阿戈美拉汀对首发抑郁症及性功能障碍的疗效
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摘要
目的观察阿戈美拉汀对首发抑郁症及性功能障碍的疗效。方法将90例首发抑郁患者随机分为两组,各45例,研究组予以阿戈美拉汀治疗6周,对照组予以氟西汀治疗6周,于治疗前,治疗1、2、4、6周末用汉密尔顿抑郁量表(HAMD-17)、亚利桑那性体验量表(ASEX)评定疗效和性功能,6周末用治疗副反应量表(TESS)评定药物的安全性。结果抑郁症状有效率研究组为86.67%,对照组为84.44%,两组差异无统计学意义(P>0.05);1、2周末,研究组HAMD-17评分低于对照组(P<0.05);两组TESS评分比较差异无统计学意义(P>0.05)。治疗后研究组ASEX评分及性功能障碍发生率均低于对照组(P<0.05)。结论阿戈美拉汀对首发抑郁症疗效较好、同时对抑郁患者的性功能有一定的改善作用。
Objective To observe the effects of agomelatine on depression symptoms and sexual function of patients with first-episode depression. Methods A total of 90 patients with first-episode depression was randomly divided into research group(45 cases treated with agomelatine)and control group(45 cases treated with fluoxetine)for 6 weeks. HAMD-17 was used to evaluate the clinical efficacy before treatment and at the 1 st,2 nd,4 th and 6 th weekend of treatment,the ASEX to assess sexual function,and the adverse reactions were assessed with the TESS at the 6 th weekend of treatment. Results The effective rate of the research group was 86.67%,while the control group was 84.44%. There was no statistical significance between the two groups(P> 0.05). The total score of HAMD-17 in the research group were lower than that in the control group at the 1 st and 2 nd weekend of treatment(P< 0.05). At the 6 th weekend of treatment,there was no significant difference in the TESS scores of the two groups(P> 0.05). ASEX score after treatment and the incidence of sexual dysfunction in the research were lower than those in the control group(P<0.05). Conclusion Argomeladine has a relatively good effect on the initial depression and has a certain effect on sexual function.
Objective To observe the effects of agomelatine on depression symptoms and sexual function of patients with first-episode depression. Methods A total of 90 patients with first-episode depression was randomly divided into research group(45 cases treated with agomelatine)and control group(45 cases treated with fluoxetine)for 6 weeks. HAMD-17 was used to evaluate the clinical efficacy before treatment and at the 1 st,2 nd,4 th and 6 th weekend of treatment,the ASEX to assess sexual function,and the adverse reactions were assessed with the TESS at the 6 th weekend of treatment. Results The effective rate of the research group was 86.67%,while the control group was 84.44%. There was no statistical significance between the two groups(P> 0.05). The total score of HAMD-17 in the research group were lower than that in the control group at the 1 st and 2 nd weekend of treatment(P< 0.05). At the 6 th weekend of treatment,there was no significant difference in the TESS scores of the two groups(P> 0.05). ASEX score after treatment and the incidence of sexual dysfunction in the research were lower than those in the control group(P<0.05). Conclusion Argomeladine has a relatively good effect on the initial depression and has a certain effect on sexual function.
引文
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4.Lee KU,Lee YM,Nam JM,et al.Antidepressant-Induced Sexual Dysfunction among Newer Antidepressants in a Naturalistic Setting.Psychiatry Investig.2010;7(1):55-59
5.Cheng Y.Analysis of Influencing Factors of Medication Compliance in Discharged Depressive Patients and Recurrence Situation.Journal of Psychiatry and Brain Science,2016;1(3):1
6.杨志,迟强,栾中山。阿戈美拉汀与文拉法辛治疗抑郁症的临床对照研究。神经损伤与功能重建,2015;10(4):356-357
7.Carney RM,Shelton RC.Agomelatine for the treatment of major depressive disorder.Expert Opin Pharmacother,2011;12(15):2411-2419
8.McGahuey CA1,Gelenberg AJ,Laukes CA,et al.The Arizona Sexual Experience Scale(ASEX):reliability and validity.J Sex Marital Ther.2000;26(1):25-40
9.宋海锋,杨亚锋,乔西民,等。归脾丸联合复方玄驹胶囊治疗抗抑郁药所致阴茎勃起功能障碍的临床观察。国际精神病学杂志,2016;(03):437-439
10.Blier P1,Ward HE,Tremblay P,et al.Combination of antidepressant medications from treatment initiation for major depressive disorder:a double-blind randomized study.Am JPsychiatry,2010;167(3):281-288
11.Demyttenaere K,Corruble E,Hale A,et al.,A pooled analysis of six month comparative efficacy and tolerability in four randomized clinical trials:agomelatine versus escitalopram,fluoxetine,and sertraline.CNS Spectr.2013;18(3):163-170
13.Kennedy SH,Rizvi S,Fulton K,et al.A double-blind comparison of sexual functioning,antidepressant efficacy,and tolerability between agomelatine and venlafaxine XR.JClin Psychopharmacol.2008;28(3):329-333
2.Williams K,Reynolds MF.Sexual dysfunction in major depression.CNS Spectr.2006;11(8 Suppl 9):19-23
3.Montejo AL,Perahia DG,Spann ME,et al.Sexual function during long-term duloxetine treatment in patients with recurrent major depressive disorder.J Sex Med.2011;8(3):773-782
4.Lee KU,Lee YM,Nam JM,et al.Antidepressant-Induced Sexual Dysfunction among Newer Antidepressants in a Naturalistic Setting.Psychiatry Investig.2010;7(1):55-59
5.Cheng Y.Analysis of Influencing Factors of Medication Compliance in Discharged Depressive Patients and Recurrence Situation.Journal of Psychiatry and Brain Science,2016;1(3):1
6.杨志,迟强,栾中山。阿戈美拉汀与文拉法辛治疗抑郁症的临床对照研究。神经损伤与功能重建,2015;10(4):356-357
7.Carney RM,Shelton RC.Agomelatine for the treatment of major depressive disorder.Expert Opin Pharmacother,2011;12(15):2411-2419
8.McGahuey CA1,Gelenberg AJ,Laukes CA,et al.The Arizona Sexual Experience Scale(ASEX):reliability and validity.J Sex Marital Ther.2000;26(1):25-40
9.宋海锋,杨亚锋,乔西民,等。归脾丸联合复方玄驹胶囊治疗抗抑郁药所致阴茎勃起功能障碍的临床观察。国际精神病学杂志,2016;(03):437-439
10.Blier P1,Ward HE,Tremblay P,et al.Combination of antidepressant medications from treatment initiation for major depressive disorder:a double-blind randomized study.Am JPsychiatry,2010;167(3):281-288
11.Demyttenaere K,Corruble E,Hale A,et al.,A pooled analysis of six month comparative efficacy and tolerability in four randomized clinical trials:agomelatine versus escitalopram,fluoxetine,and sertraline.CNS Spectr.2013;18(3):163-170
13.Kennedy SH,Rizvi S,Fulton K,et al.A double-blind comparison of sexual functioning,antidepressant efficacy,and tolerability between agomelatine and venlafaxine XR.JClin Psychopharmacol.2008;28(3):329-333