不同痛经表现的子宫腺肌病患者外周血肿瘤标记物表达水平比较
摘要
目的比较不同痛经表现的子宫腺肌病(UAM)患者外周血肿瘤标记物表达水平。方法连续选择近期确诊的UAM患者75例,根据痛经表现分组,同时进行手术前碳水化合物抗原125(CA125)、碳水化合物抗原199(CA199)和血清癌胚抗原(CEA)标本采集和检测。结果有不同痛经表现的UAM患者外周血CA199、CA125和CEA表达水平均明显高于无痛经组,痛经程度重组和痛经持续时间长组外周血CA125[(29.56±7.22)U/ml和(28.49±7.15)U/ml]、CA199[(32.75±7.80)U/ml和(33.28±8.13)U/ml]和CEA[(52.45±10.77)U/ml和(54.35±12.60)U/ml]表达水平均明显高于痛经程度轻、痛经持续时间短以及无痛经患者(P均<0.05)。结论 UAM患者的痛经表现与外周血肿瘤标记物表达水平密切相关。
引文
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[2]季培英,徐莲薇,卢敏,等.CA125、CA199、CEA在五种妇科良性肿瘤中的表达及临床意义.临床医学,2009,13:90-91.
[3]Socolov R,Butureanu S,Angioni S,et al.The value of serological markers in the diagnosis and prognosis of endometriosis:a prospective case-control study.Eur J Obstet Gynecol Reprod Biol,2011,154:215-217.
[4]胡树红,廖谦和,陈利琼,等.细胞核相关抗原、血管内皮生长因子与子宫腺肌症发生发展的相关性.中国妇幼保健,2010,25:27-29.
[5]孙笑,周应芳.TGF-β1与子宫腺肌病痛经的相关性研究.中国妇幼保健,2008,23:73-75.
[6]彭超,周应芳,廖秦平.子宫腺肌病患者痛经强度与前列腺素的相关性研究.实用妇产科杂志,2006,22:27-29.
[7]Kurdoglu Z,Gursoy R,Kurdoglu M,et al.Comparison of the clinical value of CA19-9versus CA125for the diagnosis of endometriosis.Fertil Steril,2009,92:1761-1763.
[8]Bordin L,Fiore C,DonàG,et al.Evaluation of erythrocyte band3phosphotyrosine level,glutathione content,CA-125,and human epidid-ymal secretory protein E4as combined parameters in endometriosis.Fertil Steril,2010,94:1616-1621.
[9]易自生,刘一平,李华良,等.子宫腺肌症MRI、超声及血清肿瘤标志物诊断分析与评价.临床放射学杂志,2009,28:268-269.
[10]Yang CB,Chen Y,Jin HM,et al.Influence of Xianglingwan on dys-menorrhea and serum CA125in treating patients with endometriosis.Zhongguo Zhong Yao Za Zhi,2008,33:567-569.
[11]刘秋慧.血清CA125测定在子宫腺肌病中的诊断价值.北京医学,2007,29:268-269.
[12]Maiorana A,Cicerone C,Niceta M,et al.Evaluation of serum CA125levels in patients with pelvic pain related to endometriosis.Int J Biol Markers,2007,22:200-202.