两栖动物皮肤生物活性肽研究进展
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摘要
生物活性肽在细胞生理以及机体代谢方面具有重要的调节作用。近些年来,研究者们在两栖动物体的皮肤分泌物中发现大量的生物活性肽。文中在查阅大量的相关文献基础上,对两栖动物皮肤中分泌的生物活性肽的种类、来源、作用机理及相关的生理作用等进行了综述,以期为扩大生物活性肽的研究与应用提供参考。
Bioactive peptides play an important regulatory role in cell physiological and body metabolism. In recent years,researchers have found a large number of bioactive peptides in the skin secretions of amphibians. Based on the large amount of references,this paper reviewed the types,sources,mechanism and related physiological functions of biologically active peptides secreted in the skin of amphibians,so as to provide reference for the expansion of research and application of bioactive peptides.
Bioactive peptides play an important regulatory role in cell physiological and body metabolism. In recent years,researchers have found a large number of bioactive peptides in the skin secretions of amphibians. Based on the large amount of references,this paper reviewed the types,sources,mechanism and related physiological functions of biologically active peptides secreted in the skin of amphibians,so as to provide reference for the expansion of research and application of bioactive peptides.
引文
[1]李维,兰海楠,郭风,等.生物活性肽的研究进展[J].中国畜牧兽医,2012,39(10):105-107.
[2]巢警殳,张岚,杜娟,等.生物活性肽的研究进展[J].吉林医药学院学报,2010,31(6):359-362.
[3]王竹清,李八方.生物活性肽及其研究进展[J].中国海洋药物,2010(2):60-68.
[4]Clarke B T.The natural history of amphibian skin secretions,their normal functioning and potential medical applications[J].Biol Rev Camb Philos Soc,1997,72(3):365-379.
[5]赖仞,李建许.两栖动物皮肤抗感染多肽组学研究[C]∥中国生物毒素学术研讨会论文集.南宁:中国毒理学会生物毒素毒理专业委员会,2007.
[6]Pukala T L,Bowie J H,Maselli V M,et al.Host-defence peptides from the glandular secretions of amphibians:structure and activity[J].Lancet Infectious Diseases,2008,8(8):368-393.
[7]赖仞,粱建国,张云.两栖类皮肤抗菌多肽及其应用[J].动物学研究,2004,25(5):465-468.
[8]陈雯,叶书培,李秋燕,等.两栖类动物抗菌肽对病原微生物作用研究进展[J].广东农业科学,2012,39(16):175-178.
[9]Li J,Xu X,Xu C,et al.Anti-infection Peptidomics of Amphibian Skin[J].Molecular&Cellular Proteomics Mcp,2007,6(5):882.
[10]刘华.虎纹蛙皮肤分泌物活性肽的分离纯化及表征[D].福州:福州大学,2013.
[11]Ali M F,Soto A,Knoop F C,et al.Antimicrobial peptides isolated from skin secretions of the diploid frog,Xenopus tropicalis(Pipidae)[J].Biochimica et Biophysica Acta,2001,1550(1):81.
[12]Lai R,Zheng Y T,Shen J H,et al.Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima[J].Peptides,2002,23(3):427-435.
[13]Brand G D,Leite J R,Silva L P,et al.Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta.AntiTrypanosoma cruzi activity without cytotoxicity to mammalian cells[J].Journal of Biological Chemistry,2002,277(51):49332-49340.
[14]侯国宾.黑斑侧褶蛙皮肤生物活性肽的筛选与性质研究[D].昆明:昆明理工大学,2012.
[15]马瑜,孙燕,李治.两栖类皮肤抗菌肽的分离纯化与抗菌活性检测技术[J].药物生物技术,2010(1):83-86.
[16]赵瑞利.牛蛙(Rana catesbeiana)皮肤活性肽的分子克隆及其生物学活性研究[D].长春:吉林大学,2009.
[17]秦垂新,姚松君,唐青涛,等.抗氧化肽及其化学活性测定方法的研究概述[J].食品工业科技,2014,35(1):394-400.
[18]Yang H,Wang X X,Wu J,et al.Antioxidant peptidomics reveals novel skin antioxidant system[J].Molecular&Cellular Proteomics Mcp,2009,8(3):571.
[19]Liu C,Hong J,Yang H,et al.Frog skins keep redox homeostasis by antioxidant peptides with rapid radical scavenging ability[J].Free Radical Biology&Medicine,2010,48(9):1173.
[20]周涌,张岚,李杰,等.林蛙皮活性肽抗氧化活性研究[J].安徽农业科学,2012,40(14):8080-8082.
[21]官玉红,李仁立.缓激肽与心血管疾病[J].心血管病学进展,2005(增刊):39-42.
[22]Gabra B H,Sirois P.Role of bradykinin B1,receptors in diabetes-induced hyperalgesia in streptozotocin-treated mice[J].European Journal of Pharmacology,2002,457(2/3):115.
[23]Maestri R,Milia A F,Salis M B,et al.Cardiac hypertrophy and microvascular deficit in kinin B2 receptor knockout mice[J].Hypertension,2003,41(5):1151-1155.
[24]Conlon J M.Bradykinin and its receptors in non-mammalian vertebrates[J].Regulatory Peptides,1999,79(2/3):71-81.
[25]Lai R,Liu H,Wen H L,et al.A Novel Bradykinin-Related Peptide from Skin Secretions of Toad Bombina maxima,and Its Precursor Containing Six Identical Copies of the Final Product[J].Biochemical&Biophysical Research Communications,2001,286(2):259-263.
[26]Lee W H,Liu S B,Shen J H,et al.Cloning of bradykinin precursor c DNAs from skin of Bombina maxima,reveals novel bombinakinin M antagonists and a bradykinin potential peptide[J].Regul Pept,2005,127(1/2/3):207-215.
[27]Basir Y J,Knoop F C,Dulka J,et al.Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog,Rana palustris[J].Biochimica Et Biophysica Acta,2000,1543(1):95-105.
[28]Conlon J M,Kolodziejek J,Nowotny N.Antimicrobial peptides from ranid frogs:taxonomic and phylogenetic markers and a potential source of new therapeutic agents.[J].Biochimica Et Biophysica Acta,2004,1696(1):1-14.
[29]李俊峰.中国林蛙皮肤生物活性肽的分离纯化、结构鉴定及生物活性检测[D].沈阳:辽宁师范大学,2009.
[30]冯浩,李宗杰,吕毅,等.棕点湍蛙皮肤分泌液中促胰岛素释放肽的分离纯化、基因克隆及活性分析[J].动物学研究,2009,30(2):165-170.
[31]刘莹莹,陈春燕,李宗杰.云南小狭口蛙促胰岛素释放肽的分离纯化与结构鉴定[J].药物生物技术,2011(2):111-114.
[32]Marenah L,Flatt P R,Orr D F,et al.Brevinin-1 and multiple insulin-releasing peptides in the skin of the frog Rana palustris[J].Journal of Endocrinology,2004,181(2):347-354.
[33]李宗杰,李建许,王梅玉,等.无指盘自蛙皮肤分泌液中促胰岛素释放肽的分离纯化与活性初步研究[J].南京农业大学学报,2008,31(2):144-148.
[34]Abdelwahab Y H,Marenah L,Flatt P R,et al.Insulin releasing properties of the temporin family of antimicrobial peptides[J].Protein&Peptide Letters,2007,14(7):702-707.
[35]Conlon J M,Abdelwahab Y H,Flatt P R,et al.A glycine-leucine-rich peptide structurally related to the plasticins from skin secretions of the frog Leptodactylus laticeps(Leptodactylidae)[J].Peptides,2009,30(5):888-892.
[36]Baroni A,Perfetto B,Canozo N,et al.Bombesin:a possible role in wound repair[J].Peptides,2008,29(7):1157-1166.
[37]Wang L,Zhou M,Lynch L,et al.Kassina senegalensis skin tachykinins:molecular cloning of kassinin and(Thr2,Ile9)-kassinin biosynthetic precursor c DNAs and comparative bioactivity of mature tachykinins on the smooth muscle of rat urinary bladder[J].Biochimie,2009,91(5):613-619.
[38]Li J,Liu T,Xu X,et al.Amphibian tachykinin precursor[J].Biochemical&Biophysical Research Communications,2006,350(4):983-986.
[39]Jackway R J,Pukala T L,Maselli V M,et al.Disulfide-containing peptides from the glandular skin secretions of froglets of the genus Crinia:Structure,activity and evolutionary trends[J].Regulatory Peptides,2008,151(3):80-87.
[40]Wabnitz P A,Bowie J H,Tyler M J,et al.Differences in the skin peptides of the male and female Australian tree frog Litoria splendida.The discovery of the aquatic male sex pheromone splendipherin,together with phe8 caerulein and a new antibiotic peptide caerin 1.10.[J].European Journal of Biochemistry,2000,267(1):269.
[41]Wiedermann C J.Bombesin-like peptides as growth factors[J].Wiener Klinische Wochenschrift,1989,101(13):435-440.
[42]Wiedermann C J,Ruff M R,Pert C B.Bombesin-like peptides:neuropeptides with mitogenic activity[J].Brain Behavior&Immunity,1988,2(4):301.
[43]Wang M,Wang L,Chen T,et al.Identification and molecular cloning of a novel amphibian Bowman Birk-type trypsin inhibitor from the skin of the Hejiang Odorous Frog;Odorrana hejiangensis[J].Peptides,2012,33(2):245-250.
[44]王剑.黑斑蛙皮肤生物活性肽的分离纯化、结构鉴定及生物活性检测[D].沈阳:辽宁师范大学,2011.
[45]Zhou Y,Jiang Y,Wang R,et al.PD-sauvagine:a novel sauvagine/corticotropin releasing factor analogue from the skin secretion of the Mexican giant leaf frog,Pachymedusa dacnicolor[J].Amino Acids,2012,43(3):1147-1156.
[46]Gomes A,Giri B,Saha A,et al.Bioactive molecules from amphibian skin:their biological activities with reference to therapeutic potentials for possible drug development[J].Indian Journal of Experimental Biology,2007,45(7):579-593.
[47]徐兴军,陈丽,吕建伟,等.中国林蛙和中华蟾蜍皮肤抗菌肽的分离纯化及其抗菌活性[J].四川动物,2009,28(2):164-167.
[48]杨红玲,陈志强,刘璇,等.Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor[J].中国天然药物,2016,14(4):294.
[49]徐佳佳.特定细菌胁迫下东北林蛙(Rana dybowskii)皮肤抗菌肽分泌的动态变化[D].哈尔滨:东北林业大学,2010.
[50]王利锋,李学英,王大忠.大鲵皮肤分泌液中抗菌肽的鉴定及生物活性研究[J].中国生化药物杂志,2011,32(4):269-272.
[51]范译文.野生黑斑蛙皮肤抗菌多肽的分离纯化及活性研究[D].长春:吉林农业大学,2012.
[2]巢警殳,张岚,杜娟,等.生物活性肽的研究进展[J].吉林医药学院学报,2010,31(6):359-362.
[3]王竹清,李八方.生物活性肽及其研究进展[J].中国海洋药物,2010(2):60-68.
[4]Clarke B T.The natural history of amphibian skin secretions,their normal functioning and potential medical applications[J].Biol Rev Camb Philos Soc,1997,72(3):365-379.
[5]赖仞,李建许.两栖动物皮肤抗感染多肽组学研究[C]∥中国生物毒素学术研讨会论文集.南宁:中国毒理学会生物毒素毒理专业委员会,2007.
[6]Pukala T L,Bowie J H,Maselli V M,et al.Host-defence peptides from the glandular secretions of amphibians:structure and activity[J].Lancet Infectious Diseases,2008,8(8):368-393.
[7]赖仞,粱建国,张云.两栖类皮肤抗菌多肽及其应用[J].动物学研究,2004,25(5):465-468.
[8]陈雯,叶书培,李秋燕,等.两栖类动物抗菌肽对病原微生物作用研究进展[J].广东农业科学,2012,39(16):175-178.
[9]Li J,Xu X,Xu C,et al.Anti-infection Peptidomics of Amphibian Skin[J].Molecular&Cellular Proteomics Mcp,2007,6(5):882.
[10]刘华.虎纹蛙皮肤分泌物活性肽的分离纯化及表征[D].福州:福州大学,2013.
[11]Ali M F,Soto A,Knoop F C,et al.Antimicrobial peptides isolated from skin secretions of the diploid frog,Xenopus tropicalis(Pipidae)[J].Biochimica et Biophysica Acta,2001,1550(1):81.
[12]Lai R,Zheng Y T,Shen J H,et al.Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima[J].Peptides,2002,23(3):427-435.
[13]Brand G D,Leite J R,Silva L P,et al.Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta.AntiTrypanosoma cruzi activity without cytotoxicity to mammalian cells[J].Journal of Biological Chemistry,2002,277(51):49332-49340.
[14]侯国宾.黑斑侧褶蛙皮肤生物活性肽的筛选与性质研究[D].昆明:昆明理工大学,2012.
[15]马瑜,孙燕,李治.两栖类皮肤抗菌肽的分离纯化与抗菌活性检测技术[J].药物生物技术,2010(1):83-86.
[16]赵瑞利.牛蛙(Rana catesbeiana)皮肤活性肽的分子克隆及其生物学活性研究[D].长春:吉林大学,2009.
[17]秦垂新,姚松君,唐青涛,等.抗氧化肽及其化学活性测定方法的研究概述[J].食品工业科技,2014,35(1):394-400.
[18]Yang H,Wang X X,Wu J,et al.Antioxidant peptidomics reveals novel skin antioxidant system[J].Molecular&Cellular Proteomics Mcp,2009,8(3):571.
[19]Liu C,Hong J,Yang H,et al.Frog skins keep redox homeostasis by antioxidant peptides with rapid radical scavenging ability[J].Free Radical Biology&Medicine,2010,48(9):1173.
[20]周涌,张岚,李杰,等.林蛙皮活性肽抗氧化活性研究[J].安徽农业科学,2012,40(14):8080-8082.
[21]官玉红,李仁立.缓激肽与心血管疾病[J].心血管病学进展,2005(增刊):39-42.
[22]Gabra B H,Sirois P.Role of bradykinin B1,receptors in diabetes-induced hyperalgesia in streptozotocin-treated mice[J].European Journal of Pharmacology,2002,457(2/3):115.
[23]Maestri R,Milia A F,Salis M B,et al.Cardiac hypertrophy and microvascular deficit in kinin B2 receptor knockout mice[J].Hypertension,2003,41(5):1151-1155.
[24]Conlon J M.Bradykinin and its receptors in non-mammalian vertebrates[J].Regulatory Peptides,1999,79(2/3):71-81.
[25]Lai R,Liu H,Wen H L,et al.A Novel Bradykinin-Related Peptide from Skin Secretions of Toad Bombina maxima,and Its Precursor Containing Six Identical Copies of the Final Product[J].Biochemical&Biophysical Research Communications,2001,286(2):259-263.
[26]Lee W H,Liu S B,Shen J H,et al.Cloning of bradykinin precursor c DNAs from skin of Bombina maxima,reveals novel bombinakinin M antagonists and a bradykinin potential peptide[J].Regul Pept,2005,127(1/2/3):207-215.
[27]Basir Y J,Knoop F C,Dulka J,et al.Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog,Rana palustris[J].Biochimica Et Biophysica Acta,2000,1543(1):95-105.
[28]Conlon J M,Kolodziejek J,Nowotny N.Antimicrobial peptides from ranid frogs:taxonomic and phylogenetic markers and a potential source of new therapeutic agents.[J].Biochimica Et Biophysica Acta,2004,1696(1):1-14.
[29]李俊峰.中国林蛙皮肤生物活性肽的分离纯化、结构鉴定及生物活性检测[D].沈阳:辽宁师范大学,2009.
[30]冯浩,李宗杰,吕毅,等.棕点湍蛙皮肤分泌液中促胰岛素释放肽的分离纯化、基因克隆及活性分析[J].动物学研究,2009,30(2):165-170.
[31]刘莹莹,陈春燕,李宗杰.云南小狭口蛙促胰岛素释放肽的分离纯化与结构鉴定[J].药物生物技术,2011(2):111-114.
[32]Marenah L,Flatt P R,Orr D F,et al.Brevinin-1 and multiple insulin-releasing peptides in the skin of the frog Rana palustris[J].Journal of Endocrinology,2004,181(2):347-354.
[33]李宗杰,李建许,王梅玉,等.无指盘自蛙皮肤分泌液中促胰岛素释放肽的分离纯化与活性初步研究[J].南京农业大学学报,2008,31(2):144-148.
[34]Abdelwahab Y H,Marenah L,Flatt P R,et al.Insulin releasing properties of the temporin family of antimicrobial peptides[J].Protein&Peptide Letters,2007,14(7):702-707.
[35]Conlon J M,Abdelwahab Y H,Flatt P R,et al.A glycine-leucine-rich peptide structurally related to the plasticins from skin secretions of the frog Leptodactylus laticeps(Leptodactylidae)[J].Peptides,2009,30(5):888-892.
[36]Baroni A,Perfetto B,Canozo N,et al.Bombesin:a possible role in wound repair[J].Peptides,2008,29(7):1157-1166.
[37]Wang L,Zhou M,Lynch L,et al.Kassina senegalensis skin tachykinins:molecular cloning of kassinin and(Thr2,Ile9)-kassinin biosynthetic precursor c DNAs and comparative bioactivity of mature tachykinins on the smooth muscle of rat urinary bladder[J].Biochimie,2009,91(5):613-619.
[38]Li J,Liu T,Xu X,et al.Amphibian tachykinin precursor[J].Biochemical&Biophysical Research Communications,2006,350(4):983-986.
[39]Jackway R J,Pukala T L,Maselli V M,et al.Disulfide-containing peptides from the glandular skin secretions of froglets of the genus Crinia:Structure,activity and evolutionary trends[J].Regulatory Peptides,2008,151(3):80-87.
[40]Wabnitz P A,Bowie J H,Tyler M J,et al.Differences in the skin peptides of the male and female Australian tree frog Litoria splendida.The discovery of the aquatic male sex pheromone splendipherin,together with phe8 caerulein and a new antibiotic peptide caerin 1.10.[J].European Journal of Biochemistry,2000,267(1):269.
[41]Wiedermann C J.Bombesin-like peptides as growth factors[J].Wiener Klinische Wochenschrift,1989,101(13):435-440.
[42]Wiedermann C J,Ruff M R,Pert C B.Bombesin-like peptides:neuropeptides with mitogenic activity[J].Brain Behavior&Immunity,1988,2(4):301.
[43]Wang M,Wang L,Chen T,et al.Identification and molecular cloning of a novel amphibian Bowman Birk-type trypsin inhibitor from the skin of the Hejiang Odorous Frog;Odorrana hejiangensis[J].Peptides,2012,33(2):245-250.
[44]王剑.黑斑蛙皮肤生物活性肽的分离纯化、结构鉴定及生物活性检测[D].沈阳:辽宁师范大学,2011.
[45]Zhou Y,Jiang Y,Wang R,et al.PD-sauvagine:a novel sauvagine/corticotropin releasing factor analogue from the skin secretion of the Mexican giant leaf frog,Pachymedusa dacnicolor[J].Amino Acids,2012,43(3):1147-1156.
[46]Gomes A,Giri B,Saha A,et al.Bioactive molecules from amphibian skin:their biological activities with reference to therapeutic potentials for possible drug development[J].Indian Journal of Experimental Biology,2007,45(7):579-593.
[47]徐兴军,陈丽,吕建伟,等.中国林蛙和中华蟾蜍皮肤抗菌肽的分离纯化及其抗菌活性[J].四川动物,2009,28(2):164-167.
[48]杨红玲,陈志强,刘璇,等.Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor[J].中国天然药物,2016,14(4):294.
[49]徐佳佳.特定细菌胁迫下东北林蛙(Rana dybowskii)皮肤抗菌肽分泌的动态变化[D].哈尔滨:东北林业大学,2010.
[50]王利锋,李学英,王大忠.大鲵皮肤分泌液中抗菌肽的鉴定及生物活性研究[J].中国生化药物杂志,2011,32(4):269-272.
[51]范译文.野生黑斑蛙皮肤抗菌多肽的分离纯化及活性研究[D].长春:吉林农业大学,2012.