强迫症患者大脑皮层形态与前瞻记忆的关系
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摘要
目的:分析强迫症(obsessive-compulsive disorder, OCD)患者是否存大脑皮层形态异常,及其与前瞻记忆的关系。方法:36名强迫症患者和26名对照组被试分别完成了大脑结构磁共振扫描及评估前瞻记忆等变量的系列评估量表。比较强迫症组和对照组皮层厚度与灰质体积差异,并分别计算两组大脑皮层形态与前瞻记忆的相关。结果:OCD组左脑楔前叶等脑区皮层厚度及右脑扣带回后部等脑区灰质体积显著低于对照组。对照组前瞻记忆分量表得分与右脑中颞叶等脑区灰质体积和左脑扣带回后部等脑区皮层厚度呈显著负相关。OCD组前瞻记忆分量表得分与上额叶等脑区灰质体积呈显著正相关。结论:与对照组相比,OCD组大部分皮质表现出衰退。正常人群某些脑区皮质衰退与较差的前瞻记忆有关,而OCD组不同脑区的皮层形态与前瞻记忆的关系异于对照组。
Objective: This study explored the gray matter abnormality in patients with obsessive-compulsive disorder(OCD), and the relationship between abnormal gray matter structure and prospective memory. Methods: A total of 36 OCD patients and 26 healthy controls(HC) completed brain magnetic resonance imaging and a series of psychological scales.Gray matter volumes(GMVs) in cortex and cortical thickness were optional indices. The cortex structure differences between OCD and controls were analyzed, and the cortex-prospective memory relations were also calculated. Results: The OCD group showed thinner cortical thickness in left precuneus, paracentral, and some other regions, and smaller GMVs in left precuneus, right posteriorcingulate, and some other regions compared with HC. Prospective memory score in controls was negatively correlated with GMVs in left inferiorparietal, inferiortemporal, lateraloccipital, and right middletemporal, superiorparietal, superiortempral and cortical thickness in left posteriorcingulate(P<0.05, corrected). Prospective memory score of OCD group was positively correlated with GMVs in left superiorfrontal, postcentral and right posteriorcingulate(P<0.05,corrected). Conclusion: The morphology of gray matter in OCD patients was in recession compared with HC. In controls,cortical deterioration in some brain regions was associated with poor prospective memory. While in OCD group, some brain regions had more complicated relationships with prospective memory compared with controls.
Objective: This study explored the gray matter abnormality in patients with obsessive-compulsive disorder(OCD), and the relationship between abnormal gray matter structure and prospective memory. Methods: A total of 36 OCD patients and 26 healthy controls(HC) completed brain magnetic resonance imaging and a series of psychological scales.Gray matter volumes(GMVs) in cortex and cortical thickness were optional indices. The cortex structure differences between OCD and controls were analyzed, and the cortex-prospective memory relations were also calculated. Results: The OCD group showed thinner cortical thickness in left precuneus, paracentral, and some other regions, and smaller GMVs in left precuneus, right posteriorcingulate, and some other regions compared with HC. Prospective memory score in controls was negatively correlated with GMVs in left inferiorparietal, inferiortemporal, lateraloccipital, and right middletemporal, superiorparietal, superiortempral and cortical thickness in left posteriorcingulate(P<0.05, corrected). Prospective memory score of OCD group was positively correlated with GMVs in left superiorfrontal, postcentral and right posteriorcingulate(P<0.05,corrected). Conclusion: The morphology of gray matter in OCD patients was in recession compared with HC. In controls,cortical deterioration in some brain regions was associated with poor prospective memory. While in OCD group, some brain regions had more complicated relationships with prospective memory compared with controls.
引文
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4 Gilbert AR.Gray matter differences between pediatric obsessive-compulsive disorder patients and high-risk siblings:A preliminary voxel-based morphometry study.Neuroscience Letters,2008,435(1):45-50
5 Kim JJ,Lee MC,Kim J,et al.Grey matter abnormalities in obsessive-compulsive disorder-statistical parametric mapping of segmented magnetic resonance images.British Journal of Psychiatry the Journal of Mental Science,2001,179:330-334
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8 Szeszko PR.Brain structural abnormalities in psychotropic drugnaive pediatric patients with obsessive-compulsive disorder.American Journal of Psychiatry,2004,161(6):1049-1056
9 Pujol J.Mapping structural brain alterations in obsessivecompulsive disorder.Archives of General Psychiatry,2004,61(7):720-730
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11 Yang Tianxiao,Peng Ziwen,Wang Ya,et al.The nature of prospective memory deficit in patients with obsessivecompulsive disorder.Psychiatry Research,2015,230(2):479-486
12 Jelinek L,Moritz S,Heeren D,et al.Everyday memory functioning in obsessive-compulsive disorder.Journal of the International Neuropsychological Society,2006,12(5):46-749
13 Harris L,Vaccaro L,Jones MK,et al.Evidence of impaired eventbased prospective memory in clinical obsessivecompulsive checking.Behavior Change,2010,27(2):84-92
14 Racsmany M,Demeter G,Csigo K,et al.An experimental study of prospective memory in obsessive-compulsive disorder.Journal of Clinical and Experimental Neuropsychology,2011,33(1):85-91
15 John R,Crawford.The Prospective and Retrospective Memory Questionnaire(PRMQ):Latent Structure,Normative Data and Discrepancy Analysis for Proxy-ratings.British Journal of Clinical Psychology,2006,45:83-104
16 Osman A,Downs WR,Barrios FX,et al.Factor structure and psychometric characteristics of the Beck Depression Inventory-II.Journal of Psychopathology&Behavioral Assessment,1997,19(4):359-376
17 Spielberger C.STAI manual for the State-trait anxiety inventory.Self-Evaluation Questionnaire,1983,iv:1-24
18 Zhang Xinhua,Liu Jie,Cui Jiajia,et al.Study of symptom dimensions and clinical characteristics in Chinese patients with OCD.Journal of Affective Disorders,2013,151(3):868-874
19 Inchausti F,Delgado AR,Prieto G.Obsessive-compulsive disorder and its relationship with disgust vulnerability and conscientiousness.Psicothema,2015,27(3):254-260
20 Weidt S,Lutz J,Rufer M,et al.Common and differential alterations of general emotion processing in obsessivecompulsive and social anxiety disorder.Psychological Medicine,2016,46(7):1427-1436
21 Hauser TU,Iannaccone R,Dolan RJ,et al.Increased frontostriatal reward prediction errors moderate decision making in obsessive-compulsive disorder.Psychological Medicine,2017,9:1-13
22 Vandborg SK,Hartmann TB,Bennedsen BE,et al.Memory and executive functions in patients with obsessive-compulsive disorder.Cognitive and Behavioral Neurology,2014,27(1):8-16
23 Deschamps I,Baum SR,Gracco VL.On the role of the supramarginal gyrus in phonological processing and verbal working memory:Evidence from rTMS studies.Neuropsychologia,2014,53:39-46
24 Radomsky AS,Rachman S.Memory bias in obsessivecompulsive disorder(OCD).Behaviour Research and Therapy,1999,37(7):605-618
2 V Evans DW,MD Lewis,E Iobst.The role of the orbitofrontal cortex in normally developing compulsive-like behaviors and obsessive-compulsive disorder.Brain and Cognition,2004,55(1):220-234
3 Fan Jie,Zhong Mingtian,Zhu Xiongzhao,et al.Restingstate functional connectivity between right anterior insula and right orbital frontal cortex correlate with insight level in obsessive-compulsive disorder.Neuroimage Clinical,2017,15(C):1-7
4 Gilbert AR.Gray matter differences between pediatric obsessive-compulsive disorder patients and high-risk siblings:A preliminary voxel-based morphometry study.Neuroscience Letters,2008,435(1):45-50
5 Kim JJ,Lee MC,Kim J,et al.Grey matter abnormalities in obsessive-compulsive disorder-statistical parametric mapping of segmented magnetic resonance images.British Journal of Psychiatry the Journal of Mental Science,2001,179:330-334
6 Togao O.Regional gray and white matter volume abnormalities in obsessive-compulsive disorder:A voxel-based morphometry study.Psychiatry Research,2010,184(1):29-37
7 Atmaca M.Volumetric MRI study of key brain regions implicated in obsessive-compulsive disorder.Prog Neuropsychopharmacol Biol Psychiatry,2007,31(1):46-52
8 Szeszko PR.Brain structural abnormalities in psychotropic drugnaive pediatric patients with obsessive-compulsive disorder.American Journal of Psychiatry,2004,161(6):1049-1056
9 Pujol J.Mapping structural brain alterations in obsessivecompulsive disorder.Archives of General Psychiatry,2004,61(7):720-730
10 Shin YW,Yoo SY,Lee JK,et al.Cortical thinning in obsessive compulsive disorder.Human Brain Mapping,2007,28(11):1128-1135
11 Yang Tianxiao,Peng Ziwen,Wang Ya,et al.The nature of prospective memory deficit in patients with obsessivecompulsive disorder.Psychiatry Research,2015,230(2):479-486
12 Jelinek L,Moritz S,Heeren D,et al.Everyday memory functioning in obsessive-compulsive disorder.Journal of the International Neuropsychological Society,2006,12(5):46-749
13 Harris L,Vaccaro L,Jones MK,et al.Evidence of impaired eventbased prospective memory in clinical obsessivecompulsive checking.Behavior Change,2010,27(2):84-92
14 Racsmany M,Demeter G,Csigo K,et al.An experimental study of prospective memory in obsessive-compulsive disorder.Journal of Clinical and Experimental Neuropsychology,2011,33(1):85-91
15 John R,Crawford.The Prospective and Retrospective Memory Questionnaire(PRMQ):Latent Structure,Normative Data and Discrepancy Analysis for Proxy-ratings.British Journal of Clinical Psychology,2006,45:83-104
16 Osman A,Downs WR,Barrios FX,et al.Factor structure and psychometric characteristics of the Beck Depression Inventory-II.Journal of Psychopathology&Behavioral Assessment,1997,19(4):359-376
17 Spielberger C.STAI manual for the State-trait anxiety inventory.Self-Evaluation Questionnaire,1983,iv:1-24
18 Zhang Xinhua,Liu Jie,Cui Jiajia,et al.Study of symptom dimensions and clinical characteristics in Chinese patients with OCD.Journal of Affective Disorders,2013,151(3):868-874
19 Inchausti F,Delgado AR,Prieto G.Obsessive-compulsive disorder and its relationship with disgust vulnerability and conscientiousness.Psicothema,2015,27(3):254-260
20 Weidt S,Lutz J,Rufer M,et al.Common and differential alterations of general emotion processing in obsessivecompulsive and social anxiety disorder.Psychological Medicine,2016,46(7):1427-1436
21 Hauser TU,Iannaccone R,Dolan RJ,et al.Increased frontostriatal reward prediction errors moderate decision making in obsessive-compulsive disorder.Psychological Medicine,2017,9:1-13
22 Vandborg SK,Hartmann TB,Bennedsen BE,et al.Memory and executive functions in patients with obsessive-compulsive disorder.Cognitive and Behavioral Neurology,2014,27(1):8-16
23 Deschamps I,Baum SR,Gracco VL.On the role of the supramarginal gyrus in phonological processing and verbal working memory:Evidence from rTMS studies.Neuropsychologia,2014,53:39-46
24 Radomsky AS,Rachman S.Memory bias in obsessivecompulsive disorder(OCD).Behaviour Research and Therapy,1999,37(7):605-618