两种抗真菌药治疗外耳道真菌病的疗效比较
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摘要
目的比较布替萘芬搽剂及酮康唑霜治疗外耳道真菌病的疗效。方法选择2016年1月至2017年8月我院收治的92例外耳道真菌病患者作为研究对象,将其随机分为观察组(42例)和对照组(50例)。观察组患者采用布替萘芬搽剂耳浴治疗,对照组患者采用酮康唑霜涂药治疗。比较两组患者的临床疗效。结果患者有娱乐场所"采耳"史或共用"挖耳匙"等流行病学史者65例(占70.65%,65/92);所有患者具有不同程度的耳痒、耳闷、耳鸣、听力下降、耳道分泌物等不典型症状,部分还伴有脚癣、体癣及甲真菌病(占50.00%,46/92);经治疗后,观察组患者治疗有效率为85.71%(36/42),与对照组治疗有效率为88.00%(44/50)比较,差异无统计学意义(χ~2=0.105,P=0.746)。结论布替萘芬搽剂及酮康唑霜剂这两种不同药物成分及不同剂型的抗真菌药物对外耳道真菌病治疗疗效相当,临床可根据具体情况选择用药。
Objective This study aimed to compare the efficacy of Butenafine Hydrochloride Liniment and ketoconazole cream in the treatment of otomycosis. Methods A total of 92 patients with otomycosis from January 2016 to August 2017 in our hospital were randomly divided into observation group(42 cases) and control group(50 cases).Observation group was treated with butranafine Hydrochloride liniment ear bath.The control group was treated with ketoconazole cream. All patients received therapy with 2 times a day,continuous medication for 14 days,and the efficacy of two groups was compared. Results Among 92 patients, 65(70.65%, 65/92) had the history of "ear-picking" in entertainment places or shared the history of "ear-picking keys". All patients had atypical symptoms such as ear itching, ear tightness, tinnitus, hearing loss, ear canal secretions, and some were accompanied by tinea pedis, tinea corporis and onychomycosis(50.00%, 46/92). After treatment, 31 cases were cured, 5 cases were improved, the effective rate was 85.71%(36/42) in the observation group; 40 cases were cured, 4 cases were improved, the effective rate was 88.00%(44/50) in the control group. There was no significant difference between the two group(χ~2=0.105,P=0.746).Conclusion Butenafine Hydrochloride Liniment and ketoconazole cream with different components and dosage forms are both effective in the treatment of otomycosis, which drug to choose depends on the specific situation in clinic.
Objective This study aimed to compare the efficacy of Butenafine Hydrochloride Liniment and ketoconazole cream in the treatment of otomycosis. Methods A total of 92 patients with otomycosis from January 2016 to August 2017 in our hospital were randomly divided into observation group(42 cases) and control group(50 cases).Observation group was treated with butranafine Hydrochloride liniment ear bath.The control group was treated with ketoconazole cream. All patients received therapy with 2 times a day,continuous medication for 14 days,and the efficacy of two groups was compared. Results Among 92 patients, 65(70.65%, 65/92) had the history of "ear-picking" in entertainment places or shared the history of "ear-picking keys". All patients had atypical symptoms such as ear itching, ear tightness, tinnitus, hearing loss, ear canal secretions, and some were accompanied by tinea pedis, tinea corporis and onychomycosis(50.00%, 46/92). After treatment, 31 cases were cured, 5 cases were improved, the effective rate was 85.71%(36/42) in the observation group; 40 cases were cured, 4 cases were improved, the effective rate was 88.00%(44/50) in the control group. There was no significant difference between the two group(χ~2=0.105,P=0.746).Conclusion Butenafine Hydrochloride Liniment and ketoconazole cream with different components and dosage forms are both effective in the treatment of otomycosis, which drug to choose depends on the specific situation in clinic.
引文
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[6] 王敏.氟康唑联合硝酸咪康唑治疗真菌性外耳道炎的疗效观察[J].广西医科大学学报,2017,34(1):127-129.
[7] 赵青,丁海军.86例外耳道真菌病原菌的分布及诊疗体会[J].武警后勤学院学报(医学版),2009,18(5):452-453.
[8] 李强,江红群.急性外耳道炎的临床诊疗进展[J].临床耳鼻咽喉头颈外科杂志,2016(14):1164-1167.
[2] Amatya R,Khanal B,Mahato P K,et al.Aspergillus species in clinical specimen:a seven year prevalence study from eastern Nepal[J].Nepal Medical College Journal Nmcj,2011,13(3):175-177.
[3] 周梓昭,杨海弟,郑亿庆,等.60例门诊外耳道炎分泌物真菌培养结果和治疗效果分析[J].临床耳鼻咽喉头颈外科杂志,2015(10):899-902.
[4] 韩飞,王启荣,崔新华.曲安奈德益康唑乳膏局部涂布治疗外耳道真菌病的疗效观察[J].中华耳科学杂志,2010,08(3):352-353.
[5] 管骅,慈军,王昌阳,等.外耳道炎患者感染真菌分布与临床治疗分析[J].中华医院感染学杂志,2016,26(8):1837-1839.
[6] 王敏.氟康唑联合硝酸咪康唑治疗真菌性外耳道炎的疗效观察[J].广西医科大学学报,2017,34(1):127-129.
[7] 赵青,丁海军.86例外耳道真菌病原菌的分布及诊疗体会[J].武警后勤学院学报(医学版),2009,18(5):452-453.
[8] 李强,江红群.急性外耳道炎的临床诊疗进展[J].临床耳鼻咽喉头颈外科杂志,2016(14):1164-1167.