宣肺化痰方标准煎剂与煮散剂药理作用对比
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摘要
目的:对比观察宣肺化痰方标准煎剂及煮散剂的药理作用。方法:大鼠分为8组,分别灌入等体积蒸馏水、急支糖浆、宣肺化痰方标准煎剂高、中、低剂量(含生药46.80,23.40,11.70 g.kg-1)、宣肺化痰方煮散剂高、中、低剂量(含生药23.40,11.70,5.85 g.kg-1),观察对小鼠毛细血管通透性的影响、对氨水致小鼠咳嗽的影响、对磷酸组胺诱发豚鼠哮喘的影响、对小鼠气管酚红排泌的影响、对慢性支气管炎大鼠超氧化物歧化酶(SOD)、丙二醛(MDA)的影响。结果:宣肺化痰方标准煎剂和煮散剂均能显著降低小鼠毛细血管通透性;延长小鼠咳嗽潜伏期和减少咳嗽次数;延长豚鼠引喘潜伏期;增加小鼠气管酚红排泌量;升高慢性支气管炎大鼠血清SOD活性,降低MDA含量。宣肺化痰方标准煎剂和煮散剂比较,两者在同剂量组级别(高、中、低)之间作用无显著性差异。结论:宣肺化痰方标准煎剂和煮散剂均有显著抗炎、止咳、平喘和化痰作用,两者作用无显著性差异。
Objective: To compare the pharmacological effects between the powdered Xuanfei Huatan decoction(PXHD) and the ordinary decoction(OXHD) of the same prescription.Method: A variety of experimental models was used,and rats,mice and guinea pigs were involved in the study.Rats were divided into eight groups.The rats in different groups were given distilled water,JI-ZHI syrup,3 doses of DXHD(46.80,23.40,11.70 g.kg-1) and 3 doses of PXHD(23.40,11.70,5.85 g.kg-1) respectively.The pharmacodynamic comparison between SXHD and OXHD included the follows: ammonia-induced cough in mice,phosphorylation histamine-induced asthma in guinea pigs,tracheal secretion of phenol red in mice,capillary permeability in mice and superoside dismutas(SOD) and malondialdehyde(MDA) in rats with chronic bronchitis.Result: PXHD and OXHD both could prolong the incubation period and reduce the cough frequency in mice;extend the latent period of asthma in guinea pigs;increase the amount of tracheal secretion of phenol red;reduce capillary permeability,and increase SOD and reduce MDA in rat with chronic bronchitis.No significant difference was found between the according level of PXHD and OXHD.Conclusion: Both PXHD and OXHD have the ability of suppressing cough,asthma and phlegm,and the ability of anti-inflammatory and antioxidant.
Objective: To compare the pharmacological effects between the powdered Xuanfei Huatan decoction(PXHD) and the ordinary decoction(OXHD) of the same prescription.Method: A variety of experimental models was used,and rats,mice and guinea pigs were involved in the study.Rats were divided into eight groups.The rats in different groups were given distilled water,JI-ZHI syrup,3 doses of DXHD(46.80,23.40,11.70 g.kg-1) and 3 doses of PXHD(23.40,11.70,5.85 g.kg-1) respectively.The pharmacodynamic comparison between SXHD and OXHD included the follows: ammonia-induced cough in mice,phosphorylation histamine-induced asthma in guinea pigs,tracheal secretion of phenol red in mice,capillary permeability in mice and superoside dismutas(SOD) and malondialdehyde(MDA) in rats with chronic bronchitis.Result: PXHD and OXHD both could prolong the incubation period and reduce the cough frequency in mice;extend the latent period of asthma in guinea pigs;increase the amount of tracheal secretion of phenol red;reduce capillary permeability,and increase SOD and reduce MDA in rat with chronic bronchitis.No significant difference was found between the according level of PXHD and OXHD.Conclusion: Both PXHD and OXHD have the ability of suppressing cough,asthma and phlegm,and the ability of anti-inflammatory and antioxidant.
引文
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[9]田宁,老昌辉,苏文聪,等.理肺止咳汤标准煎剂与煮散剂化学成分对比研究[J].新中医,2013,45(2):144.
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[2]陈奇.中药药理研究方法学[M].北京:人民卫生出版社,2005:636.
[3]Vogel H G,Vogel W H.Drug discovery and evaluation:pharmacological assays[M].Springer-Verlag:BerlinHeidelberg,1997:639.
[4]赵世光,王林.灵芝发酵液酸性醇提物抗慢性支气管炎疗效的研究[J].菌物学报,2009,28(6):832.
[5]程宏.发展“免煎中药饮片”需要解决的几个问题[J].中国药房,2000,11(5):240.
[6]黄礼之,宋民义,孙华山.浅谈中药煮散剂的临床应用[J].陕西中医,2002,23(8):746.
[7]张爱华.甘草与附子配伍煎液中甘草黄酮含量测定[J].中成药,1999,24(4):196.
[8]江泳,冯欣,杨殿兴,等.对中药煮散剂现状的认识与思考[J].四川中医,2010,28(5):69.
[9]田宁,老昌辉,苏文聪,等.理肺止咳汤标准煎剂与煮散剂化学成分对比研究[J].新中医,2013,45(2):144.
[10]黄雪君,老昌辉,杜铁良,等.理肺止咳汤煮散剂药效学实验研究[J].江西中医学院学报,2012,24(4):58.