(COPD)and acute exacerbation(AECOPD).Methods In this study,160 cases of COPD patients were collected from September 2016 to May 2018 in our hospital,including 60 patients in the stable period of COPD and 100 cases of AECOPD patients.Two groups of patients were detected BNP and cTnI respectively,and their correlation was analyzed.Results The BNP and cTnI levels of patients with AECOPD were higher than those in the stable period,and the difference of data was statistically significant(P<0.05).In the patients with AECOPD,the level of detection of two indexes was significantly higher than that of moderate and mild patients,and the level of two indexes in moderate patients was significantly higher than those of light patients.The significance of the study was(P<0.05);there was no significant difference in the statistical difference between the diagnosis effect of BNP and cTnI on the diagnosis of AECOPD and the combined detection of two indexes(P>0.05).Conclusion The level of BNP and cTnI can effectively reflect the severity of AECOPD patients,and the combined detection of the two is effective in the diagnosis of AECOPD.
引文
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