心理韧性的神经机制研究进展
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摘要
心理韧性对于提高心理健康状况、预防心理疾病有重大研究价值。现有基于神经影像学的心理韧性神经机制研究主要针对经历严重压力或逆境后仍适应良好的现象展开,研究结果主要体现在3方面:第一,大脑结构,如顶叶、前额叶皮质、前扣带回、岛叶等的相关功能;第二,神经回路,如奖赏、恐惧、情绪调节、社会行为回路等的相关功能和机制研究;第三,脑神经网络,涉及网络去相关活动以及跨网络连接的韧性相关机制。未来可进一步研究不同神经机制间的交互、各自与韧性相关维度(如自我效能、乐观、坚韧)的对应关系、以及相关干预方法对其神经机制的影响。
引文
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[30]Brunetti M,Marzetti L,Sepede G,et al. Resilience and cross-network connectivity:A neural model for post-trauma survival[J].Prog Neuro-Psychoph,2017,77:110-119. DOI:10. 1016/j.pnpbp. 2017. 04. 010.
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[2] Wu G,Feder A,Cohen H,et al. Understanding resilience[J].Front Behav Neurosci,2013,7:10. DOI:10. 3389/fnbeh. 2013.00010.
[3]Gupta A,Love A,Kilpatrick LA,et al. Morphological brain measures of cortico-limbic inhibition related to resilience[J]. J Neurosci Res,2017,95(9):1760. DOI:10. 1002/jnr. 24007.
[4]Werff SJAVD,Berg SMVD,Pannekoek JN,et al. Neuroimaging resilience to stress:a review[J]. Front Behav Neurosci,2013,7:39. DOI:10. 3389/fnbeh. 2013. 00039.
[5]Patel R,Spreng RN,Shin LM,et al. Neurocircuitry models of posttraumatic stress disorder and beyond:a meta-analysis of functional neuroimaging studies[J]. Neurosci Biobehav R,2012,36(9):2130-2142. DOI:10. 1016/j. neubiorev. 2012. 06. 003.
[6]胡婷,刘伟志.创伤后应激障碍的认知异常及神经机制[J].解放军医学杂志,2017,42(9):826-832. DOI:10. 11855/j.issn. 0557-7402. 2017. 09. 14.
[7]Dickie EW,Brunet A,Akerib V,et al. Neural correlates of recovery from post-traumatic stress disorder:a longitudinal f MRI investigation of memory encoding[J]. Neuropsychologia,2011,49(7):1771-1778. DOI:10. 1016/j. neuropsychologia. 2011. 02. 055.
[8]Qi S,Mu Y,Liu K,et al. Cortical inhibition deficits in recent onset PTSD after a single prolonged trauma exposure[J]. NeuroImageClin,2013,3:226-233. DOI:10. 1016/j. nicl. 2013. 08. 013.
[9]Kim MJ,Loucks RA,Palmer AL,et al. The structural and functional connectivity of the amygdala:from normal emotion to pathological anxiety[J]. Behav Brain Res,2011,223(2):403-410. DOI:10. 1016/j. bbr. 2011. 04. 025.
[10]Chan SWY,Harmer CJ,Norbury R,et al. Hippocampal volume in vulnerability and resilience to depression[J]. J Affect Disorders,2016,189:199-202. DOI:10. 1016/j. jad. 2015. 09. 021.
[11]Rubin M,Shvil E,Papini S,et al. Greater hippocampal volume is associated with ptsd treatment response[J]. Psychiat Res-Neuroim,2016,252(1):36-39. DOI:10. 1016/j. pscychresns.2016. 05. 001.
[12] Veer IM,Oei NYL,Buchem MAV,et al. Evidence for smaller right amygdala volumes in posttraumatic stress disorder following childhood trauma[J]. Psychiat Res-Neuroim,2015,233(3):436-442. DOI:10. 1016/j. pscychresns. 2015. 07. 016.
[13]Daniels JK,Hegadoren KM,Coupland NJ,et al. Neural correlates and predictive power of trait resilience in an acutely traumatized sample:a pilot investigation[J]. J Clin Psychiat,2012,73(3):327-332. DOI:10. 4088/JCP. 10m06293.
[14]Ke J,Zhang L,Qi R,et al. A longitudinal f MRI investigation in acute post-traumatic stress disorder(PTSD)[J]. Acta Radiol,2016,57(11):1387. DOI:10. 1177/0284185115585848.
[15]Waugh CE,Wager TD,Fredrickson BL,et al. The neural correlates of trait resilience when anticipating and recovering from threat[J]. Soc Cogn Affect Neur,2008,3(4):322-332. DOI:10.1093/scan/nsn024.
[16]Vythilingam M,Nelson EE,Scaramozza M,et al. Reward circuitry in resilience to severe trauma:an fmri investigation of resilient special forces soldiers[J]. Psychiat Res Neuroim,2009,172(1):75-77. DOI:10. 1016/j. pscychresns. 2008. 06. 008.
[17]Franklin TB,Saab BJ,&Mansuy IM. Neural mechanisms of stress resilience and vulnerability[J]. Neuron,2012,75(5):747-761. DOI:10. 1016/j. neuron. 2012. 08. 016.
[18]Charney DS. Psychobiological mechanisms of resilience and vulnerability:implications for successful adaptation to extreme stress[J].Am J Psychiat,2004,161(2):195-216.
[19]靳长风.汶川地震后慢性创伤后应激障碍神经通路脑影像研究[D].中南大学,2014.
[20]Blair KS,Vythilingam M,Crowe SL,et al. Cognitive control of attention is differentially affected in trauma-exposed individuals with and without post-traumatic stress disorder[J]. Psychol Med,2013,43(1):85-95. DOI:10. 1017/S0033291712000840.
[21]Wager TD,Davidson ML,Hughes BL,et al. Prefrontal-subcortical pathways mediating successful emotion regulation[J]. Neuron,2008,59(6):1037-1050. DOI:10. 1016/j. neuron. 2008. 09.006.
[22]张静雅,顾晨龙,刘铁榜.双相障碍患者情绪调节研究(综述)[J].中国心理卫生杂志,2017,31(11):840-844. DOI:10.3969/j. issn. 1000-6729. 2017. 11. 002.
[23]Morishima Y,Schunk D,Bruhin A,et al. Linking brain structure and activation in temporoparietal junction to explain the neurobiology of human altruism[J]. Neuron,2012,75(1):73. DOI:10.1016/j. neuron. 2012. 05. 021.
[24]Hein G,Morishima Y,Leiberg S,et al. The brain’s functional network architecture reveals human motives[J]. Science,2016,351(6277):1074. DOI:10. 1126/science. aac7992.
[25]Lemmers-Jansen ILJ,Krabbendam L,Amodio DM,et al. Giving others the option of choice:an f MRI study on low-cost cooperation[J]. Neuropsychologia,2018,109(1):1-9. DOI:10. 1016/j.neuropsychologia. 2017. 12. 009.
[26]James LM,Engdahl BE,Leuthold AC,et al. Neural network modulation by trauma as a marker of resilience:differences between veterans with posttraumatic stress disorder and resilient controls[J].Jama Psychiat,2013,70(4):410. DOI:10. 1001/jamapsychiatry. 2013. 878.
[27]Fox MD,Snyder AZ,Vincent JL,et al. The human brain is intrinsically organized into dynamic,anticorrelated functional networks[J]. P Natl Acad Sci USA,2005,102(27):9673-9678. DOI:10. 1073/pnas. 0504136102.
[28]Reuveni I,Bonne O,Giesser R,et al. Anatomical and functional connectivity in the default mode network of post-traumatic stress disorder patients after civilian and military-related trauma[J]. Hum Brain Mapp,2016,37(2):589-599. DOI:10. 1002/hbm.23051.
[29]张又雪.基于静息态功能磁共振成像的创伤后应激障碍脑连接研究[D].电子科技大学,2017.
[30]Brunetti M,Marzetti L,Sepede G,et al. Resilience and cross-network connectivity:A neural model for post-trauma survival[J].Prog Neuro-Psychoph,2017,77:110-119. DOI:10. 1016/j.pnpbp. 2017. 04. 010.
[31]Shao R,Lau WKW,Leung MK,et al. Subgenual anterior cingulate-insula resting-state connectivity as a neural correlate to trait and state stress resilience[J]. Brain Cogn,2018,124:73-81.DOI:10. 1016/j. bandc. 2018. 05. 001.
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