点舌丸联合丹参酮胶囊治疗肺经风热型痤疮疗效观察
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摘要
目的:观察分析点舌丸联合丹参酮胶囊治疗肺经风热型痤疮的临床疗效。方法:选取2015年6月—2017年6月期间于本院就诊的120例肺经风热型痤疮患者作为研究对象,应用随机数表法分为对照组和观察组,各60例。对照组患者应用丹参酮胶囊口服联合维A酸乳膏局部治疗,观察组患者在此基础上联合应用点舌丸口服治疗。评估两组临床疗效及药物安全性,并观察两组患者皮肤状态改善情况及治疗后复发情况。结果:治疗后,观察组治疗总有效率93. 33%(56/60)高于对照组的75. 00%(45/60),差异有统计学意义(P <0. 05);治疗期间观察组不良反应发生率15. 00%(9/60)与对照组13. 33%(8/60)相比,差异无统计学意义(P> 0. 05);治疗前,两组患者脸部皮肤p H、油脂程度、皮肤水分含量对比,差异无统计学意义(P> 0. 05);治疗后,观察组患者脸部皮肤p H、油脂程度低于对照组,皮肤水分含量高于对照组,差异有统计学意义(P <0. 05);治疗后8周及16周后,观察组痤疮复发率[3. 33%(2/60),8. 33%(5/60)]均低于对照组的[13. 33%(8/60),23. 33%(14/60)],差异有统计学意义(P <0. 05)。结论:联合应用点舌丸与丹参酮胶囊治疗肺经风热型痤疮疗效显著,安全性高,可有效改善患者皮肤状态,降低痤疮复发几率,预后良好。
Objective: To observe and analyze the clinical efficacy of Dianshe Pills combined with Danshentong Capsule in the treatment of pulmonary heat-acne type acne. Methods: Totally 120 cases of patients with rheumatic fever and acne vulgaris treated in our hospital from June 2015 to June 2017 were selected as subjects and divided into control group and observation group with60 cases in each group. The patients in the control group were treated with Danshentong Capsules and Vitamin A acid cream,and the patients in the observation group were treated with Dianshe Pills for treatment on the basis of the control group. The clinical efficacy and drug safety of the two groups were evaluated. The improvement of skin condition and relapse after treatment were observed in both groups. Results: The total effective rate of the observation group was 93. 33%( 56/60),higher than that of the control group( 75. 00%,45/60) and the difference was statistically significant( P < 0. 05). The incidence of adverse reactions in the observation group during the treatment period was 15. 00%( 9/60) and that was 13. 33%( 8/60) in the control group. There was no significant difference( P > 0. 05). Before treatment,there was no significant difference between the two groups in facial skin p H,oil level or skin moisture content( P > 0. 05). After treatment,the facial skin p H and the degree of oil in the observation group were lower than those in the control group,and the skin moisture content was higher than that in the control group( P <0. 05). The rates of recurrence of acne in the observation group were significantly lower than those in the control group[13. 33%( 8/60),23. 33%( 14/60) ]after 8 and 16 weeks of treatment[3. 33%( 2/60),8. 33%]. The difference was statistically significant( P < 0. 05). Conclusion: The combination of Dianshe Pills and Danshentong Capsules for the treatment of lung heat type acne is significantly effective and safe,and can effectively improve the patients' skin condition and reduce the incidence of acne recurrence. The prognosis is good.
Objective: To observe and analyze the clinical efficacy of Dianshe Pills combined with Danshentong Capsule in the treatment of pulmonary heat-acne type acne. Methods: Totally 120 cases of patients with rheumatic fever and acne vulgaris treated in our hospital from June 2015 to June 2017 were selected as subjects and divided into control group and observation group with60 cases in each group. The patients in the control group were treated with Danshentong Capsules and Vitamin A acid cream,and the patients in the observation group were treated with Dianshe Pills for treatment on the basis of the control group. The clinical efficacy and drug safety of the two groups were evaluated. The improvement of skin condition and relapse after treatment were observed in both groups. Results: The total effective rate of the observation group was 93. 33%( 56/60),higher than that of the control group( 75. 00%,45/60) and the difference was statistically significant( P < 0. 05). The incidence of adverse reactions in the observation group during the treatment period was 15. 00%( 9/60) and that was 13. 33%( 8/60) in the control group. There was no significant difference( P > 0. 05). Before treatment,there was no significant difference between the two groups in facial skin p H,oil level or skin moisture content( P > 0. 05). After treatment,the facial skin p H and the degree of oil in the observation group were lower than those in the control group,and the skin moisture content was higher than that in the control group( P <0. 05). The rates of recurrence of acne in the observation group were significantly lower than those in the control group[13. 33%( 8/60),23. 33%( 14/60) ]after 8 and 16 weeks of treatment[3. 33%( 2/60),8. 33%]. The difference was statistically significant( P < 0. 05). Conclusion: The combination of Dianshe Pills and Danshentong Capsules for the treatment of lung heat type acne is significantly effective and safe,and can effectively improve the patients' skin condition and reduce the incidence of acne recurrence. The prognosis is good.
引文
[1]陈文慧,刘乐,曹煜.黄地养阴颗粒联合米诺环素胶囊治疗中重度痤疮[J].贵州医科大学学报,2016,41(1):118-120.
[2] Baran U,Wang Ruikang K,Kalkan G,et al. High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography[J]. Lasers Surg Med,2015,47(3):231-238.
[3]钱夏琪,何克林,马睿杰.刺络拔罐联合中药对肺经风热型痤疮疗效观察[J].上海针灸杂志,2017,36(5):594-597.
[4]燕群,董心亚.异维A酸胶囊联合丹参酮胶囊治疗中重度痤疮的疗效观察[J].中华疾病控制杂志,2016,20(7):752-754.
[5]郑莜萸.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:349-354.
[6]卢静,刘秀敏,韩晓东,等.清热除湿解毒方治疗寻常痤疮肠胃湿热证的临床研究[J].南京中医药大学学报,2017,33(2):125-128.
[7]陈小艳.丹参酮联合盐酸伐昔洛韦片治疗带状疱疹神经痛的临床观察[J].湖南师范大学学报(医学版),2016,13(1):128-130.
[8]马亚峰,袁超,杨丽洁,等.轻中度痤疮中医体质类型与皮肤屏障相关性研究[J].中国麻风皮肤病杂志,2017,33(4):239-240,256.
[9]赵婧,严霞.红蓝光联合中药丹参酮治疗中重度寻常痤疮的疗效及对外周血IL-8和TNF-α表达的影响[J].现代中西医结合杂志,2015,24(15):1603-1605.
[10]李宗超,叶伟.枇杷清肺饮治疗肺胃蕴热型皮肤病的临床研究[J].世界中医药,2015,10(12):1894-1896.
[11]李劲然,王连有,王震,等.红蓝光照射联合西黄胶囊治疗面部中重度痤疮疗效及安全性评价[J].吉林大学学报(医学版),2016,42(4):803-806.
[12]卢富琼,余珍,杨帆.中药倒模联合红蓝光照射治疗面部痤疮临床观察及护理[J].广州医科大学学报,2016,44(3):121-123.
[13]庞利涛.红蓝光照射联合西黄胶囊治疗面部中重度寻常痤疮的疗效观察[J].医药论坛杂志,2017,38(1):23-26.
[14]朱珂,齐庆,李东海,等.枇杷清肺饮加减联合红蓝光照射治疗中、重度寻常性痤疮疗效观察及安全性评价[J].中国美容医学,2017,26(2):114-117.
[15]朱金鸽,徐立华,候严珂.红蓝光结合中西医联合治疗痤疮的临床疗效观察[J].中国临床研究,2014,6(11):85-86.
[16]余佳林,刘军,黄闰娣.红蓝光照射联合清热暗疮胶囊口服及夫西地酸乳膏外用治疗寻常痤疮疗效观察[J].中国实用医药,2017,12(16):140-141.
[17]李毅明,温志娟.清痤散面膜联合维胺酯胶囊治疗面部中重度痤疮疗效评价[J].中国麻风皮肤病杂志,2016,32(2):122,126.
[18]彭安厚,陆洪光,梁巍.复方甘草酸苷片联合多西环素胶囊、0. 025%维A酸乳膏治疗中重度痤疮的临床观察[J].中华皮肤科杂志,2014,47(11):828-829.
[19]李天举,丁治云,黄玉成.丹参酮胶囊联合异维A酸红霉素凝胶治疗轻、中度寻常型痤疮疗效观察[J].中国中西医结合皮肤性病学杂志,2017,16(2):140-141.
[20]施健健,陶茂灿.五味消毒饮合枇杷清肺饮治疗肺经风热型痤疮120例临床观察[J].浙江中医药大学学报,2015,39(5):355-357.
[2] Baran U,Wang Ruikang K,Kalkan G,et al. High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography[J]. Lasers Surg Med,2015,47(3):231-238.
[3]钱夏琪,何克林,马睿杰.刺络拔罐联合中药对肺经风热型痤疮疗效观察[J].上海针灸杂志,2017,36(5):594-597.
[4]燕群,董心亚.异维A酸胶囊联合丹参酮胶囊治疗中重度痤疮的疗效观察[J].中华疾病控制杂志,2016,20(7):752-754.
[5]郑莜萸.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:349-354.
[6]卢静,刘秀敏,韩晓东,等.清热除湿解毒方治疗寻常痤疮肠胃湿热证的临床研究[J].南京中医药大学学报,2017,33(2):125-128.
[7]陈小艳.丹参酮联合盐酸伐昔洛韦片治疗带状疱疹神经痛的临床观察[J].湖南师范大学学报(医学版),2016,13(1):128-130.
[8]马亚峰,袁超,杨丽洁,等.轻中度痤疮中医体质类型与皮肤屏障相关性研究[J].中国麻风皮肤病杂志,2017,33(4):239-240,256.
[9]赵婧,严霞.红蓝光联合中药丹参酮治疗中重度寻常痤疮的疗效及对外周血IL-8和TNF-α表达的影响[J].现代中西医结合杂志,2015,24(15):1603-1605.
[10]李宗超,叶伟.枇杷清肺饮治疗肺胃蕴热型皮肤病的临床研究[J].世界中医药,2015,10(12):1894-1896.
[11]李劲然,王连有,王震,等.红蓝光照射联合西黄胶囊治疗面部中重度痤疮疗效及安全性评价[J].吉林大学学报(医学版),2016,42(4):803-806.
[12]卢富琼,余珍,杨帆.中药倒模联合红蓝光照射治疗面部痤疮临床观察及护理[J].广州医科大学学报,2016,44(3):121-123.
[13]庞利涛.红蓝光照射联合西黄胶囊治疗面部中重度寻常痤疮的疗效观察[J].医药论坛杂志,2017,38(1):23-26.
[14]朱珂,齐庆,李东海,等.枇杷清肺饮加减联合红蓝光照射治疗中、重度寻常性痤疮疗效观察及安全性评价[J].中国美容医学,2017,26(2):114-117.
[15]朱金鸽,徐立华,候严珂.红蓝光结合中西医联合治疗痤疮的临床疗效观察[J].中国临床研究,2014,6(11):85-86.
[16]余佳林,刘军,黄闰娣.红蓝光照射联合清热暗疮胶囊口服及夫西地酸乳膏外用治疗寻常痤疮疗效观察[J].中国实用医药,2017,12(16):140-141.
[17]李毅明,温志娟.清痤散面膜联合维胺酯胶囊治疗面部中重度痤疮疗效评价[J].中国麻风皮肤病杂志,2016,32(2):122,126.
[18]彭安厚,陆洪光,梁巍.复方甘草酸苷片联合多西环素胶囊、0. 025%维A酸乳膏治疗中重度痤疮的临床观察[J].中华皮肤科杂志,2014,47(11):828-829.
[19]李天举,丁治云,黄玉成.丹参酮胶囊联合异维A酸红霉素凝胶治疗轻、中度寻常型痤疮疗效观察[J].中国中西医结合皮肤性病学杂志,2017,16(2):140-141.
[20]施健健,陶茂灿.五味消毒饮合枇杷清肺饮治疗肺经风热型痤疮120例临床观察[J].浙江中医药大学学报,2015,39(5):355-357.