茶叶组分促进皮肤伤口愈合作用的研究进展
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摘要
茶叶作为健康饮品的代表,具有多种生理活性作用,包括抗氧化、抗炎、抗菌等。表没食子儿茶素没食子酸酯(EGCG)等茶叶中主要成分具有抗炎和促进伤口愈合的作用,已经被大量的研究证实。皮肤伤口愈合是由炎症反应、组织增生等调节过程组成的一系列的生理生化反应过程,糖尿病等疾病会引起伤口愈合过程的延长或停滞。茶叶等植物组分对伤口愈合的促进作用,已经成为治疗和预防慢性伤口相关药物研发的热点。该文介绍了EGCG促进皮肤伤口愈合的作用和机制,综述了最新研究进展,为促进糖尿病伤口愈合药物研发和茶叶应用领域的开拓提供参考和思路。
As a kind of healthy beverage,tea has a variety of physiological activities,including antioxidant,anti-inflammatory,antibacterial and so on.The effect of(-)-epigallocatechin-3-gallate(EGCG)and other main componens in tea on anti-inflammatory and facilitating wound healing have been confirmed by numerous studies.Skin wound healing is a series of physiological and biochemical processes which are composed of inflammatory reaction,tissue hyperplasia and other regulatory processes.Diseases such as diabetes can impair or block the healing process.The promoting effect of tea and other plant components on wound healing has become a focus of drug research and development for the treatment and prevention of chronic wound healing.In this paper,the effect and mechanism of EGCG on facilitating skin wound healing were introduced and we summarizes the latest research progress,which could provide reference and ideas for the drug research and development on promoting diabetes wound healing and expanding the application field of tea.
As a kind of healthy beverage,tea has a variety of physiological activities,including antioxidant,anti-inflammatory,antibacterial and so on.The effect of(-)-epigallocatechin-3-gallate(EGCG)and other main componens in tea on anti-inflammatory and facilitating wound healing have been confirmed by numerous studies.Skin wound healing is a series of physiological and biochemical processes which are composed of inflammatory reaction,tissue hyperplasia and other regulatory processes.Diseases such as diabetes can impair or block the healing process.The promoting effect of tea and other plant components on wound healing has become a focus of drug research and development for the treatment and prevention of chronic wound healing.In this paper,the effect and mechanism of EGCG on facilitating skin wound healing were introduced and we summarizes the latest research progress,which could provide reference and ideas for the drug research and development on promoting diabetes wound healing and expanding the application field of tea.
引文
[1]Korting H C,Sch?llmann C,White R J.Management of minor acute cutaneous wounds:importance of wound healing in a moist environment[J].Journal of the European Academy of Dermatology&Venereology,2011,25(2):130-137.
[2]Kabashima K,Honda T,Ginhoux F,et al.The immunological anatomy of the skin[J].Nature Reviews Immunology,2019,19(1):19-30.
[3]Gurtner G C,Werner S,Barrandon Y,et al.Wound repair and regeneration[J].Nature,2008,453(7193):314-321.
[4]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华内分泌代谢杂志,2014,30(10):893-942.
[5]Pang B,Lian F M,Li X L,et al.Different intervention strategies for preventing type 2 diabetes mellitus:a systematic review and metaanalysis of randomized controlled trials[J].Diabetes Obesity&Metabolism,2017,20(3).
[6]贾伟平.中国2型糖尿病防治指南(2017年版)[J].中华医学会糖尿病学分会,2017.
[7]Zheng Y,Ley S H,Hu F B.Global aetiology and epidemiology of type 2 diabetes mellitus and its complications[J].Nature Reviews Endocrinology,2017,14:88.
[8]文祎,蔡淑娴,黄建安.茶叶活性成分的抗炎作用及其机制研究进展[J].食品安全质量检测学报,2017(10):233-238.
[9]Sharangi A B.Medicinal and therapeutic potentialities of tea(Camellia sinensis L.)-A review[J].Food Research International,2009,42(5):529-535.
[10]Hsu S,Bollag W B,Lewis J,et al.Green Tea Polyphenols Induce Differentiation and Proliferation in Epidermal Keratinocytes[J].Journal of Pharmacology&Experimental Therapeutics,2003,306(1):29.
[11]马春霓.茶叶中的化学成分[J].农村经济与科技,2017,28(14):43.
[12]方萍,沈佳佳,鲁越青.5类茶叶总组分的核磁氢谱指纹图谱研究[J].绍兴文理学院学报(自然科学),2012(1):61-66.
[13]陈继英,郭嘉林,张存彦,等.茶多酚的研究进展[J].中草药,2004,35(10):1011-1013.
[14]Cabrera C,Artacho R,Giménez R.Beneficial Effects of Green Tea-A Review[J].Journal of the American College of Nutrition,2006,25(2):79-99.
[15]高海荣,黄振旭,李华敏.16种中国茶叶中茶多酚含量对比研究[J].食品研究与开发,2016,37(7):33-36.
[16]赵磊,高民,马燕芬.茶多酚的抗氧化作用及其机制[J].动物营养学报,2017,29(6):1861-1865.
[17]Chakrawarti L,Agrawal R,Dang S,et al.Therapeutic effects of EGCG:a patent review[J].Expert Opinion on Therapeutic Patents,2016,26(8):907-916.
[18]方崇业,付学奇,盛军.茶叶组分抗菌、抗病毒和免疫增强作用的研究进展[J].中国生物制品学杂志,2010,23(8):910-912.
[19]Mehta M,Ahmed S,Dryden G.Refractory pouchitis improves after administration of the green tea polyphenol EGCG:a retrospective review[J].International Journal of Colorectal Disease,2017,33(1):1-4.
[20]Inflammation,Involves,Reepithelization,et al.Therapeutic Effects of Medicinal Plants on Cutaneous Wound Healing in Humans:ASystematic Review[J].Mediators of Inflammation,2018,(2018-4-1),2018,2018(10):1-12.
[21]Reygaert W C.The antimicrobial possibilities of green tea[J].Frontiers in Microbiology,2014,5(434):434.
[22]张梁,陈欣,陈博,等.茶多酚体内吸收、分布、代谢和排泄研究进展[J].安徽农业大学学报,2016,43(5):667-675.
[23]柳敏,饶国武,华允芬.EGCG衍生物合成及药理活性研究进展[J].茶叶科学,2016,36(2):119-130.
[24]张晓梦,倪艳,李先荣.茶多酚的药理作用研究进展[J].药物评价研究,2013,36(2):157-160.
[25]穆兵,吕海鹏,朱荫,等.茶叶中挥发性成分对映异构体研究进展[J].食品科学,2018,39(11).
[26]周露露,高原,牛知慧,等.茶叶中儿茶素的药理作用及其研究进展[J].辽宁化工,2018(4).
[27]Violeta G.Raneva Y S a H S.Antioxidant Activity in Plasma and Tissues Distribution of(-)-Epigallocatechin Gallate after Oral Administration to Rats[J].JOURNAL OF OLEO SCIENCE,2005,54:289-298.
[28]朱桂勤,李建科.茶多酚的功能研究进展[J].食品研究与开发,2005,26(1):33-35.
[29]崔英.茶多酚抗癌分子机制及其对肿瘤防治作用的研究进展[J].中国癌症防治杂志,2005,(2):143-146.
[30]杨普香.茶叶有效成分的医疗保健功效[J].蚕桑茶叶通讯,2016,(3):39-39.
[31]徐先祥.儿茶素的药理作用研究综述[J].轻工学报,2012,27(4):60-64.
[32]Mukhtar H.Tea polyphenols for health promotion[J].Life Sciences,2007,81(7):519-533.
[33]隋丽华,郭珉.茶多酚皮肤药理学的研究进展[J].医药导报,2003,22(11):795-797.
[34]Bielefeld K A,Amini-Nik S,Alman B A.Cutaneous wound healing:recruiting developmental pathways for regeneration[J].Cellular and Molecular Life Sciences,2013,70(12):2059-2081.
[35]Harding K G,Morris H L,Patel G K.Healing chronic wounds[J].BMJ,2002,324(3):197-206.
[36]Li J,Chen J,Kirsner R.Pathophysiology of acute wound healing[J].Clin Dermatol,2007,25(1):9-18.
[37]Velnar T,Bailey T,Smrkolj V.The wound healing process:an overview of the cellular and molecular mechanisms[J].J Int Med Res,2009,37(5):1528-1542.
[38]Dreifke M B,Jayasuriya A A,Jayasuriya A C.Current wound healing procedures and potential care[J].Mater Sci Eng C Mater Biol Appl,2015,48:651-662.
[39]Baltzis D,Eleftheriadou I,Veves A.Pathogenesis and Treatment of Impaired Wound Healing in Diabetes Mellitus:New Insights[J].Advances in Therapy,2014,31(8):817-836.
[40]Sadri M,Arab-Sorkhi S,Vatani H,et al.New wound dressing polymeric nanofiber containing green tea extract prepared by electrospinning method[J].Fibers&Polymers,2015,16(8):1742-1750.
[41]Park S Y,Lee H U,Lee Y C,et al.Wound healing potential of antibacterial microneedles loaded with green tea extracts[J].Materials Science&Engineering C,2014,42:757-762.
[42]Asadi S Y,Parsaei P,Karimi M,et al.Effect of green tea(Camellia sinensis)extract on healing process of surgical wounds in rat[J].International Journal of Surgery,2013,11(4):332-337.
[43]Fatemi M J,Nikoomaram B,Rahimi A a K,et al.Effect of green tea on the second degree burn wounds in rats[J].Indian Journal of Plastic Surgery Official Publication of the Association of Plastic Surgeons of India,2014,47(3):370.
[44]Romana-Souza B,Pires T C,Monte-Alto-Costa A.Mate tea-mediated reduction in catecholamine synthesis improves cutaneous wound healing of chronically stressed mice[J].Food Research International,2015,71:32-40.
[45]Ojeh N,Stojadinovic O,Pastar I,et al.The effects of caffeine on wound healing[J].International Wound Journal,2016,13(5):605-613.
[46]Bonyanian Z,Rose'meyer R B.Caffeine and its Potential Role in Attenuating Impaired Wound Healing in Diabetes[J].2015:150908124802004.
[47]Jaiswal M,Gupta A,Agrawal A K,et al.Bi-layer composite dressing of gelatin nanofibrous mat and poly vinyl alcohol hydrogel for drug delivery and wound healing application:in-vitro and in-vivo studies[J].Journal of Biomedical Nanotechnology,2013,9(9):1495-1508.
[48]Kim H L,Lee J H,Kwon B J,et al.Promotion of full-thickness wound healing using epigallocatechin-3-o-gallate/poly(lactic-coglycolic Acid)membrane as temporary wound dressing[J].Artificial Organs,2014,38(5):411.
[49]Yu-Hsin L,Jui-Hsiang L,Tzong-Shiun L,et al.Dressing with epigallocatechin gallate nanoparticles for wound regeneration[J].Wound Repair and Regeneration,2016,24(2):287-301.
[50]Leu J G,Chen S A,Chen H M,et al.The effects of gold nanoparticles in wound healing with antioxidant epigallocatechin gallate(上接16页)andα-lipoic acid[J].Nanomedicine Nanotechnology Biology&Medicine,2012,8(5):767-775.
[51]Chiaverini C,Roger C,Fontas E,et al.Oral epigallocatechin-3-gallate for treatment of dystrophic epidermolysis bullosa:a multicentre,randomized,crossover,double-blind,placebo-controlled clinical trial[J].Orphanet Journal of Rare Diseases,2016,11(1):1-3.
[52]Greenhalgh D G.Wound healing and diabetes mellitus[J].Clinics in Plastic Surgery,2003,30(1):37-45.
[53]Mirza R E,Fang M M,Weinheimerhaus E M,et al.Sustained inflammasome activity in macrophages impairs wound healing in type 2 diabetic humans and mice[J].Diabetes,2014,63(3):1103-1114.
[54]Kimball A S,Joshi A D,Boniakowski A E,et al.Notch Regulates Macrophage-Mediated Inflammation in Diabetic Wound Healing[J].Front Immunol,2017,8:635.
[55]Shin Y C,Shin D M,Lee E J,et al.Hyaluronic Acid/PLGA Core/Shell Fiber Matrices Loaded with EGCG Beneficial to Diabetic Wound Healing[J].Advanced Healthcare Materials,2016,5(23):3035.
[56]Ye-Wei H,Qiang-Qiang Z,Xiao-Ying Y,et al.Wound healing can be improved by(-)-epigallocatechin gallate through targeting Notch in streptozotocin-induced diabetic mice[J].The FASEBJournal,2018:fj.201800337R.
[2]Kabashima K,Honda T,Ginhoux F,et al.The immunological anatomy of the skin[J].Nature Reviews Immunology,2019,19(1):19-30.
[3]Gurtner G C,Werner S,Barrandon Y,et al.Wound repair and regeneration[J].Nature,2008,453(7193):314-321.
[4]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华内分泌代谢杂志,2014,30(10):893-942.
[5]Pang B,Lian F M,Li X L,et al.Different intervention strategies for preventing type 2 diabetes mellitus:a systematic review and metaanalysis of randomized controlled trials[J].Diabetes Obesity&Metabolism,2017,20(3).
[6]贾伟平.中国2型糖尿病防治指南(2017年版)[J].中华医学会糖尿病学分会,2017.
[7]Zheng Y,Ley S H,Hu F B.Global aetiology and epidemiology of type 2 diabetes mellitus and its complications[J].Nature Reviews Endocrinology,2017,14:88.
[8]文祎,蔡淑娴,黄建安.茶叶活性成分的抗炎作用及其机制研究进展[J].食品安全质量检测学报,2017(10):233-238.
[9]Sharangi A B.Medicinal and therapeutic potentialities of tea(Camellia sinensis L.)-A review[J].Food Research International,2009,42(5):529-535.
[10]Hsu S,Bollag W B,Lewis J,et al.Green Tea Polyphenols Induce Differentiation and Proliferation in Epidermal Keratinocytes[J].Journal of Pharmacology&Experimental Therapeutics,2003,306(1):29.
[11]马春霓.茶叶中的化学成分[J].农村经济与科技,2017,28(14):43.
[12]方萍,沈佳佳,鲁越青.5类茶叶总组分的核磁氢谱指纹图谱研究[J].绍兴文理学院学报(自然科学),2012(1):61-66.
[13]陈继英,郭嘉林,张存彦,等.茶多酚的研究进展[J].中草药,2004,35(10):1011-1013.
[14]Cabrera C,Artacho R,Giménez R.Beneficial Effects of Green Tea-A Review[J].Journal of the American College of Nutrition,2006,25(2):79-99.
[15]高海荣,黄振旭,李华敏.16种中国茶叶中茶多酚含量对比研究[J].食品研究与开发,2016,37(7):33-36.
[16]赵磊,高民,马燕芬.茶多酚的抗氧化作用及其机制[J].动物营养学报,2017,29(6):1861-1865.
[17]Chakrawarti L,Agrawal R,Dang S,et al.Therapeutic effects of EGCG:a patent review[J].Expert Opinion on Therapeutic Patents,2016,26(8):907-916.
[18]方崇业,付学奇,盛军.茶叶组分抗菌、抗病毒和免疫增强作用的研究进展[J].中国生物制品学杂志,2010,23(8):910-912.
[19]Mehta M,Ahmed S,Dryden G.Refractory pouchitis improves after administration of the green tea polyphenol EGCG:a retrospective review[J].International Journal of Colorectal Disease,2017,33(1):1-4.
[20]Inflammation,Involves,Reepithelization,et al.Therapeutic Effects of Medicinal Plants on Cutaneous Wound Healing in Humans:ASystematic Review[J].Mediators of Inflammation,2018,(2018-4-1),2018,2018(10):1-12.
[21]Reygaert W C.The antimicrobial possibilities of green tea[J].Frontiers in Microbiology,2014,5(434):434.
[22]张梁,陈欣,陈博,等.茶多酚体内吸收、分布、代谢和排泄研究进展[J].安徽农业大学学报,2016,43(5):667-675.
[23]柳敏,饶国武,华允芬.EGCG衍生物合成及药理活性研究进展[J].茶叶科学,2016,36(2):119-130.
[24]张晓梦,倪艳,李先荣.茶多酚的药理作用研究进展[J].药物评价研究,2013,36(2):157-160.
[25]穆兵,吕海鹏,朱荫,等.茶叶中挥发性成分对映异构体研究进展[J].食品科学,2018,39(11).
[26]周露露,高原,牛知慧,等.茶叶中儿茶素的药理作用及其研究进展[J].辽宁化工,2018(4).
[27]Violeta G.Raneva Y S a H S.Antioxidant Activity in Plasma and Tissues Distribution of(-)-Epigallocatechin Gallate after Oral Administration to Rats[J].JOURNAL OF OLEO SCIENCE,2005,54:289-298.
[28]朱桂勤,李建科.茶多酚的功能研究进展[J].食品研究与开发,2005,26(1):33-35.
[29]崔英.茶多酚抗癌分子机制及其对肿瘤防治作用的研究进展[J].中国癌症防治杂志,2005,(2):143-146.
[30]杨普香.茶叶有效成分的医疗保健功效[J].蚕桑茶叶通讯,2016,(3):39-39.
[31]徐先祥.儿茶素的药理作用研究综述[J].轻工学报,2012,27(4):60-64.
[32]Mukhtar H.Tea polyphenols for health promotion[J].Life Sciences,2007,81(7):519-533.
[33]隋丽华,郭珉.茶多酚皮肤药理学的研究进展[J].医药导报,2003,22(11):795-797.
[34]Bielefeld K A,Amini-Nik S,Alman B A.Cutaneous wound healing:recruiting developmental pathways for regeneration[J].Cellular and Molecular Life Sciences,2013,70(12):2059-2081.
[35]Harding K G,Morris H L,Patel G K.Healing chronic wounds[J].BMJ,2002,324(3):197-206.
[36]Li J,Chen J,Kirsner R.Pathophysiology of acute wound healing[J].Clin Dermatol,2007,25(1):9-18.
[37]Velnar T,Bailey T,Smrkolj V.The wound healing process:an overview of the cellular and molecular mechanisms[J].J Int Med Res,2009,37(5):1528-1542.
[38]Dreifke M B,Jayasuriya A A,Jayasuriya A C.Current wound healing procedures and potential care[J].Mater Sci Eng C Mater Biol Appl,2015,48:651-662.
[39]Baltzis D,Eleftheriadou I,Veves A.Pathogenesis and Treatment of Impaired Wound Healing in Diabetes Mellitus:New Insights[J].Advances in Therapy,2014,31(8):817-836.
[40]Sadri M,Arab-Sorkhi S,Vatani H,et al.New wound dressing polymeric nanofiber containing green tea extract prepared by electrospinning method[J].Fibers&Polymers,2015,16(8):1742-1750.
[41]Park S Y,Lee H U,Lee Y C,et al.Wound healing potential of antibacterial microneedles loaded with green tea extracts[J].Materials Science&Engineering C,2014,42:757-762.
[42]Asadi S Y,Parsaei P,Karimi M,et al.Effect of green tea(Camellia sinensis)extract on healing process of surgical wounds in rat[J].International Journal of Surgery,2013,11(4):332-337.
[43]Fatemi M J,Nikoomaram B,Rahimi A a K,et al.Effect of green tea on the second degree burn wounds in rats[J].Indian Journal of Plastic Surgery Official Publication of the Association of Plastic Surgeons of India,2014,47(3):370.
[44]Romana-Souza B,Pires T C,Monte-Alto-Costa A.Mate tea-mediated reduction in catecholamine synthesis improves cutaneous wound healing of chronically stressed mice[J].Food Research International,2015,71:32-40.
[45]Ojeh N,Stojadinovic O,Pastar I,et al.The effects of caffeine on wound healing[J].International Wound Journal,2016,13(5):605-613.
[46]Bonyanian Z,Rose'meyer R B.Caffeine and its Potential Role in Attenuating Impaired Wound Healing in Diabetes[J].2015:150908124802004.
[47]Jaiswal M,Gupta A,Agrawal A K,et al.Bi-layer composite dressing of gelatin nanofibrous mat and poly vinyl alcohol hydrogel for drug delivery and wound healing application:in-vitro and in-vivo studies[J].Journal of Biomedical Nanotechnology,2013,9(9):1495-1508.
[48]Kim H L,Lee J H,Kwon B J,et al.Promotion of full-thickness wound healing using epigallocatechin-3-o-gallate/poly(lactic-coglycolic Acid)membrane as temporary wound dressing[J].Artificial Organs,2014,38(5):411.
[49]Yu-Hsin L,Jui-Hsiang L,Tzong-Shiun L,et al.Dressing with epigallocatechin gallate nanoparticles for wound regeneration[J].Wound Repair and Regeneration,2016,24(2):287-301.
[50]Leu J G,Chen S A,Chen H M,et al.The effects of gold nanoparticles in wound healing with antioxidant epigallocatechin gallate(上接16页)andα-lipoic acid[J].Nanomedicine Nanotechnology Biology&Medicine,2012,8(5):767-775.
[51]Chiaverini C,Roger C,Fontas E,et al.Oral epigallocatechin-3-gallate for treatment of dystrophic epidermolysis bullosa:a multicentre,randomized,crossover,double-blind,placebo-controlled clinical trial[J].Orphanet Journal of Rare Diseases,2016,11(1):1-3.
[52]Greenhalgh D G.Wound healing and diabetes mellitus[J].Clinics in Plastic Surgery,2003,30(1):37-45.
[53]Mirza R E,Fang M M,Weinheimerhaus E M,et al.Sustained inflammasome activity in macrophages impairs wound healing in type 2 diabetic humans and mice[J].Diabetes,2014,63(3):1103-1114.
[54]Kimball A S,Joshi A D,Boniakowski A E,et al.Notch Regulates Macrophage-Mediated Inflammation in Diabetic Wound Healing[J].Front Immunol,2017,8:635.
[55]Shin Y C,Shin D M,Lee E J,et al.Hyaluronic Acid/PLGA Core/Shell Fiber Matrices Loaded with EGCG Beneficial to Diabetic Wound Healing[J].Advanced Healthcare Materials,2016,5(23):3035.
[56]Ye-Wei H,Qiang-Qiang Z,Xiao-Ying Y,et al.Wound healing can be improved by(-)-epigallocatechin gallate through targeting Notch in streptozotocin-induced diabetic mice[J].The FASEBJournal,2018:fj.201800337R.