口腔来源蛋白及多肽诱导牙釉质仿生矿化的研究进展
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摘要
牙釉质生物矿化过程中,成釉细胞分泌各种蛋白介导有序棱柱状羟磷灰石晶体的形成,最终形成高度复杂而有序的牙釉质结构。当牙釉质结构遭到破坏后,寻求可诱导釉质微结构再生的仿生修复材料和方法是目前牙体修复研究的一大难点和热点。利用口腔来源的蛋白及多肽人工诱导牙釉质矿化过程,以实现牙釉质结构再生的仿生矿化修复被认为是一种很有前景的治疗手段。本文就近年来口腔来源的蛋白及其多肽诱导牙釉质仿生矿化的相关研究作一综述。
During enamel biomineralization, ameloblasts secrete proteins to mediate the hydroxyapatite crystallites to form the well-organized prism pattern. Finally, a highly complex and ordered enamel structure is formed. When the enamel is destructed, it is of great difficulties and high popularity to find biomimetic reparative materials or methods that can induce the regeneration of enamel microstructure at present. Among them, enamel biomimetic mineralization using proteins derived from oral environment and their derived peptides is a promising way to rebuild the enamel. In this paper, we review the advancement of enamel biomimetic mineralization induced by proteins and their derived peptides from oral cavity according to the latest reports in recent years.
During enamel biomineralization, ameloblasts secrete proteins to mediate the hydroxyapatite crystallites to form the well-organized prism pattern. Finally, a highly complex and ordered enamel structure is formed. When the enamel is destructed, it is of great difficulties and high popularity to find biomimetic reparative materials or methods that can induce the regeneration of enamel microstructure at present. Among them, enamel biomimetic mineralization using proteins derived from oral environment and their derived peptides is a promising way to rebuild the enamel. In this paper, we review the advancement of enamel biomimetic mineralization induced by proteins and their derived peptides from oral cavity according to the latest reports in recent years.
引文
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[15] Prajapati S,Ruan Q,Mukherjee K,et al.The presence of MMP-20 reinforces biomimetic enamel regrowth [J].J Dent Res,2018,97(1):84-90.
[16] Shafiei F,Hossein BG,Farajollahi MM,et al.Leucine-rich amelogenin peptide (LRAP) as a surface primer for biomimetic remineralization of superficial enamel defects:An in vitro study [J].Scanning,2015,37(3):179-185.
[17] Kwak SY,Litman A,Margolis HC,et al.Biomimetic enamel regeneration mediated by leucine-rich amelogenin peptide [J].J Dent Res,2017,96(5):524-530.
[18] Lv XP,Yang Y,Han SL,et al.Potential of an amelogenin based peptide in promoting reminerlization of initial enamel caries [J].Arch Oral Bio,2015,60(10):1482-1487.
[19] Han SL,Fan YY,Zhou ZL,et al.Promotion of enamel caries remineralization by an amelogenin-derived peptide in a rat model [J].Arch Oral Bio,2017,73:66-71.
[20] Li QL,Ning TY,Cao Y,et al.A novel self-assembled oligopeptide amphiphile for biomimetic mineralization of enamel [J].BMC Biotechnol,2014,14(1):1-11.
[21] Martini D,Trire A,Breschi L,et al.Dentin matrix protein 1 and dentin sialophosphoprotein in human sound and carious teeth:an immunohistochemical and colorimetric assay [J].Eur J Histochem,2013,57(4):e32.
[22] Yarbrough DK,Hagerman E,Eckert R,et al.Specific binding and mineralization of calcified surfaces by small peptides [J].Calcif Tissue Int,2010,86(1):58-66.
[23] Yang Y,Lv XP,Shi W,et al.8DSS-promoted remineralization of initial enamel caries in vitro [J].J Dent Res,2014,93(5):520-524.
[24] Yang Y,Lv XP,Shi WY,et al.Synergistic inhibition of enamel demineralization by peptide 8DSS and fluoride [J].Caries Res,2016,50(1):32-39.
[25] Dodds MW,Johnson DA,Yeh CK.Health benefits of saliva:a review [J].J Dent,2005,33(3):223-233.
[26] Misbah MH,Espanol M,Quintanilla L,et al.Formation of calcium phosphate nanostructures under the influence of self-assembling hybrid elastin-like-statherin recombinamers [J].RSC Adv,2016,6(37):31225-31234.
[27] Kosoric J,Williams RAD,Hector MP,et al.A synthetic peptide based on a natural salivary protein reduces demineralisation in model systems for dental caries and erosion [J].Int J Pept Res Ther,2007,13(4):497-503.
[28] Yang YX,Yang B,Li MZ,et al.Salivary acquired pellicle-inspired DpSpSEEKC peptide for the restoration of demineralized tooth enamel [J].Biomed Mater,2017,12(2):025007.
[29] Yang X,Yang B,He LB,et al.Bioinspired peptide-decorated tannic acid for in situ remineralization of tooth enamel:in vitro and in vivo evaluation [J].Acs Biomater Sci Eng,2017,3(12):3553-3562.
[30] Liu Y,Ding C,He L,et al.Bioinspired heptapeptides as functionalized mineralization inducers with enhanced hydroxyapatite affinity [J].J Mater Chem B,2018,6(13):1984-1994.
[31] Wang K,Wang XQ,Li HR,et al.A statherin-derived peptide promotes hydroxyapatite crystallization and in situ remineralization of artificial enamel caries [J].RSC Adv,2018,8(3):1647-1655.
[2] Ruan Q,Moradian-Oldak J.Amelogenin and enamel biomimetics [J].J Mater Chem B,2015,3(16):3112-3129.
[3] Moradian-Oldak J.Protein-mediated enamel mineralization [J].Front Biosci (Landmark Ed),2012,17:1996-2023.
[4] Nurbaeva MK,Eckstein M,Feske S,et al.Ca2+ transport and signalling in enamel cells [J].J Physiol,2017,595(10):3015-3039.
[5] Luo JJ,Ning TY,Cao Y,et al.Biomimic enamel remineralization by hybridization calcium- and phosphate-loaded liposomes with amelogenin-inspired peptide [J].Key Eng Mater,2012,512-515:1727-1730.
[6] Wu XG,Zhao X,Li Y,et al.In situ synthesis carbonated hydroxyapatite layers on enamel slices with acidic amino acids by a novel two-step method [J].Mater Sci Eng C Mater Biol Appl,2015,54:150-157.
[7] Amaechi BT.Remineralization therapies for initial caries lesions [J].Curr Oral Health Rep,2015,2(2):95-101.
[8] Shyam R,Bc M,kumar A,et al.Role of casein phosphopeptide-amorphous calcium phosphate (Cpp-Acp) in prevention of dental caries:a review [J].Int J Adv Res,2017,5(7):999-1004.
[9] Chung HY,Li CC.Asparagine-serine-serine peptide regulates enamel remineralization in vitro [J].J Mater Res,2013,28(20):2890-2896.
[10] Cao CY,Mei ML,Li QL,et al.Methods for biomimetic mineralisation of human enamel:a systematic review [J].Materials,2015,8(6):2873-2886.
[11] Ding CM,Chen ZX,Li JS.From molecules to macrostructures:recent development of bioinspired hard tissue repair [J].Biomater Sci,2017,5(8):1435-1449.
[12] Fincham AG,Moradian-Oldak J,Simmer JP.The structural biology of the developing dental enamel matrix [J].J Struct Biol,1999,126(3):270-299.
[13] 林智恺,束蓉,宋忠臣.重组釉原蛋白的研究进展[J].牙体牙髓牙周病学杂志,2011,21(1):48-51.
[14] Ruan QC,Moradian-Oldak J.Development of amelogenin-chitosan hydrogel for in vitro enamel regrowth with a dense interface [J].J Vis Exp,2014(89):e51606-e51606.
[15] Prajapati S,Ruan Q,Mukherjee K,et al.The presence of MMP-20 reinforces biomimetic enamel regrowth [J].J Dent Res,2018,97(1):84-90.
[16] Shafiei F,Hossein BG,Farajollahi MM,et al.Leucine-rich amelogenin peptide (LRAP) as a surface primer for biomimetic remineralization of superficial enamel defects:An in vitro study [J].Scanning,2015,37(3):179-185.
[17] Kwak SY,Litman A,Margolis HC,et al.Biomimetic enamel regeneration mediated by leucine-rich amelogenin peptide [J].J Dent Res,2017,96(5):524-530.
[18] Lv XP,Yang Y,Han SL,et al.Potential of an amelogenin based peptide in promoting reminerlization of initial enamel caries [J].Arch Oral Bio,2015,60(10):1482-1487.
[19] Han SL,Fan YY,Zhou ZL,et al.Promotion of enamel caries remineralization by an amelogenin-derived peptide in a rat model [J].Arch Oral Bio,2017,73:66-71.
[20] Li QL,Ning TY,Cao Y,et al.A novel self-assembled oligopeptide amphiphile for biomimetic mineralization of enamel [J].BMC Biotechnol,2014,14(1):1-11.
[21] Martini D,Trire A,Breschi L,et al.Dentin matrix protein 1 and dentin sialophosphoprotein in human sound and carious teeth:an immunohistochemical and colorimetric assay [J].Eur J Histochem,2013,57(4):e32.
[22] Yarbrough DK,Hagerman E,Eckert R,et al.Specific binding and mineralization of calcified surfaces by small peptides [J].Calcif Tissue Int,2010,86(1):58-66.
[23] Yang Y,Lv XP,Shi W,et al.8DSS-promoted remineralization of initial enamel caries in vitro [J].J Dent Res,2014,93(5):520-524.
[24] Yang Y,Lv XP,Shi WY,et al.Synergistic inhibition of enamel demineralization by peptide 8DSS and fluoride [J].Caries Res,2016,50(1):32-39.
[25] Dodds MW,Johnson DA,Yeh CK.Health benefits of saliva:a review [J].J Dent,2005,33(3):223-233.
[26] Misbah MH,Espanol M,Quintanilla L,et al.Formation of calcium phosphate nanostructures under the influence of self-assembling hybrid elastin-like-statherin recombinamers [J].RSC Adv,2016,6(37):31225-31234.
[27] Kosoric J,Williams RAD,Hector MP,et al.A synthetic peptide based on a natural salivary protein reduces demineralisation in model systems for dental caries and erosion [J].Int J Pept Res Ther,2007,13(4):497-503.
[28] Yang YX,Yang B,Li MZ,et al.Salivary acquired pellicle-inspired DpSpSEEKC peptide for the restoration of demineralized tooth enamel [J].Biomed Mater,2017,12(2):025007.
[29] Yang X,Yang B,He LB,et al.Bioinspired peptide-decorated tannic acid for in situ remineralization of tooth enamel:in vitro and in vivo evaluation [J].Acs Biomater Sci Eng,2017,3(12):3553-3562.
[30] Liu Y,Ding C,He L,et al.Bioinspired heptapeptides as functionalized mineralization inducers with enhanced hydroxyapatite affinity [J].J Mater Chem B,2018,6(13):1984-1994.
[31] Wang K,Wang XQ,Li HR,et al.A statherin-derived peptide promotes hydroxyapatite crystallization and in situ remineralization of artificial enamel caries [J].RSC Adv,2018,8(3):1647-1655.