摘要
目前去甲基化药物地西他滨(DAC)治疗骨髓增生异常综合征(MDS)的疗效已得到普遍认可且已广泛应用于临床。本文简述其治疗作用机制及近年DAC对不同分型MDS治疗及其剂量、联合用药、分子学标志物预测、不良反应,总结现有临床及实验研究资料,为今后的精准用药治疗提供经验及参考。
The efficacy of the demethylating drug decitabine(DAC) in the treatment of myelodysplastic syndrome(MDS) has been widely recognized and widely used in clinical practice. This article briefly describes its therapeutic mechanism and recent DAC treatment of different types of MDS and its dose, combination, molecular marker prediction, adverse reactions, summarizing existing clinical and experimental research data, providing experience for future accurate drug treatment and reference.
引文
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