载Zn~(2+)、Cr~(3+)离子的凹凸棒石黏土对鸡艾美耳球虫病的防治效果研究
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摘要
研究载Zn~(2+)、Cr~(3+)离子的凹凸棒石黏土对鸡艾美耳球虫病的治疗和预防效果。通过离子交换的方法制备载Zn~(2+)、Cr~(3+)离子的凹凸棒石黏土。治疗试验:将雏鸡饲养至14日龄,随机分为5组,即空白对照组、感染不给药组、载Zn~(2+)、Cr~(3+)离子的凹凸棒石黏土治疗组、地克珠利治疗组、地克珠利和黏土联合治疗组,每组30只。感染后通过临床症状、粪便、体重、盲肠病变、卵囊值、抗球虫指数等评价载Zn~(2+)、Cr~(3+)离子的凹凸棒石黏土对鸡球虫病的治疗效果。预防试验:12日龄雏鸡随机分4组,空白对照组、3个预防组,每组各150只鸡。通过观察临床症状、血便堆数、卵囊数等综合评价载Zn~(2+)、Cr~(3+)离子的凹凸棒石黏土对自然发生的鸡球虫病的预防效果。治疗试验结果显示,地克珠利和黏土联合治疗组抗球虫指数达179.06,接近高效抗球虫药,载Zn~(2+)、Cr~(3+)离子的凹凸棒石黏土效果优于地克珠利。预防试验结果显示,在饲料中添加载Zn~(2+)、Cr~(3+)离子的凹凸棒石黏土可缩短球虫所致鸡血便持续时间,显著降低球虫感染造成的生长迟缓。上述结果表明,载Zn~(2+)、Cr~(3+)离子的凹凸棒石黏土对鸡球虫病具有较好的治疗效果和预防效果。
This research was to investigate the effects of Zn~(2+) and Cr~(3+)-modified palygorskite on treatment and prevention of chicken coccidiosis. The Zn~(2+) and Cr~(3+)-modified palygorskite was prepared by the ion exchange processes between Zn~(2+)/Cr~(3+) and palygorskite cations. In the treatment test, 150 fourteen-day-old chickens were randomly divided into five groups: the control group, the infection group, the treatment group(with Zn~(2+) and Cr~(3+)-modified palygorskite, Diclazuril, Diclazuril and Zn~(2+) and Cr~(3+)-modified palygorskite combination). During the experiment, clinical signs, faeces, relative weight gain, caecal lesion score, oocyst index, and anticoccidial index of the chickens were recorded to evaluate their anticoccidial activity. In the preventive test, twelve-day-old chickens were divided into four groups: the control group, three prevention groups. Each group included one hundred and fifty chickens. Clinical signs, blood faeces, oocyst of the chickens were recorded to evaluate the preventive effect. The results showed that the ACIs of the combination of Zn~(2+) and Cr~(3+)-modified palygorskite and Diclazuril group were 179.06, indicating an almost excellent activity. The anticoccidial activity of the Zn~(2+) and Cr~(3+)-modified palygorskite was better than the activity of Diclazuril alone. The results of the preventive test showed that the duration of blood faeces was shortened and the weight gain was improved in the prevention group. The above results suggested that Zn~(2+) and Cr~(3+)-modified palygorskite had good effect on treatment and prevention of chicken coccidiosis.
This research was to investigate the effects of Zn~(2+) and Cr~(3+)-modified palygorskite on treatment and prevention of chicken coccidiosis. The Zn~(2+) and Cr~(3+)-modified palygorskite was prepared by the ion exchange processes between Zn~(2+)/Cr~(3+) and palygorskite cations. In the treatment test, 150 fourteen-day-old chickens were randomly divided into five groups: the control group, the infection group, the treatment group(with Zn~(2+) and Cr~(3+)-modified palygorskite, Diclazuril, Diclazuril and Zn~(2+) and Cr~(3+)-modified palygorskite combination). During the experiment, clinical signs, faeces, relative weight gain, caecal lesion score, oocyst index, and anticoccidial index of the chickens were recorded to evaluate their anticoccidial activity. In the preventive test, twelve-day-old chickens were divided into four groups: the control group, three prevention groups. Each group included one hundred and fifty chickens. Clinical signs, blood faeces, oocyst of the chickens were recorded to evaluate the preventive effect. The results showed that the ACIs of the combination of Zn~(2+) and Cr~(3+)-modified palygorskite and Diclazuril group were 179.06, indicating an almost excellent activity. The anticoccidial activity of the Zn~(2+) and Cr~(3+)-modified palygorskite was better than the activity of Diclazuril alone. The results of the preventive test showed that the duration of blood faeces was shortened and the weight gain was improved in the prevention group. The above results suggested that Zn~(2+) and Cr~(3+)-modified palygorskite had good effect on treatment and prevention of chicken coccidiosis.
引文
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[3] 王黎霞,张永红,曹授俊,等. 柔嫩艾美耳球虫田间分离株药物耐药性调查[J].中国兽医杂志,2014,50(2):17-19.
[4] More J, Fioramonti J,Bueno L. Changes in gastrointestinal mucins due to attapulgite-an experimental-study in the rat[J].Gastroenterol Clinique Et Biologique,1992,16(12):988-993.
[5] 丁阳,姚大伟,李娜,等. 载铜凹土棒石黏土膏剂对沙门氏菌体外抑菌效果的观察[J].畜牧与兽医,2015,47(9):104-106.
[6] 王唯坚,肖正达,谢宇野,等. 凹凸棒石黏土口服制剂治疗消化道黏膜病变临床观察[J].海军医学杂志,2002,23 (1):24-26.
[7] 高新菊. 载铬凹凸棒粘土的制备及对小鼠细菌性腹泻的防治效果研究[D].南京:南京农业大学,2014.
[8] 郭志廷,梁剑平,韦旭斌,等. 常山提取物对人工感染鸡柔嫩艾美耳球虫病疗效的观察[J].中国兽医学报,2013,33(7):1093-1085.
[9] 李娜,姚大伟,许家荣,等. 载铜凹土棒石黏土对鸡白痢的预防和治疗效果[J].中国兽医学报,2017,37(7):1365-1371.
[10] 夏枚生,许梓荣,胡彩虹,等. 改性坡缕石对肉鸭日粮中黄曲霉毒素B1的去毒作用及机理[J].畜牧兽医学报,2005,36(1):21-27.
[11] 韩立秋. 载铜载铬凹凸棒黏土在犬细小病毒病治疗上的应用研究[D].南京:南京农业大学,2015.
[12] Yao D,Yu Z,Li N et al. Copper-modified palygorskite is effective in preventing and treating diarrhea caused by S. typhimurium[J].J Zhejiang Univ Sci B,2017,18(6):474-480.
[13] 罗有文,王龙昌,郭芳,等. 载Zn2+凹土棒石黏土对肉鸡生长、免疫和血液生化指标的影响[J].中国粮油学报,2008,23(3):131-135.
[2] 蔡建平. 鸡球虫病和坏死性肠炎的流行病学与防治技术[J].兽医导刊,2012,11:26-30.
[3] 王黎霞,张永红,曹授俊,等. 柔嫩艾美耳球虫田间分离株药物耐药性调查[J].中国兽医杂志,2014,50(2):17-19.
[4] More J, Fioramonti J,Bueno L. Changes in gastrointestinal mucins due to attapulgite-an experimental-study in the rat[J].Gastroenterol Clinique Et Biologique,1992,16(12):988-993.
[5] 丁阳,姚大伟,李娜,等. 载铜凹土棒石黏土膏剂对沙门氏菌体外抑菌效果的观察[J].畜牧与兽医,2015,47(9):104-106.
[6] 王唯坚,肖正达,谢宇野,等. 凹凸棒石黏土口服制剂治疗消化道黏膜病变临床观察[J].海军医学杂志,2002,23 (1):24-26.
[7] 高新菊. 载铬凹凸棒粘土的制备及对小鼠细菌性腹泻的防治效果研究[D].南京:南京农业大学,2014.
[8] 郭志廷,梁剑平,韦旭斌,等. 常山提取物对人工感染鸡柔嫩艾美耳球虫病疗效的观察[J].中国兽医学报,2013,33(7):1093-1085.
[9] 李娜,姚大伟,许家荣,等. 载铜凹土棒石黏土对鸡白痢的预防和治疗效果[J].中国兽医学报,2017,37(7):1365-1371.
[10] 夏枚生,许梓荣,胡彩虹,等. 改性坡缕石对肉鸭日粮中黄曲霉毒素B1的去毒作用及机理[J].畜牧兽医学报,2005,36(1):21-27.
[11] 韩立秋. 载铜载铬凹凸棒黏土在犬细小病毒病治疗上的应用研究[D].南京:南京农业大学,2015.
[12] Yao D,Yu Z,Li N et al. Copper-modified palygorskite is effective in preventing and treating diarrhea caused by S. typhimurium[J].J Zhejiang Univ Sci B,2017,18(6):474-480.
[13] 罗有文,王龙昌,郭芳,等. 载Zn2+凹土棒石黏土对肉鸡生长、免疫和血液生化指标的影响[J].中国粮油学报,2008,23(3):131-135.