玄参化学成分的研究
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摘要
目的研究玄参Scropularia ningpoensis Hemsl.的化学成分。方法玄参80%甲醇提取物采用硅胶和Sephadex LH-20进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到13个化合物,分别鉴定为对羟基肉桂酸甲酯(1)、3, 4-二甲氧基肉桂酸(2)、对羟基苯甲醛(3)、3-羟基对甲氧基苯甲醛(4)、对羟基苯乙酮(5)、肉桂酸(6)、2-(3′,4′-二羟基苯基)-1,3-苯并二茂恶-5-甲醛(7)、3-羟基对甲氧基苯甲酸(8)、对羟基肉桂酸(9)、阿魏酸(10)、3-甲氧基对羟基肉桂醛(11)、对羟基苯乙醇(12)、5-羟甲基糠醛(13)。结论化合物2、4、7～8、11～12为首次从该植物中分离得到。
AIM To study the chemical constituents from Scropularia ningpoensis Hemsl.. METHODS The 80% methanol extract from S. ningpoensis was isolated and purified by silica and Sephadex LH-20,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Thirteen compounds were isolated and identified as methyl p-hydroxycinnamate(1), 3,4-dimethoxycinnamic acid(2), p-hydroxybenzaldehyde(3), 3-hydroxy-p-methoxybenzaldehyde(4), p-hydroxyacetophenone(5), cinnamic acid(6), 2-(3′,4′-dihydroxyphenyl)-1,3-benzodioxole-5-carboxaldehyde(7), 3-hydroxy-p-methoxybenzoic acid(8), p-hydroxycinnamic acid(9), ferulic acid(10), 3-methoxy-p-hydroxycinnamaldehyde(11), p-hydroxyphenethyl alcohol(12), 5-(hydroxymethyl)-furfura(13).CONCLUSION Compounds 2, 4, 7-8 and 11-12 are isolated from this plant for the first time.
AIM To study the chemical constituents from Scropularia ningpoensis Hemsl.. METHODS The 80% methanol extract from S. ningpoensis was isolated and purified by silica and Sephadex LH-20,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Thirteen compounds were isolated and identified as methyl p-hydroxycinnamate(1), 3,4-dimethoxycinnamic acid(2), p-hydroxybenzaldehyde(3), 3-hydroxy-p-methoxybenzaldehyde(4), p-hydroxyacetophenone(5), cinnamic acid(6), 2-(3′,4′-dihydroxyphenyl)-1,3-benzodioxole-5-carboxaldehyde(7), 3-hydroxy-p-methoxybenzoic acid(8), p-hydroxycinnamic acid(9), ferulic acid(10), 3-methoxy-p-hydroxycinnamaldehyde(11), p-hydroxyphenethyl alcohol(12), 5-(hydroxymethyl)-furfura(13).CONCLUSION Compounds 2, 4, 7-8 and 11-12 are isolated from this plant for the first time.
引文
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[17] 赵贵钧,张崇禧,吴志军, 等.肿柄菊乙酸乙酯部位的化学成分[J].第二军医大学学报, 2010, 31(2):189-192.
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[2] Pasdaran A, Hamedi A. The genus Scrophularia: a source of iridoids and terpenoids with a diverse biological activity[J]. Pharm Biol, 2017, 55(1): 2211-2233.
[3] Ma Q, Han L, Mu Y, et al. New Iridoids from Scrophularia ningpoensis[J]. Chem Pharm Bull(Tokyo), 2017, 65(9): 869-873.
[4] Hung J Y,Yang C J,Tsai Y M,et al. Antiproliferative activity of aucubin is through cell cycle arrest and apoptosisin human non-small cell lung cancer A549 cells[J]. Clin Exp Pharm Physiol, 2008, 35(9): 995-1001.
[5] Hua J, Qi J, Yu B Y. Iridoid and phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl. and their α-glucosidase inhibitory activities[J]. Fitoterapia, 2014, 93: 67-73.
[6] Chen X, Liu Y H, Chen P. Iridoid glycosyl esters from Scrophularia ningpoensis[J]. Nat Prod Res, 2007, 21(13): 1187-1190.
[7] 贾献慧,王晓,张永清.忍冬藤酚酸类化学成分分离[J].中国实验方剂学杂志, 2015,21(5):69-71.
[8] 贺峥嵘,潘卫东,卢玉振,等.贵州蜂胶中的有机酸成分研究[J]. 中草药, 2002, 33(5): 405-406.
[9] 杜文鹏,徐彭,刘波, 等.毛竹笋化学成分研究(Ⅰ)[J].中草药, 2015, 46(3):334-338.
[10] 王佳平,管正叶,董传福,等.中缅八角化学成分研究[J].中国中药杂志, 2014, 39(13):2526-2530.
[11] 李翼鹏,周玉枝,陈刚,等.徐长卿中酚类成分的分离与鉴定[J].沈阳药科大学学报, 2014, 31(6):444-447.
[12] Wang Y, Yang M, Yuan C S, et al. Sesquiterpenes and other constituents from Cacalia deltophylla[J]. Die Pharmazie-An Int J Pharm Sci, 2003, 58(8): 596-598.
[13] Tagashira M, Ohtake Y. A new antioxidative 1, 3-benzodioxole from Melissa officinalis[J]. Planta Medica, 1998, 64(6): 555-558.
[14] Ding H Y, Lin H C, Teng C M, et al. Phytochemical and pharmacological studies on Chinese Paeonia species[J]. J Chin Chem Soc, 2000, 47(2): 381-388.
[15] 周惠燕,李士敏.竹叶化学成分研究[J].中国药学杂志,2006,41(9):662-663.
[16] 薛刚强,杜婧,潘新艳, 等.玄参化学成分研究[J].中药材,2014,37(9):1597-1599.
[17] 赵贵钧,张崇禧,吴志军, 等.肿柄菊乙酸乙酯部位的化学成分[J].第二军医大学学报, 2010, 31(2):189-192.
[18] 李艳茸,李春,王智民,等.藏药甘青乌头化学成分研究(Ⅲ)[J].中国中药杂志, 2014, 39(7):1163-1167.
[19] 季新宇,刘慧,刘斌.玄参化学成分研究[J].天然产物研究与开发,2014,26(11):1775-1779,1848.
[20] 王国红,郭直岳,石松林,等.肉桂酸对人骨肉瘤MG-63细胞增殖和分化的影响[J].中国药理学通报,2012,28(9):1262-1266.
[21] 张春乐,宋康康,陈祥仁,等.肉桂酸及其衍生物的抑菌活性研究[J].厦门大学学报(自然科学版),2006,45(S1):16-18,72.