摘要
[目的]通过Meta分析方法探讨初次全膝关节置换术(total knee arthroplasty,TKA)中切除滑膜对失血量和临床疗效的影响。[方法]计算机检索数据库Pub Med、EBSCO、The Cochrane Library、WANFANG、CNKI、VIP中关于人工全膝关节置换术中切除滑膜与不切除的随机对照试验(RCT)或半随机对照试验(q-RCT),检索时限为2000年01月~2017年10月。本Meta分析使用Rev Man5.2软件,采用质量评价和发表偏倚评价筛选的文献。[结果]纳入7篇文献,968例患者,切除滑膜组473例,不切除滑膜组495例。Meta分析结果显示:切除滑膜组与不切除组相比,术后引流量[WMD=133.18,95%CI(94.36,172.00),P<0.001]、隐性失血量[WMD=191.35,95%CI(106.48,276.22),P<0.001]、手术时间[WMD=0.16,95%CI(0.05,0.26),P=0.004]两组间差异有统计学意义;术后VAS评分[WMD=-0.03,95%CI(-0.46,0.40),P=0.890]、ROM[WMD=0.60,95%CI(-0.84,2.05),P=0.400]、CKSS[WMD=-0.35,95%CI(-0.91,0.22),P=0.230]、FKSS[WMD=-0.70,95%CI(-1.42,0.01),P=0.050]差异无统计学意义。[结论]TKA术中切除滑膜显著增加了术后引流量、隐性失血量,同时延长了手术时间,而对术后疼痛的缓解和功能恢复并无显著优势。
[Objective] To review the effect of synovectomy on bleeding and clinical outcomes of primary total knee arthroplasty(TKA). [Methods] We electronically searched Pub Med, EBSCO, the Cochrane Library, CNKI and Wanfang Data from January 2000 to October 2017 to identify randomized controlled trial(RCT) and quasi-randomized controlled trial( q RCT) with or without synovectomy in primary TKA. The methodological quality of the included trials was assessed. Data were analyzed using Rev Man 5.2 software. [Results] A total of seven articles were taken in this study involving 968 patients, including 473 in the synovectomy group and 495 in the non-synovectomy group. There were significant differences between the two groups regarding postoperative blood loss from drains [WMD=133.18, 95% CI(94.36, 172.00), P<0.000 01], concealed blood loss [WMD=191.35, 95%CI(106.48, 276.22), P<0.000 01], operating time [WMD=0.16,95%CI(0.05, 0.26), P=0.004]. However, there were no significant differences between the two groups regarding to VAS for pain [WMD=-0.03, 95%CI(-0.46, 0.40), P=0.89],ROM [WMD=0.60, 95%CI(-0.84, 2.05), P=0.4], Clinical Knee Society Score [WMD=-0.35, 95%CI(-0.91, 0.22), P=0.23],Functional Knee Society Score [WMD=-0.70, 95%CI(-1.42, 0.01), P=0.05]. [Conclusion] The patients with synovectomy in TKA have a higher postoperative blood loss from drain, concealed blood loss and longer surgery time without any clinical advantages in pain relief and functional recovery.
引文
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