预防性使用益生菌对重症手足口病患儿肠道功能的影响
|
摘要
目的研究预防性使用益生菌对于重症手足口病患儿的肠道功能的影响。方法 2016年7月至2018年5月,将我院收治的108例重症手足口病患儿,按照随机数字表法分为对照组和试验组。对照组采取常规治疗,试验组采用常规治疗辅助使用益生菌。分别比较2组在治疗前后肠道菌群、肠道屏障功能指标的差异,比较2组症状恢复时间以及腹泻情况等方面的差异。结果治疗后试验组患儿双歧杆菌、乳酸杆菌、大肠埃希菌含量高于对照组患儿(P<0.05);治疗后试验组患儿内毒素(ET)、二胺氧化酶(DAO)、D-乳酸(D-LA)水平低于对照组患儿(P<0.05);试验组患儿体温恢复时间低于对照组患儿(P<0.05);试验组患儿腹泻的发生率显著低于对照组患儿(P<0.05)。结论益生菌有利于保障肠道内正常菌群的稳定性,维持肠道屏障,加快体温的恢复以及降低患儿腹泻的发生率。
Objective To observe the effect of probiotics on intestinal function in children with severe hand,foot and mouth disease(HFMD). Methods From July 2016 to May 2018, 108 children with severe HFMD were randomly divided into the control group and experimental group. The control group was treated with routine therapy,while the experimental group was treated with probiotics. The differences of intestinal flora, intestinal barrier function,recovery time and diarrhea were compared between the two groups before and after treatment. Results After treatment, the experimental group was compared with the control group. The levels of Bifidobacterium, Lactobacillus, Escherichia coli in children of the experimental group were significantly higher than those in the control group(P<0.05),and the ET, DAO, D-LA indexes in the experimental group were significantly lower than those in the control group after treatment(P<0.05). The recovery time of body temperature in the experimental group was significantly lower than that in the control group(P<0.05). The incidence of diarrhea in the experimental group was significantly lower than that in the control group(P<0.05). Conclusion Probiotics can protect the stability of normal intestinal flora, maintain intestinal barrier, accelerate body temperature recovery and significantly reduce the incidence of diarrhea in patients.
Objective To observe the effect of probiotics on intestinal function in children with severe hand,foot and mouth disease(HFMD). Methods From July 2016 to May 2018, 108 children with severe HFMD were randomly divided into the control group and experimental group. The control group was treated with routine therapy,while the experimental group was treated with probiotics. The differences of intestinal flora, intestinal barrier function,recovery time and diarrhea were compared between the two groups before and after treatment. Results After treatment, the experimental group was compared with the control group. The levels of Bifidobacterium, Lactobacillus, Escherichia coli in children of the experimental group were significantly higher than those in the control group(P<0.05),and the ET, DAO, D-LA indexes in the experimental group were significantly lower than those in the control group after treatment(P<0.05). The recovery time of body temperature in the experimental group was significantly lower than that in the control group(P<0.05). The incidence of diarrhea in the experimental group was significantly lower than that in the control group(P<0.05). Conclusion Probiotics can protect the stability of normal intestinal flora, maintain intestinal barrier, accelerate body temperature recovery and significantly reduce the incidence of diarrhea in patients.
引文
[1]中华人民共和国国家卫生健康委员会.手足口病诊疗指南(2018年版)[J].中国病毒学杂志,2018,8(5):347-352.
[2]柯胜忠,张多.肠道益生菌联合人免疫球蛋白治疗重症手足口病的疗效分析及对肠黏膜屏障功能的影响[J].中国免疫学杂志,2018,34(8):1226-1229,1236.
[3]李文莲,李文菊,陈寿珊,等.肠道病毒71与肺炎支原体二重感染对手足口病患儿免疫功能的影响[J].中国现代医学杂志,2018,28(21):53-57.
[4]徐良银,林振浪.早产儿坏死性小肠结肠炎危险因素分析及益生菌预防效果观察[J].中国妇幼保健,2018,33(22):5150-5153.
[5]翟云,托娅.益生菌的免疫调节作用及其相关应用研究进展[J].中国微生态学杂志,2018,30(2):235-239.
[6]程丽华,王艳,杨光,等.手足口病患者肠道病毒感染特征分析[J].中国病原生物学杂志,2018,13(2):199-201.
[7]钱慧莉,王秀霞,阎志新,等.肠道病毒71型危重症手足口病多脏器损害的机制[J].临床荟萃,2017,32(10):917-920.
[8] Pathinayake PS,Hsu AC,Wark PA. Innate immunity and immune evasion by enterovirus 71[J]. Viruses,2015,7(12):6613-6630.
[9]中国疾病预防控制中心.肠道病毒71型灭活疫苗使用技术指南[J].中国病毒病杂志,2016,6(46):241-247.
[10]方炳雄,蔡勉珊,林创辉,等.脓毒症患者肠道屏障功能和降钙素原监测的临床价值[J].国际检验医学杂志,2018,39(1):93-95.
[11]苏宇飞,陈镜,王列,等.重症手足口病患儿肠道菌群和肠黏膜通透性的相关研究[J].中国妇幼保健研究,2016,27(3):323-325.
[2]柯胜忠,张多.肠道益生菌联合人免疫球蛋白治疗重症手足口病的疗效分析及对肠黏膜屏障功能的影响[J].中国免疫学杂志,2018,34(8):1226-1229,1236.
[3]李文莲,李文菊,陈寿珊,等.肠道病毒71与肺炎支原体二重感染对手足口病患儿免疫功能的影响[J].中国现代医学杂志,2018,28(21):53-57.
[4]徐良银,林振浪.早产儿坏死性小肠结肠炎危险因素分析及益生菌预防效果观察[J].中国妇幼保健,2018,33(22):5150-5153.
[5]翟云,托娅.益生菌的免疫调节作用及其相关应用研究进展[J].中国微生态学杂志,2018,30(2):235-239.
[6]程丽华,王艳,杨光,等.手足口病患者肠道病毒感染特征分析[J].中国病原生物学杂志,2018,13(2):199-201.
[7]钱慧莉,王秀霞,阎志新,等.肠道病毒71型危重症手足口病多脏器损害的机制[J].临床荟萃,2017,32(10):917-920.
[8] Pathinayake PS,Hsu AC,Wark PA. Innate immunity and immune evasion by enterovirus 71[J]. Viruses,2015,7(12):6613-6630.
[9]中国疾病预防控制中心.肠道病毒71型灭活疫苗使用技术指南[J].中国病毒病杂志,2016,6(46):241-247.
[10]方炳雄,蔡勉珊,林创辉,等.脓毒症患者肠道屏障功能和降钙素原监测的临床价值[J].国际检验医学杂志,2018,39(1):93-95.
[11]苏宇飞,陈镜,王列,等.重症手足口病患儿肠道菌群和肠黏膜通透性的相关研究[J].中国妇幼保健研究,2016,27(3):323-325.