原发性高血压患者血清脂蛋白a和胱抑素C及与高血压分级的相关性
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摘要
目的研究原发性高血压患者脂蛋白a和胱抑素C血清水平与高血压分级的相关性,探讨脂蛋白a及胱抑素C在高血压患者病情严重程度评估的临床应用价值。方法将342例原发性高血压患者根据高血压分级标准分为低危组56例,中危组78例,高危组101例,极高危组107例,比较各组原发性高血压患者脂蛋白a和胱抑素C血清水平的差异,并研究脂蛋白a和胱抑素C血清水平与高血压分级的相关性。结果脂蛋白a与胱抑素C血清水平在低危组、中危组、高危组及极高危组依次升高,任意组间比较,差异均有统计学意义(P<0.05),脂蛋白a和胱抑素C血清水平与高血压分级均呈正相关,差异均有统计学意义(r=0.617、0.669,P<0.05)。结论脂蛋白a、胱抑素C血清水平的监测有助于了解原发性高血压患者病情的危重程度,对高血压的防治具有重要的临床意义。
Objective To study the relationship between hypertension and lipoprotein a serum cystatin C level and the grade of hypertension,investigate lipoprotein A and cystatin C in patients with hypertension disease severity assessment of the clinical value.Methods 342 cases of primary hypertension patients according to the grading criteria of hypertension were divided into low-risk group 56 cases,78 cases of risk group,high risk group of 101 cases,107 cases of high risk group,the differences were compared in patients with essential hypertension and lipoprotein a serum levels of cystatin C,and lipoprotein associated a and cystatin C in blood clear the level and the grade of hypertension.Results the serum lipoprotein A and serum cystatin C levels were significantly higher in the low risk group,medium risk group,high risk group and high risk group,any differences between groups were statistically significant(P<0.05),apolipoprotein A(r=0.617)and cystatin C(r=0.669)serum levels and hypertension grade were statistically significant(P<0.05).Conclusion the monitoring of lipoprotein A and cystatin c serum concentration is helpful for clinical understanding of the critical condition of patients with essential hypertension,and has important clinical significance for the prevention and treatment of hypertension.
Objective To study the relationship between hypertension and lipoprotein a serum cystatin C level and the grade of hypertension,investigate lipoprotein A and cystatin C in patients with hypertension disease severity assessment of the clinical value.Methods 342 cases of primary hypertension patients according to the grading criteria of hypertension were divided into low-risk group 56 cases,78 cases of risk group,high risk group of 101 cases,107 cases of high risk group,the differences were compared in patients with essential hypertension and lipoprotein a serum levels of cystatin C,and lipoprotein associated a and cystatin C in blood clear the level and the grade of hypertension.Results the serum lipoprotein A and serum cystatin C levels were significantly higher in the low risk group,medium risk group,high risk group and high risk group,any differences between groups were statistically significant(P<0.05),apolipoprotein A(r=0.617)and cystatin C(r=0.669)serum levels and hypertension grade were statistically significant(P<0.05).Conclusion the monitoring of lipoprotein A and cystatin c serum concentration is helpful for clinical understanding of the critical condition of patients with essential hypertension,and has important clinical significance for the prevention and treatment of hypertension.
引文
[1]许志贤,蓝剑.对称动态动脉硬化指数预测高血压早期肾损伤的价值[J].实用临床医学,2017,18(4):26-27.
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[9]任俊,张蕾,刘征.血清胱抑素C水平与早期高血压肾脏功能损伤关系的Meta分析[J].标记免疫分析与临床,2017,24(1):12-15.
[10]乔晓亮.血清胱抑素C、超敏C反应蛋白和β2-微球蛋白水平变化对诊断妊娠高血压的临床意义[J].实验与检验医学,2017,35(2):241-242.
[11]石沙.血脂检验在心脑血管病诊治中的临床应用[J].临床合理用药杂志,2017,10(10):3-4.
[12]曹云和,董晓飞.原发性高血压早期肾损害患者胱抑素C联合同型半胱氨酸检测的临床意义[J].中国循证心血管医学杂志,2017,9(7):854-855.
[13]文宇,吴屹.原发性高血压患者肾功能损害与肥胖的关系[J].中华老年心脑血管病杂志,2017,19(5):472-474.
[14]乔蕊,张捷.脂蛋白(a)——血脂家族的重要一员[J].检验医学,2017,32(7):561-565.
[15]UMOH U,CHARLES DAVIES M A,ADELEYE J.Serum testosterone and lipids in relation to sexual dysfunction in males with metabol-ic syndrome and type 2diabetes mellitus[J].Int Med Sci,2010,17(1):402-412.
[16]莫新玲,杨锡恒,谢婷,等.H型高血压合并2型糖尿病患者血浆Hcy、Cyst-C水平与颈动脉内膜中层厚度的关系[J].广东医学,2017,38(6):855-858.
[17]任丽丽,赵昕,张效林,等.高血压前期患者血脂与冠状动脉粥样硬化的相关性[J].岭南心血管病杂志,2017,23(1):1-6.
[18]赵敏,沈小梅,张红灵,等.原发性高血压患者血清胱抑素C与血管内皮功能的相关性[J].中华高血压杂志,2015,23(9):832.
[2]李利娟.门冬胰岛素联合参芪地黄降糖颗粒治疗妊娠期糖尿病的效果及对血清Hcy、Cys-C的影响分析[J].中国妇幼保健,2017,32(14):3159-3161.
[3]刘振良,刘海燕.肾素-血管紧张素系统抑制剂对老年高血压患者胱抑素C水平的影响[J].中国老年学杂志,2017,37(5):1129-1132.
[4]安丽丽,黄文正,张新梅,等.氯沙坦钾氢氯噻嗪联合叶酸片治疗H型高血压效果观察[J].河北医科大学学报,2017,38(5):506-509.
[5]杨会明,艾倩.中等强度有氧运动联合降压药物对高血压患者血压和心肾功能的影响[J].浙江临床医学,2017,19(7):1274-1276.
[6]徐新献,姚武位,李鑫,等.不同年龄组老年高血压患者24h动态脉压和血清胱抑素C水平的比较[J].中华诊断学电子杂志,2017,5(2):90-92.
[7]迟新栋,马丽,何佳,等.同型半胱氨酸(Hcy)与血清胱抑素C(Cys C)及尿微量清蛋白(U-mALB)联合检测对高血压早期肾损伤的诊断价值[J].中国实验诊断学,2017,21(6):939-941.
[8]中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华心血管病杂志,2011,39(7):579-616.
[9]任俊,张蕾,刘征.血清胱抑素C水平与早期高血压肾脏功能损伤关系的Meta分析[J].标记免疫分析与临床,2017,24(1):12-15.
[10]乔晓亮.血清胱抑素C、超敏C反应蛋白和β2-微球蛋白水平变化对诊断妊娠高血压的临床意义[J].实验与检验医学,2017,35(2):241-242.
[11]石沙.血脂检验在心脑血管病诊治中的临床应用[J].临床合理用药杂志,2017,10(10):3-4.
[12]曹云和,董晓飞.原发性高血压早期肾损害患者胱抑素C联合同型半胱氨酸检测的临床意义[J].中国循证心血管医学杂志,2017,9(7):854-855.
[13]文宇,吴屹.原发性高血压患者肾功能损害与肥胖的关系[J].中华老年心脑血管病杂志,2017,19(5):472-474.
[14]乔蕊,张捷.脂蛋白(a)——血脂家族的重要一员[J].检验医学,2017,32(7):561-565.
[15]UMOH U,CHARLES DAVIES M A,ADELEYE J.Serum testosterone and lipids in relation to sexual dysfunction in males with metabol-ic syndrome and type 2diabetes mellitus[J].Int Med Sci,2010,17(1):402-412.
[16]莫新玲,杨锡恒,谢婷,等.H型高血压合并2型糖尿病患者血浆Hcy、Cyst-C水平与颈动脉内膜中层厚度的关系[J].广东医学,2017,38(6):855-858.
[17]任丽丽,赵昕,张效林,等.高血压前期患者血脂与冠状动脉粥样硬化的相关性[J].岭南心血管病杂志,2017,23(1):1-6.
[18]赵敏,沈小梅,张红灵,等.原发性高血压患者血清胱抑素C与血管内皮功能的相关性[J].中华高血压杂志,2015,23(9):832.